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CNS demyelinating autoimmune disease

MedGen UID:
199756
Concept ID:
C0751873
Disease or Syndrome
Synonyms: Autoimmune Demyelinating Diseases, Central Nervous System; Autoimmune Demyelinating Diseases, CNS; Autoimmune Demyelinating Disorders, CNS; CNS Autoimmune Demyelinating Disorders; CNS Demyelinating Autoimmune Diseases; Demyelinating Autoimmune Diseases, Central Nervous System; Demyelinating Autoimmune Diseases, CNS; Demyelinating Autoimmune Disorders, CNS; Demyelinating Disease, Autoimmune, CNS
 
Monarch Initiative: MONDO:0006704

Definition

Conditions characterized by loss or dysfunction of myelin (see myelin sheath) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or oligodendroglia associated autoantigens. [from MONDO]

Professional guidelines

PubMed

Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG; International Panel for NMO Diagnosis
Neurology 2015 Jul 14;85(2):177-89. Epub 2015 Jun 19 doi: 10.1212/WNL.0000000000001729. PMID: 26092914Free PMC Article

Recent clinical studies

Etiology

Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH
Brain 2023 Aug 1;146(8):3431-3443. doi: 10.1093/brain/awad073. PMID: 36864688Free PMC Article
Stoiloudis P, Kesidou E, Bakirtzis C, Sintila SA, Konstantinidou N, Boziki M, Grigoriadis N
Nutrients 2022 Mar 9;14(6) doi: 10.3390/nu14061150. PMID: 35334810Free PMC Article
Chan KH, Lee CY
Int J Mol Sci 2021 Aug 11;22(16) doi: 10.3390/ijms22168638. PMID: 34445343Free PMC Article
Bruijstens AL, Wendel EM, Lechner C, Bartels F, Finke C, Breu M, Flet-Berliac L, de Chalus A, Adamsbaum C, Capobianco M, Laetitia G, Hacohen Y, Hemingway C, Wassmer E, Lim M, Baumann M, Wickström R, Armangue T, Rostasy K, Deiva K, Neuteboom RF
Eur J Paediatr Neurol 2020 Nov;29:41-53. Epub 2020 Nov 4 doi: 10.1016/j.ejpn.2020.10.005. PMID: 33176999
Algahtani H, Shirah B, Alassiri A
Mult Scler Relat Disord 2017 May;14:72-79. Epub 2017 Apr 9 doi: 10.1016/j.msard.2017.04.003. PMID: 28619436

Diagnosis

Steck AJ
J Neuroimmunol 2021 Dec 15;361:577725. Epub 2021 Sep 28 doi: 10.1016/j.jneuroim.2021.577725. PMID: 34610502
Marignier R, Hacohen Y, Cobo-Calvo A, Pröbstel AK, Aktas O, Alexopoulos H, Amato MP, Asgari N, Banwell B, Bennett J, Brilot F, Capobianco M, Chitnis T, Ciccarelli O, Deiva K, De Sèze J, Fujihara K, Jacob A, Kim HJ, Kleiter I, Lassmann H, Leite MI, Linington C, Meinl E, Palace J, Paul F, Petzold A, Pittock S, Reindl M, Sato DK, Selmaj K, Siva A, Stankoff B, Tintore M, Traboulsee A, Waters P, Waubant E, Weinshenker B, Derfuss T, Vukusic S, Hemmer B
Lancet Neurol 2021 Sep;20(9):762-772. doi: 10.1016/S1474-4422(21)00218-0. PMID: 34418402
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977
Kamińska J, Koper OM, Piechal K, Kemona H
Postepy Hig Med Dosw (Online) 2017 Jun 30;71(0):551-563. doi: 10.5604/01.3001.0010.3836. PMID: 28665284

Therapy

Steck AJ
J Neuroimmunol 2021 Dec 15;361:577725. Epub 2021 Sep 28 doi: 10.1016/j.jneuroim.2021.577725. PMID: 34610502
Bruijstens AL, Wendel EM, Lechner C, Bartels F, Finke C, Breu M, Flet-Berliac L, de Chalus A, Adamsbaum C, Capobianco M, Laetitia G, Hacohen Y, Hemingway C, Wassmer E, Lim M, Baumann M, Wickström R, Armangue T, Rostasy K, Deiva K, Neuteboom RF
Eur J Paediatr Neurol 2020 Nov;29:41-53. Epub 2020 Nov 4 doi: 10.1016/j.ejpn.2020.10.005. PMID: 33176999
Guerrero BL, Sicotte NL
Front Immunol 2020;11:374. Epub 2020 Mar 20 doi: 10.3389/fimmu.2020.00374. PMID: 32265902Free PMC Article
Salama S, Khan M, Pardo S, Izbudak I, Levy M
Mult Scler 2019 Oct;25(11):1427-1433. Epub 2019 Mar 25 doi: 10.1177/1352458519837705. PMID: 30907249Free PMC Article
Algahtani H, Shirah B, Alassiri A
Mult Scler Relat Disord 2017 May;14:72-79. Epub 2017 Apr 9 doi: 10.1016/j.msard.2017.04.003. PMID: 28619436

Prognosis

Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH
Brain 2023 Aug 1;146(8):3431-3443. doi: 10.1093/brain/awad073. PMID: 36864688Free PMC Article
Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Stoiloudis P, Kesidou E, Bakirtzis C, Sintila SA, Konstantinidou N, Boziki M, Grigoriadis N
Nutrients 2022 Mar 9;14(6) doi: 10.3390/nu14061150. PMID: 35334810Free PMC Article
Kamińska J, Koper OM, Piechal K, Kemona H
Postepy Hig Med Dosw (Online) 2017 Jun 30;71(0):551-563. doi: 10.5604/01.3001.0010.3836. PMID: 28665284
McKeon A, Tracy JA
Muscle Nerve 2017 Jul;56(1):15-27. Epub 2017 Apr 11 doi: 10.1002/mus.25565. PMID: 28063151

Clinical prediction guides

Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH
Brain 2023 Aug 1;146(8):3431-3443. doi: 10.1093/brain/awad073. PMID: 36864688Free PMC Article
Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Margoni M, Preziosa P, Filippi M, Rocca MA
J Neurol 2022 Mar;269(3):1316-1334. Epub 2021 Aug 11 doi: 10.1007/s00415-021-10744-x. PMID: 34382120Free PMC Article
Chan KH, Lee CY
Int J Mol Sci 2021 Aug 11;22(16) doi: 10.3390/ijms22168638. PMID: 34445343Free PMC Article
McKeon A, Tracy JA
Muscle Nerve 2017 Jul;56(1):15-27. Epub 2017 Apr 11 doi: 10.1002/mus.25565. PMID: 28063151

Recent systematic reviews

Gonzalez-Lorenzo M, Ridley B, Minozzi S, Del Giovane C, Peryer G, Piggott T, Foschi M, Filippini G, Tramacere I, Baldin E, Nonino F
Cochrane Database Syst Rev 2024 Jan 4;1(1):CD011381. doi: 10.1002/14651858.CD011381.pub3. PMID: 38174776Free PMC Article
Tramacere I, Virgili G, Perduca V, Lucenteforte E, Benedetti MD, Capobussi M, Castellini G, Frau S, Gonzalez-Lorenzo M, Featherstone R, Filippini G
Cochrane Database Syst Rev 2023 Nov 30;11(11):CD012186. doi: 10.1002/14651858.CD012186.pub2. PMID: 38032059Free PMC Article
Giannopapas V, Kitsos D, Tsogka A, Tzartos JS, Paraskevas G, Tsivgoulis G, Voumvourakis K, Giannopoulos S, Bakalidou D
Neurol Sci 2023 Mar;44(3):873-880. Epub 2022 Dec 31 doi: 10.1007/s10072-022-06572-0. PMID: 36585597Free PMC Article
Marini A, Bernardini A, Gigli GL, Valente M, Muñiz-Castrillo S, Honnorat J, Vogrig A
Neurology 2021 Apr 20;96(16):754-766. Epub 2021 Mar 2 doi: 10.1212/WNL.0000000000011795. PMID: 33653902
Jagannath VA, Filippini G, Di Pietrantonj C, Asokan GV, Robak EW, Whamond L, Robinson SA
Cochrane Database Syst Rev 2018 Sep 24;9(9):CD008422. doi: 10.1002/14651858.CD008422.pub3. PMID: 30246874Free PMC Article

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