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Precancerous condition

MedGen UID:
19442
•Concept ID:
C0032927
•
Neoplastic Process
Synonyms: Condition, Precancerous; Conditions, Precancerous; Precancerous Condition; Precancerous Conditions
 
Monarch Initiative: MONDO:0021074

Definition

A pathological process with signs indicating it may become cancerous. Representative examples include leukoplakia, dysplastic nevus, actinic keratosis, xeroderma pigmentosum, and intraepithelial neoplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrecancerous condition

Professional guidelines

PubMed

Tirbanibulin for the Treatment of Actinic Keratosis: A Review.
Miller AC, Adjei S, Temiz LA, Tyring SK
Skin Therapy Lett 2022 Jul;27(4):4-7. PMID: 35857917
Gastroesophageal reflux disease and Barrett esophagus: an overview of evidence-based guidelines.
Ratcliffe EG, Jankowski JA
Pol Arch Intern Med 2019 Aug 29;129(7-8):516-525. Epub 2019 May 13 doi: 10.20452/pamw.14828. PMID: 31080232
Effect of diagnosis, surveillance, and treatment of Barrett's oesophagus on health-related quality of life.
Britton J, Keld R, Prasad N, Hamdy S, McLaughlin J, Ang Y
Lancet Gastroenterol Hepatol 2018 Jan;3(1):57-65. Epub 2017 Sep 29 doi: 10.1016/S2468-1253(17)30213-3. PMID: 28970029

Recent clinical studies

Etiology

Juvenile polyposis syndrome: An overview.
Dal Buono A, Gaiani F, Poliani L, Laghi L
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101799. Epub 2022 Apr 4 doi: 10.1016/j.bpg.2022.101799. PMID: 35988962
The 'reversibility' of chronic atrophic gastritis after the eradication of Helicobacter pylori.
Yang H, Zhou X, Hu B
Postgrad Med 2022 Jun;134(5):474-479. Epub 2022 Apr 13 doi: 10.1080/00325481.2022.2063604. PMID: 35382697
Metformin for endometrial hyperplasia.
Clement NS, Oliver TR, Shiwani H, Sanner JR, Mulvaney CA, Atiomo W
Cochrane Database Syst Rev 2017 Oct 27;10(10):CD012214. doi: 10.1002/14651858.CD012214.pub2. PMID: 29077194Free PMC Article
Barrett esophagus: an update.
Badreddine RJ, Wang KK
Nat Rev Gastroenterol Hepatol 2010 Jul;7(7):369-78. Epub 2010 Jun 1 doi: 10.1038/nrgastro.2010.78. PMID: 20517288
Laryngeal papilloma--precancerous condition?
Klozar J, Taudy M, Betka J, Kana R
Acta Otolaryngol Suppl 1997;527:100-2. PMID: 9197493

Diagnosis

Esophageal lichen planus: Current knowledge, challenges and future perspectives.
Decker A, Schauer F, Lazaro A, Monasterio C, Schmidt AR, Schmitt-Graeff A, Kreisel W
World J Gastroenterol 2022 Nov 7;28(41):5893-5909. doi: 10.3748/wjg.v28.i41.5893. PMID: 36405107Free PMC Article
Juvenile polyposis syndrome: An overview.
Dal Buono A, Gaiani F, Poliani L, Laghi L
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101799. Epub 2022 Apr 4 doi: 10.1016/j.bpg.2022.101799. PMID: 35988962
Diagnosis of Pre-HCC Disease by Hepatobiliary-Specific Contrast-Enhanced Magnetic Resonance Imaging: A Review.
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Barrett esophagus: an update.
Badreddine RJ, Wang KK
Nat Rev Gastroenterol Hepatol 2010 Jul;7(7):369-78. Epub 2010 Jun 1 doi: 10.1038/nrgastro.2010.78. PMID: 20517288
Laryngeal papilloma--precancerous condition?
Klozar J, Taudy M, Betka J, Kana R
Acta Otolaryngol Suppl 1997;527:100-2. PMID: 9197493

Therapy

Diagnosis of Pre-HCC Disease by Hepatobiliary-Specific Contrast-Enhanced Magnetic Resonance Imaging: A Review.
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Segmentation and analysis of surface characteristics of oral tissues obtained by scanning electron microscopy to differentiate normal and oral precancerous condition.
Nag R, Pal M, Paul RR, Chatterjee J, Kumar Das R
Tissue Cell 2019 Aug;59:82-87. Epub 2019 Jul 16 doi: 10.1016/j.tice.2019.07.004. PMID: 31383292
Metformin for endometrial hyperplasia.
Clement NS, Oliver TR, Shiwani H, Sanner JR, Mulvaney CA, Atiomo W
Cochrane Database Syst Rev 2017 Oct 27;10(10):CD012214. doi: 10.1002/14651858.CD012214.pub2. PMID: 29077194Free PMC Article
HNE and cholesterol oxidation products in colorectal inflammation and carcinogenesis.
Rossin D, Calfapietra S, Sottero B, Poli G, Biasi F
Free Radic Biol Med 2017 Oct;111:186-195. Epub 2017 Jan 13 doi: 10.1016/j.freeradbiomed.2017.01.017. PMID: 28089726
Thermal Ablation of Renal Tumors: Indications, Techniques and Results.
Regier M, Chun F
Dtsch Arztebl Int 2015 Jun 12;112(24):412-8. doi: 10.3238/arztebl.2015.0412. PMID: 26159218Free PMC Article

Prognosis

Esophageal lichen planus: Current knowledge, challenges and future perspectives.
Decker A, Schauer F, Lazaro A, Monasterio C, Schmidt AR, Schmitt-Graeff A, Kreisel W
World J Gastroenterol 2022 Nov 7;28(41):5893-5909. doi: 10.3748/wjg.v28.i41.5893. PMID: 36405107Free PMC Article
Diagnosis of Pre-HCC Disease by Hepatobiliary-Specific Contrast-Enhanced Magnetic Resonance Imaging: A Review.
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Molecular biology of pancreatic cancer.
Zavoral M, Minarikova P, Zavada F, Salek C, Minarik M
World J Gastroenterol 2011 Jun 28;17(24):2897-908. doi: 10.3748/wjg.v17.i24.2897. PMID: 21734801Free PMC Article
Oral lichenoid disease as a premalignant condition: the controversies and the unknown.
Cortés-Ramírez DA, Gainza-Cirauqui ML, Echebarria-Goikouria MA, Aguirre-Urizar JM
Med Oral Patol Oral Cir Bucal 2009 Mar 1;14(3):E118-22. PMID: 19242390
Laryngeal papilloma--precancerous condition?
Klozar J, Taudy M, Betka J, Kana R
Acta Otolaryngol Suppl 1997;527:100-2. PMID: 9197493

Clinical prediction guides

The effect of smoking on clinical presentation and expression of TLR-2 and CD34 in Oral lichen Planus patients: clinical and immunohistochemical study.
Amin NR, Yussif N, Ahmed E
BMC Oral Health 2020 Apr 29;20(1):129. doi: 10.1186/s12903-020-01118-2. PMID: 32349717Free PMC Article
Diagnosis of Pre-HCC Disease by Hepatobiliary-Specific Contrast-Enhanced Magnetic Resonance Imaging: A Review.
Yang Y, Liu C, Qi L, Zhao T, Feng Y, Ai X, Zhao X, Li J, Zhu Q
Dig Dis Sci 2020 Sep;65(9):2492-2502. Epub 2019 Dec 5 doi: 10.1007/s10620-019-05981-0. PMID: 31808004
Immunohistochemical evaluation of prime molecules in cervical lesions towards assessment of malignant potentiality.
Das L, Naskar S, Sarkar T, Maiti AK, Das S, Chatterjee J
J Cancer Res Ther 2018 Jan-Mar;14(2):377-381. doi: 10.4103/0973-1482.158029. PMID: 29516923
Effect of diagnosis, surveillance, and treatment of Barrett's oesophagus on health-related quality of life.
Britton J, Keld R, Prasad N, Hamdy S, McLaughlin J, Ang Y
Lancet Gastroenterol Hepatol 2018 Jan;3(1):57-65. Epub 2017 Sep 29 doi: 10.1016/S2468-1253(17)30213-3. PMID: 28970029
Dietary patterns and risk of colorectal adenoma: a systematic review and meta-analysis of observational studies.
Godos J, Bella F, Torrisi A, Sciacca S, Galvano F, Grosso G
J Hum Nutr Diet 2016 Dec;29(6):757-767. Epub 2016 Jul 14 doi: 10.1111/jhn.12395. PMID: 27412573

Recent systematic reviews

Comparison of Salivary Electrolytes Profile in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma.
Saavedra JA, Novo DR, Mesko MF, Uchoa Vasconcellos AC, Duarte Da Silva K, Rojas Zuñiga G, Ramires RF, Tarquinio SBC
Asian Pac J Cancer Prev 2022 Mar 1;23(3):1031-1039. doi: 10.31557/APJCP.2022.23.3.1031. PMID: 35345377Free PMC Article
Metformin for endometrial hyperplasia.
Clement NS, Oliver TR, Shiwani H, Sanner JR, Mulvaney CA, Atiomo W
Cochrane Database Syst Rev 2017 Oct 27;10(10):CD012214. doi: 10.1002/14651858.CD012214.pub2. PMID: 29077194Free PMC Article
Dietary patterns and risk of colorectal adenoma: a systematic review and meta-analysis of observational studies.
Godos J, Bella F, Torrisi A, Sciacca S, Galvano F, Grosso G
J Hum Nutr Diet 2016 Dec;29(6):757-767. Epub 2016 Jul 14 doi: 10.1111/jhn.12395. PMID: 27412573
Oesophageal adenocarcinoma or gastric cancer with or without eradication of Helicobacter pylori infection in chronic atrophic gastritis patients: a hypothetical opinion from a systematic review.
Nakajima S, Hattori T
Aliment Pharmacol Ther 2004 Jul;20 Suppl 1:54-61. doi: 10.1111/j.1365-2036.2004.01975.x. PMID: 15298606

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