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Malignant Genitourinary System Neoplasm

MedGen UID:: 199685
•Concept ID:: C0751569
•: Neoplastic Process

Synonyms:

Cancer, Genito-urinary; Cancer, Genitourinary; Cancer, Urogenital; Cancers, Genito-urinary; Cancers, Genitourinary; Cancers, Urogenital; Genito urinary Cancer; Genito-urinary Cancer; Genito-urinary Cancers; Genitourinary Cancer; Genitourinary Cancers; Urogenital Cancer; Urogenital Cancers

Definition

A primary or metastatic malignant neoplasm that affects the genitourinary system. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Genitourinary System Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of the genitourinary system
        Genitourinary System Neoplasm
        Malignant Genitourinary System Neoplasm
        Genitourinary System Carcinoma
        Female Reproductive System Carcinoma
        Carcinoma of cervix
        Carcinoma of fallopian tube
        Endometrial carcinoma
        Ovarian carcinoma
        Vaginal carcinoma
        Vulvar carcinoma
        Male Reproductive System Carcinoma
        Epididymal adenocarcinoma
        Penile carcinoma
        Prostate carcinoma
        Recurrent Male Reproductive System Carcinoma
        Refractory Male Reproductive System Carcinoma
        Rete testis adenocarcinoma
        Seminal vesicle adenocarcinoma
        Metastatic Genitourinary System Carcinoma
        Advanced Genitourinary System Carcinoma
        Locally Advanced Genitourinary System Carcinoma
        Metastatic Bladder Carcinoma
        Metastatic Cervical Carcinoma
        Metastatic Endometrial Carcinoma
        Metastatic Fallopian Tube Carcinoma
        Metastatic Kidney Carcinoma
        Metastatic Ovarian Carcinoma
        Metastatic Penile Carcinoma
        Metastatic prostate carcinoma
        Metastatic Ureter Carcinoma
        Metastatic Urethral Carcinoma
        Metastatic Urothelial Carcinoma
        Metastatic Vaginal Carcinoma
        Metastatic Vulvar Carcinoma
        Urinary System Carcinoma
        Recurrent Urinary System Carcinoma
        Refractory Urinary System Carcinoma
        Renal carcinoma
        Renal Pelvis and Ureter Carcinoma
        Ureter carcinoma
        Urethral Carcinoma
        Urinary bladder carcinoma
        Urothelial carcinoma
        Malignant Urinary Tract Neoplasm
        Hereditary Malignant Urinary System Neoplasm
        Hereditary renal cell carcinoma
        Hereditary Wilms tumor
        Malignant tumor of kidney
        Childhood malignant kidney neoplasm
        Kidney Lymphoma
        Malignant Kidney Neoplasm Except Pelvis
        Malignant mixed epithelial stromal tumor of the kidney
        Malignant renal pelvis neoplasm
        Metastatic Malignant Neoplasm in the Kidney
        Nephroblastoma
        Peripheral Primitive Neuroectodermal Tumor of the Kidney
        Renal sarcoma
        Malignant tumor of ureter
        Metastatic Malignant Neoplasm in the Ureter
        Regional ureteric cancer
        Ureteral lymphoma
        Malignant tumor of urinary bladder
        Bladder lymphoma
        Bladder Malignant PEComa
        Bladder Melanoma
        Bladder sarcoma
        Metastatic Bladder Paraganglioma
        Metastatic Malignant Neoplasm in the Bladder
        Recurrent Malignant Bladder Neoplasm
        Malignant Urethral Neoplasm
        Anterior urethra cancer
        Female urethral cancer
        Male urethral cancer
        Malignant Accessory Urethral Gland Neoplasm
        Metastatic Malignant Neoplasm in the Urethra
        Posterior urethra cancer
        Regional Malignant Urethral Neoplasm
        Urethral Melanoma
        Metastatic Malignant Neoplasm in the Urinary System
        Mucosal Melanoma of the Urinary System
        Recurrent Malignant Urinary System Neoplasm
        Recurrent Kidney Wilms Tumor
        Recurrent Rhabdoid Tumor of the Kidney
        Refractory Malignant Urinary System Neoplasm
        Refractory Rhabdoid Tumor of the Kidney
        Metastatic Malignant Genitourinary System Neoplasm
        Advanced Malignant Genitourinary System Neoplasm
        Advanced Malignant Female Reproductive System Neoplasm
        Metastatic Malignant Female Reproductive System Neoplasm
        Locally Advanced Malignant Female Reproductive System Neoplasm
        Mucosal Melanoma of the Genitourinary System
        Mucosal Melanoma of the Female Genital Tract
        Cervix melanoma
        Vaginal melanoma
        Vulvar melanoma
        Penile Mucosal Melanoma
        Recurrent Malignant Genitourinary System Neoplasm
        Recurrent Malignant Female Reproductive System Neoplasm
        Recurrent Extrarenal Rhabdoid Tumor of the Ovary
        Recurrent Female Reproductive System Carcinoma
        Recurrent Malignant Endocervical Neoplasm
        Recurrent Malignant Ovarian Granulosa Cell Tumor
        Recurrent Ovarian Carcinosarcoma
        Recurrent Ovarian Germ Cell Tumor
        Recurrent Uterine Corpus Cancer
        Recurrent Uterine Corpus Sarcoma
        Recurrent Malignant Male Reproductive System Neoplasm
        Recurrent Malignant Spermatic Cord Neoplasm
        Recurrent Malignant Testicular Germ Cell Tumor
        Recurrent Testicular Lymphoma
        Reproductive system cancer
        Female reproductive organ cancer
        Adenosarcoma
        Fallopian tube cancer
        Gestational choriocarcinoma
        Malignant Mixed Mesodermal (Mullerian) Tumor
        Malignant Vaginal Neoplasm
        Malignant Vulvar Neoplasm
        Mesonephric adenocarcinoma
        Mesonephric-Like Adenocarcinoma
        Ovarian cancer
        Placenta cancer
        Refractory Malignant Female Reproductive System Neoplasm
        Resectable Malignant Female Reproductive System Neoplasm
        Rete ovarii adenocarcinoma
        Undifferentiated Stromal Sarcoma
        Uterine cancer
        Uterine ligament cancer
        Malignant Male Reproductive System Neoplasm
        Epididymis cancer
        Malignant Seminal Vesicle Neoplasm
        Malignant tumor of prostate
        Malignant tumor of testis
        Paratesticular Leiomyosarcoma
        Paratesticular Liposarcoma
        Paratesticular Malignant Mesothelioma
        Paratesticular Rhabdomyosarcoma
        Paratesticular Squamous Cell Carcinoma
        Paratesticular Wilms Tumor
        Penile cancer
        Refractory Malignant Male Reproductive System Neoplasm
        Spermatic cord cancer
        Malignant Sex Cord-Stromal Tumor
        Malignant sex cord stromal tumor of ovary
        Malignant Testicular Sex Cord-Stromal Tumor

Professional guidelines

PubMed

Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Oaknin A, Bosse TJ, Creutzberg CL, Giornelli G, Harter P, Joly F, Lorusso D, Marth C, Makker V, Mirza MR, Ledermann JA, Colombo N; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Sep;33(9):860-877. Epub 2022 Jun 8 doi: 10.1016/j.annonc.2022.05.009. PMID: 35690222

Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.

Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888

Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Parker C, Castro E, Fizazi K, Heidenreich A, Ost P, Procopio G, Tombal B, Gillessen S; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2020 Sep;31(9):1119-1134. Epub 2020 Jun 25 doi: 10.1016/j.annonc.2020.06.011. PMID: 32593798

See all (30628)

Recent clinical studies

Etiology

HIV-Associated Urogenital Malignancies.

Hentrich M, Pfister D
Oncol Res Treat 2017;40(3):106-112. Epub 2017 Feb 24 doi: 10.1159/000457130. PMID: 28253510

Lichen Sclerosus-Presentation, Diagnosis and Management.

Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363 Free PMC Article

Neonatal cancer.

Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, Baruchel A, Zerah M, Seigneur E, Peuchmaur M, Doz F
Lancet Oncol 2013 Dec;14(13):e609-20. doi: 10.1016/S1470-2045(13)70236-5. PMID: 24275134

Pediatric urologic oncology.

Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

Pediatric genitourinary tumors.

Buckley KS
Curr Opin Oncol 2011 May;23(3):297-302. doi: 10.1097/CCO.0b013e3283458613. PMID: 21460723

See all (179708)

Diagnosis

Application and Pitfalls of Immunohistochemistry in Diagnosis of Challenging Genitourinary Cases.

Ross J, Li G, Yang XJ
Arch Pathol Lab Med 2020 Mar;144(3):290-304. doi: 10.5858/arpa.2019-0550-RA. PMID: 32101059

HIV-Associated Urogenital Malignancies.

Hentrich M, Pfister D
Oncol Res Treat 2017;40(3):106-112. Epub 2017 Feb 24 doi: 10.1159/000457130. PMID: 28253510

Lichen Sclerosus-Presentation, Diagnosis and Management.

Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363 Free PMC Article

Neonatal cancer.

Pediatric urologic oncology.

Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

See all (171933)

Therapy

Biotech and Breakthroughs in Immuno-Oncology.

Bockman JM
Urol Clin North Am 2020 Nov;47(4):511-521. Epub 2020 Sep 9 doi: 10.1016/j.ucl.2020.07.006. PMID: 33008500

An evaluation of avelumab for the treatment of genitourinary tumors.

Stühler V, Maas JM, Walz S, Stenzl A, Bedke J
Expert Opin Biol Ther 2020 Sep;20(9):971-979. Epub 2020 Jun 3 doi: 10.1080/14712598.2020.1769596. PMID: 32407144

Novel immunotherapy combinations for genitourinary cancers.

Al Harthy M, Redman J, Madan RA
Expert Opin Biol Ther 2020 Mar;20(3):253-262. Epub 2020 Jan 27 doi: 10.1080/14712598.2020.1713086. PMID: 31914333

Immunotherapy in genitourinary malignancies.

Wattenberg MM, Fong L, Madan RA, Gulley JL
Curr Opin Urol 2016 Nov;26(6):501-7. doi: 10.1097/MOU.0000000000000331. PMID: 27471994 Free PMC Article

Lichen Sclerosus-Presentation, Diagnosis and Management.

Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363 Free PMC Article

See all (126974)

Prognosis

Worldwide trends in cervical cancer incidence and mortality, with predictions for the next 15 years.

Lin S, Gao K, Gu S, You L, Qian S, Tang M, Wang J, Chen K, Jin M
Cancer 2021 Nov 1;127(21):4030-4039. Epub 2021 Aug 9 doi: 10.1002/cncr.33795. PMID: 34368955

A Review of Cervical Cancer: Incidence and Disparities.

Buskwofie A, David-West G, Clare CA
J Natl Med Assoc 2020 Apr;112(2):229-232. Epub 2020 Apr 8 doi: 10.1016/j.jnma.2020.03.002. PMID: 32278478

Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.

Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369 Free PMC Article

Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review.

Shrestha AD, Neupane D, Vedsted P, Kallestrup P
Asian Pac J Cancer Prev 2018 Feb 26;19(2):319-324. doi: 10.22034/APJCP.2018.19.2.319. PMID: 29479954 Free PMC Article

Pediatric urologic oncology.

Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

See all (139719)

Clinical prediction guides

Common Diagnostic Challenges and Pitfalls in Genitourinary Organs, With Emphasis on Immunohistochemical and Molecular Updates.

Jia L, Deng FM, Kong MX, Wu CL, Yang XJ
Arch Pathol Lab Med 2021 Nov 1;145(11):1387-1404. doi: 10.5858/arpa.2021-0107-RA. PMID: 34673910

Pathomics in urology.

Schuettfort VM, Pradere B, Rink M, Comperat E, Shariat SF
Curr Opin Urol 2020 Nov;30(6):823-831. doi: 10.1097/MOU.0000000000000813. PMID: 32881725

Evolving Role of Genomics in Genitourinary Neoplasms.

Devitt ME, Dreicer R
Acta Med Acad 2019 Apr;48(1):68-77. doi: 10.5644/ama2006-124.243. PMID: 31264434

Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).

Panebianco V, Narumi Y, Altun E, Bochner BH, Efstathiou JA, Hafeez S, Huddart R, Kennish S, Lerner S, Montironi R, Muglia VF, Salomon G, Thomas S, Vargas HA, Witjes JA, Takeuchi M, Barentsz J, Catto JWF
Eur Urol 2018 Sep;74(3):294-306. Epub 2018 May 10 doi: 10.1016/j.eururo.2018.04.029. PMID: 29755006 Free PMC Article

Syndromes that Link the Endocrine System and Genitourinary Tract.

Özlük Y, Kılıçaslan I
Turk Patoloji Derg 2015;31 Suppl 1:155-71. doi: 10.5146/tjpath.2015.01322. PMID: 26177325

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Recent systematic reviews

2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.

Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314

Radiotherapy of oligometastatic prostate cancer: a systematic review.

Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437 Free PMC Article

EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.

Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724

Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.

Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

Screening for cervical cancer: a systematic review and meta-analysis.

Peirson L, Fitzpatrick-Lewis D, Ciliska D, Warren R
Syst Rev 2013 May 24;2:35. doi: 10.1186/2046-4053-2-35. PMID: 23706117 Free PMC Article

See all (5846)

MedGen

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Malignant Genitourinary System Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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