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Priapism

MedGen UID:
19462
Concept ID:
C0033117
Disease or Syndrome
Synonym: Priapisms
SNOMED CT: Priapism (6273006); Mentulagra (6273006); Pathologic erection (6273006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0200023
Monarch Initiative: MONDO:0004745
Orphanet: ORPHA140949

Definition

A painful and harmful medical condition in which the erect penis doesn't return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours. [from HPO]

Term Hierarchy

Conditions with this feature

Hb SS disease
MedGen UID:
287
Concept ID:
C0002895
Disease or Syndrome
Sickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. Vaso-occlusive events result in tissue ischemia leading to acute and chronic pain as well as organ damage that can affect any organ system, including the bones, spleen, liver, brain, lungs, kidneys, and joints. Dactylitis (pain and/or swelling of the hands or feet) is often the earliest manifestation of SCD. In children, the spleen can become engorged with blood cells in a "splenic sequestration." The spleen is particularly vulnerable to infarction and the majority of individuals with SCD who are not on hydroxyurea or transfusion therapy become functionally asplenic in early childhood, increasing their risk for certain types of bacterial infections, primarily encapsulated organisms. Acute chest syndrome (ACS) is a major cause of mortality in SCD. Chronic hemolysis can result in varying degrees of anemia, jaundice, cholelithiasis, and delayed growth and sexual maturation as well as activating pathways that contribute to the pathophysiology directly. Individuals with the highest rates of hemolysis are at higher risk for pulmonary artery hypertension, priapism, and leg ulcers and may be relatively protected from vaso-occlusive pain.

Professional guidelines

PubMed

Fantus RJ, Brannigan RE, Davis AM
JAMA 2023 Aug 8;330(6):559-560. doi: 10.1001/jama.2023.13377. PMID: 37471069
Ericson C, Baird B, Broderick GA
Urol Clin North Am 2021 Nov;48(4):565-576. Epub 2021 Aug 25 doi: 10.1016/j.ucl.2021.07.003. PMID: 34602176
Podolej GS, Babcock C
Emerg Med Pract 2017 Jan;19(1):1-16. Epub 2017 Jan 1 PMID: 28027457

Recent clinical studies

Etiology

Levy JA, Burnett AL, Minniti CP, Ennis W, Vittal A, Heller T, Kleiner D, Thein SL
Hematol Oncol Clin North Am 2022 Dec;36(6):1187-1199. doi: 10.1016/j.hoc.2022.08.001. PMID: 36400538Free PMC Article
Olson C, Jhawar A, Elfessi Z, Doyle R
Am J Emerg Med 2021 Oct;48:375.e5-375.e6. Epub 2021 Mar 24 doi: 10.1016/j.ajem.2021.03.066. PMID: 33836933
Nader E, Romana M, Connes P
Front Immunol 2020;11:454. Epub 2020 Mar 13 doi: 10.3389/fimmu.2020.00454. PMID: 32231672Free PMC Article
Ataga KI, Kutlar A, Kanter J, Liles D, Cancado R, Friedrisch J, Guthrie TH, Knight-Madden J, Alvarez OA, Gordeuk VR, Gualandro S, Colella MP, Smith WR, Rollins SA, Stocker JW, Rother RP
N Engl J Med 2017 Feb 2;376(5):429-439. Epub 2016 Dec 3 doi: 10.1056/NEJMoa1611770. PMID: 27959701Free PMC Article
Sadeghi-Nejad H, Dogra V, Seftel AD, Mohamed MA
Radiol Clin North Am 2004 Mar;42(2):427-43. doi: 10.1016/j.rcl.2004.01.008. PMID: 15136026

Diagnosis

Fantus RJ, Brannigan RE, Davis AM
JAMA 2023 Aug 8;330(6):559-560. doi: 10.1001/jama.2023.13377. PMID: 37471069
Ericson C, Baird B, Broderick GA
Urol Clin North Am 2021 Nov;48(4):565-576. Epub 2021 Aug 25 doi: 10.1016/j.ucl.2021.07.003. PMID: 34602176
Offenbacher J, Barbera A
Emerg Med Clin North Am 2019 Nov;37(4):583-592. Epub 2019 Aug 16 doi: 10.1016/j.emc.2019.07.001. PMID: 31563196
Manjunath AS, Hofer MD
Med Clin North Am 2018 Mar;102(2):373-385. Epub 2017 Dec 20 doi: 10.1016/j.mcna.2017.10.013. PMID: 29406065
Ludvigson AE, Beaule LT
Surg Clin North Am 2016 Jun;96(3):407-24. doi: 10.1016/j.suc.2016.02.001. PMID: 27261785

Therapy

Idris IM, Burnett AL, DeBaun MR
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):450-458. doi: 10.1182/hematology.2022000380. PMID: 36485155Free PMC Article
Olson C, Jhawar A, Elfessi Z, Doyle R
Am J Emerg Med 2021 Oct;48:375.e5-375.e6. Epub 2021 Mar 24 doi: 10.1016/j.ajem.2021.03.066. PMID: 33836933
Hwang T, Shah T, Sadeghi-Nejad H
Sex Med Rev 2021 Jul;9(3):464-471. Epub 2020 Nov 16 doi: 10.1016/j.sxmr.2020.10.003. PMID: 33214060
Podolej GS, Babcock C
Emerg Med Pract 2017 Jan;19(1):1-16. Epub 2017 Jan 1 PMID: 28027457
Kheirandish P, Chinegwundoh F, Kulkarni S
BJU Int 2011 Oct;108(7):1068-72. doi: 10.1111/j.1464-410X.2011.10367.x. PMID: 21914108

Prognosis

Mulloy E, Li S, Belladelli F, Del Giudice F, Glover F, Eisenberg ML
J Sex Med 2023 Mar 31;20(4):536-541. doi: 10.1093/jsxmed/qdad017. PMID: 36881738
Balawender K, Pliszka A, Krowiak A, Sito M, Grabarek BO, Boroń D
Curr Pharm Biotechnol 2022;23(15):1792-1799. doi: 10.2174/1389201023666220307102147. PMID: 35255789
Hwang T, Shah T, Sadeghi-Nejad H
Sex Med Rev 2021 Jul;9(3):464-471. Epub 2020 Nov 16 doi: 10.1016/j.sxmr.2020.10.003. PMID: 33214060
Marcu D, Iorga L, Mischianu D, Bacalbasa N, Balescu I, Bratu O
In Vivo 2020 Sep-Oct;34(5):2225-2232. doi: 10.21873/invivo.12033. PMID: 32871745Free PMC Article
Scherzer ND, Reddy AG, Le TV, Chernobylsky D, Hellstrom WJG
Sex Med Rev 2019 Apr;7(2):283-292. Epub 2018 Nov 28 doi: 10.1016/j.sxmr.2018.09.002. PMID: 30503727

Clinical prediction guides

Mulloy E, Li S, Belladelli F, Del Giudice F, Glover F, Eisenberg ML
J Sex Med 2023 Mar 31;20(4):536-541. doi: 10.1093/jsxmed/qdad017. PMID: 36881738
Kavanagh PL, Fasipe TA, Wun T
JAMA 2022 Jul 5;328(1):57-68. doi: 10.1001/jama.2022.10233. PMID: 35788790
Hwang T, Shah T, Sadeghi-Nejad H
Sex Med Rev 2021 Jul;9(3):464-471. Epub 2020 Nov 16 doi: 10.1016/j.sxmr.2020.10.003. PMID: 33214060
Ingram AR, Stillings SA, Jenkins LC
Sex Med Rev 2020 Jan;8(1):140-149. Epub 2019 Apr 12 doi: 10.1016/j.sxmr.2019.03.004. PMID: 30987934
Burnett AL, Sharlip ID
J Sex Med 2013 Jan;10(1):180-94. Epub 2012 Mar 29 doi: 10.1111/j.1743-6109.2012.02707.x. PMID: 22462660

Recent systematic reviews

Ali EA, Sardar S, Yassin MA
Hematol Oncol Stem Cell Ther 2022 Dec 23;15(4):176-182. doi: 10.1016/j.hemonc.2021.05.003. PMID: 34157311
Burnett AL
Fertil Steril 2020 Jan;113(1):6-12. doi: 10.1016/j.fertnstert.2019.11.013. PMID: 32033724
Capece M, La Rocca R, Mirone V, Bivalacqua TJ, Castiglione F, Albersen M, Ralph DJ, Muneer A, Garaffa G
Sex Med Rev 2019 Jul;7(3):530-534. Epub 2019 Mar 19 doi: 10.1016/j.sxmr.2018.10.007. PMID: 30898595
Yücel ÖB, Pazır Y, Kadıoğlu A
Sex Med Rev 2018 Apr;6(2):310-318. Epub 2017 Sep 12 doi: 10.1016/j.sxmr.2017.08.002. PMID: 28916463
Chinegwundoh FI, Smith S, Anie KA
Cochrane Database Syst Rev 2017 Sep 19;9(9):CD004198. doi: 10.1002/14651858.CD004198.pub3. PMID: 28926088Free PMC Article

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