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Slow Virus Diseases

MedGen UID:
20001
Concept ID:
C0037341
Disease or Syndrome
Synonyms: Disease, Slow Virus; Diseases, Slow Virus; Slow Virus Disease; Virus Disease, Slow; Virus Diseases, Slow

Definition

Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES. [from MeSH]

Professional guidelines

PubMed

Brambilla L, Genovese G, Berti E, Peris K, Rongioletti F, Micali G, Ayala F, Della Bella S, Mancuso R, Calzavara Pinton P, Tourlaki A
Ital J Dermatol Venerol 2021 Jun;156(3):356-365. Epub 2020 Nov 12 doi: 10.23736/S2784-8671.20.06703-6. PMID: 33179877
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246
Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A
Neurology 2013 Apr 9;80(15):1430-8. doi: 10.1212/WNL.0b013e31828c2fa1. PMID: 23568998Free PMC Article

Recent clinical studies

Etiology

Prusiner SB
Trends Biochem Sci 1996 Dec;21(12):482-7. doi: 10.1016/s0968-0004(96)10063-3. PMID: 9009832
Bradley R, Matthews D
Rev Sci Tech 1992 Jun;11(2):605-34. doi: 10.20506/rst.11.2.609. PMID: 1617204
Collee JG
Lancet 1990 Nov 24;336(8726):1300-3. doi: 10.1016/0140-6736(90)92976-o. PMID: 1978125
Mocsny N
Rehabil Nurs 1989 May-Jun;14(3):130-2. doi: 10.1002/j.2048-7940.1989.tb01076.x. PMID: 2727376
Adams JM
West J Med 1975 May;122(5):380-93. PMID: 165638Free PMC Article

Diagnosis

Thurnher MM, Sundgren PC
Neuroimaging Clin N Am 2008 Feb;18(1):133-48; ix. doi: 10.1016/j.nic.2007.12.014. PMID: 18319159
Bradley R, Matthews D
Rev Sci Tech 1992 Jun;11(2):605-34. doi: 10.20506/rst.11.2.609. PMID: 1617204
Lantos PL
Histopathology 1992 Jan;20(1):1-11. doi: 10.1111/j.1365-2559.1992.tb00909.x. PMID: 1531331
Alfrey AC
Annu Rev Med 1978;29:93-8. doi: 10.1146/annurev.me.29.020178.000521. PMID: 348053
Fratkin JD, Smith AG
Surv Ophthalmol 1977 Jan-Feb;21(4):356-65. doi: 10.1016/0039-6257(77)90116-3. PMID: 402037

Therapy

Weinstein M
Neurol Res 1992 Sep;14(4):355-6. doi: 10.1080/01616412.1992.11740084. PMID: 1360634
Prusiner SB
Crit Rev Biochem Mol Biol 1991;26(5-6):397-438. doi: 10.3109/10409239109086789. PMID: 1684745
Collee JG
Lancet 1990 Nov 24;336(8726):1300-3. doi: 10.1016/0140-6736(90)92976-o. PMID: 1978125
Alfrey AC
Annu Rev Med 1978;29:93-8. doi: 10.1146/annurev.me.29.020178.000521. PMID: 348053
Cogan DG
Am J Ophthalmol 1977 Jun;83(6):777-88. doi: 10.1016/0002-9394(77)90903-5. PMID: 194482

Prognosis

Weinstein M
Neurol Res 1992 Sep;14(4):355-6. doi: 10.1080/01616412.1992.11740084. PMID: 1360634
Dal Canto MC
Ital J Neurol Sci 1991 Apr;12(2):147-53. doi: 10.1007/BF02337026. PMID: 1676992
Gilden DH
Postgrad Med 1983 Jan;73(1):99-101, 104-8. doi: 10.1080/00325481.1983.11698316. PMID: 6849001
Torack RM
Neurosurgery 1979 May;4(5):434-42. doi: 10.1227/00006123-197905000-00011. PMID: 379682
Gajdusek DC
Ann Clin Res 1973 Oct;5(5):254-61. PMID: 4209650

Clinical prediction guides

Roberts GW, Lofthouse R, Allsop D, Landon M, Kidd M, Prusiner SB, Crow TJ
Neurology 1988 Oct;38(10):1534-40. doi: 10.1212/wnl.38.10.1534. PMID: 2901696
Merz PA, Rohwer RG, Kascsak R, Wisniewski HM, Somerville RA, Gibbs CJ Jr, Gajdusek DC
Science 1984 Jul 27;225(4660):437-40. doi: 10.1126/science.6377496. PMID: 6377496
Howatson AF, Fornasier VL
Intervirology 1982;18(3):150-9. doi: 10.1159/000149318. PMID: 6292129
Gudnadóttir M
Med Biol 1981 Apr;59(2):77-84. PMID: 6273667
Matthews WB
Postgrad Med J 1978 Sep;54(635):591-4. doi: 10.1136/pgmj.54.635.591. PMID: 103082Free PMC Article

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