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Acute chest syndrome

MedGen UID:
196643
•Concept ID:
C0742343
•
Disease or Syndrome
Synonyms: Acute Chest Syndrome; Acute Chest Syndromes; Syndrome, Acute Chest; Syndromes, Acute Chest
SNOMED CT: Acute chest syndrome (372146004); Acute chest syndrome in sickle cell disease (372146004)
 
Monarch Initiative: MONDO:0005632

Definition

A vaso-occlusive crisis of the pulmonary vasculature occurring in patients with sickle cell disease. It is characterized by the presence of a new radiodensity on a chest radiograph accompanied by fever, cough, sputum production, dyspnea, or hypoxia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute chest syndrome

Professional guidelines

PubMed

Plastic Bronchitis in Adult and Pediatric Patients: A Review of its Presentation, Diagnosis, and Treatment.
Patel N, Patel M, Inja R, Krvavac A, Lechner AJ
Mo Med 2021 Jul-Aug;118(4):363-373. PMID: 34373673Free PMC Article
Sickle cell disease: current treatment and emerging therapies.
Neumayr LD, Hoppe CC, Brown C
Am J Manag Care 2019 Nov;25(18 Suppl):S335-S343. PMID: 31809007
Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.
Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, Tanabe PJ, Ware RE, Murad MH, Goldsmith JC, Ortiz E, Fulwood R, Horton A, John-Sowah J
JAMA 2014 Sep 10;312(10):1033-48. doi: 10.1001/jama.2014.10517. PMID: 25203083

Recent clinical studies

Etiology

Hydroxyurea (hydroxycarbamide) for sickle cell disease.
Rankine-Mullings AE, Nevitt SJ
Cochrane Database Syst Rev 2022 Sep 1;9(9):CD002202. doi: 10.1002/14651858.CD002202.pub3. PMID: 36047926Free PMC Article
Current and emerging treatments for sickle cell disease.
Monus T, Howell CM
JAAPA 2019 Sep;32(9):1-5. doi: 10.1097/01.JAA.0000578812.47138.99. PMID: 31460979
Acute chest syndrome in sickle cell disease.
Farooq S, Abu Omar M, Salzman GA
Hosp Pract (1995) 2018 Aug;46(3):144-151. Epub 2018 Apr 23 doi: 10.1080/21548331.2018.1464363. PMID: 29648482
Sickle cell disease.
Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene-Frempong K, Krishnamurti L, Smith WR, Panepinto JA, Weatherall DJ, Costa FF, Vichinsky EP
Nat Rev Dis Primers 2018 Mar 15;4:18010. doi: 10.1038/nrdp.2018.10. PMID: 29542687
Crises in Sickle Cell Disease.
Novelli EM, Gladwin MT
Chest 2016 Apr;149(4):1082-93. Epub 2015 Dec 28 doi: 10.1016/j.chest.2015.12.016. PMID: 26836899Free PMC Article

Diagnosis

Sickle Cell Disease: A Review.
Kavanagh PL, Fasipe TA, Wun T
JAMA 2022 Jul 5;328(1):57-68. doi: 10.1001/jama.2022.10233. PMID: 35788790
Hematology Emergencies in Critically Ill Adults: Benign Hematology.
Spring J, Munshi L
Chest 2022 May;161(5):1285-1296. Epub 2022 Jan 7 doi: 10.1016/j.chest.2021.12.650. PMID: 35007552
Posterior Reversible Encephalopathy Syndrome.
Gewirtz AN, Gao V, Parauda SC, Robbins MS
Curr Pain Headache Rep 2021 Feb 25;25(3):19. doi: 10.1007/s11916-020-00932-1. PMID: 33630183Free PMC Article
Sickle cell disease.
Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene-Frempong K, Krishnamurti L, Smith WR, Panepinto JA, Weatherall DJ, Costa FF, Vichinsky EP
Nat Rev Dis Primers 2018 Mar 15;4:18010. doi: 10.1038/nrdp.2018.10. PMID: 29542687
Sickle-cell disease.
Rees DC, Williams TN, Gladwin MT
Lancet 2010 Dec 11;376(9757):2018-31. Epub 2010 Dec 3 doi: 10.1016/S0140-6736(10)61029-X. PMID: 21131035

Therapy

Sickle Cell Disease: A Review.
Kavanagh PL, Fasipe TA, Wun T
JAMA 2022 Jul 5;328(1):57-68. doi: 10.1001/jama.2022.10233. PMID: 35788790
Red cell transfusion and alloimmunization in sickle cell disease.
Linder GE, Chou ST
Haematologica 2021 Jul 1;106(7):1805-1815. doi: 10.3324/haematol.2020.270546. PMID: 33792218Free PMC Article
Crises in Sickle Cell Disease.
Novelli EM, Gladwin MT
Chest 2016 Apr;149(4):1082-93. Epub 2015 Dec 28 doi: 10.1016/j.chest.2015.12.016. PMID: 26836899Free PMC Article
Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.
Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, Tanabe PJ, Ware RE, Murad MH, Goldsmith JC, Ortiz E, Fulwood R, Horton A, John-Sowah J
JAMA 2014 Sep 10;312(10):1033-48. doi: 10.1001/jama.2014.10517. PMID: 25203083
Sickle-cell disease.
Rees DC, Williams TN, Gladwin MT
Lancet 2010 Dec 11;376(9757):2018-31. Epub 2010 Dec 3 doi: 10.1016/S0140-6736(10)61029-X. PMID: 21131035

Prognosis

Posterior Reversible Encephalopathy Syndrome.
Gewirtz AN, Gao V, Parauda SC, Robbins MS
Curr Pain Headache Rep 2021 Feb 25;25(3):19. doi: 10.1007/s11916-020-00932-1. PMID: 33630183Free PMC Article
Vitamin D supplementation for sickle cell disease.
Soe HHK, Abas AB, Than NN, Ni H, Singh J, Said ARBM, Osunkwo I
Cochrane Database Syst Rev 2020 May 28;5(5):CD010858. doi: 10.1002/14651858.CD010858.pub3. PMID: 32462740Free PMC Article
Managing Acute Complications Of Sickle Cell Disease In Pediatric Patients.
Subramaniam S, Chao JH
Pediatr Emerg Med Pract 2016 Nov;13(11):1-28. Epub 2016 Nov 2 PMID: 27775898
Sickle-cell disease.
Rees DC, Williams TN, Gladwin MT
Lancet 2010 Dec 11;376(9757):2018-31. Epub 2010 Dec 3 doi: 10.1016/S0140-6736(10)61029-X. PMID: 21131035
Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review.
Ashley-Koch A, Yang Q, Olney RS
Am J Epidemiol 2000 May 1;151(9):839-45. doi: 10.1093/oxfordjournals.aje.a010288. PMID: 10791557

Clinical prediction guides

Hydroxyurea (hydroxycarbamide) for sickle cell disease.
Rankine-Mullings AE, Nevitt SJ
Cochrane Database Syst Rev 2022 Sep 1;9(9):CD002202. doi: 10.1002/14651858.CD002202.pub3. PMID: 36047926Free PMC Article
Sickle Cell Disease: A Review.
Kavanagh PL, Fasipe TA, Wun T
JAMA 2022 Jul 5;328(1):57-68. doi: 10.1001/jama.2022.10233. PMID: 35788790
Manifestations of HbSE sickle cell disease: a systematic review.
Khamees I, Ata F, Choudry H, Soliman AT, De Sanctis V, Yassin MA
J Transl Med 2021 Jun 16;19(1):262. doi: 10.1186/s12967-021-02931-1. PMID: 34134694Free PMC Article
Hydroxyurea (hydroxycarbamide) for sickle cell disease.
Nevitt SJ, Jones AP, Howard J
Cochrane Database Syst Rev 2017 Apr 20;4(4):CD002202. doi: 10.1002/14651858.CD002202.pub2. PMID: 28426137Free PMC Article
Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.
Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, Tanabe PJ, Ware RE, Murad MH, Goldsmith JC, Ortiz E, Fulwood R, Horton A, John-Sowah J
JAMA 2014 Sep 10;312(10):1033-48. doi: 10.1001/jama.2014.10517. PMID: 25203083

Recent systematic reviews

Hydroxyurea (hydroxycarbamide) for sickle cell disease.
Rankine-Mullings AE, Nevitt SJ
Cochrane Database Syst Rev 2022 Sep 1;9(9):CD002202. doi: 10.1002/14651858.CD002202.pub3. PMID: 36047926Free PMC Article
Pregnancy in the Sickle Cell Disease and Fetomaternal Outcomes in Different Sickle cell Genotypes: A Systematic Review and Meta-Analysis.
Aghamolaei T, Pormehr-Yabandeh A, Hosseini Z, Roozbeh N, Arian M, Ghanbarnezhad A
Ethiop J Health Sci 2022 Jul;32(4):849-864. doi: 10.4314/ejhs.v32i4.23. PMID: 35950054Free PMC Article
Manifestations of HbSE sickle cell disease: a systematic review.
Khamees I, Ata F, Choudry H, Soliman AT, De Sanctis V, Yassin MA
J Transl Med 2021 Jun 16;19(1):262. doi: 10.1186/s12967-021-02931-1. PMID: 34134694Free PMC Article
Hydroxyurea (hydroxycarbamide) for sickle cell disease.
Nevitt SJ, Jones AP, Howard J
Cochrane Database Syst Rev 2017 Apr 20;4(4):CD002202. doi: 10.1002/14651858.CD002202.pub2. PMID: 28426137Free PMC Article
Vitamin D supplementation for sickle cell disease.
Soe HH, Abas AB, Than NN, Ni H, Singh J, Said AR, Osunkwo I
Cochrane Database Syst Rev 2017 Jan 20;1(1):CD010858. doi: 10.1002/14651858.CD010858.pub2. PMID: 28105733Free PMC Article

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