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Dermatofibroma

MedGen UID:: 1930
•Concept ID:: C0002991
•: Neoplastic Process

Synonym:	Cutaneous fibrous histiocytoma
SNOMED CT:	Sclerosing angioma of skin (403999006); Benign fibrous histiocytoma of skin (254750001); Fibrous xanthoma of skin (254750001); Sclerosing angioma (403999006); Sclerosing angioma (134302009); Dermatofibroma (427186000); Cutaneous histiocytoma (427186000); Subepidermal nodular fibrosis (427186000); Fibrous histiocytoma of skin (254750001); Dermatofibroma lenticulare (1162532000); Cutaneous histiocytoma (1162532000); Dermatofibroma (1162532000); Subepidermal nodular fibrosis (1162532000)

Monarch Initiative:	MONDO:0006717

Definition

A solitary, slowly growing, nodular tumor most often affecting the extremities. It is composed of fibrous and histiocytic cells which infiltrate the dermis and occasionally the underlying subcutaneous tissue. Usually local excision is curative. Recurrences are reported only in a small minority of cases. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDermatofibroma

Neoplasm by Special Category
- Benign neoplasm
  - Benign connective and soft tissue neoplasm
    - Benign Fibrohistiocytic Neoplasm
      - Histiocytoma
        Benign fibrous histiocytoma
        Dermatofibroma
        Skin Fibrous Histiocytoma, Cellular Variant
        Skin Fibrous Histiocytoma, Epithelioid Variant
        Skin Fibrous Histiocytoma, Fibroblastic Variant
        Skin Fibrous Histiocytoma, Histiocytic Variant

Professional guidelines

PubMed

Cutaneous sarcoma: a review and practical approach to management.

Stoneham S, Hunter A, Raahimi M, Livesey A, Mitchell CD, Keohane S
Clin Exp Dermatol 2023 Jul 21;48(8):866-872. doi: 10.1093/ced/llad166. PMID: 37127912

Top 10 Differential Diagnoses for Desmoplastic Melanoma.

Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737 Free PMC Article

Dermoscopy in Primary Care.

Pokhrel PK, Helm MF, Greene A, Helm LA, Partin M
Prim Care 2022 Mar;49(1):99-118. Epub 2022 Jan 3 doi: 10.1016/j.pop.2021.10.004. PMID: 35125161

See all (18)

Recent clinical studies

Etiology

Can ultrasound distinguish between dermatofibroma and subcutaneous epidermal tumors? - Imaging features and reproducibility.

Choi JY, Park HJ, Kim JN, Kim MS, Chae SW, Lee YT, Park JY
Clin Imaging 2021 Nov;79:52-55. Epub 2021 Apr 15 doi: 10.1016/j.clinimag.2021.03.036. PMID: 33882367

Current Update on the Molecular Biology of Cutaneous Sarcoma: Dermatofibrosarcoma Protuberans.

Iwasaki T, Yamamoto H, Oda Y
Curr Treat Options Oncol 2019 Mar 14;20(4):29. doi: 10.1007/s11864-019-0628-3. PMID: 30874910

Unique histopathologic features of the eyelid dermatofibroma.

Abdelhakim AH, Dunbar KE, Godfrey KJ, Abascal Ananza C, Silvers DN, Kazim M
Orbit 2019 Aug;38(4):274-278. Epub 2018 Sep 5 doi: 10.1080/01676830.2018.1513045. PMID: 30183445

The limitations of dermoscopy: false-positive and false-negative tumours.

Papageorgiou V, Apalla Z, Sotiriou E, Papageorgiou C, Lazaridou E, Vakirlis S, Ioannides D, Lallas A
J Eur Acad Dermatol Venereol 2018 Jun;32(6):879-888. Epub 2018 Jan 24 doi: 10.1111/jdv.14782. PMID: 29314288

Cryosurgery for common skin conditions.

Andrews MD
Am Fam Physician 2004 May 15;69(10):2365-72. PMID: 15168956

See all (98)

Diagnosis

Cutaneous sarcoma: a review and practical approach to management.

Stoneham S, Hunter A, Raahimi M, Livesey A, Mitchell CD, Keohane S
Clin Exp Dermatol 2023 Jul 21;48(8):866-872. doi: 10.1093/ced/llad166. PMID: 37127912

Top 10 Differential Diagnoses for Desmoplastic Melanoma.

Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737 Free PMC Article

Dermoscopy in Primary Care.

Pokhrel PK, Helm MF, Greene A, Helm LA, Partin M
Prim Care 2022 Mar;49(1):99-118. Epub 2022 Jan 3 doi: 10.1016/j.pop.2021.10.004. PMID: 35125161

Pseudomyogenic Hemangioendothelioma.

Ansai SI, Morimoto M, Akaishi S
J Nippon Med Sch 2019;86(2):126-130. doi: 10.1272/jnms.JNMS.2019_86-209. PMID: 31130564

Histologic Mimics of Basal Cell Carcinoma.

Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946

See all (383)

Therapy

Dermatofibroma Versus Dermatofibrosarcoma Protuberans: A Nuclear Morphology Study.

Khamdan F, Brailsford C, Dirr MA, Sagut P, Nietert PJ, Elston D
Am J Dermatopathol 2023 Sep 1;45(9):631-634. doi: 10.1097/DAD.0000000000002526. PMID: 37625803 Free PMC Article

Cutaneous Complications Related to Tattoos: 31 Cases from Finland.

Kluger N
Dermatology 2017;233(1):100-109. Epub 2017 Apr 26 doi: 10.1159/000468536. PMID: 28441655

Skin metastasis: a pathologist's perspective.

Hussein MR
J Cutan Pathol 2010 Sep;37(9):e1-20. Epub 2009 Nov 17 doi: 10.1111/j.1600-0560.2009.01469.x. PMID: 19922483

Cryosurgery for common skin conditions.

Andrews MD
Am Fam Physician 2004 May 15;69(10):2365-72. PMID: 15168956

Cryosurgery for common skin lesions. Treatment in family physicians' offices.

Wetmore SJ
Can Fam Physician 1999 Apr;45:964-74. PMID: 10216795 Free PMC Article

See all (30)

Prognosis

Top 10 Differential Diagnoses for Desmoplastic Melanoma.

Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737 Free PMC Article

Dermoscopy in Primary Care.

Pokhrel PK, Helm MF, Greene A, Helm LA, Partin M
Prim Care 2022 Mar;49(1):99-118. Epub 2022 Jan 3 doi: 10.1016/j.pop.2021.10.004. PMID: 35125161

Epithelioid Fibrous Histiocytoma: A Concise Review.

Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773

Cutaneous mesenchymal tumours: an update.

Mentzel T
Pathology 2014 Feb;46(2):149-59. doi: 10.1097/PAT.0000000000000046. PMID: 24378387

Dermatofibrosarcoma protuberans--an update.

Breuninger H, Sebastian G, Garbe C
J Dtsch Dermatol Ges 2004 Aug;2(8):661-7. doi: 10.1046/j.1439-0353.2004.04056.x. PMID: 16279228

See all (71)

Clinical prediction guides

Can ultrasound distinguish between dermatofibroma and subcutaneous epidermal tumors? - Imaging features and reproducibility.

Choi JY, Park HJ, Kim JN, Kim MS, Chae SW, Lee YT, Park JY
Clin Imaging 2021 Nov;79:52-55. Epub 2021 Apr 15 doi: 10.1016/j.clinimag.2021.03.036. PMID: 33882367

Epithelioid Fibrous Histiocytoma: A Concise Review.

Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773

The Role of CD34 and D2-40 in the Differentiation of Dermatofibroma and Dermatofibrosarcoma Protuberans.

Sadullahoğlu C, Dere Y, Atasever TR, Öztop MT, Karaaslan Ö
Turk Patoloji Derg 2017;1(1):223-227. doi: 10.5146/tjpath.2017.01402. PMID: 28832078

Dermoscopy for the family physician.

Marghoob AA, Usatine RP, Jaimes N
Am Fam Physician 2013 Oct 1;88(7):441-50. PMID: 24134084

Granular cell dermatofibroma.

Soyer HP, Metze D, Kerl H
Am J Dermatopathol 1997 Apr;19(2):168-73. doi: 10.1097/00000372-199704000-00011. PMID: 9129702

See all (126)