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Intracranial vasospasm

MedGen UID:
199760
•Concept ID:
C0751895
•
Disease or Syndrome
Synonyms: Angiospasm, Intracranial; Angiospasms, Intracranial; Intracranial Angiospasm; Intracranial Angiospasms; Intracranial Vascular Spasm; Intracranial Vascular Spasms; Intracranial Vasospasm; Intracranial Vasospasms; Spasm, Intracranial Vascular; Spasms, Intracranial Vascular; Vascular Spasm, Intracranial; Vascular Spasms, Intracranial; Vasospasm, Intracranial; Vasospasms, Intracranial
 
Monarch Initiative: MONDO:0006812

Definition

Constriction of arteries in the skull due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and brain ischemia that may lead to hypoxic-ischemic brain injury (hypoxia-ischemia, brain). [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntracranial vasospasm

Professional guidelines

PubMed

Current Treatment Strategies for Intracranial Aneurysms: An Overview.
Zhao J, Lin H, Summers R, Yang M, Cousins BG, Tsui J
Angiology 2018 Jan;69(1):17-30. Epub 2017 Mar 30 doi: 10.1177/0003319717700503. PMID: 28355880Free PMC Article
Delayed cerebral ischaemia prevention and treatment after aneurysmal subarachnoid haemorrhage: a systematic review.
Veldeman M, Höllig A, Clusmann H, Stevanovic A, Rossaint R, Coburn M
Br J Anaesth 2016 Jul;117(1):17-40. Epub 2016 May 8 doi: 10.1093/bja/aew095. PMID: 27160932Free PMC Article
Review of aneurysmal subarachnoid hemorrhage--focus on treatment, anesthesia, cerebral vasospasm prophylaxis, and therapy.
Lin BF, Kuo CY, Wu ZF
Acta Anaesthesiol Taiwan 2014 Jun;52(2):77-84. Epub 2014 Jun 17 doi: 10.1016/j.aat.2014.04.005. PMID: 25016512

Recent clinical studies

Etiology

Reversible cerebral vasoconstriction syndrome: review of neuroimaging findings.
Perillo T, Paolella C, Perrotta G, Serino A, Caranci F, Manto A
Radiol Med 2022 Sep;127(9):981-990. Epub 2022 Aug 6 doi: 10.1007/s11547-022-01532-2. PMID: 35932443Free PMC Article
Headache in cerebrovascular diseases.
Lu J, Liu W, Zhao H
Stroke Vasc Neurol 2020 Jun;5(2):205-210. Epub 2020 Mar 26 doi: 10.1136/svn-2020-000333. PMID: 32606088Free PMC Article
Neuro-ultrasonography.
Hakimi R, Alexandrov AV, Garami Z
Neurol Clin 2020 Feb;38(1):215-229. doi: 10.1016/j.ncl.2019.09.006. PMID: 31761060
Neuroanesthesiology update.
Pasternak JJ, Lanier WL
J Neurosurg Anesthesiol 2010 Apr;22(2):86-109. doi: 10.1097/ANA.0b013e3181d2ef96. PMID: 20308816
Migrainous stroke.
Rothrock JF, Walicke P, Swenson MR, Lyden PD, Logan WR
Arch Neurol 1988 Jan;45(1):63-7. doi: 10.1001/archneur.1988.00520250069023. PMID: 3337678

Diagnosis

Clazosentan: First Approval.
Lee A
Drugs 2022 Apr;82(6):697-702. doi: 10.1007/s40265-022-01708-0. PMID: 35362854
A Review of the Management of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage.
Li K, Barras CD, Chandra RV, Kok HK, Maingard JT, Carter NS, Russell JH, Lai L, Brooks M, Asadi H
World Neurosurg 2019 Jun;126:513-527. Epub 2019 Mar 18 doi: 10.1016/j.wneu.2019.03.083. PMID: 30898740
Headache: Headache Emergencies.
Walling A
FP Essent 2018 Oct;473:21-25. PMID: 30346681
Reversible cerebral vasoconstriction syndrome.
Ducros A
Lancet Neurol 2012 Oct;11(10):906-17. doi: 10.1016/S1474-4422(12)70135-7. PMID: 22995694
Neuroanesthesiology update.
Pasternak JJ, Lanier WL
J Neurosurg Anesthesiol 2010 Apr;22(2):86-109. doi: 10.1097/ANA.0b013e3181d2ef96. PMID: 20308816

Therapy

Pharmacotherapy in SAH: Clinical Trial Lessons.
Apostolakis S, Stavrinou P
CNS Neurol Disord Drug Targets 2024;23(11):1308-1319. doi: 10.2174/0118715273251761231127095039. PMID: 38243987
Clazosentan: First Approval.
Lee A
Drugs 2022 Apr;82(6):697-702. doi: 10.1007/s40265-022-01708-0. PMID: 35362854
Neuro-ultrasonography.
Hakimi R, Alexandrov AV, Garami Z
Neurol Clin 2020 Feb;38(1):215-229. doi: 10.1016/j.ncl.2019.09.006. PMID: 31761060
Cerebral vasospasm.
Baggott CD, Aagaard-Kienitz B
Neurosurg Clin N Am 2014 Jul;25(3):497-528. doi: 10.1016/j.nec.2014.04.008. PMID: 24994087
Neuroanesthesiology update.
Pasternak JJ, Lanier WL
J Neurosurg Anesthesiol 2010 Apr;22(2):86-109. doi: 10.1097/ANA.0b013e3181d2ef96. PMID: 20308816

Prognosis

Targeting Hemoglobin to Reduce Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
Zeineddine HA, Honarpisheh P, McBride D, Pandit PKT, Dienel A, Hong SH, Grotta J, Blackburn S
Transl Stroke Res 2022 Oct;13(5):725-735. Epub 2022 Feb 14 doi: 10.1007/s12975-022-00995-9. PMID: 35157256Free PMC Article
Diagnosing Vasospasm After Subarachnoid Hemorrhage: CTA and CTP.
Wilson CD, Shankar JJ
Can J Neurol Sci 2014 May;41(3):314-9. doi: 10.1017/s031716710001725x. PMID: 24718816
Reversible cerebral vasoconstriction syndrome.
Ducros A
Lancet Neurol 2012 Oct;11(10):906-17. doi: 10.1016/S1474-4422(12)70135-7. PMID: 22995694
Deadly vasospasm.
Eijking DP, Reichert CL, Wagenvoort AM, Van Geel BM, Toornvliet AC, Honing ML
Resuscitation 2009 Nov;80(11):1318-20. Epub 2009 Aug 21 doi: 10.1016/j.resuscitation.2009.07.009. PMID: 19699573
Migrainous stroke.
Rothrock JF, Walicke P, Swenson MR, Lyden PD, Logan WR
Arch Neurol 1988 Jan;45(1):63-7. doi: 10.1001/archneur.1988.00520250069023. PMID: 3337678

Clinical prediction guides

Reversible Cerebral Vasoconstriction Syndrome and Female Sex: A Narrative Review.
Nelson SE
Stroke 2024 Apr;55(4):1113-1117. Epub 2024 Feb 16 doi: 10.1161/STROKEAHA.123.046312. PMID: 38362763
Post-reversible cerebral vasoconstriction syndrome headache.
Ling YH, Wang YF, Lirng JF, Fuh JL, Wang SJ, Chen SP
J Headache Pain 2021 Mar 25;22(1):14. doi: 10.1186/s10194-021-01223-9. PMID: 33765906Free PMC Article
How do I manage cerebral vasospasm and delayed cerebral ischemia?
Gaspard N
Minerva Anestesiol 2020 Dec;86(12):1331-1339. Epub 2020 May 21 doi: 10.23736/S0375-9393.20.14507-3. PMID: 32441086
Diagnosing Vasospasm After Subarachnoid Hemorrhage: CTA and CTP.
Wilson CD, Shankar JJ
Can J Neurol Sci 2014 May;41(3):314-9. doi: 10.1017/s031716710001725x. PMID: 24718816
Anemia and transfusion after aneurysmal subarachnoid hemorrhage.
Rosenberg NF, Koht A, Naidech AM
J Neurosurg Anesthesiol 2013 Jan;25(1):66-74. doi: 10.1097/ANA.0b013e31826cfc1d. PMID: 23047622

Recent systematic reviews

Comment on the 2023 Guidelines for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage.
Spears WE, Greer DM, Nguyen TN
Stroke 2023 Oct;54(10):2708-2712. Epub 2023 Aug 15 doi: 10.1161/STROKEAHA.123.043541. PMID: 37581267
Efficacy and Safety of Clazosentan After Aneurysmal Subarachnoid Hemorrhage: An Updated Meta-Analysis.
Pontes JPM, Santos MDC, Gibram FC, Rodrigues NMV, Cavalcante-Neto JF, Barros ADM, Solla DJF
Neurosurgery 2023 Dec 1;93(6):1208-1219. Epub 2023 Jul 18 doi: 10.1227/neu.0000000000002601. PMID: 37462365
A Comparison Between Enteral and Intravenous Nimodipine in Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis.
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Aneurysmal subarachnoid hemorrhage during pregnancy: a comprehensive and systematic review of the literature.
Beighley A, Glynn R, Scullen T, Mathkour M, Werner C, Berry JF, Carr C, Abou-Al-Shaar H, Aysenne A, Nerva JD, Dumont AS
Neurosurg Rev 2021 Oct;44(5):2511-2522. Epub 2021 Jan 7 doi: 10.1007/s10143-020-01457-2. PMID: 33409763
Systematic review of reversible cerebral vasoconstriction syndrome.
Sattar A, Manousakis G, Jensen MB
Expert Rev Cardiovasc Ther 2010 Oct;8(10):1417-21. doi: 10.1586/erc.10.124. PMID: 20936928Free PMC Article

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