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Pinealoma

MedGen UID:
19315
Concept ID:
C0031941
Neoplastic Process
Synonyms: Neoplasm, Pineal; Neoplasms, Pineal; Pineal Gland Tumor; Pineal Gland Tumors; Pineal Neoplasm; Pineal Neoplasms; Pineal Parenchymal Tumor; Pineal Parenchymal Tumors; Pineal Tumor; Pineal Tumors; Pinealomas; Tumor, Pineal; Tumor, Pineal Gland; Tumor, Pineal Parenchymal; Tumors, Pineal; Tumors, Pineal Gland; Tumors, Pineal Parenchymal
SNOMED CT: Pineal tumor (127026004); Tumor of pineal gland (127026004); Neoplasm of pineal gland (127026004); Pinealoma (359619007)
 
HPO: HP:0010799

Definition

A neoplasm of the pineal gland. [from HPO]

Conditions with this feature

Retinoblastoma
MedGen UID:
20552
Concept ID:
C0035335
Neoplastic Process
Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors.

Professional guidelines

PubMed

Tian ZM, Liu ZH, Kang GQ, Zhang Y, Li SY, Chen XH, Chui Y, Feng H
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SCHLESINGER EB, TAVERAS JM, CUMMINS FM
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Recent clinical studies

Etiology

Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA, Dufour C, Snuderl M, Karajannis MA, Rosenblum MK, Hwang EI, Ng HK, Hansford JR, Szathmari A, Faure-Conter C, Merchant TE, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson GW, Gajjar A, Pfister SM, Bouffet E, Northcott PA, Jones DTW, Huang A
Acta Neuropathol 2021 May;141(5):771-785. Epub 2021 Feb 22 doi: 10.1007/s00401-021-02284-5. PMID: 33619588Free PMC Article
Mathieu D, Iorio-Morin C
Prog Neurol Surg 2019;34:173-183. Epub 2019 May 16 doi: 10.1159/000493062. PMID: 31096261
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435

Diagnosis

Gempt J, Ringel F, Oexle K, Delbridge C, Förschler A, Schlegel J, Meyer B, Schmidt-Graf F
Acta Neurochir (Wien) 2012 Aug;154(8):1413-6. Epub 2012 Jun 15 doi: 10.1007/s00701-012-1402-5. PMID: 22699425
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647
Linggood RM, Chapman PH
J Neurooncol 1992 Jan;12(1):85-91. doi: 10.1007/BF00172460. PMID: 1541982
Baumgartner JE, Edwards MS
Neurosurg Clin N Am 1992 Oct;3(4):853-62. PMID: 1392580
Backman HA
Am J Optom Physiol Opt 1987 Jul;64(7):543-4. doi: 10.1097/00006324-198707000-00011. PMID: 3631213

Therapy

Rosenberg T, Cooney T
Pediatr Neurosurg 2023;58(5):299-306. Epub 2023 May 26 doi: 10.1159/000531256. PMID: 37245504
Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA, Dufour C, Snuderl M, Karajannis MA, Rosenblum MK, Hwang EI, Ng HK, Hansford JR, Szathmari A, Faure-Conter C, Merchant TE, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson GW, Gajjar A, Pfister SM, Bouffet E, Northcott PA, Jones DTW, Huang A
Acta Neuropathol 2021 May;141(5):771-785. Epub 2021 Feb 22 doi: 10.1007/s00401-021-02284-5. PMID: 33619588Free PMC Article
Sonabend AM, Bowden S, Bruce JN
J Neurooncol 2016 Nov;130(2):351-366. Epub 2016 May 19 doi: 10.1007/s11060-016-2138-5. PMID: 27193692
Matsutani M
Prog Neurol Surg 2009;23:76-85. Epub 2009 Mar 23 doi: 10.1159/000210054. PMID: 19329862
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

Prognosis

Sonabend AM, Bowden S, Bruce JN
J Neurooncol 2016 Nov;130(2):351-366. Epub 2016 May 19 doi: 10.1007/s11060-016-2138-5. PMID: 27193692
Zacharia BE, Bruce JN
Neurosurg Clin N Am 2011 Jul;22(3):359-66, viii. doi: 10.1016/j.nec.2011.05.008. PMID: 21801984
Baumgartner JE, Edwards MS
Neurosurg Clin N Am 1992 Oct;3(4):853-62. PMID: 1392580
Disclafani A, Hudgins RJ, Edwards MS, Wara W, Wilson CB, Levin VA
Cancer 1989 Jan 15;63(2):302-4. doi: 10.1002/1097-0142(19890115)63:2<302::aid-cncr2820630216>3.0.co;2-d. PMID: 2910435
Backman HA
Am J Optom Physiol Opt 1987 Jul;64(7):543-4. doi: 10.1097/00006324-198707000-00011. PMID: 3631213

Clinical prediction guides

Xie T, Qu C, Zhang X, Yang Q, Yeh Y, Li C, Liu T, Liu S, Li Z, Hu F, Yang L, Yang H
World Neurosurg 2022 Dec;168:63-73. Epub 2022 Sep 21 doi: 10.1016/j.wneu.2022.09.074. PMID: 36152938
Zhu Y, Li Z, Xiong Z, Zhang T, Chen J
Contrast Media Mol Imaging 2022;2022:5702309. Epub 2022 Aug 10 doi: 10.1155/2022/5702309. PMID: 36017015Free PMC Article
Le Reste PJ, Avril T, Quillien V, Morandi X, Chevet E
Brain Res 2016 Jul 1;1642:59-69. Epub 2016 Mar 23 doi: 10.1016/j.brainres.2016.03.015. PMID: 27016056
Biswas A, Mallick S, Purkait S, Gandhi A, Sarkar C, Singh M, Julka PK, Rath GK
Childs Nerv Syst 2015 Aug;31(8):1291-304. Epub 2015 Jun 4 doi: 10.1007/s00381-015-2751-1. PMID: 26040934
Miškovská V, Usakova V, Vertakova-Krakovska B, Mrinakova B, Lehotská V, Chorváth M, Rychlý B, Steno J, Ondruš D
Klin Onkol 2013;26(1):19-24. doi: 10.14735/amko201319. PMID: 23528168

Recent systematic reviews

Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090
Yamaki VN, Solla DJF, Ribeiro RR, da Silva SA, Teixeira MJ, Figueiredo EG
Neurosurgery 2019 Sep 1;85(3):E420-E429. doi: 10.1093/neuros/nyz062. PMID: 30989225
Clark AJ, Ivan ME, Sughrue ME, Yang I, Aranda D, Han SJ, Kane AJ, Parsa AT
J Neurosurg 2010 Aug;113(2):319-24. doi: 10.3171/2009.12.JNS091683. PMID: 20136388

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