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Uniparental isodisomy

MedGen UID:
197433
Concept ID:
C0969676
Cell or Molecular Dysfunction
Synonyms: Isodisomies, Uniparental; Uniparental Isodisomies; Uniparental Isodisomy
 
HPO: HP:0032384

Definition

A type of uniparental disomy in which the two identical chromosomes (or chromosome segments) of the same parent are transmitted. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUniparental isodisomy

Professional guidelines

PubMed

Defabianis P, Mussa A, Ninivaggi R, Carli D, Romano F
Int J Environ Res Public Health 2022 Feb 20;19(4) doi: 10.3390/ijerph19042448. PMID: 35206635Free PMC Article
Baker SW, Ryan E, Kalish JM, Ganguly A
Prenat Diagn 2021 Jun;41(7):817-822. Epub 2021 May 18 doi: 10.1002/pd.5953. PMID: 33974722
Sheppard SE, Lalonde E, Adzick NS, Beck AE, Bhatti T, De Leon DD, Duffy KA, Ganguly A, Hathaway E, Ji J, Linn R, Lord K, Randolph LM, Sajorda B, States L, Conlin LK, Kalish JM
Genet Med 2019 Nov;21(11):2644-2649. Epub 2019 May 31 doi: 10.1038/s41436-019-0551-9. PMID: 31147633Free PMC Article

Recent clinical studies

Therapy

Akutsu SN, Miyamoto T, Oba D, Tomioka K, Ochiai H, Ohashi H, Matsuura S
PLoS One 2022;17(3):e0264965. Epub 2022 Mar 10 doi: 10.1371/journal.pone.0264965. PMID: 35271616Free PMC Article
Bharucha-Goebel DX, Norato G, Saade D, Paredes E, Biancavilla V, Donkervoort S, Kaur R, Lehky T, Fink M, Armao D, Gray SJ, Waite M, Debs S, Averion G, Hu Y, Zein WM, Foley AR, Jain M, Bönnemann CG
Brain 2021 Nov 29;144(10):3239-3250. doi: 10.1093/brain/awab179. PMID: 34114613Free PMC Article
Garcin L, Kariyawasam D, Busiah K, Fauret-Amsellem AL, Le Bourgeois F, Vaivre-Douret L, Cavé H, Polak M, Beltrand J
Pediatr Diabetes 2018 Jun;19(4):663-669. Epub 2018 Mar 4 doi: 10.1111/pedi.12635. PMID: 29504184
Poradosu S, Bravenboer B, Takatani R, Jüppner H
BMJ Case Rep 2016 May 11;2016 doi: 10.1136/bcr-2016-214673. PMID: 27170606Free PMC Article
Spits C, Guzman L, Mertzanidou A, Jacobs K, Ortega-Hrepich C, Gilchrist RB, Thompson JG, De Vos M, Smitz J, Sermon K
Hum Reprod 2015 Mar;30(3):653-63. Epub 2014 Dec 4 doi: 10.1093/humrep/deu329. PMID: 25475586

Prognosis

Baker SW, Ryan E, Kalish JM, Ganguly A
Prenat Diagn 2021 Jun;41(7):817-822. Epub 2021 May 18 doi: 10.1002/pd.5953. PMID: 33974722
Cassini TA, Robertson AK, Bican AG, Cogan JD, Hannig VL, Newman JH, Hamid R, Phillips JA 3rd; Undiagnosed Diseases Network
Am J Med Genet A 2018 May;176(5):1175-1179. Epub 2018 Jan 17 doi: 10.1002/ajmg.a.38493. PMID: 29341437Free PMC Article
Kalish JM, Boodhansingh KE, Bhatti TR, Ganguly A, Conlin LK, Becker SA, Givler S, Mighion L, Palladino AA, Adzick NS, De León DD, Stanley CA, Deardorff MA
J Med Genet 2016 Jan;53(1):53-61. Epub 2015 Nov 6 doi: 10.1136/jmedgenet-2015-103394. PMID: 26545876Free PMC Article
Coffey AJ, Durkie M, Hague S, McLay K, Emmerson J, Lo C, Klaffke S, Joyce CJ, Dhawan A, Hadzic N, Mieli-Vergani G, Kirk R, Elizabeth Allen K, Nicholl D, Wong S, Griffiths W, Smithson S, Giffin N, Taha A, Connolly S, Gillett GT, Tanner S, Bonham J, Sharrack B, Palotie A, Rattray M, Dalton A, Bandmann O
Brain 2013 May;136(Pt 5):1476-87. Epub 2013 Mar 21 doi: 10.1093/brain/awt035. PMID: 23518715Free PMC Article
Asselta R, Duga S, Tenchini ML
J Thromb Haemost 2006 Oct;4(10):2115-29. doi: 10.1111/j.1538-7836.2006.02094.x. PMID: 16999847

Clinical prediction guides

Jüppner H
J Clin Endocrinol Metab 2021 May 13;106(6):1541-1552. doi: 10.1210/clinem/dgab060. PMID: 33529330Free PMC Article
Tafaj O, Jüppner H
J Endocrinol Invest 2017 Apr;40(4):347-356. Epub 2016 Dec 19 doi: 10.1007/s40618-016-0588-4. PMID: 27995443
Coffey AJ, Durkie M, Hague S, McLay K, Emmerson J, Lo C, Klaffke S, Joyce CJ, Dhawan A, Hadzic N, Mieli-Vergani G, Kirk R, Elizabeth Allen K, Nicholl D, Wong S, Griffiths W, Smithson S, Giffin N, Taha A, Connolly S, Gillett GT, Tanner S, Bonham J, Sharrack B, Palotie A, Rattray M, Dalton A, Bandmann O
Brain 2013 May;136(Pt 5):1476-87. Epub 2013 Mar 21 doi: 10.1093/brain/awt035. PMID: 23518715Free PMC Article
Castanet M, Polak M
Horm Res Paediatr 2010;73(6):423-9. Epub 2010 May 6 doi: 10.1159/000281438. PMID: 20453517
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS
Nature 2003 May 15;423(6937):293-8. Epub 2003 Apr 25 doi: 10.1038/nature01629. PMID: 12714972Free PMC Article

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