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Demyelinating Autoimmune Diseases, CNS

MedGen UID:
199756
Concept ID:
C0751873
Disease or Syndrome
Synonyms: Autoimmune Demyelinating Diseases, Central Nervous System; Autoimmune Demyelinating Diseases, CNS; Autoimmune Demyelinating Disorders, CNS; CNS Autoimmune Demyelinating Disorders; CNS Demyelinating Autoimmune Diseases; Demyelinating Autoimmune Diseases, Central Nervous System; Demyelinating Autoimmune Disorders, CNS; Demyelinating Disease, Autoimmune, CNS

Definition

Conditions characterized by loss or dysfunction of myelin (see MYELIN SHEATH) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or OLIGODENDROGLIA associated autoantigens. [from MeSH]

Professional guidelines

PubMed

Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977

Recent clinical studies

Etiology

Bruijstens AL, Wendel EM, Lechner C, Bartels F, Finke C, Breu M, Flet-Berliac L, de Chalus A, Adamsbaum C, Capobianco M, Laetitia G, Hacohen Y, Hemingway C, Wassmer E, Lim M, Baumann M, Wickström R, Armangue T, Rostasy K, Deiva K, Neuteboom RF
Eur J Paediatr Neurol 2020 Nov;29:41-53. Epub 2020 Nov 4 doi: 10.1016/j.ejpn.2020.10.005. PMID: 33176999
Bruijstens AL, Lechner C, Flet-Berliac L, Deiva K, Neuteboom RF, Hemingway C, Wassmer E; E.U. paediatric MOG consortium, Baumann M, Bartels F, Finke C, Adamsbaum C, Hacohen Y, Rostasy K
Eur J Paediatr Neurol 2020 Nov;29:2-13. Epub 2020 Nov 4 doi: 10.1016/j.ejpn.2020.10.006. PMID: 33162302
Ramanathan S, Mohammad S, Tantsis E, Nguyen TK, Merheb V, Fung VSC, White OB, Broadley S, Lechner-Scott J, Vucic S, Henderson APD, Barnett MH, Reddel SW, Brilot F, Dale RC; Australasian and New Zealand MOG Study Group
J Neurol Neurosurg Psychiatry 2018 Feb;89(2):127-137. Epub 2017 Nov 15 doi: 10.1136/jnnp-2017-316880. PMID: 29142145Free PMC Article
Algahtani H, Shirah B, Alassiri A
Mult Scler Relat Disord 2017 May;14:72-79. Epub 2017 Apr 9 doi: 10.1016/j.msard.2017.04.003. PMID: 28619436
Spatola M, Dalmau J
Curr Opin Neurol 2017 Jun;30(3):345-353. doi: 10.1097/WCO.0000000000000449. PMID: 28234800Free PMC Article

Diagnosis

Steck AJ
J Neuroimmunol 2021 Dec 15;361:577725. Epub 2021 Sep 28 doi: 10.1016/j.jneuroim.2021.577725. PMID: 34610502
Marignier R, Hacohen Y, Cobo-Calvo A, Pröbstel AK, Aktas O, Alexopoulos H, Amato MP, Asgari N, Banwell B, Bennett J, Brilot F, Capobianco M, Chitnis T, Ciccarelli O, Deiva K, De Sèze J, Fujihara K, Jacob A, Kim HJ, Kleiter I, Lassmann H, Leite MI, Linington C, Meinl E, Palace J, Paul F, Petzold A, Pittock S, Reindl M, Sato DK, Selmaj K, Siva A, Stankoff B, Tintore M, Traboulsee A, Waters P, Waubant E, Weinshenker B, Derfuss T, Vukusic S, Hemmer B
Lancet Neurol 2021 Sep;20(9):762-772. doi: 10.1016/S1474-4422(21)00218-0. PMID: 34418402
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Algahtani H, Shirah B, Alassiri A
Mult Scler Relat Disord 2017 May;14:72-79. Epub 2017 Apr 9 doi: 10.1016/j.msard.2017.04.003. PMID: 28619436
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article

Therapy

Steck AJ
J Neuroimmunol 2021 Dec 15;361:577725. Epub 2021 Sep 28 doi: 10.1016/j.jneuroim.2021.577725. PMID: 34610502
Ambrosius W, Michalak S, Kozubski W, Kalinowska A
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010100. PMID: 33374173Free PMC Article
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Algahtani H, Shirah B, Alassiri A
Mult Scler Relat Disord 2017 May;14:72-79. Epub 2017 Apr 9 doi: 10.1016/j.msard.2017.04.003. PMID: 28619436
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article

Prognosis

Ambrosius W, Michalak S, Kozubski W, Kalinowska A
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010100. PMID: 33374173Free PMC Article
Bruijstens AL, Wendel EM, Lechner C, Bartels F, Finke C, Breu M, Flet-Berliac L, de Chalus A, Adamsbaum C, Capobianco M, Laetitia G, Hacohen Y, Hemingway C, Wassmer E, Lim M, Baumann M, Wickström R, Armangue T, Rostasy K, Deiva K, Neuteboom RF
Eur J Paediatr Neurol 2020 Nov;29:41-53. Epub 2020 Nov 4 doi: 10.1016/j.ejpn.2020.10.005. PMID: 33176999
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
Spatola M, Dalmau J
Curr Opin Neurol 2017 Jun;30(3):345-353. doi: 10.1097/WCO.0000000000000449. PMID: 28234800Free PMC Article
McKeon A, Tracy JA
Muscle Nerve 2017 Jul;56(1):15-27. Epub 2017 Apr 11 doi: 10.1002/mus.25565. PMID: 28063151

Clinical prediction guides

Ismail II, Salama S
J Neuroimmunol 2022 Jan 15;362:577765. Epub 2021 Nov 9 doi: 10.1016/j.jneuroim.2021.577765. PMID: 34839149Free PMC Article
Ringelstein M, Ayzenberg I, Lindenblatt G, Fischer K, Gahlen A, Novi G, Hayward-Könnecke H, Schippling S, Rommer PS, Kornek B, Zrzavy T, Biotti D, Ciron J, Audoin B, Berthele A, Giglhuber K, Zephir H, Kümpfel T, Berger R, Röther J, Häußler V, Stellmann JP, Whittam D, Jacob A, Kraemer M, Gueguen A, Deschamps R, Bayas A, Hümmert MW, Trebst C, Haarmann A, Jarius S, Wildemann B, Grothe M, Siebert N, Ruprecht K, Paul F, Collongues N, Marignier R, Levy M, Karenfort M, Deppe M, Albrecht P, Hellwig K, Gold R, Hartung HP, Meuth SG, Kleiter I, Aktas O; Neuromyelitis Optica Study Group (NEMOS)
Neurol Neuroimmunol Neuroinflamm 2022 Jan;9(1) Epub 2021 Nov 16 doi: 10.1212/NXI.0000000000001100. PMID: 34785575Free PMC Article
Ambrosius W, Michalak S, Kozubski W, Kalinowska A
Int J Mol Sci 2020 Dec 24;22(1) doi: 10.3390/ijms22010100. PMID: 33374173Free PMC Article
Brown MA, Weinberg RB
Front Immunol 2018;9:514. Epub 2018 Mar 21 doi: 10.3389/fimmu.2018.00514. PMID: 29619025Free PMC Article
McKeon A, Tracy JA
Muscle Nerve 2017 Jul;56(1):15-27. Epub 2017 Apr 11 doi: 10.1002/mus.25565. PMID: 28063151

Recent systematic reviews

Wang X, Kong L, Zhao Z, Shi Z, Chen H, Lang Y, Lin X, Du Q, Zhou H
Front Immunol 2022;13:953993. Epub 2022 Jul 26 doi: 10.3389/fimmu.2022.953993. PMID: 35958613Free PMC Article
Nepal G, Kharel S, Coghlan MA, Rayamajhi P, Ojha R
J Neuroimmunol 2022 Mar 15;364:577812. Epub 2022 Jan 13 doi: 10.1016/j.jneuroim.2022.577812. PMID: 35063726
Ismail II, Salama S
J Neuroimmunol 2022 Jan 15;362:577765. Epub 2021 Nov 9 doi: 10.1016/j.jneuroim.2021.577765. PMID: 34839149Free PMC Article
Gombolay GY, Gadde JA
J Neuroimmunol 2021 Sep 15;358:577653. Epub 2021 Jul 1 doi: 10.1016/j.jneuroim.2021.577653. PMID: 34229204
Duncan M, Carroll S, Cockburn R, Johnston C, Bullock H, Mitchell S, Hemingway C
Dev Med Child Neurol 2020 Nov;62(11):1250-1258. Epub 2020 Aug 4 doi: 10.1111/dmcn.14629. PMID: 32749683

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