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Unspecified Diabetes Mellitus in Pregnancy, Unspecified Trimester

MedGen UID:
19447
•Concept ID:
C0032969
•
Disease or Syndrome
Synonyms: Pregnancy in Diabete; Pregnancy in Diabetes; Pregnancy in Diabetic; Pregnancy in Diabetics

Definition

The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnspecified Diabetes Mellitus in Pregnancy, Unspecified Trimester

Professional guidelines

PubMed

Obesity in Pregnancy: ACOG Practice Bulletin, Number 230.
Obstet Gynecol 2021 Jun 1;137(6):e128-e144. doi: 10.1097/AOG.0000000000004395. PMID: 34011890
Management of Preexisting Diabetes in Pregnancy: A Review.
Alexopoulos AS, Blair R, Peters AL
JAMA 2019 May 14;321(18):1811-1819. doi: 10.1001/jama.2019.4981. PMID: 31087027Free PMC Article
ACOG Practice Bulletin No. 201: Pregestational Diabetes Mellitus.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Obstet Gynecol 2018 Dec;132(6):e228-e248. doi: 10.1097/AOG.0000000000002960. PMID: 30461693

Recent clinical studies

Etiology

Congenital Abnormalities in the Infant of a Diabetic Mother.
Kokhanov A
Neoreviews 2022 May 1;23(5):e319-e327. doi: 10.1542/neo.23-5-e319. PMID: 35490182
Management of Preexisting Diabetes in Pregnancy: A Review.
Alexopoulos AS, Blair R, Peters AL
JAMA 2019 May 14;321(18):1811-1819. doi: 10.1001/jama.2019.4981. PMID: 31087027Free PMC Article
Pregestational Diabetes in Pregnancy.
Sugrue R, Zera C
Obstet Gynecol Clin North Am 2018 Jun;45(2):315-331. doi: 10.1016/j.ogc.2018.01.002. PMID: 29747733
Diabetic ketoacidosis in pregnancy.
Sibai BM, Viteri OA
Obstet Gynecol 2014 Jan;123(1):167-178. doi: 10.1097/AOG.0000000000000060. PMID: 24463678
International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.
International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, Dyer AR, Leiva Ad, Hod M, Kitzmiler JL, Lowe LP, McIntyre HD, Oats JJ, Omori Y, Schmidt MI
Diabetes Care 2010 Mar;33(3):676-82. doi: 10.2337/dc09-1848. PMID: 20190296Free PMC Article

Diagnosis

Congenital Abnormalities in the Infant of a Diabetic Mother.
Kokhanov A
Neoreviews 2022 May 1;23(5):e319-e327. doi: 10.1542/neo.23-5-e319. PMID: 35490182
ACOG Practice Bulletin No. 201: Pregestational Diabetes Mellitus.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Obstet Gynecol 2018 Dec;132(6):e228-e248. doi: 10.1097/AOG.0000000000002960. PMID: 30461693
Maternal complications in pregnancy with diabetes.
Kulshrestha V, Agarwal N
J Pak Med Assoc 2016 Sep;66(9 Suppl 1):S74-7. PMID: 27582159
Diabetic ketoacidosis in pregnancy.
Sibai BM, Viteri OA
Obstet Gynecol 2014 Jan;123(1):167-178. doi: 10.1097/AOG.0000000000000060. PMID: 24463678
International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.
International Association of Diabetes and Pregnancy Study Groups Consensus Panel, Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, Dyer AR, Leiva Ad, Hod M, Kitzmiler JL, Lowe LP, McIntyre HD, Oats JJ, Omori Y, Schmidt MI
Diabetes Care 2010 Mar;33(3):676-82. doi: 10.2337/dc09-1848. PMID: 20190296Free PMC Article

Therapy

Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta-analysis.
Depla AL, De Wit L, Steenhuis TJ, Slieker MG, Voormolen DN, Scheffer PG, De Heus R, Van Rijn BB, Bekker MN
Ultrasound Obstet Gynecol 2021 Apr;57(4):539-550. doi: 10.1002/uog.22163. PMID: 32730637Free PMC Article
Type 1 Diabetes in Pregnancy.
McCance DR, Casey C
Endocrinol Metab Clin North Am 2019 Sep;48(3):495-509. doi: 10.1016/j.ecl.2019.05.008. PMID: 31345519
Management of Preexisting Diabetes in Pregnancy: A Review.
Alexopoulos AS, Blair R, Peters AL
JAMA 2019 May 14;321(18):1811-1819. doi: 10.1001/jama.2019.4981. PMID: 31087027Free PMC Article
ACOG Practice Bulletin No. 201: Pregestational Diabetes Mellitus.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics
Obstet Gynecol 2018 Dec;132(6):e228-e248. doi: 10.1097/AOG.0000000000002960. PMID: 30461693
Continuous glucose monitoring during diabetic pregnancy (GlucoMOMS): A multicentre randomized controlled trial.
Voormolen DN, DeVries JH, Sanson RME, Heringa MP, de Valk HW, Kok M, van Loon AJ, Hoogenberg K, Bekedam DJ, Brouwer TCB, Porath M, Erdtsieck RJ, NijBijvank B, Kip H, van der Heijden OWH, Elving LD, Hermsen BB, Potter van Loon BJ, Rijnders RJP, Jansen HJ, Langenveld J, Akerboom BMC, Kiewiet RM, Naaktgeboren CA, Mol BWJ, Franx A, Evers IM
Diabetes Obes Metab 2018 Aug;20(8):1894-1902. Epub 2018 May 8 doi: 10.1111/dom.13310. PMID: 29603547

Prognosis

MODY diabetes and screening of gestational diabetes.
Urbanová J, Brunerová L, Nunes MA, Brož J
Ceska Gynekol 2020 Winter;85(2):124-130. PMID: 32527107
Guideline No. 393-Diabetes in Pregnancy.
Berger H, Gagnon R, Sermer M
J Obstet Gynaecol Can 2019 Dec;41(12):1814-1825.e1. doi: 10.1016/j.jogc.2019.03.008. PMID: 31785800
Type 1 Diabetes in Pregnancy.
McCance DR, Casey C
Endocrinol Metab Clin North Am 2019 Sep;48(3):495-509. doi: 10.1016/j.ecl.2019.05.008. PMID: 31345519
Continuous glucose monitoring during diabetic pregnancy (GlucoMOMS): A multicentre randomized controlled trial.
Voormolen DN, DeVries JH, Sanson RME, Heringa MP, de Valk HW, Kok M, van Loon AJ, Hoogenberg K, Bekedam DJ, Brouwer TCB, Porath M, Erdtsieck RJ, NijBijvank B, Kip H, van der Heijden OWH, Elving LD, Hermsen BB, Potter van Loon BJ, Rijnders RJP, Jansen HJ, Langenveld J, Akerboom BMC, Kiewiet RM, Naaktgeboren CA, Mol BWJ, Franx A, Evers IM
Diabetes Obes Metab 2018 Aug;20(8):1894-1902. Epub 2018 May 8 doi: 10.1111/dom.13310. PMID: 29603547
Role of ultrasound in the management of diabetes in pregnancy.
Ahmed B, Abushama M, Khraisheh M, Dudenhausen J
J Matern Fetal Neonatal Med 2015;28(15):1856-63. Epub 2014 Nov 4 doi: 10.3109/14767058.2014.971745. PMID: 25367382

Clinical prediction guides

Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta-analysis.
Depla AL, De Wit L, Steenhuis TJ, Slieker MG, Voormolen DN, Scheffer PG, De Heus R, Van Rijn BB, Bekker MN
Ultrasound Obstet Gynecol 2021 Apr;57(4):539-550. doi: 10.1002/uog.22163. PMID: 32730637Free PMC Article
Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring.
Helle E, Priest JR
J Am Heart Assoc 2020 Apr 21;9(8):e011541. Epub 2020 Apr 20 doi: 10.1161/JAHA.119.011541. PMID: 32308111Free PMC Article
Management of Preexisting Diabetes in Pregnancy: A Review.
Alexopoulos AS, Blair R, Peters AL
JAMA 2019 May 14;321(18):1811-1819. doi: 10.1001/jama.2019.4981. PMID: 31087027Free PMC Article
Role of ultrasound in the management of diabetes in pregnancy.
Ahmed B, Abushama M, Khraisheh M, Dudenhausen J
J Matern Fetal Neonatal Med 2015;28(15):1856-63. Epub 2014 Nov 4 doi: 10.3109/14767058.2014.971745. PMID: 25367382
Diabetes and pregnancy.
Landon MB, Gabbe SG
Med Clin North Am 1988 Nov;72(6):1493-511. doi: 10.1016/s0025-7125(16)30718-0. PMID: 3054364

Recent systematic reviews

Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.
Ye W, Luo C, Huang J, Li C, Liu Z, Liu F
BMJ 2022 May 25;377:e067946. doi: 10.1136/bmj-2021-067946. PMID: 35613728Free PMC Article
Gestational diabetes mellitus (GDM) and adverse pregnancy outcome in South Asia: A systematic review.
Mistry SK, Das Gupta R, Alam S, Kaur K, Shamim AA, Puthussery S
Endocrinol Diabetes Metab 2021 Oct;4(4):e00285. Epub 2021 Jul 3 doi: 10.1002/edm2.285. PMID: 34505412Free PMC Article
Gestational Diabetes Mellitus and Diet: A Systematic Review and Meta-analysis of Randomized Controlled Trials Examining the Impact of Modified Dietary Interventions on Maternal Glucose Control and Neonatal Birth Weight.
Yamamoto JM, Kellett JE, Balsells M, García-Patterson A, Hadar E, Solà I, Gich I, van der Beek EM, Castañeda-Gutiérrez E, Heinonen S, Hod M, Laitinen K, Olsen SF, Poston L, Rueda R, Rust P, van Lieshout L, Schelkle B, Murphy HR, Corcoy R
Diabetes Care 2018 Jul;41(7):1346-1361. doi: 10.2337/dc18-0102. PMID: 29934478
Association of Gestational Weight Gain With Maternal and Infant Outcomes: A Systematic Review and Meta-analysis.
Goldstein RF, Abell SK, Ranasinha S, Misso M, Boyle JA, Black MH, Li N, Hu G, Corrado F, Rode L, Kim YJ, Haugen M, Song WO, Kim MH, Bogaerts A, Devlieger R, Chung JH, Teede HJ
JAMA 2017 Jun 6;317(21):2207-2225. doi: 10.1001/jama.2017.3635. PMID: 28586887Free PMC Article
Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies.
Bartsch E, Medcalf KE, Park AL, Ray JG; High Risk of Pre-eclampsia Identification Group
BMJ 2016 Apr 19;353:i1753. doi: 10.1136/bmj.i1753. PMID: 27094586Free PMC Article

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