U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aphakia

MedGen UID:
2005
•Concept ID:
C0003534
•
Anatomical Abnormality
Synonyms: Aphakias; Aphakic Eye; Aphakic Eyes; Eye, Aphakic
SNOMED CT: Aphakia (24010005); Absence of lens (24010005)

Definition

The absence of the crystalline lens of the eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAphakia

Professional guidelines

PubMed

RISK FACTORS, TREATMENT STRATEGIES, AND OUTCOMES OF ENDOPHTHALMITIS ASSOCIATED WITH SEVERE FUNGAL KERATITIS.
Wan L, Cheng J, Zhang J, Chen N, Gao Y, Xie LX
Retina 2019 Jun;39(6):1076-1082. doi: 10.1097/IAE.0000000000002112. PMID: 29474308
FOXE3 mutations: genotype-phenotype correlations.
Plaisancié J, Ragge NK, Dollfus H, Kaplan J, Lehalle D, Francannet C, Morin G, Colineaux H, Calvas P, Chassaing N
Clin Genet 2018 Apr;93(4):837-845. doi: 10.1111/cge.13177. PMID: 29136273
Molecular pathogenesis and management strategies of ectopia lentis.
Chandra A, Charteris D
Eye (Lond) 2014 Feb;28(2):162-8. Epub 2014 Jan 10 doi: 10.1038/eye.2013.274. PMID: 24406422Free PMC Article

Recent clinical studies

Etiology

Role of Intraocular Lens Implantation in Children.
Bothun ED
J Binocul Vis Ocul Motil 2023 Oct 2;73(4):93-96. Epub 2023 Nov 6 PMID: 37931124
Congenital primary aphakia.
Ernst J, Medsinge A, Scanga HL, Hiasat J, Moore W, Ali A, Levin AV, Stahl ED, Nischal KK
J AAPOS 2022 Feb;26(1):4.e1-4.e5. Epub 2022 Jan 17 doi: 10.1016/j.jaapos.2021.09.008. PMID: 35051625
Intrascleral IOL Fixation.
Jacob S
Asia Pac J Ophthalmol (Phila) 2017 Jul-Aug;6(4):381-387. Epub 2017 Jun 26 doi: 10.22608/APO.2017158. PMID: 28726356
Complications of pediatric cataract surgery.
Whitman MC, Vanderveen DK
Semin Ophthalmol 2014 Sep-Nov;29(5-6):414-20. doi: 10.3109/08820538.2014.959192. PMID: 25325868
Brown-McLean syndrome.
Kam KW, Jhanji V, Young AL
BMJ Case Rep 2013 Oct 9;2013 doi: 10.1136/bcr-2013-201280. PMID: 24108775Free PMC Article

Diagnosis

Congenital primary aphakia.
Ernst J, Medsinge A, Scanga HL, Hiasat J, Moore W, Ali A, Levin AV, Stahl ED, Nischal KK
J AAPOS 2022 Feb;26(1):4.e1-4.e5. Epub 2022 Jan 17 doi: 10.1016/j.jaapos.2021.09.008. PMID: 35051625
Soemmering's Ring.
Mandal AK, Gollakota R
Ophthalmology 2017 Jul;124(7):1064. doi: 10.1016/j.ophtha.2017.01.016. PMID: 28645340
Brown-McLean syndrome.
Kam KW, Jhanji V, Young AL
BMJ Case Rep 2013 Oct 9;2013 doi: 10.1136/bcr-2013-201280. PMID: 24108775Free PMC Article
Cataracts in children.
Zetterström C, Lundvall A, Kugelberg M
J Cataract Refract Surg 2005 Apr;31(4):824-40. doi: 10.1016/j.jcrs.2005.01.012. PMID: 15899463
Pediatric cataracts.
Hamill MB, Koch DD
Curr Opin Ophthalmol 1999 Feb;10(1):4-9. doi: 10.1097/00055735-199902000-00002. PMID: 10387318

Therapy

Long-term Effect of Intraocular Lens vs Contact Lens Correction on Visual Acuity After Cataract Surgery During Infancy: A Randomized Clinical Trial.
Lambert SR, Cotsonis G, DuBois L, Nizam Ms A, Kruger SJ, Hartmann EE, Weakley DR Jr, Drews-Botsch C; Infant Aphakia Treatment Study Group
JAMA Ophthalmol 2020 Apr 1;138(4):365-372. doi: 10.1001/jamaophthalmol.2020.0006. PMID: 32077909Free PMC Article
Complications of Scleral-Fixated Intraocular Lenses.
Davies EC, Pineda R 2nd
Semin Ophthalmol 2018;33(1):23-28. Epub 2017 Sep 12 doi: 10.1080/08820538.2017.1353808. PMID: 28898111
Brown-McLean syndrome.
Kam KW, Jhanji V, Young AL
BMJ Case Rep 2013 Oct 9;2013 doi: 10.1136/bcr-2013-201280. PMID: 24108775Free PMC Article
Endoscopic cyclophotocoagulation.
Lin S
Br J Ophthalmol 2002 Dec;86(12):1434-8. doi: 10.1136/bjo.86.12.1434. PMID: 12446381Free PMC Article
Aphakic glaucoma.
Scheie HG, Ewing MQ
Trans Ophthalmol Soc U K (1962) 1978 Apr;98(1):111-7. PMID: 373170

Prognosis

Congenital primary aphakia.
Ernst J, Medsinge A, Scanga HL, Hiasat J, Moore W, Ali A, Levin AV, Stahl ED, Nischal KK
J AAPOS 2022 Feb;26(1):4.e1-4.e5. Epub 2022 Jan 17 doi: 10.1016/j.jaapos.2021.09.008. PMID: 35051625
Long-term Effect of Intraocular Lens vs Contact Lens Correction on Visual Acuity After Cataract Surgery During Infancy: A Randomized Clinical Trial.
Lambert SR, Cotsonis G, DuBois L, Nizam Ms A, Kruger SJ, Hartmann EE, Weakley DR Jr, Drews-Botsch C; Infant Aphakia Treatment Study Group
JAMA Ophthalmol 2020 Apr 1;138(4):365-372. doi: 10.1001/jamaophthalmol.2020.0006. PMID: 32077909Free PMC Article
Corneal transplantation and glaucoma.
Haddadin RI, Chodosh J
Semin Ophthalmol 2014 Sep-Nov;29(5-6):380-96. doi: 10.3109/08820538.2014.959201. PMID: 25325864
Brown-McLean syndrome.
Kam KW, Jhanji V, Young AL
BMJ Case Rep 2013 Oct 9;2013 doi: 10.1136/bcr-2013-201280. PMID: 24108775Free PMC Article
Cataracts in children.
Zetterström C, Lundvall A, Kugelberg M
J Cataract Refract Surg 2005 Apr;31(4):824-40. doi: 10.1016/j.jcrs.2005.01.012. PMID: 15899463

Clinical prediction guides

Glaucoma following Infant Lensectomy: 2021 Update.
Walton DS, Yeung HH
Klin Monbl Augenheilkd 2021 Oct;238(10):1065-1068. Epub 2021 Sep 17 doi: 10.1055/a-1554-5398. PMID: 34535026
Update on Intraocular Lens Formulas and Calculations.
Xia T, Martinez CE, Tsai LM
Asia Pac J Ophthalmol (Phila) 2020 May-Jun;9(3):186-193. doi: 10.1097/APO.0000000000000293. PMID: 32501896Free PMC Article
Incidence and risk factors for post-penetrating keratoplasty glaucoma: A systematic review and meta-analysis.
Wu S, Xu J
PLoS One 2017;12(4):e0176261. Epub 2017 Apr 21 doi: 10.1371/journal.pone.0176261. PMID: 28430806Free PMC Article
Pediatric cataract surgery.
Vasavada AR, Nihalani BR
Curr Opin Ophthalmol 2006 Feb;17(1):54-61. doi: 10.1097/01.icu.0000193069.32369.e1. PMID: 16436925
Endoscopic cyclophotocoagulation.
Lin S
Br J Ophthalmol 2002 Dec;86(12):1434-8. doi: 10.1136/bjo.86.12.1434. PMID: 12446381Free PMC Article

Recent systematic reviews

Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis.
Xiang J, Fan J, Wang J
PLoS One 2023;18(10):e0292698. Epub 2023 Oct 30 doi: 10.1371/journal.pone.0292698. PMID: 37903162Free PMC Article
Surgical interventions for bilateral congenital cataract in children aged two years and under.
Singh R, Barker L, Chen SI, Shah A, Long V, Dahlmann-Noor A
Cochrane Database Syst Rev 2022 Sep 15;9(9):CD003171. doi: 10.1002/14651858.CD003171.pub3. PMID: 36107778Free PMC Article
The influence of the Artisan-Verisyse position on the postoperative outcomes: A systematic review and meta-analysis.
Romero D, Escolano J, Fernández C, Martínez-Toldos JJ, Monera CE, Castilla G, Moyá A
Indian J Ophthalmol 2022 Sep;70(9):3213-3221. doi: 10.4103/ijo.IJO_880_22. PMID: 36018090Free PMC Article
Iris-Claw Intraocular Lens: Anterior Chamber or Retropupillary Implantation? A Systematic Review and Meta-Analysis.
Liang IC, Chang YH, Hernández Martínez A, Hung CF
Medicina (Kaunas) 2021 Jul 30;57(8) doi: 10.3390/medicina57080785. PMID: 34440990Free PMC Article
Incidence and risk factors for post-penetrating keratoplasty glaucoma: A systematic review and meta-analysis.
Wu S, Xu J
PLoS One 2017;12(4):e0176261. Epub 2017 Apr 21 doi: 10.1371/journal.pone.0176261. PMID: 28430806Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...