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Central Nervous System Protozoal Infections

MedGen UID:
199830
Concept ID:
C0752182
Disease or Syndrome
Synonyms: CNS Protozoal Infection; CNS Protozoal Infections; Infection, Central Nervous System, Protozoal; Infection, CNS Protozoal; Infections, CNS Protozoal; Infections, Protozoal, Central Nervous System; Protozoal Infection, CNS; Protozoal Infections, Central Nervous System; Protozoal Infections, CNS

Definition

Infections of the brain, spinal cord, or meninges by single celled organisms of the former subkingdom known as protozoa. The central nervous system may be the primary or secondary site of protozoal infection. These diseases may occur as OPPORTUNISTIC INFECTIONS or arise in immunocompetent hosts. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Protozoal Infections

Professional guidelines

PubMed

Song X, Wei W, Cheng W, Zhu H, Wang W, Dong H, Li J
Front Cell Infect Microbiol 2022;12:939532. Epub 2022 Jul 25 doi: 10.3389/fcimb.2022.939532. PMID: 35959375Free PMC Article
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246
Grace E, Asbill S, Virga K
Antimicrob Agents Chemother 2015 Nov;59(11):6677-81. Epub 2015 Aug 10 doi: 10.1128/AAC.01293-15. PMID: 26259797Free PMC Article

Recent clinical studies

Etiology

Haston JC, Cope JR
Curr Opin Infect Dis 2023 Jun 1;36(3):186-191. Epub 2023 Apr 10 doi: 10.1097/QCO.0000000000000923. PMID: 37093056Free PMC Article
Figarella K, Wolburg H, Garaschuk O, Duszenko M
Biol Rev Camb Philos Soc 2020 Apr;95(2):333-349. Epub 2019 Nov 4 doi: 10.1111/brv.12566. PMID: 31682077
Jahangeer M, Mahmood Z, Munir N, Waraich UE, Tahir IM, Akram M, Ali Shah SM, Zulfqar A, Zainab R
Clin Exp Pharmacol Physiol 2020 Feb;47(2):199-212. Epub 2019 Nov 15 doi: 10.1111/1440-1681.13192. PMID: 31612525
Bellini NK, Santos TM, da Silva MTA, Thiemann OH
Exp Parasitol 2018 Apr;187:1-11. Epub 2018 Mar 1 doi: 10.1016/j.exppara.2018.02.010. PMID: 29501696
Visvesvara GS
Handb Clin Neurol 2013;114:153-68. doi: 10.1016/B978-0-444-53490-3.00010-8. PMID: 23829906

Diagnosis

Haston JC, Cope JR
Curr Opin Infect Dis 2023 Jun 1;36(3):186-191. Epub 2023 Apr 10 doi: 10.1097/QCO.0000000000000923. PMID: 37093056Free PMC Article
Güémez A, García E
Biomolecules 2021 Sep 6;11(9) doi: 10.3390/biom11091320. PMID: 34572533Free PMC Article
Jahangeer M, Mahmood Z, Munir N, Waraich UE, Tahir IM, Akram M, Ali Shah SM, Zulfqar A, Zainab R
Clin Exp Pharmacol Physiol 2020 Feb;47(2):199-212. Epub 2019 Nov 15 doi: 10.1111/1440-1681.13192. PMID: 31612525
Grace E, Asbill S, Virga K
Antimicrob Agents Chemother 2015 Nov;59(11):6677-81. Epub 2015 Aug 10 doi: 10.1128/AAC.01293-15. PMID: 26259797Free PMC Article
Schmutzhard E, Helbok R
Handb Clin Neurol 2014;121:1403-43. doi: 10.1016/B978-0-7020-4088-7.00096-1. PMID: 24365428

Therapy

Güémez A, García E
Biomolecules 2021 Sep 6;11(9) doi: 10.3390/biom11091320. PMID: 34572533Free PMC Article
Jahangeer M, Mahmood Z, Munir N, Waraich UE, Tahir IM, Akram M, Ali Shah SM, Zulfqar A, Zainab R
Clin Exp Pharmacol Physiol 2020 Feb;47(2):199-212. Epub 2019 Nov 15 doi: 10.1111/1440-1681.13192. PMID: 31612525
Bellini NK, Santos TM, da Silva MTA, Thiemann OH
Exp Parasitol 2018 Apr;187:1-11. Epub 2018 Mar 1 doi: 10.1016/j.exppara.2018.02.010. PMID: 29501696
Grace E, Asbill S, Virga K
Antimicrob Agents Chemother 2015 Nov;59(11):6677-81. Epub 2015 Aug 10 doi: 10.1128/AAC.01293-15. PMID: 26259797Free PMC Article
Enanga B, Burchmore RJ, Stewart ML, Barrett MP
Cell Mol Life Sci 2002 May;59(5):845-58. doi: 10.1007/s00018-002-8472-0. PMID: 12088284Free PMC Article

Prognosis

Rojo JU, Rajendran R, Salazar JH
Lab Med 2023 Sep 5;54(5):e124-e132. doi: 10.1093/labmed/lmac158. PMID: 36638160
Harris GR, Batra R
N Engl J Med 2020 Sep 10;383(11):1057. doi: 10.1056/NEJMicm2002528. PMID: 32905679
Masocha W, Kristensson K
Virulence 2012 Mar-Apr;3(2):202-12. Epub 2012 Mar 1 doi: 10.4161/viru.19178. PMID: 22460639Free PMC Article
Enanga B, Burchmore RJ, Stewart ML, Barrett MP
Cell Mol Life Sci 2002 May;59(5):845-58. doi: 10.1007/s00018-002-8472-0. PMID: 12088284Free PMC Article
Corti M
AIDS Patient Care STDS 2000 Nov;14(11):581-8. doi: 10.1089/10872910050193752. PMID: 11155899

Clinical prediction guides

Rodríguez-Mera IB, Carrasco-Yépez MM, Vásquez-Moctezuma I, Correa-Basurto J, Salinas GR, Castillo-Ramírez DA, Rosales-Cruz É, Rojas-Hernández S
Parasitol Res 2022 Nov;121(11):3287-3303. Epub 2022 Sep 20 doi: 10.1007/s00436-022-07660-y. PMID: 36125528Free PMC Article
Soontrapa P, Jitmuang A, Ruenchit P, Tiewcharoen S, Sarasombath PT, Rattanabannakit C
Front Cell Infect Microbiol 2022;12:931546. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.931546. PMID: 35909963Free PMC Article
Maciver SK, Piñero JE, Lorenzo-Morales J
Trends Parasitol 2020 Jan;36(1):19-28. Epub 2019 Nov 18 doi: 10.1016/j.pt.2019.10.008. PMID: 31744676
Wiwanitkit V
MedGenMed 2004 Mar 8;6(1):2. PMID: 15208515Free PMC Article
Antunes AC, Cecchini FM, Bolli Fv, Oliveira PP, Reboucas RG, Monte TL, Fricke D
Arq Neuropsiquiatr 2002 Sep;60(3-B):730-3. PMID: 12364939

Recent systematic reviews

Ahmad Zamzuri M'I, Abd Majid FN, Mihat M, Ibrahim SS, Ismail M, Abd Aziz S, Mohamed Z, Rejali L, Yahaya H, Abdullah Z, Hassan MR, Dapari R, Mohd Isa AM
Int J Environ Res Public Health 2023 Feb 9;20(4) doi: 10.3390/ijerph20043021. PMID: 36833715Free PMC Article

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