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Metastatic Malignant Neoplasm in the Sternum

MedGen UID:
195774
•Concept ID:
C0684572
•
Neoplastic Process
Synonyms: Metastasis to the Sternum; Metastatic malignant neoplasm of sternum; Metastatic malignant neoplasm to sternum; Metastatic Malignant Neoplasm to the Sternum; Metastatic Malignant Tumor to the Sternum; Metastatic Neoplasm to the Sternum; Metastatic Tumor to the Sternum; Secondary malignant neoplasm of sternum
SNOMED CT: Secondary malignant neoplasm of sternum (94605004); Metastatic malignant neoplasm to sternum (94605004); Metastatic malignant neoplasm of sternum (94605004)

Definition

A malignant neoplasm that has spread to the sternum from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Sternum

Professional guidelines

PubMed

Treatment of Oligometastatic Disease in Squamous Cell Carcinoma of the Head and Neck.
Vincent AG, Wang W, Shokri T, Ducic Y
Laryngoscope 2021 May;131(5):E1476-E1480. Epub 2020 Oct 12 doi: 10.1002/lary.29115. PMID: 33044014Free PMC Article
Stereotactic Body Radiation Therapy for Nonspine Bone Metastases: International Practice Patterns to Guide Treatment Planning.
Nguyen TK, Sahgal A, Dagan R, Eppinga W, Guckenberger M, Kim JH, Lo SS, Redmond KJ, Siva S, Stish BJ, Tseng CL
Pract Radiat Oncol 2020 Nov-Dec;10(6):e452-e460. Epub 2020 Mar 11 doi: 10.1016/j.prro.2020.02.011. PMID: 32171852
A role for curative surgery in the treatment of selected patients with metastatic breast cancer.
Singletary SE, Walsh G, Vauthey JN, Curley S, Sawaya R, Weber KL, Meric F, Hortobágyi GN
Oncologist 2003;8(3):241-51. doi: 10.1634/theoncologist.8-3-241. PMID: 12773746

Recent clinical studies

Etiology

Sternal metastasis as first presentation of a well-differentiated papillary thyroid carcinoma.
Spartalis E, Moris D, Tomos P
Surgery 2017 Dec;162(6):1336-1337. Epub 2017 Feb 22 doi: 10.1016/j.surg.2017.01.016. PMID: 28237641
Saving a life: balancing risks, harms, and benefits in palliative care.
Glare PA
J Clin Oncol 2014 Feb 1;32(4):355-6. Epub 2013 Dec 23 doi: 10.1200/JCO.2013.53.9338. PMID: 24366934
Radiation-induced osteosarcoma 17 years after mediastinal irradiation following surgical removal of thymoma.
Kadota Y, Utsumi T, Inoue M, Sawabata N, Minami M, Okumura M
Gen Thorac Cardiovasc Surg 2010 Dec;58(12):651-3. Epub 2010 Dec 18 doi: 10.1007/s11748-010-0587-x. PMID: 21170638
Salvage surgery for childhood osteosarcoma.
Pastorino U, Gasparini M, Azzarelli A, Tavecchio L, Ravasi G
Cancer Treat Res 1993;62:251-60. doi: 10.1007/978-1-4615-3518-8_30. PMID: 8096742
Clinical significance of isolated scintigraphic sternal lesions in patients with breast cancer.
Kwai AH, Stomper PC, Kaplan WD
J Nucl Med 1988 Mar;29(3):324-8. PMID: 3346742

Diagnosis

Bony swellings: an enigma.
Shekhawat VS, Bhansali A
BMJ Case Rep 2018 Jan 23;2018 doi: 10.1136/bcr-2017-222084. PMID: 29367363Free PMC Article
Follicular thyroid cancer with sternal metastasis - challenges and outcomes.
Syazni MA, Gendeh HS, Kosai NR, Ramzisham AR, Gendeh BS, Basiron NH, Imran FH
Med J Malaysia 2017 Feb;72(1):80-82. PMID: 28255152
Profuse mediastinal hemorrhage due to mediastinitis after a sternal infection.
Kamiyoshihara M, Ibe T, Igai H, Kawatani N, Hayashi H, Shimizu K, Takeyoshi I
Ann Thorac Cardiovasc Surg 2014;20 Suppl:629-31. Epub 2013 Aug 30 doi: 10.5761/atcs.cr.13-00010. PMID: 23995346
Bone Metastases From HCC.
Chavez M, Danniel J, Miick R, Jarrar D, Khanmoradi K, Ortiz J
JAMA Surg 2013 Feb;148(2):203-4. doi: 10.1001/jamasurgery.2013.417b. PMID: 23426600
Hepatocellular carcinoma with sternal metastasis.
Wu CY, Su CW, Lee FY
Clin Gastroenterol Hepatol 2011 May;9(5):e46-7. Epub 2011 Jan 14 doi: 10.1016/j.cgh.2011.01.007. PMID: 21238611

Therapy

Stereotactic Body Radiation Therapy for Nonspine Bone Metastases: International Practice Patterns to Guide Treatment Planning.
Nguyen TK, Sahgal A, Dagan R, Eppinga W, Guckenberger M, Kim JH, Lo SS, Redmond KJ, Siva S, Stish BJ, Tseng CL
Pract Radiat Oncol 2020 Nov-Dec;10(6):e452-e460. Epub 2020 Mar 11 doi: 10.1016/j.prro.2020.02.011. PMID: 32171852
Prostate Cancer With Isolated Bony Metastasis: Sternal Struggle.
Corkum MT
Int J Radiat Oncol Biol Phys 2017 Jul 1;98(3):492-493. doi: 10.1016/j.ijrobp.2017.03.035. PMID: 28581385
Internal Mammary Misfortune.
Fang P
Int J Radiat Oncol Biol Phys 2017 Mar 1;97(3):447. doi: 10.1016/j.ijrobp.2016.10.032. PMID: 28126294
Cushing's disease as a cause of severe osteoporosis: a clinical challenge.
Abdel-Kader N, Cardiel MH, Navarro Compan V, Piedra Priego J, González A
Reumatol Clin 2012 Sep-Oct;8(5):278-9. Epub 2012 Mar 14 doi: 10.1016/j.reuma.2011.11.004. PMID: 22421455
Radiation-induced osteosarcoma 17 years after mediastinal irradiation following surgical removal of thymoma.
Kadota Y, Utsumi T, Inoue M, Sawabata N, Minami M, Okumura M
Gen Thorac Cardiovasc Surg 2010 Dec;58(12):651-3. Epub 2010 Dec 18 doi: 10.1007/s11748-010-0587-x. PMID: 21170638

Prognosis

Bony swellings: an enigma.
Shekhawat VS, Bhansali A
BMJ Case Rep 2018 Jan 23;2018 doi: 10.1136/bcr-2017-222084. PMID: 29367363Free PMC Article
Sternal cutaneous metastasis of hilar cholangiocarcinoma.
Fernández López AJ, Tamayo-Rodríguez ME, Paniza-Mendoza MÁ
Rev Esp Enferm Dig 2017 Sep;109(9):674. doi: 10.17235/reed.2017.4979/2017. PMID: 28776385
Follicular thyroid cancer with sternal metastasis - challenges and outcomes.
Syazni MA, Gendeh HS, Kosai NR, Ramzisham AR, Gendeh BS, Basiron NH, Imran FH
Med J Malaysia 2017 Feb;72(1):80-82. PMID: 28255152
Sternal metastasis of renal cell carcinoma: the role of metastasectomy.
Ikoma N, Vaporciyan A
J Thorac Cardiovasc Surg 2014 Nov;148(5):e230-1. Epub 2014 Jul 22 doi: 10.1016/j.jtcvs.2014.06.081. PMID: 25152477
Radiation-induced osteosarcoma 17 years after mediastinal irradiation following surgical removal of thymoma.
Kadota Y, Utsumi T, Inoue M, Sawabata N, Minami M, Okumura M
Gen Thorac Cardiovasc Surg 2010 Dec;58(12):651-3. Epub 2010 Dec 18 doi: 10.1007/s11748-010-0587-x. PMID: 21170638

Clinical prediction guides

Palliative Arterial Embolization for Metastases of the Sternum.
Papalexis N, Peta G, Vara G, Spinnato P, Errani C, Martella C, Miceli M, Facchini G
Cardiovasc Intervent Radiol 2023 Jun;46(6):794-798. Epub 2023 May 15 doi: 10.1007/s00270-023-03459-1. PMID: 37188897
Incidence of bone metastasis in head and neck malignancy: A retrospective study.
Gupta S, Dubey V, Verma S, Ali T, Palod S, Lodhi A, Bhandari V
J Cancer Res Ther 2022 Dec;18(Supplement):S210-S214. doi: 10.4103/jcrt.JCRT_146_20. PMID: 36510966
Clinical characteristics and risk factors for developing bone metastases in patients with breast cancer.
Chen WZ, Shen JF, Zhou Y, Chen XY, Liu JM, Liu ZL
Sci Rep 2017 Sep 12;7(1):11325. doi: 10.1038/s41598-017-11700-4. PMID: 28900285Free PMC Article
Resection of Primary and Secondary Tumors of the Sternum: An Analysis of Prognostic Variables.
Ahmad U, Yang H, Sima C, Buitrago DH, Ripley RT, Suzuki K, Bains MS, Rizk NP, Rusch VW, Huang J, Adusumilli PS, Rocco G, Jones DR
Ann Thorac Surg 2015 Jul;100(1):215-21; discussion 221-2. Epub 2015 May 20 doi: 10.1016/j.athoracsur.2015.03.013. PMID: 26002443Free PMC Article
Solitary sternal metastasis of nasopharyngeal carcinoma: a case report.
Akbas T, Ugurluer G, Arpaci T
Eur Rev Med Pharmacol Sci 2012 Dec;16(14):1947-50. PMID: 23242721

Recent systematic reviews

Bone metastasis from glioblastoma: a systematic review.
Strong MJ, Koduri S, Allison JA, Pesavento CM, Ogunsola S, Ogunsola O, Yee TJ, Khalsa SSS, Saadeh YS, Joseph JR, Kashlan ON, Park P, Oppenlander ME, Szerlip NJ
J Neurooncol 2022 Jul;158(3):379-392. Epub 2022 May 17 doi: 10.1007/s11060-022-04025-4. PMID: 35578056
Systematic review of site distribution of bone metastases in differentiated thyroid cancer.
Osorio M, Moubayed SP, Su H, Urken ML
Head Neck 2017 Apr;39(4):812-818. Epub 2017 Jan 11 doi: 10.1002/hed.24655. PMID: 28079945

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