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Metastatic Malignant Neoplasm in the Parathyroid Glands

MedGen UID:
195788
•Concept ID:
C0686507
•
Neoplastic Process
Synonyms: Metastasis to the Parathyroid Gland; Metastatic malignant neoplasm of parathyroid gland; Metastatic malignant neoplasm to parathyroid gland; Metastatic Malignant Neoplasm to the Parathyroid Glands; Metastatic Neoplasm to the Parathyroid; Metastatic Neoplasm to the Parathyroid Gland; Metastatic Tumor to the Parathyroid; Metastatic Tumor to the Parathyroid Gland; Secondary malignant neoplasm of parathyroid gland
SNOMED CT: Secondary malignant neoplasm of parathyroid gland (94467003); Metastatic malignant neoplasm to parathyroid gland (94467003); Metastatic malignant neoplasm of parathyroid gland (94467003)

Definition

A malignant neoplasm either directly extending to the parathyroid glands from adjacent anatomic structures, or spreading to the parathyroid glands from distant anatomic sites, most frequently breast, lung, kidney, soft tissues, and skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Parathyroid Glands

Professional guidelines

PubMed

ACR Appropriateness Criteria® Parathyroid Adenoma.
Expert Panel on Neurological Imaging, Zander D, Bunch PM, Policeni B, Juliano AF, Carneiro-Pla D, Dubey P, Gule-Monroe MK, Hagiwara M, Hoang JK, Jain V, Kim LT, Moonis G, Parsons MS, Rath TJ, Solórzano CC, Subramaniam RM, Taheri MR, DuChene Thoma K, Trout AT, Zafereo ME Jr, Corey AS
J Am Coll Radiol 2021 Nov;18(11S):S406-S422. doi: 10.1016/j.jacr.2021.08.013. PMID: 34794597
The future: medical advances in MEN1 therapeutic approaches and management strategies.
van Leeuwaarde RS, de Laat JM, Pieterman CRC, Dreijerink K, Vriens MR, Valk GD
Endocr Relat Cancer 2017 Oct;24(10):T179-T193. Epub 2017 Aug 2 doi: 10.1530/ERC-17-0225. PMID: 28768698
Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1).
Gaztambide S, Vazquez F, Castaño L
Minerva Endocrinol 2013 Mar;38(1):17-28. PMID: 23435440

Recent clinical studies

Etiology

New therapies for patients with multiple endocrine neoplasia type 1.
Geslot A, Vialon M, Caron P, Grunenwald S, Vezzosi D
Ann Endocrinol (Paris) 2021 Apr;82(2):112-120. Epub 2021 Apr 8 doi: 10.1016/j.ando.2021.03.005. PMID: 33839123
Environmental chemicals and metabolic disruption in primary and secondary human parathyroid tumors.
Hu X, Saunders N, Safley S, Smith MR, Liang Y, Tran V, Sharma J, Jones DP, Weber CJ
Surgery 2021 Jan;169(1):102-108. Epub 2020 Aug 5 doi: 10.1016/j.surg.2020.06.010. PMID: 32771296Free PMC Article
The future: medical advances in MEN1 therapeutic approaches and management strategies.
van Leeuwaarde RS, de Laat JM, Pieterman CRC, Dreijerink K, Vriens MR, Valk GD
Endocr Relat Cancer 2017 Oct;24(10):T179-T193. Epub 2017 Aug 2 doi: 10.1530/ERC-17-0225. PMID: 28768698
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Primary and metastatic parathyroid malignancies: a rare or underdiagnosed condition?
Shifrin A, LiVolsi V, Shifrin-Douglas S, Zheng M, Erler B, Matulewicz T, Davis J
J Clin Endocrinol Metab 2015 Mar;100(3):E478-81. Epub 2014 Dec 9 doi: 10.1210/jc.2014-2760. PMID: 25490272

Diagnosis

Parathyroid Imaging.
Lalonde MN, Correia RD, Syktiotis GP, Schaefer N, Matter M, Prior JO
Semin Nucl Med 2023 Jul;53(4):490-502. Epub 2023 Mar 14 doi: 10.1053/j.semnuclmed.2023.02.004. PMID: 36922339
Advances and Updates in Parathyroid Pathology.
Gokozan HN, Scognamiglio T
Adv Anat Pathol 2023 Jan 1;30(1):24-33. Epub 2022 Nov 1 doi: 10.1097/PAP.0000000000000379. PMID: 36315270
Overview of the 2022 WHO Classification of Parathyroid Tumors.
Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ
Endocr Pathol 2022 Mar;33(1):64-89. Epub 2022 Feb 17 doi: 10.1007/s12022-022-09709-1. PMID: 35175514
Neoplastic metastases to the endocrine glands.
Angelousi A, Alexandraki KI, Kyriakopoulos G, Tsoli M, Thomas D, Kaltsas G, Grossman A
Endocr Relat Cancer 2020 Jan;27(1):R1-R20. doi: 10.1530/ERC-19-0263. PMID: 31645015
Parathyroid carcinoma.
Dudney WC, Bodenner D, Stack BC Jr
Otolaryngol Clin North Am 2010 Apr;43(2):441-53, xi. doi: 10.1016/j.otc.2010.01.011. PMID: 20510726

Therapy

Assessment and Comparison of (18)F-Fluorocholine PET and (99m)Tc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis.
Whitman J, Allen IE, Bergsland EK, Suh I, Hope TA
J Nucl Med 2021 Sep 1;62(9):1285-1291. Epub 2021 Jan 15 doi: 10.2967/jnumed.120.257303. PMID: 33452040Free PMC Article
Reduction in parathyroid adenomas by cinacalcet therapy in patients with primary hyperparathyroidism.
Minezaki M, Takashi Y, Ochi K, Mitsuoka R, Yamao Y, Kudo T, Kawanami D, Kobayashi K, Abe I
J Bone Miner Metab 2021 Jul;39(4):583-588. Epub 2021 Jan 6 doi: 10.1007/s00774-020-01190-2. PMID: 33409573
Environmental chemicals and metabolic disruption in primary and secondary human parathyroid tumors.
Hu X, Saunders N, Safley S, Smith MR, Liang Y, Tran V, Sharma J, Jones DP, Weber CJ
Surgery 2021 Jan;169(1):102-108. Epub 2020 Aug 5 doi: 10.1016/j.surg.2020.06.010. PMID: 32771296Free PMC Article
Recurrent or persistent hyperparathyroidism.
Wells SA Jr, Debenedetti MK, Doherty GM
J Bone Miner Res 2002 Nov;17 Suppl 2:N158-62. PMID: 12412795
Tumor ablation with radio-frequency energy.
Gazelle GS, Goldberg SN, Solbiati L, Livraghi T
Radiology 2000 Dec;217(3):633-46. doi: 10.1148/radiology.217.3.r00dc26633. PMID: 11110923

Prognosis

Parathyroid carcinoma: molecular therapeutic targets.
Marini F, Giusti F, Palmini G, Aurilia C, Donati S, Brandi ML
Endocrine 2023 Sep;81(3):409-418. Epub 2023 May 9 doi: 10.1007/s12020-023-03376-w. PMID: 37160841
Advances and Updates in Parathyroid Pathology.
Gokozan HN, Scognamiglio T
Adv Anat Pathol 2023 Jan 1;30(1):24-33. Epub 2022 Nov 1 doi: 10.1097/PAP.0000000000000379. PMID: 36315270
Neoplastic metastases to the endocrine glands.
Angelousi A, Alexandraki KI, Kyriakopoulos G, Tsoli M, Thomas D, Kaltsas G, Grossman A
Endocr Relat Cancer 2020 Jan;27(1):R1-R20. doi: 10.1530/ERC-19-0263. PMID: 31645015
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Parathyroid carcinoma.
Cordeiro AC, Montenegro FL, Kulcsar MA, Dellanegra LA, Tavares MR, Michaluart P Jr, Ferraz AR
Am J Surg 1998 Jan;175(1):52-5. doi: 10.1016/s0002-9610(97)00228-6. PMID: 9445240

Clinical prediction guides

Predictive factors for post-total thyroidectomy hypocalcaemia.
Halwani C, Turki S, Akkari K
Tunis Med 2020 Oct;98(10):720-725. PMID: 33479944
Clinicopathological correlates of hyperparathyroidism.
Duan K, Gomez Hernandez K, Mete O
J Clin Pathol 2015 Oct;68(10):771-87. Epub 2015 Jul 10 doi: 10.1136/jclinpath-2015-203186. PMID: 26163537
Ultrasound in head and neck surgery: thyroid, parathyroid, and cervical lymph nodes.
Senchenkov A, Staren ED
Surg Clin North Am 2004 Aug;84(4):973-1000, v. doi: 10.1016/j.suc.2004.04.007. PMID: 15261750
Parathyroid cytopathology.
Davey DD, Glant MD, Berger EK
Diagn Cytopathol 1986 Jan-Mar;2(1):76-80. doi: 10.1002/dc.2840020116. PMID: 2424691
Tertiary hyperparathyroidism.
Davies DR, Dent CE, Watson L
Br Med J 1968 Aug 17;3(5615):395-9. doi: 10.1136/bmj.3.5615.395. PMID: 5691200Free PMC Article

Recent systematic reviews

Carbon Nanoparticles for Thyroidectomy and Central Lymph Node Dissection for Thyroid Cancer.
Zhang RJ, Chen YL, Deng X, Yang H
Am Surg 2023 Jun;89(6):2227-2236. Epub 2022 Apr 6 doi: 10.1177/00031348221086780. PMID: 35387525
The Potential Role of Carbon Nanoparticles in Lymph Node Tracing, Recurrent Laryngeal Nerve Identification and Parathyroid Preservation During Thyroid Surgery: A Systematic Review.
Spartalis E, Giannakodimos A, Athanasiadis DI, Chrysikos D, Paschou SA, Schizas D, Patelis N, Papasilekas T, Themistoklis K, Spartalis M, Troupis T, Nikiteas N
Curr Pharm Des 2021;27(21):2505-2511. doi: 10.2174/1381612826666200922154824. PMID: 32962609
Spontaneous neck hematoma secondary to parathyroid adenoma: a case series.
Tessler I, Adi M, Diment J, Lahav Y, Halperin D, Cohen O
Eur Arch Otorhinolaryngol 2020 Sep;277(9):2551-2558. Epub 2020 Apr 11 doi: 10.1007/s00405-020-05959-z. PMID: 32279105
Parathyroid imaging: how good is it and how should it be done?
Kettle AG, O'Doherty MJ
Semin Nucl Med 2006 Jul;36(3):206-11. doi: 10.1053/j.semnuclmed.2006.03.003. PMID: 16762611

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