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Phencyclidine abuse

MedGen UID:
19234
•Concept ID:
C0031391
•
Mental or Behavioral Dysfunction
Synonyms: Abuse, Angel Dust; Abuse, PCP; Abuse, Phencyclidine; Angel Dust Abuse; PCP Abuse; Phencyclidine Abuse; Phencyclidine Abuses
SNOMED CT: PCP abuse (7071007); Phencyclidine abuse (7071007); Phencyclidine (PCP) abuse (7071007)
 
Monarch Initiative: MONDO:0005912

Definition

The misuse of phencyclidine with associated psychological symptoms and impairment in social or occupational functioning. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPhencyclidine abuse

Professional guidelines

PubMed

Pharmacokinetic strategies for treatment of drug overdose and addiction.
Gorelick DA
Future Med Chem 2012 Feb;4(2):227-43. doi: 10.4155/fmc.11.190. PMID: 22300100Free PMC Article
Dextromethorphan abuse: clinical effects and management.
Romanelli F, Smith KM
J Am Pharm Assoc (2003) 2009 Mar-Apr;49(2):e20-5; quiz e26-7. doi: 10.1331/JAPhA.2009.08091. PMID: 19289333
Immunotherapy for the treatment of drug abuse.
Kosten T, Owens SM
Pharmacol Ther 2005 Oct;108(1):76-85. doi: 10.1016/j.pharmthera.2005.06.009. PMID: 16023218

Recent clinical studies

Therapy

The evolving high: new designer drugs of abuse.
Pourmand A, Armstrong P, Mazer-Amirshahi M, Shokoohi H
Hum Exp Toxicol 2014 Oct;33(10):993-9. Epub 2014 Feb 5 doi: 10.1177/0960327113514100. PMID: 24501103
Therapeutic vaccines for substance dependence.
Haney M, Kosten TR
Expert Rev Vaccines 2004 Feb;3(1):11-8. doi: 10.1586/14760584.3.1.11. PMID: 14761239
Ketamine as a street drug.
Stewart CE
Emerg Med Serv 2001 Nov;30(11):30, 32, 34 passim. PMID: 11759641
PCP and hallucinogens.
Carroll ME
Adv Alcohol Subst Abuse 1990;9(1-2):167-90. doi: 10.1300/J251v09n01_10. PMID: 2198784
Phencyclidine: pharmacologic and clinical review.
Dove HW
Psychiatr Med 1984 Jun;2(2):189-209. PMID: 6400596

Prognosis

Quantitation of Cocaine and Metabolites, Phencyclidine, Butalbital and Phenobarbital in Meconium by Liquid Chromatography-Tandem Mass Spectrometry.
Scroggin TL, McMillin GA
J Anal Toxicol 2018 Apr 1;42(3):177-182. doi: 10.1093/jat/bkx097. PMID: 29244082
Phencyclidine analog use in Sweden--intoxication cases involving 3-MeO-PCP and 4-MeO-PCP from the STRIDA project.
Bäckberg M, Beck O, Helander A
Clin Toxicol (Phila) 2015 Nov;53(9):856-64. Epub 2015 Aug 21 doi: 10.3109/15563650.2015.1079325. PMID: 26295489
Psychiatric intensive care of dementia praecox.
Gaszner G, Bartha A
Neuropsychopharmacol Hung 2013 Jun;15(2):118-21. PMID: 23817362
Phencyclidine and violence: clinical and legal issues.
Brecher M, Wang BW, Wong H, Morgan JP
J Clin Psychopharmacol 1988 Dec;8(6):397-401. PMID: 3069880
Perinatal addiction: the effects of maternal narcotic and nonnarcotic substance abuse on the fetus and neonate.
Chasnoff IJ, Burns WJ, Schnoll SH
NIDA Res Monogr 1984 Mar;49:220-6. PMID: 6434963

Clinical prediction guides

Quantitation of Cocaine and Metabolites, Phencyclidine, Butalbital and Phenobarbital in Meconium by Liquid Chromatography-Tandem Mass Spectrometry.
Scroggin TL, McMillin GA
J Anal Toxicol 2018 Apr 1;42(3):177-182. doi: 10.1093/jat/bkx097. PMID: 29244082
Phencyclidine Intoxication Case Series Study.
Dominici P, Kopec K, Manur R, Khalid A, Damiron K, Rowden A
J Med Toxicol 2015 Sep;11(3):321-5. doi: 10.1007/s13181-014-0453-9. PMID: 25502414Free PMC Article
PCP: from pharmacology to modelling schizophrenia.
Morris BJ, Cochran SM, Pratt JA
Curr Opin Pharmacol 2005 Feb;5(1):101-6. doi: 10.1016/j.coph.2004.08.008. PMID: 15661633
Phencyclidine and violence: clinical and legal issues.
Brecher M, Wang BW, Wong H, Morgan JP
J Clin Psychopharmacol 1988 Dec;8(6):397-401. PMID: 3069880
Phencyclidine: effects on the fetus and neonate.
Chasnoff IJ, Burns WJ, Hatcher RP, Burns KA
Dev Pharmacol Ther 1983;6(6):404-8. doi: 10.1159/000457343. PMID: 6641470

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