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Pulmonary sarcoidosis

MedGen UID:
19873
•Concept ID:
C0036205
•
Disease or Syndrome
Synonyms: Pulmonary Sarcoidoses; Pulmonary Sarcoidosis; Sarcoidoses, Pulmonary; Sarcoidosis, Pulmonary
SNOMED CT: Sarcoidosis of lung (24369008); Pulmonary sarcoidosis (24369008)
 
Monarch Initiative: MONDO:0001708

Definition

Sarcoidosis affecting the lung parenchyma. It is characterized by the presence of non-necrotizing granulomas in the lung tissues. It is manifested with dyspnea, cough, fever, night sweats, fatigue, and weight loss. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary sarcoidosis

Professional guidelines

PubMed

Diagnosis and Treatment of Pulmonary Sarcoidosis: A Review.
Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
Management of Advanced Pulmonary Sarcoidosis.
Gupta R, Judson MA, Baughman RP
Am J Respir Crit Care Med 2022 Mar 1;205(5):495-506. doi: 10.1164/rccm.202106-1366CI. PMID: 34813386
Treatment of sarcoidosis.
Baughman RP
Panminerva Med 2013 Jun;55(2):175-89. PMID: 23676958

Recent clinical studies

Etiology

Efzofitimod for the Treatment of Pulmonary Sarcoidosis.
Culver DA, Aryal S, Barney J, Hsia CCW, James WE, Maier LA, Marts LT, Obi ON, Sporn PHS, Sweiss NJ, Shukla S, Kinnersley N, Walker G, Baughman R
Chest 2023 Apr;163(4):881-890. Epub 2022 Nov 8 doi: 10.1016/j.chest.2022.10.037. PMID: 36356657Free PMC Article
Management of Advanced Pulmonary Sarcoidosis.
Gupta R, Judson MA, Baughman RP
Am J Respir Crit Care Med 2022 Mar 1;205(5):495-506. doi: 10.1164/rccm.202106-1366CI. PMID: 34813386
Lung transplantation for pulmonary sarcoidosis.
Meyer KC
Sarcoidosis Vasc Diffuse Lung Dis 2019;36(2):92-107. Epub 2019 May 1 doi: 10.36141/svdld.v36i2.7163. PMID: 32476942Free PMC Article
JCS 2016 Guideline on Diagnosis and Treatment of Cardiac Sarcoidosis　- Digest Version.
Terasaki F, Azuma A, Anzai T, Ishizaka N, Ishida Y, Isobe M, Inomata T, Ishibashi-Ueda H, Eishi Y, Kitakaze M, Kusano K, Sakata Y, Shijubo N, Tsuchida A, Tsutsui H, Nakajima T, Nakatani S, Horii T, Yazaki Y, Yamaguchi E, Yamaguchi T, Ide T, Okamura H, Kato Y, Goya M, Sakakibara M, Soejima K, Nagai T, Nakamura H, Noda T, Hasegawa T, Morita H, Ohe T, Kihara Y, Saito Y, Sugiyama Y, Morimoto SI, Yamashina A; Japanese Circulation Society Joint Working Group
Circ J 2019 Oct 25;83(11):2329-2388. Epub 2019 Oct 9 doi: 10.1253/circj.CJ-19-0508. PMID: 31597819
Pulmonary Sarcoidosis.
Valeyre D, Bernaudin JF, Jeny F, Duchemann B, Freynet O, Planès C, Kambouchner M, Nunes H
Clin Chest Med 2015 Dec;36(4):631-41. doi: 10.1016/j.ccm.2015.08.006. PMID: 26593138

Diagnosis

Diagnosis and Treatment of Pulmonary Sarcoidosis: A Review.
Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
BTS Clinical Statement on pulmonary sarcoidosis.
Thillai M, Atkins CP, Crawshaw A, Hart SP, Ho LP, Kouranos V, Patterson K, Screaton NJ, Whight J, Wells AU
Thorax 2021 Jan;76(1):4-20. Epub 2020 Dec 2 doi: 10.1136/thoraxjnl-2019-214348. PMID: 33268456
Challenges in Cardiac and Pulmonary Sarcoidosis: JACC State-of-the-Art Review.
Trivieri MG, Spagnolo P, Birnie D, Liu P, Drake W, Kovacic JC, Baughman R, Fayad ZA, Judson MA
J Am Coll Cardiol 2020 Oct 20;76(16):1878-1901. doi: 10.1016/j.jacc.2020.08.042. PMID: 33059834Free PMC Article
Advanced pulmonary sarcoidosis.
Patel DC, Valeyre D
Curr Opin Pulm Med 2020 Sep;26(5):574-581. doi: 10.1097/MCP.0000000000000705. PMID: 32740378
Pulmonary sarcoidosis.
Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU
Lancet Respir Med 2018 May;6(5):389-402. Epub 2018 Apr 3 doi: 10.1016/S2213-2600(18)30064-X. PMID: 29625772

Therapy

Efzofitimod for the Treatment of Pulmonary Sarcoidosis.
Culver DA, Aryal S, Barney J, Hsia CCW, James WE, Maier LA, Marts LT, Obi ON, Sporn PHS, Sweiss NJ, Shukla S, Kinnersley N, Walker G, Baughman R
Chest 2023 Apr;163(4):881-890. Epub 2022 Nov 8 doi: 10.1016/j.chest.2022.10.037. PMID: 36356657Free PMC Article
Challenges in Cardiac and Pulmonary Sarcoidosis: JACC State-of-the-Art Review.
Trivieri MG, Spagnolo P, Birnie D, Liu P, Drake W, Kovacic JC, Baughman R, Fayad ZA, Judson MA
J Am Coll Cardiol 2020 Oct 20;76(16):1878-1901. doi: 10.1016/j.jacc.2020.08.042. PMID: 33059834Free PMC Article
Advanced Pulmonary Sarcoidosis.
Gupta R, Baughman RP
Semin Respir Crit Care Med 2020 Oct;41(5):700-715. Epub 2020 Aug 10 doi: 10.1055/s-0040-1709495. PMID: 32777853
Therapeutic strategies for pulmonary sarcoidosis.
James WE, Judson MA
Expert Rev Respir Med 2020 Apr;14(4):391-403. Epub 2020 Jan 31 doi: 10.1080/17476348.2020.1721284. PMID: 32003264
Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999.
Am J Respir Crit Care Med 1999 Aug;160(2):736-55. doi: 10.1164/ajrccm.160.2.ats4-99. PMID: 10430755

Prognosis

Advanced pulmonary sarcoidosis.
Patel DC, Valeyre D
Curr Opin Pulm Med 2020 Sep;26(5):574-581. doi: 10.1097/MCP.0000000000000705. PMID: 32740378
Trends and risk factors of mortality and disability adjusted life years for chronic respiratory diseases from 1990 to 2017: systematic analysis for the Global Burden of Disease Study 2017.
Li X, Cao X, Guo M, Xie M, Liu X
BMJ 2020 Feb 19;368:m234. doi: 10.1136/bmj.m234. PMID: 32075787Free PMC Article
Advanced sarcoidosis.
Baughman RP, Wells A
Curr Opin Pulm Med 2019 Sep;25(5):497-504. doi: 10.1097/MCP.0000000000000612. PMID: 31365384
Interstitial Lung Diseases in Developing Countries.
Rivera-Ortega P, Molina-Molina M
Ann Glob Health 2019 Jan 22;85(1) doi: 10.5334/aogh.2414. PMID: 30741505Free PMC Article
Pulmonary sarcoidosis.
Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU
Lancet Respir Med 2018 May;6(5):389-402. Epub 2018 Apr 3 doi: 10.1016/S2213-2600(18)30064-X. PMID: 29625772

Clinical prediction guides

Efzofitimod for the Treatment of Pulmonary Sarcoidosis.
Culver DA, Aryal S, Barney J, Hsia CCW, James WE, Maier LA, Marts LT, Obi ON, Sporn PHS, Sweiss NJ, Shukla S, Kinnersley N, Walker G, Baughman R
Chest 2023 Apr;163(4):881-890. Epub 2022 Nov 8 doi: 10.1016/j.chest.2022.10.037. PMID: 36356657Free PMC Article
Diagnosis and Treatment of Pulmonary Sarcoidosis: A Review.
Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, Lynch JP 3rd
JAMA 2022 Mar 1;327(9):856-867. doi: 10.1001/jama.2022.1570. PMID: 35230389
Pulmonary sarcoidosis.
Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU
Lancet Respir Med 2018 May;6(5):389-402. Epub 2018 Apr 3 doi: 10.1016/S2213-2600(18)30064-X. PMID: 29625772
Chest Imaging.
Keijsers RG, Veltkamp M, Grutters JC
Clin Chest Med 2015 Dec;36(4):603-19. doi: 10.1016/j.ccm.2015.08.004. PMID: 26593136
Advanced pulmonary sarcoidosis.
Valeyre D, Nunes H, Bernaudin JF
Curr Opin Pulm Med 2014 Sep;20(5):488-95. doi: 10.1097/MCP.0000000000000075. PMID: 25046429

Recent systematic reviews

MicroRNAs in pulmonary sarcoidosis: A systematic review.
Pattnaik B, Sryma PB, Mittal S, Agrawal A, Guleria R, Madan K
Respir Investig 2020 Jul;58(4):232-238. Epub 2020 Apr 15 doi: 10.1016/j.resinv.2020.02.008. PMID: 32305227
Sarcoidosis and cancer risk: systematic review and meta-analysis of observational studies.
Bonifazi M, Bravi F, Gasparini S, La Vecchia C, Gabrielli A, Wells AU, Renzoni EA
Chest 2015 Mar;147(3):778-791. doi: 10.1378/chest.14-1475. PMID: 25340385
Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis.
Paramothayan S, Lasserson TJ, Walters EH
Cochrane Database Syst Rev 2006 Jul 19;2006(3):CD003536. doi: 10.1002/14651858.CD003536.pub2. PMID: 16856012Free PMC Article
Corticosteroid therapy in pulmonary sarcoidosis: a systematic review.
Paramothayan S, Jones PW
JAMA 2002 Mar 13;287(10):1301-7. doi: 10.1001/jama.287.10.1301. PMID: 11886322
Corticosteroids for pulmonary sarcoidosis.
Paramothayan NS, Jones PW
Cochrane Database Syst Rev 2000;(4):CD001114. doi: 10.1002/14651858.CD001114. PMID: 11034698

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