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Central Nervous System Cavernous Hemangioma

MedGen UID:
199825
•Concept ID:
C0752160
•
Congenital Abnormality
Synonyms: Cavernous Hemangioma, Central Nervous System; Hemangioma, Cavernous, Central Nervous System

Definition

A cavernous hemangioma arising from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Cavernous Hemangioma

Professional guidelines

PubMed

Neuroradiology: Differential Diagnosis, Follow-Up, and Reporting.
Splendiani A, Bruno F, Cerase A
Methods Mol Biol 2020;2152:97-107. doi: 10.1007/978-1-0716-0640-7_8. PMID: 32524547
Clinical Management of Cavernous Malformations.
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Recent clinical studies

Etiology

Pediatric Cerebral Cavernous Malformations.
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
CCM3 and cerebral cavernous malformation disease.
Wang K, Zhou HJ, Wang M
Stroke Vasc Neurol 2019 Jul;4(2):67-70. Epub 2019 Mar 2 doi: 10.1136/svn-2018-000195. PMID: 31338212Free PMC Article
Pharmacotherapy for cavernous malformations.
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Diagnosis

Pediatric Cerebral Cavernous Malformations.
Paddock M, Lanham S, Gill K, Sinha S, Connolly DJA
Pediatr Neurol 2021 Mar;116:74-83. Epub 2020 Nov 27 doi: 10.1016/j.pediatrneurol.2020.11.004. PMID: 33494000
Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
Familial Cavernous Hemangioma.
Torres G, Kini AT, Al Othman B, Lee AG
J Neuroophthalmol 2020 Jun;40(2):262-264. doi: 10.1097/WNO.0000000000000778. PMID: 30893269
Molecular diagnosis in cerebral cavernous malformations.
Mondejar R, Lucas M
Neurologia 2017 Oct;32(8):540-545. Epub 2015 Aug 21 doi: 10.1016/j.nrl.2015.07.001. PMID: 26304651
Cavernous malformations.
Smith ER, Scott RM
Neurosurg Clin N Am 2010 Jul;21(3):483-90. doi: 10.1016/j.nec.2010.03.003. PMID: 20561497

Therapy

Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial.
Lanfranconi S, Scola E, Meessen JMTA, Pallini R, Bertani GA, Al-Shahi Salman R, Dejana E, Latini R; Treat_CCM Investigators
Lancet Neurol 2023 Jan;22(1):35-44. Epub 2022 Nov 17 doi: 10.1016/S1474-4422(22)00409-4. PMID: 36403580
Familial Cerebral Cavernous Malformations.
Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL, Mabray MC, Vigil C, Tang AT, Kahn ML, Yonas H, Lawton MT, Kim H, Morrison L
Stroke 2019 May;50(5):1294-1301. doi: 10.1161/STROKEAHA.118.022314. PMID: 30909834Free PMC Article
Clinical Management of Cavernous Malformations.
Flemming KD
Curr Cardiol Rep 2017 Oct 18;19(12):122. doi: 10.1007/s11886-017-0931-1. PMID: 29046973
Pharmacotherapy for cavernous malformations.
Rudy RF, Du R
Handb Clin Neurol 2017;143:309-316. doi: 10.1016/B978-0-444-63640-9.00031-X. PMID: 28552155
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article

Prognosis

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.
Hong T, Xiao X, Ren J, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H, Wang Y
Brain 2021 Oct 22;144(9):2648-2658. doi: 10.1093/brain/awab117. PMID: 33729480
Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.
Idiculla PS, Gurala D, Philipose J, Rajdev K, Patibandla P
Eur Neurol 2020;83(4):360-368. Epub 2020 Jul 30 doi: 10.1159/000508748. PMID: 32731220
Nontraumatic Pediatric Intracerebral Hemorrhage.
Boulouis G, Blauwblomme T, Hak JF, Benichi S, Kirton A, Meyer P, Chevignard M, Tournier-Lasserve E, Mackay MT, Chabrier S, Cordonnier C, Kossorotoff M, Naggara O
Stroke 2019 Dec;50(12):3654-3661. Epub 2019 Oct 22 doi: 10.1161/STROKEAHA.119.025783. PMID: 31637968
Epidemiology of cavernous malformations.
Goldstein HE, Solomon RA
Handb Clin Neurol 2017;143:241-247. doi: 10.1016/B978-0-444-63640-9.00023-0. PMID: 28552146
Natural history of spinal cavernous malformations.
Otten M, Mccormick P
Handb Clin Neurol 2017;143:233-239. doi: 10.1016/B978-0-444-63640-9.00022-9. PMID: 28552145

Clinical prediction guides

Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids.
Dao L, You Z, Lu L, Xu T, Sarkar AK, Zhu H, Liu M, Calandrelli R, Yoshida G, Lin P, Miao Y, Mierke S, Kalva S, Zhu H, Gu M, Vadivelu S, Zhong S, Huang LF, Guo Z
Cell Stem Cell 2024 Jun 6;31(6):818-833.e11. Epub 2024 May 15 doi: 10.1016/j.stem.2024.04.019. PMID: 38754427Free PMC Article
Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial.
Lanfranconi S, Scola E, Meessen JMTA, Pallini R, Bertani GA, Al-Shahi Salman R, Dejana E, Latini R; Treat_CCM Investigators
Lancet Neurol 2023 Jan;22(1):35-44. Epub 2022 Nov 17 doi: 10.1016/S1474-4422(22)00409-4. PMID: 36403580
Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations.
Hong T, Xiao X, Ren J, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H, Wang Y
Brain 2021 Oct 22;144(9):2648-2658. doi: 10.1093/brain/awab117. PMID: 33729480
Cerebral cavernous malformations: natural history and clinical management.
Gross BA, Du R
Expert Rev Neurother 2015;15(7):771-7. Epub 2015 Jun 22 doi: 10.1586/14737175.2015.1055323. PMID: 26098013
Brainstem cavernous malformations.
Petr O, Lanzino G
J Neurosurg Sci 2015 Sep;59(3):271-82. Epub 2015 May 6 PMID: 25943871

Recent systematic reviews

Radiation-Induced Cerebral Cavernous Malformations: A Single-Center Experience and Systematic Literature Review.
Koester SW, Rhodenhiser EG, Dabrowski SJ, Benner D, Rumalla K, Scherschinski L, Catapano JS, Graffeo CS, Srinivasan VM, Lawton MT
World Neurosurg 2023 Nov;179:222-232.e2. Epub 2023 Aug 17 doi: 10.1016/j.wneu.2023.08.036. PMID: 37595838
Surgery for cerebral cavernous malformations: a systematic review and meta-analysis.
Harris L, Poorthuis MHF, Grover P, Kitchen N, Al-Shahi Salman R
Neurosurg Rev 2022 Feb;45(1):231-241. Epub 2021 Jun 30 doi: 10.1007/s10143-021-01591-5. PMID: 34191202
Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel.
Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K
Neurosurgery 2017 May 1;80(5):665-680. doi: 10.1093/neuros/nyx091. PMID: 28387823Free PMC Article
Stereotactic radiosurgery of brainstem cavernous malformations: a systematic review and meta-analysis.
Lu XY, Sun H, Xu JG, Li QY
J Neurosurg 2014 Apr;120(4):982-7. Epub 2014 Feb 7 doi: 10.3171/2013.12.JNS13990. PMID: 24506243
Brainstem cavernous malformations.
Gross BA, Batjer HH, Awad IA, Bendok BR
Neurosurgery 2009 May;64(5):E805-18; discussion E818. doi: 10.1227/01.NEU.0000343668.44288.18. PMID: 19404127

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