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Congenital rubella syndrome

MedGen UID:
19841
•Concept ID:
C0035921
•
Disease or Syndrome
Synonyms: Congenital Rubella Syndrome; Congenital Rubella Syndromes; Rubella Syndrome, Congenital; Rubella Syndromes, Congenital; Syndrome, Congenital Rubella; Syndromes, Congenital Rubella
SNOMED CT: Congenital rubella syndrome (1857005); Gestational rubella syndrome (1857005); Gregg's syndrome (1857005); Congenital rubella (1857005)

Definition

A condition, whose clinical manifestations include intrauterine growth restriction, petechial rash, jaundice, generalized lymphadenopathy, hepatosplenomegaly, peripheral pulmonary stenosis, cataracts, and sensorineural deafness, that is caused by fetal exposure to the rubella virus during the first trimester of pregnancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital rubella syndrome
Follow this link to review classifications for Congenital rubella syndrome in Orphanet.

Professional guidelines

PubMed

No. 368-RUBELLA IN PREGNANCY.
Boucoiran I, Castillo E
J Obstet Gynaecol Can 2018 Dec;40(12):1646-1656. doi: 10.1016/j.jogc.2018.07.003. PMID: 30527073
No. 203-Rubella in Pregnancy.
Dontigny L, Arsenault MY, Martel MJ
J Obstet Gynaecol Can 2018 Aug;40(8):e615-e621. doi: 10.1016/j.jogc.2018.05.009. PMID: 30103885
Rubella and pregnancy: diagnosis, management and outcomes.
Bouthry E, Picone O, Hamdi G, Grangeot-Keros L, Ayoubi JM, Vauloup-Fellous C
Prenat Diagn 2014 Dec;34(13):1246-53. Epub 2014 Sep 16 doi: 10.1002/pd.4467. PMID: 25066688

Recent clinical studies

Etiology

Rubella in Poland in 2020.
Bogusz J, Augustynowicz E, Paradowska-Stankiewicz I
Przegl Epidemiol 2022;76(4):554-560. doi: 10.32394/pe.76.50. PMID: 37017447
Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism.
Mawson AR, Croft AM
Int J Environ Res Public Health 2019 Sep 22;16(19) doi: 10.3390/ijerph16193543. PMID: 31546693Free PMC Article
Congenital and perinatal infections.
Ostrander B, Bale JF
Handb Clin Neurol 2019;162:133-153. doi: 10.1016/B978-0-444-64029-1.00006-0. PMID: 31324308
Rubella and rubeola.
Rosa C
Semin Perinatol 1998 Aug;22(4):318-22. doi: 10.1016/s0146-0005(98)80020-7. PMID: 9738996
Rubella.
Boniuk V
Int Ophthalmol Clin 1975 Winter;15(4):229-41. doi: 10.1097/00004397-197501540-00019. PMID: 773881

Diagnosis

Rubella.
Winter AK, Moss WJ
Lancet 2022 Apr 2;399(10332):1336-1346. doi: 10.1016/S0140-6736(21)02691-X. PMID: 35367004
Congenital and perinatal infections.
Ostrander B, Bale JF
Handb Clin Neurol 2019;162:133-153. doi: 10.1016/B978-0-444-64029-1.00006-0. PMID: 31324308
Measles.
Moss WJ
Lancet 2017 Dec 2;390(10111):2490-2502. Epub 2017 Jun 30 doi: 10.1016/S0140-6736(17)31463-0. PMID: 28673424
Rubella.
Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA
Lancet 2015 Jun 6;385(9984):2297-307. Epub 2015 Jan 8 doi: 10.1016/S0140-6736(14)60539-0. PMID: 25576992Free PMC Article
Rubella and pregnancy: diagnosis, management and outcomes.
Bouthry E, Picone O, Hamdi G, Grangeot-Keros L, Ayoubi JM, Vauloup-Fellous C
Prenat Diagn 2014 Dec;34(13):1246-53. Epub 2014 Sep 16 doi: 10.1002/pd.4467. PMID: 25066688

Therapy

Measles.
Moss WJ
Lancet 2017 Dec 2;390(10111):2490-2502. Epub 2017 Jun 30 doi: 10.1016/S0140-6736(17)31463-0. PMID: 28673424
Epidemiology of rubella and congenital rubella syndrome in Japan before 1989.
Ueda K
Vaccine 2016 Apr 7;34(16):1971-4. Epub 2015 Oct 23 doi: 10.1016/j.vaccine.2015.10.010. PMID: 26469722
TORCH infections.
Neu N, Duchon J, Zachariah P
Clin Perinatol 2015 Mar;42(1):77-103, viii. Epub 2014 Dec 20 doi: 10.1016/j.clp.2014.11.001. PMID: 25677998
Rubella.
Lambert N, Strebel P, Orenstein W, Icenogle J, Poland GA
Lancet 2015 Jun 6;385(9984):2297-307. Epub 2015 Jan 8 doi: 10.1016/S0140-6736(14)60539-0. PMID: 25576992Free PMC Article
Rubella.
Banatvala JE, Brown DW
Lancet 2004 Apr 3;363(9415):1127-37. doi: 10.1016/S0140-6736(04)15897-2. PMID: 15064032

Prognosis

Rubella in Poland in 2020.
Bogusz J, Augustynowicz E, Paradowska-Stankiewicz I
Przegl Epidemiol 2022;76(4):554-560. doi: 10.32394/pe.76.50. PMID: 37017447
Rubella in Poland in 2019.
Bogusz J, Augustynowicz E, Paradowska-Stankiewicz I
Przegl Epidemiol 2021;75(4):588-596. doi: 10.32394/pe.75.55. PMID: 35543505
Rubella (German measles) revisited.
Leung AKC, Hon KL, Leong KF
Hong Kong Med J 2019 Apr;25(2):134-141. Epub 2019 Apr 10 doi: 10.12809/hkmj187785. PMID: 30967519
Epidemiology of rubella and congenital rubella syndrome in Japan before 1989.
Ueda K
Vaccine 2016 Apr 7;34(16):1971-4. Epub 2015 Oct 23 doi: 10.1016/j.vaccine.2015.10.010. PMID: 26469722
Rubella and rubeola.
Rosa C
Semin Perinatol 1998 Aug;22(4):318-22. doi: 10.1016/s0146-0005(98)80020-7. PMID: 9738996

Clinical prediction guides

Rubella in Poland in 2020.
Bogusz J, Augustynowicz E, Paradowska-Stankiewicz I
Przegl Epidemiol 2022;76(4):554-560. doi: 10.32394/pe.76.50. PMID: 37017447
Rubella in Poland in 2019.
Bogusz J, Augustynowicz E, Paradowska-Stankiewicz I
Przegl Epidemiol 2021;75(4):588-596. doi: 10.32394/pe.75.55. PMID: 35543505
Rubella in Poland in 2017.
Bogusz J, Paradowska-Stankiewicz I
Przegl Epidemiol 2019;73(3):305-310. doi: 10.32394/pe.73.35. PMID: 31766826
No. 368-RUBELLA IN PREGNANCY.
Boucoiran I, Castillo E
J Obstet Gynaecol Can 2018 Dec;40(12):1646-1656. doi: 10.1016/j.jogc.2018.07.003. PMID: 30527073
Rubella.
Boniuk V
Int Ophthalmol Clin 1975 Winter;15(4):229-41. doi: 10.1097/00004397-197501540-00019. PMID: 773881

Recent systematic reviews

The end of measles and congenital rubella: an achievable dream?
Adamo G, Sturabotti G, D'Andrea E, Baccolini V, Romano F, Iannazzo S, Marzuillo C, Villari P
Ann Ig 2017 Jan-Feb;29(1):1-26. doi: 10.7416/ai.2017.2128. PMID: 28067934
Systematic Review of Measles and Rubella Serology Studies.
Thompson KM, Odahowski CL
Risk Anal 2016 Jul;36(7):1459-86. Epub 2015 Jun 16 doi: 10.1111/risa.12430. PMID: 26077609
Systematic Review of the Manifestations of Congenital Rubella Syndrome in Infants and Characterization of Disability-Adjusted Life Years (DALYs).
Simons EA, Reef SE, Cooper LZ, Zimmerman L, Thompson KM
Risk Anal 2016 Jul;36(7):1332-56. Epub 2014 Aug 12 doi: 10.1111/risa.12263. PMID: 25115193
Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome.
Young MK, Cripps AW, Nimmo GR, van Driel ML
Cochrane Database Syst Rev 2015 Sep 9;2015(9):CD010586. doi: 10.1002/14651858.CD010586.pub2. PMID: 26350479Free PMC Article
Burden of Congenital Rubella Syndrome (CRS) in India: a systematic review.
Dewan P, Gupta P
Indian Pediatr 2012 May;49(5):377-99. doi: 10.1007/s13312-012-0087-4. PMID: 22700664

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