U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign Lymphoproliferative Disorder

MedGen UID:
196657
•Concept ID:
C0746351
•
Disease or Syndrome

Definition

A proliferation of lymphocytes without atypia seen in infections, hypersensitivity reactions or autoimmune diseases. [from NCI]

Professional guidelines

PubMed

Treatment and outcome of Unicentric Castleman Disease: a retrospective analysis of 71 cases.
Boutboul D, Fadlallah J, Chawki S, Fieschi C, Malphettes M, Dossier A, Gérard L, Mordant P, Meignin V, Oksenhendler E, Galicier L
Br J Haematol 2019 Jul;186(2):269-273. Epub 2019 Apr 23 doi: 10.1111/bjh.15921. PMID: 31016730

Recent clinical studies

Etiology

Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD).
Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, Van Damme A, Brichard B
J Clin Immunol 2021 Jan;41(1):51-58. Epub 2020 Oct 4 doi: 10.1007/s10875-020-00883-7. PMID: 33011939
Treatment and outcome of Unicentric Castleman Disease: a retrospective analysis of 71 cases.
Boutboul D, Fadlallah J, Chawki S, Fieschi C, Malphettes M, Dossier A, Gérard L, Mordant P, Meignin V, Oksenhendler E, Galicier L
Br J Haematol 2019 Jul;186(2):269-273. Epub 2019 Apr 23 doi: 10.1111/bjh.15921. PMID: 31016730
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Steroids for symptom control in infectious mononucleosis.
Rezk E, Nofal YH, Hamzeh A, Aboujaib MF, AlKheder MA, Al Hammad MF
Cochrane Database Syst Rev 2015 Nov 8;2015(11):CD004402. doi: 10.1002/14651858.CD004402.pub3. PMID: 26558642Free PMC Article
Hepatitis C virus and non-Hodgkin's lymphomas.
Mazzaro C, Zagonel V, Monfardini S, Tulissi P, Pussini E, Fanni M, Sorio R, Bortolus R, Crovatto M, Santini G, Tiribelli C, Sasso F, Masutti R, Pozzato G
Br J Haematol 1996 Sep;94(3):544-50. doi: 10.1046/j.1365-2141.1996.6912313.x. PMID: 8790157

Diagnosis

Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD).
Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, Van Damme A, Brichard B
J Clin Immunol 2021 Jan;41(1):51-58. Epub 2020 Oct 4 doi: 10.1007/s10875-020-00883-7. PMID: 33011939
The role of surgical resection in Unicentric Castleman's disease: a systematic review.
Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N
Adv Respir Med 2018;86(1):36-43. doi: 10.5603/ARM.2018.0008. PMID: 29490420
Lymphoproliferative Disorders of the Lung.
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Drug-induced pseudo-Sezary syndrome: a case report and literature review.
Reeder MJ, Wood GS
Am J Dermatopathol 2015 Jan;37(1):83-6. doi: 10.1097/DAD.0000000000000169. PMID: 25033012

Therapy

The role of surgical resection in Unicentric Castleman's disease: a systematic review.
Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N
Adv Respir Med 2018;86(1):36-43. doi: 10.5603/ARM.2018.0008. PMID: 29490420
Steroids for symptom control in infectious mononucleosis.
Rezk E, Nofal YH, Hamzeh A, Aboujaib MF, AlKheder MA, Al Hammad MF
Cochrane Database Syst Rev 2015 Nov 8;2015(11):CD004402. doi: 10.1002/14651858.CD004402.pub3. PMID: 26558642Free PMC Article
Drug-induced pseudo-Sezary syndrome: a case report and literature review.
Reeder MJ, Wood GS
Am J Dermatopathol 2015 Jan;37(1):83-6. doi: 10.1097/DAD.0000000000000169. PMID: 25033012
Hepatitis C virus infection and cryoglobulinaemia.
Lunel F, Musset L
Forum (Genova) 1998 Jan-Mar;8(1):95-103. PMID: 9514994
Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation.
Sansonno D, De Vita S, Cornacchiulo V, Carbone A, Boiocchi M, Dammacco F
Blood 1996 Dec 15;88(12):4638-45. PMID: 8977256

Prognosis

Primary hepatic Castleman disease.
Danis HE, Keenan C, Schaber J, Grasso SL
BMJ Case Rep 2024 Mar 13;17(3) doi: 10.1136/bcr-2023-256819. PMID: 38479827Free PMC Article
Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD).
Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, Van Damme A, Brichard B
J Clin Immunol 2021 Jan;41(1):51-58. Epub 2020 Oct 4 doi: 10.1007/s10875-020-00883-7. PMID: 33011939
The role of surgical resection in Unicentric Castleman's disease: a systematic review.
Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N
Adv Respir Med 2018;86(1):36-43. doi: 10.5603/ARM.2018.0008. PMID: 29490420
Lymphoproliferative Disorders of the Lung.
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077

Clinical prediction guides

Transient hypertriglyceridemia: a common finding during Epstein-Barr virus-induced infectious mononucleosis.
Páez-Guillán EM, Campos-Franco J, Alende R, Garitaonaindía Y, González-Quintela A
Lipids Health Dis 2021 Dec 12;20(1):177. doi: 10.1186/s12944-021-01603-9. PMID: 34895245Free PMC Article
Drug-induced pseudo-Sezary syndrome: a case report and literature review.
Reeder MJ, Wood GS
Am J Dermatopathol 2015 Jan;37(1):83-6. doi: 10.1097/DAD.0000000000000169. PMID: 25033012
Hepatitis C virus infection and cryoglobulinaemia.
Lunel F, Musset L
Forum (Genova) 1998 Jan-Mar;8(1):95-103. PMID: 9514994
Unifocal cervical Castleman disease in two children.
Tuerlinckx D, Bodart E, Delos M, Remacle M, Ninane J
Eur J Pediatr 1997 Sep;156(9):701-3. doi: 10.1007/s004310050693. PMID: 9296533
Epstein-Barr virus (EBV) infection in infectious mononucleosis: virus latency, replication and phenotype of EBV-infected cells.
Niedobitek G, Agathanggelou A, Herbst H, Whitehead L, Wright DH, Young LS
J Pathol 1997 Jun;182(2):151-9. doi: 10.1002/(SICI)1096-9896(199706)182:2<151::AID-PATH824>3.0.CO;2-3. PMID: 9274524

Recent systematic reviews

The role of surgical resection in Unicentric Castleman's disease: a systematic review.
Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N
Adv Respir Med 2018;86(1):36-43. doi: 10.5603/ARM.2018.0008. PMID: 29490420
Steroids for symptom control in infectious mononucleosis.
Rezk E, Nofal YH, Hamzeh A, Aboujaib MF, AlKheder MA, Al Hammad MF
Cochrane Database Syst Rev 2015 Nov 8;2015(11):CD004402. doi: 10.1002/14651858.CD004402.pub3. PMID: 26558642Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...