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Pancreas sarcoma

MedGen UID:
202112
•Concept ID:
C1096346
•
Neoplastic Process
Synonyms: pancreas sarcoma; Pancreatic Sarcoma; pancreatic sarcoma; Sarcoma of Pancreas; sarcoma of pancreas; Sarcoma of the Pancreas; sarcoma of the pancreas
 
Monarch Initiative: MONDO:0002117

Definition

A rare malignant soft tissue neoplasm that occurs primarily in the pancreas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreas sarcoma

Professional guidelines

PubMed

Pancreaticoduodenectomy for the Management of Pancreatic or Duodenal Metastases from Primary Sarcoma.
Huddy JR, Sodergren MH, Deguara J, Thway K, Jones RL, Mudan SS
Anticancer Res 2018 Jul;38(7):4041-4046. doi: 10.21873/anticanres.12693. PMID: 29970529
Pancreatic Cancer Arising From the Remnant Pancreas: Is It a Local Recurrence or New Primary Lesion?
Hashimoto D, Chikamoto A, Masuda T, Nakagawa S, Imai K, Yamashita YI, Reber HA, Baba H
Pancreas 2017 Oct;46(9):1083-1090. doi: 10.1097/MPA.0000000000000897. PMID: 28902776
Integration of radiation oncology with surgery as combined-modality treatment.
Gunderson LL, Ashman JB, Haddock MG, Petersen IA, Moss A, Heppell J, Gray RJ, Pockaj BA, Nelson H, Beauchamp C
Surg Oncol Clin N Am 2013 Jul;22(3):405-32. Epub 2013 Mar 13 doi: 10.1016/j.soc.2013.02.003. PMID: 23622071

Recent clinical studies

Etiology

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.
Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson MA, Janjigian Y, O'Reilly EM, Segal N, Saltz LB, Reidy-Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Aguilar JG, Klimstra DS, Diaz LA Jr, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK
J Clin Oncol 2019 Feb 1;37(4):286-295. Epub 2018 Oct 30 doi: 10.1200/JCO.18.00283. PMID: 30376427Free PMC Article
Coffee and cancer risk: a summary overview.
Alicandro G, Tavani A, La Vecchia C
Eur J Cancer Prev 2017 Sep;26(5):424-432. doi: 10.1097/CEJ.0000000000000341. PMID: 28288025
A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study.
Scott JG, Berglund A, Schell MJ, Mihaylov I, Fulp WJ, Yue B, Welsh E, Caudell JJ, Ahmed K, Strom TS, Mellon E, Venkat P, Johnstone P, Foekens J, Lee J, Moros E, Dalton WS, Eschrich SA, McLeod H, Harrison LB, Torres-Roca JF
Lancet Oncol 2017 Feb;18(2):202-211. Epub 2016 Dec 18 doi: 10.1016/S1470-2045(16)30648-9. PMID: 27993569Free PMC Article
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J
Semin Diagn Pathol 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. PMID: 17193820
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Diagnosis

NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls.
Solomon JP, Linkov I, Rosado A, Mullaney K, Rosen EY, Frosina D, Jungbluth AA, Zehir A, Benayed R, Drilon A, Hyman DM, Ladanyi M, Sireci AN, Hechtman JF
Mod Pathol 2020 Jan;33(1):38-46. Epub 2019 Aug 2 doi: 10.1038/s41379-019-0324-7. PMID: 31375766Free PMC Article
BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR
Am J Surg Pathol 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PMID: 29300189Free PMC Article
Rare Tumors and Lesions of the Pancreas.
Stauffer JA, Asbun HJ
Surg Clin North Am 2018 Feb;98(1):169-188. doi: 10.1016/j.suc.2017.09.013. PMID: 29191273
A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study.
Scott JG, Berglund A, Schell MJ, Mihaylov I, Fulp WJ, Yue B, Welsh E, Caudell JJ, Ahmed K, Strom TS, Mellon E, Venkat P, Johnstone P, Foekens J, Lee J, Moros E, Dalton WS, Eschrich SA, McLeod H, Harrison LB, Torres-Roca JF
Lancet Oncol 2017 Feb;18(2):202-211. Epub 2016 Dec 18 doi: 10.1016/S1470-2045(16)30648-9. PMID: 27993569Free PMC Article
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Therapy

Radiotherapy reimagined: Integrating nanomedicines into radiotherapy clinical trials.
DuRoss AN, Phan J, Lazar AJ, Walker JM, Guimaraes AR, Baas C, Krishnan S, Thomas CR Jr, Sun C, Bagley AF
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2023 May-Jun;15(3):e1867. Epub 2022 Oct 28 doi: 10.1002/wnan.1867. PMID: 36308008
A Narrative Review of Regional Hyperthermia: Updates From 2010 to 2019.
Fiorentini G, Sarti D, Gadaleta CD, Ballerini M, Fiorentini C, Garfagno T, Ranieri G, Guadagni S
Integr Cancer Ther 2020 Jan-Dec;19:1534735420932648. doi: 10.1177/1534735420932648. PMID: 33054425Free PMC Article
Electrochemotherapy as a New Modality in Interventional Oncology: A Review.
Probst U, Fuhrmann I, Beyer L, Wiggermann P
Technol Cancer Res Treat 2018 Jan 1;17:1533033818785329. doi: 10.1177/1533033818785329. PMID: 29986632Free PMC Article
Coffee and cancer risk: a summary overview.
Alicandro G, Tavani A, La Vecchia C
Eur J Cancer Prev 2017 Sep;26(5):424-432. doi: 10.1097/CEJ.0000000000000341. PMID: 28288025
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Prognosis

TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.
Liu W, Zhao Y, Wang G, Feng S, Ge X, Ye W, Wang Z, Zhu Y, Cai W, Bai J, Zhou X
Redox Biol 2022 Jul;53:102344. Epub 2022 May 18 doi: 10.1016/j.redox.2022.102344. PMID: 35636015Free PMC Article
Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.
Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson MA, Janjigian Y, O'Reilly EM, Segal N, Saltz LB, Reidy-Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Aguilar JG, Klimstra DS, Diaz LA Jr, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK
J Clin Oncol 2019 Feb 1;37(4):286-295. Epub 2018 Oct 30 doi: 10.1200/JCO.18.00283. PMID: 30376427Free PMC Article
A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study.
Scott JG, Berglund A, Schell MJ, Mihaylov I, Fulp WJ, Yue B, Welsh E, Caudell JJ, Ahmed K, Strom TS, Mellon E, Venkat P, Johnstone P, Foekens J, Lee J, Moros E, Dalton WS, Eschrich SA, McLeod H, Harrison LB, Torres-Roca JF
Lancet Oncol 2017 Feb;18(2):202-211. Epub 2016 Dec 18 doi: 10.1016/S1470-2045(16)30648-9. PMID: 27993569Free PMC Article
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J
Semin Diagn Pathol 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. PMID: 17193820
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Clinical prediction guides

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.
Latham A, Srinivasan P, Kemel Y, Shia J, Bandlamudi C, Mandelker D, Middha S, Hechtman J, Zehir A, Dubard-Gault M, Tran C, Stewart C, Sheehan M, Penson A, DeLair D, Yaeger R, Vijai J, Mukherjee S, Galle J, Dickson MA, Janjigian Y, O'Reilly EM, Segal N, Saltz LB, Reidy-Lagunes D, Varghese AM, Bajorin D, Carlo MI, Cadoo K, Walsh MF, Weiser M, Aguilar JG, Klimstra DS, Diaz LA Jr, Baselga J, Zhang L, Ladanyi M, Hyman DM, Solit DB, Robson ME, Taylor BS, Offit K, Berger MF, Stadler ZK
J Clin Oncol 2019 Feb 1;37(4):286-295. Epub 2018 Oct 30 doi: 10.1200/JCO.18.00283. PMID: 30376427Free PMC Article
Electrochemotherapy as a New Modality in Interventional Oncology: A Review.
Probst U, Fuhrmann I, Beyer L, Wiggermann P
Technol Cancer Res Treat 2018 Jan 1;17:1533033818785329. doi: 10.1177/1533033818785329. PMID: 29986632Free PMC Article
BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR
Am J Surg Pathol 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PMID: 29300189Free PMC Article
A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study.
Scott JG, Berglund A, Schell MJ, Mihaylov I, Fulp WJ, Yue B, Welsh E, Caudell JJ, Ahmed K, Strom TS, Mellon E, Venkat P, Johnstone P, Foekens J, Lee J, Moros E, Dalton WS, Eschrich SA, McLeod H, Harrison LB, Torres-Roca JF
Lancet Oncol 2017 Feb;18(2):202-211. Epub 2016 Dec 18 doi: 10.1016/S1470-2045(16)30648-9. PMID: 27993569Free PMC Article
Clinical characteristics and prognosis of primary leiomyosarcoma of the pancreas: a systematic review.
Xu J, Zhang T, Wang T, You L, Zhao Y
World J Surg Oncol 2013 Nov 12;11:290. doi: 10.1186/1477-7819-11-290. PMID: 24219646Free PMC Article

Recent systematic reviews

Pancreatic follicular dendritic cell sarcoma: a rare case report and systematic literature review of 7 cases.
Li X, Gu J, He Q, Han S, Wu H
World J Surg Oncol 2023 Jul 21;21(1):212. doi: 10.1186/s12957-023-03115-5. PMID: 37480085Free PMC Article
Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children.
Gómez FM, Patel PA, Stuart S, Roebuck DJ
Pediatr Radiol 2014 Oct;44(10):1281-9. Epub 2014 May 13 doi: 10.1007/s00247-014-3001-5. PMID: 24821394
Pancreatectomy for metastatic disease: a systematic review.
Adler H, Redmond CE, Heneghan HM, Swan N, Maguire D, Traynor O, Hoti E, Geoghegan JG, Conlon KC
Eur J Surg Oncol 2014 Apr;40(4):379-86. Epub 2014 Jan 15 doi: 10.1016/j.ejso.2013.12.022. PMID: 24462547
Clinical characteristics and prognosis of primary leiomyosarcoma of the pancreas: a systematic review.
Xu J, Zhang T, Wang T, You L, Zhao Y
World J Surg Oncol 2013 Nov 12;11:290. doi: 10.1186/1477-7819-11-290. PMID: 24219646Free PMC Article
Second cancers in patients with male breast cancer: a literature review.
Grenader T, Goldberg A, Shavit L
J Cancer Surviv 2008 Jun;2(2):73-8. Epub 2008 Apr 1 doi: 10.1007/s11764-008-0042-5. PMID: 18648975

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