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Primary Neoplasm

MedGen UID:
195655
•Concept ID:
C0677930
•
Neoplastic Process
Synonym: Primary Tumor

Definition

A tumor at the original site of origin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Neoplasm

Professional guidelines

PubMed

Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Krämer A, Bochtler T, Pauli C, Baciarello G, Delorme S, Hemminki K, Mileshkin L, Moch H, Oien K, Olivier T, Patrikidou A, Wasan H, Zarkavelis G, Pentheroudakis G, Fizazi K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Mar;34(3):228-246. Epub 2022 Dec 20 doi: 10.1016/j.annonc.2022.11.013. PMID: 36563965
A multidisciplinary approach to the management of adrenal incidentaloma.
Voltan G, Boscaro M, Armanini D, Scaroni C, Ceccato F
Expert Rev Endocrinol Metab 2021 Jul;16(4):201-212. Epub 2021 Jul 9 doi: 10.1080/17446651.2021.1948327. PMID: 34240680
The diagnosis and treatment of limbic encephalitis.
Asztely F, Kumlien E
Acta Neurol Scand 2012 Dec;126(6):365-75. Epub 2012 Jun 19 doi: 10.1111/j.1600-0404.2012.01691.x. PMID: 22713136

Recent clinical studies

Etiology

Long-term risks of cardiovascular death in a population-based cohort of 1,141,675 older patients with cancer.
Guan T, Jiang Y, Luo Z, Liang Y, Feng M, Lu Z, Yi M, Teng Y, Zhou R, Zeng L, Chi K, Ou C, Chen M
Age Ageing 2023 May 1;52(5) doi: 10.1093/ageing/afad068. PMID: 37192506
Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Krämer A, Bochtler T, Pauli C, Baciarello G, Delorme S, Hemminki K, Mileshkin L, Moch H, Oien K, Olivier T, Patrikidou A, Wasan H, Zarkavelis G, Pentheroudakis G, Fizazi K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Mar;34(3):228-246. Epub 2022 Dec 20 doi: 10.1016/j.annonc.2022.11.013. PMID: 36563965
Clinical and survival characteristics of primary and secondary gliosarcoma patients.
Amer A, Khose S, Alhasan H, Pokhylevych H, Fuller G, Chasen N, de Groot J, Johnson JM
Clin Neurol Neurosurg 2022 Mar;214:107146. Epub 2022 Jan 29 doi: 10.1016/j.clineuro.2022.107146. PMID: 35101778
MR Imaging of Thymic Epithelial Neoplasms.
Carter BW, Lichtenberger JP 3rd, Benveniste MF
Top Magn Reson Imaging 2018 Apr;27(2):65-71. doi: 10.1097/RMR.0000000000000160. PMID: 29613961

Diagnosis

Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Krämer A, Bochtler T, Pauli C, Baciarello G, Delorme S, Hemminki K, Mileshkin L, Moch H, Oien K, Olivier T, Patrikidou A, Wasan H, Zarkavelis G, Pentheroudakis G, Fizazi K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Mar;34(3):228-246. Epub 2022 Dec 20 doi: 10.1016/j.annonc.2022.11.013. PMID: 36563965
Sarcoidosis, the master mimicker.
Jameson A, Revels J, Wang LL, Wang DT, Wang SS
Curr Probl Diagn Radiol 2022 Jan-Feb;51(1):60-72. Epub 2020 Nov 25 doi: 10.1067/j.cpradiol.2020.10.013. PMID: 33308891
Review of Perineural Invasion in Keratinocyte Carcinomas.
Zhou AE, Hoegler KM, Khachemoune A
Am J Clin Dermatol 2021 Sep;22(5):653-666. Epub 2021 Jun 8 doi: 10.1007/s40257-021-00615-6. PMID: 34105084
Therapy-Related Myeloid Neoplasms.
Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306
Imaging thymoma.
Marom EM
J Thorac Oncol 2010 Oct;5(10 Suppl 4):S296-303. doi: 10.1097/JTO.0b013e3181f209ca. PMID: 20859123

Therapy

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Simultaneous Minimally Invasive Treatment of Colorectal Neoplasm with Synchronous Liver Metastasis.
Garritano S, Selvaggi F, Spampinato MG
Biomed Res Int 2016;2016:9328250. Epub 2016 May 15 doi: 10.1155/2016/9328250. PMID: 27294144Free PMC Article
Advanced interstitial chemotherapy for treating malignant glioma.
Tseng YY, Kau YC, Liu SJ
Expert Opin Drug Deliv 2016 Nov;13(11):1533-1544. Epub 2016 Jun 1 doi: 10.1080/17425247.2016.1193153. PMID: 27248137
Treatment-related myelodysplasia in patients with primary brain tumors.
Baehring JM, Marks PW
Neuro Oncol 2012 May;14(5):529-40. Epub 2012 Mar 29 doi: 10.1093/neuonc/nos068. PMID: 22459128Free PMC Article
Angiogenesis in oral cancer.
Hasina R, Lingen MW
J Dent Educ 2001 Nov;65(11):1282-90. PMID: 11765876

Prognosis

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Krämer A, Bochtler T, Pauli C, Baciarello G, Delorme S, Hemminki K, Mileshkin L, Moch H, Oien K, Olivier T, Patrikidou A, Wasan H, Zarkavelis G, Pentheroudakis G, Fizazi K; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Mar;34(3):228-246. Epub 2022 Dec 20 doi: 10.1016/j.annonc.2022.11.013. PMID: 36563965
Review of Perineural Invasion in Keratinocyte Carcinomas.
Zhou AE, Hoegler KM, Khachemoune A
Am J Clin Dermatol 2021 Sep;22(5):653-666. Epub 2021 Jun 8 doi: 10.1007/s40257-021-00615-6. PMID: 34105084
Imaging thymoma.
Marom EM
J Thorac Oncol 2010 Oct;5(10 Suppl 4):S296-303. doi: 10.1097/JTO.0b013e3181f209ca. PMID: 20859123
Thymoma: radiologic-pathologic correlation.
Rosado-de-Christenson ML, Galobardes J, Moran CA
Radiographics 1992 Jan;12(1):151-68. doi: 10.1148/radiographics.12.1.1734461. PMID: 1734461

Clinical prediction guides

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Late genitourinary and gastrointestinal toxicity and radiation-induced second primary cancers in patients treated with low-dose-rate brachytherapy.
Nakai Y, Tanaka N, Asakawa I, Morizawa Y, Yamaki K, Hori S, Gotoh D, Miyake M, Torimoto K, Hasegawa M, Fujimoto K
Brachytherapy 2022 Sep-Oct;21(5):626-634. Epub 2022 May 27 doi: 10.1016/j.brachy.2022.04.008. PMID: 35644732
Disease recurrence after gut transplantation.
Osman M, Parekh N, Fujiki M, D'Amico G, Abu-Elmagd K
Curr Opin Organ Transplant 2021 Apr 1;26(2):207-219. doi: 10.1097/MOT.0000000000000856. PMID: 33528222
Malignant Insulinoma: A Rare Form of Neuroendocrine Tumor.
Sada A, Glasgow AE, Vella A, Thompson GB, McKenzie TJ, Habermann EB
World J Surg 2020 Jul;44(7):2288-2294. doi: 10.1007/s00268-020-05445-x. PMID: 32128613Free PMC Article
Pathology of combined hepatocellular-cholangiocarcinoma.
Yeh MM
J Gastroenterol Hepatol 2010 Sep;25(9):1485-92. doi: 10.1111/j.1440-1746.2010.06430.x. PMID: 20796144

Recent systematic reviews

Signaling Pathways in the Relapse of Glioblastoma.
Orozco-Mera J, Peralta-Pizza F, Escobar-Vidarte O, Coll-Tello B, Ariza A
Oncology (Williston Park) 2023 Mar 21;37(3):107-117. doi: 10.46883/2023.25920986. PMID: 36961958
Synchronous resection of esophageal cancer and other organ malignancies: A systematic review.
Papaconstantinou D, Tsilimigras DI, Moris D, Michalinos A, Mastoraki A, Mpaili E, Hasemaki N, Bakopoulos A, Filippou D, Schizas D
World J Gastroenterol 2019 Jul 14;25(26):3438-3449. doi: 10.3748/wjg.v25.i26.3438. PMID: 31341367Free PMC Article
Screening for occult cancer in idiopathic venous thromboembolism - Systemic review and meta-analysis.
Klein A, Shepshelovich D, Spectre G, Goldvaser H, Raanani P, Gafter-Gvili A
Eur J Intern Med 2017 Jul;42:74-80. Epub 2017 May 12 doi: 10.1016/j.ejim.2017.05.007. PMID: 28502867
Molecular Imaging in the Management of Adrenocortical Cancer: A Systematic Review.
Wong KK, Miller BS, Viglianti BL, Dwamena BA, Gauger PG, Cook GJ, Colletti PM, Rubello D, Gross MD
Clin Nucl Med 2016 Aug;41(8):e368-82. doi: 10.1097/RLU.0000000000001112. PMID: 26825212
Image-enhanced endoscopy for detection of second primary neoplasm in patients with esophageal and head and neck cancer: A systematic review and meta-analysis.
Chung CS, Lo WC, Lee YC, Wu MS, Wang HP, Liao LJ
Head Neck 2016 Apr;38 Suppl 1:E2343-9. Epub 2015 Nov 23 doi: 10.1002/hed.24277. PMID: 26595056

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