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Slow Virus Diseases

MedGen UID:
20001
•Concept ID:
C0037341
•
Disease or Syndrome
Synonyms: Disease, Slow Virus; Diseases, Slow Virus; Slow Virus Disease; Virus Disease, Slow; Virus Diseases, Slow

Definition

Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES. [from MeSH]

Professional guidelines

PubMed

Diagnosis and treatment of classic and iatrogenic Kaposi's sarcoma: Italian recommendations.
Brambilla L, Genovese G, Berti E, Peris K, Rongioletti F, Micali G, Ayala F, Della Bella S, Mancuso R, Calzavara Pinton P, Tourlaki A
Ital J Dermatol Venerol 2021 Jun;156(3):356-365. Epub 2020 Nov 12 doi: 10.23736/S2784-8671.20.06703-6. PMID: 33179877
HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment.
Bowen LN, Smith B, Reich D, Quezado M, Nath A
Nat Rev Neurol 2016 Oct 27;12(11):662-674. doi: 10.1038/nrneurol.2016.149. PMID: 27786246
PML diagnostic criteria: consensus statement from the AAN Neuroinfectious Disease Section.
Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A
Neurology 2013 Apr 9;80(15):1430-8. doi: 10.1212/WNL.0b013e31828c2fa1. PMID: 23568998Free PMC Article

Recent clinical studies

Etiology

Molecular biology and pathogenesis of prion diseases.
Prusiner SB
Trends Biochem Sci 1996 Dec;21(12):482-7. doi: 10.1016/s0968-0004(96)10063-3. PMID: 9009832
Sub-acute, transmissible spongiform encephalopathies: current concepts and future needs.
Bradley R, Matthews D
Rev Sci Tech 1992 Jun;11(2):605-34. doi: 10.20506/rst.11.2.609. PMID: 1617204
Bovine spongiform encephalopathy.
Matthews D
J R Soc Health 1991 Feb;111(1):3-5. doi: 10.1177/146642409111100101. PMID: 1900892
Slow viruses and chronic disease of the central nervous system.
Sutton RN
Postgrad Med J 1979 Feb;55(640):143-9. doi: 10.1136/pgmj.55.640.143. PMID: 223140Free PMC Article
Persistent or slow viral infections and related diseases.
Adams JM
West J Med 1975 May;122(5):380-93. PMID: 165638Free PMC Article

Diagnosis

Imaging of slow viruses.
Thurnher MM, Sundgren PC
Neuroimaging Clin N Am 2008 Feb;18(1):133-48; ix. doi: 10.1016/j.nic.2007.12.014. PMID: 18319159
Dialysis encephalopathy syndrome.
Alfrey AC
Annu Rev Med 1978;29:93-8. doi: 10.1146/annurev.me.29.020178.000521. PMID: 348053
Slow virus infections.
Fratkin JD, Smith AG
Surv Ophthalmol 1977 Jan-Feb;21(4):356-65. doi: 10.1016/0039-6257(77)90116-3. PMID: 402037
Rabies.
Debbie JG
Prog Med Virol 1974;18(0):241-56. PMID: 4608103
Dementia reconsidered.
Wells CE
Arch Gen Psychiatry 1972 Apr;26(4):385-8. doi: 10.1001/archpsyc.1972.01750220095018. PMID: 4552132

Therapy

Creutzfeldt-Jakob disease.
Weinstein M
Neurol Res 1992 Sep;14(4):355-6. doi: 10.1080/01616412.1992.11740084. PMID: 1360634
Molecular biology and transgenetics of prion diseases.
Prusiner SB
Crit Rev Biochem Mol Biol 1991;26(5-6):397-438. doi: 10.3109/10409239109086789. PMID: 1684745
Perspectives on the etiology of Alzheimer's disease.
Mozar HN, Bal DG, Howard JT
JAMA 1987 Mar 20;257(11):1503-7. PMID: 2950247
Dialysis encephalopathy syndrome.
Alfrey AC
Annu Rev Med 1978;29:93-8. doi: 10.1146/annurev.me.29.020178.000521. PMID: 348053
Immunosuppression and eye disease. First Vail lecture.
Cogan DG
Am J Ophthalmol 1977 Jun;83(6):777-88. doi: 10.1016/0002-9394(77)90903-5. PMID: 194482

Prognosis

Creutzfeldt-Jakob disease.
Weinstein M
Neurol Res 1992 Sep;14(4):355-6. doi: 10.1080/01616412.1992.11740084. PMID: 1360634
Human and experimental spongiform encephalopathies: recent progress in pathogenesis.
Dal Canto MC
Ital J Neurol Sci 1991 Apr;12(2):147-53. doi: 10.1007/BF02337026. PMID: 1676992
Slow virus diseases of the CNS. 1. Subacute sclerosing panencephalitis, progressive rubella panencephalitis, and progressive multifocal leukoencephalopathy.
Gilden DH
Postgrad Med 1983 Jan;73(1):99-101, 104-8. doi: 10.1080/00325481.1983.11698316. PMID: 6849001
Adult dementia: history, biopsy, pathology.
Torack RM
Neurosurgery 1979 May;4(5):434-42. doi: 10.1227/00006123-197905000-00011. PMID: 379682
Kuru and Creutzfeldt-Jakob disease. Experimental models of noninflammatory degenerative slow virus disease of the central nervous system.
Gajdusek DC
Ann Clin Res 1973 Oct;5(5):254-61. PMID: 4209650

Clinical prediction guides

CNS amyloid proteins in neurodegenerative diseases.
Roberts GW, Lofthouse R, Allsop D, Landon M, Kidd M, Prusiner SB, Crow TJ
Neurology 1988 Oct;38(10):1534-40. doi: 10.1212/wnl.38.10.1534. PMID: 2901696
Infection-specific particle from the unconventional slow virus diseases.
Merz PA, Rohwer RG, Kascsak R, Wisniewski HM, Somerville RA, Gibbs CJ Jr, Gajdusek DC
Science 1984 Jul 27;225(4660):437-40. doi: 10.1126/science.6377496. PMID: 6377496
Microfilaments associated with Paget's disease of bone: comparison with nucleocapsids of measles virus and respiratory syncytial virus.
Howatson AF, Fornasier VL
Intervirology 1982;18(3):150-9. doi: 10.1159/000149318. PMID: 6292129
Slow viral infections of animals: experimental models for human disease.
Gudnadóttir M
Med Biol 1981 Apr;59(2):77-84. PMID: 6273667
Creutzfeldt--Jakob disease.
Matthews WB
Postgrad Med J 1978 Sep;54(635):591-4. doi: 10.1136/pgmj.54.635.591. PMID: 103082Free PMC Article

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