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Myocardial calcification

MedGen UID:
202115
•Concept ID:
C1096561
•
Pathologic Function
Synonym: Calcified myocardium
 
HPO: HP:0006690

Definition

Calcium deposition in the myocardium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial calcification

Conditions with this feature

Congenital heart block
MedGen UID:
57432
•Concept ID:
C0149530
•
Disease or Syndrome
Congenital heart block (CHB) is a rare disorder of atrioventricular conduction, characterized by absence of conduction of atrial impulses to the ventricles with slower ventricular rhythm (atrioventricular dissociation). CHB can occur in association with immunological evidence of maternal connective disease (autoimmune CHD), fetal structural CHD or can be idiopathic.
See: Condition Record
Congenital heart block

Professional guidelines

PubMed

Myocardial calcifications: pathophysiology, etiologies, differential diagnoses, and imaging findings.
Nance JW Jr, Crane GM, Halushka MK, Fishman EK, Zimmerman SL
J Cardiovasc Comput Tomogr 2015 Jan-Feb;9(1):58-67. Epub 2014 Oct 22 doi: 10.1016/j.jcct.2014.10.004. PMID: 25456525
Hyperphosphataemia in renal failure: causes, consequences and current management.
Albaaj F, Hutchison A
Drugs 2003;63(6):577-96. doi: 10.2165/00003495-200363060-00005. PMID: 12656655

Recent clinical studies

Etiology

Pacemaker lead insertion sites contribute to abnormalities of myocardial function and histopathology.
Castellanos DA, Carreon CK, Prakash A, Sanders SP, Lee G, Eildermann K, Sigler M, O'Leary ET, Baird C, Fynn-Thompson F, Gauvreau K, Ghelani SJ, Mah DY
Heart Rhythm 2023 Dec;20(12):1739-1749. Epub 2023 Jun 28 doi: 10.1016/j.hrthm.2023.06.018. PMID: 37390910
Myocardial calcification is associated with endocardial ablation failure of post-myocardial infarction ventricular tachycardia.
de Riva M, Naruse Y, Ebert M, Watanabe M, Scholte AJ, Wijnmaalen AP, Trines SA, Schalij MJ, Montero-Cabezas JM, Zeppenfeld K
Europace 2021 Aug 6;23(8):1275-1284. doi: 10.1093/europace/euab003. PMID: 33550383
Myocardial calcification secondary to toxic shock syndrome: a comparative review of 17 cases.
Ahmed T, Inayat F, Haq M, Ahmed T
BMJ Case Rep 2019 Jan 10;12(1) doi: 10.1136/bcr-2018-228054. PMID: 30635313Free PMC Article
A proposed role for sepsis in the pathogenesis of myocardial calcification.
Bower G, Ashrafian H, Cappelletti S, Lee LM, Harling L, Ciallella C, Aromatario M, Athanasiou T
Acta Cardiol 2017 Jun;72(3):249-255. Epub 2017 Mar 30 doi: 10.1080/00015385.2017.1305163. PMID: 28636521
The continuing enigma of the fetal echogenic intracardiac focus in prenatal ultrasound.
Rodriguez R, Herrero B, Bartha JL
Curr Opin Obstet Gynecol 2013 Apr;25(2):145-51. doi: 10.1097/GCO.0b013e32835e14eb. PMID: 23340246

Diagnosis

Reversible Myocardial Calcification Following Acute Heart Failure and Kidney Injury Caused by Valsalva Sinus Rupture.
Chen W, Liu J, Ma G, Liu X, Miao Q, Zhang C
Heart Surg Forum 2022 Jul 12;25(4):E510-E513. doi: 10.1532/hsf.4759. PMID: 36052913
Dystrophic myocardial calcification.
Ananthakrishna R, Moorthy N
Indian Heart J 2016 Sep;68 Suppl 2(Suppl 2):S180-S181. Epub 2016 Feb 28 doi: 10.1016/j.ihj.2016.02.016. PMID: 27751283Free PMC Article
Myocardial calcifications: pathophysiology, etiologies, differential diagnoses, and imaging findings.
Nance JW Jr, Crane GM, Halushka MK, Fishman EK, Zimmerman SL
J Cardiovasc Comput Tomogr 2015 Jan-Feb;9(1):58-67. Epub 2014 Oct 22 doi: 10.1016/j.jcct.2014.10.004. PMID: 25456525
Sepsis-related myocardial calcification.
van Kruijsdijk RC, van der Heijden JJ, Uijlings R, Otterspoor LC
Circ Heart Fail 2011 Sep;4(5):e16-8. doi: 10.1161/CIRCHEARTFAILURE.111.962183. PMID: 21934087
Porcelain heart.
Hajsadeghi F, Ahmadi N, Eshaghian S, Budoff M
J Cardiovasc Comput Tomogr 2011 May-Jun;5(3):183-5. Epub 2011 Jan 28 doi: 10.1016/j.jcct.2011.01.010. PMID: 21367683

Therapy

Pacemaker lead insertion sites contribute to abnormalities of myocardial function and histopathology.
Castellanos DA, Carreon CK, Prakash A, Sanders SP, Lee G, Eildermann K, Sigler M, O'Leary ET, Baird C, Fynn-Thompson F, Gauvreau K, Ghelani SJ, Mah DY
Heart Rhythm 2023 Dec;20(12):1739-1749. Epub 2023 Jun 28 doi: 10.1016/j.hrthm.2023.06.018. PMID: 37390910
Myocardial calcification is associated with endocardial ablation failure of post-myocardial infarction ventricular tachycardia.
de Riva M, Naruse Y, Ebert M, Watanabe M, Scholte AJ, Wijnmaalen AP, Trines SA, Schalij MJ, Montero-Cabezas JM, Zeppenfeld K
Europace 2021 Aug 6;23(8):1275-1284. doi: 10.1093/europace/euab003. PMID: 33550383
Myocardial Calcification and the Demise of an Infant With Surgically Treated Hypoplastic Left Heart Syndrome.
Reyes Barron C, Katzman PJ
Pediatr Dev Pathol 2021 Jan-Feb;24(1):68-72. Epub 2021 Jan 12 doi: 10.1177/1093526620970822. PMID: 33433253
Cardiac Calcifications in Adults with Congenital Heart Defects.
Halpern DG, Steigner ML, Prabhu SP, Valente AM, Sanders SP
Congenit Heart Dis 2015 Sep-Oct;10(5):396-402. Epub 2015 Jan 7 doi: 10.1111/chd.12243. PMID: 25564755
Hyperphosphataemia in renal failure: causes, consequences and current management.
Albaaj F, Hutchison A
Drugs 2003;63(6):577-96. doi: 10.2165/00003495-200363060-00005. PMID: 12656655

Prognosis

Myocardial Calcification and the Demise of an Infant With Surgically Treated Hypoplastic Left Heart Syndrome.
Reyes Barron C, Katzman PJ
Pediatr Dev Pathol 2021 Jan-Feb;24(1):68-72. Epub 2021 Jan 12 doi: 10.1177/1093526620970822. PMID: 33433253
Acute extensive myocardial calcification.
Glick Y, Dubin I, Schattner A
Postgrad Med J 2020 Nov;96(1141):719. Epub 2020 Jan 5 doi: 10.1136/postgradmedj-2019-137211. PMID: 31907226
Septic myocardial calcification: A case report.
Maiese A, Manetti F, La Russa R, Di Fazio N, De Matteis A, Frati P, Fineschi V
J Forensic Leg Med 2019 Jul;65:45-47. Epub 2019 May 11 doi: 10.1016/j.jflm.2019.05.004. PMID: 31100653
A proposed role for sepsis in the pathogenesis of myocardial calcification.
Bower G, Ashrafian H, Cappelletti S, Lee LM, Harling L, Ciallella C, Aromatario M, Athanasiou T
Acta Cardiol 2017 Jun;72(3):249-255. Epub 2017 Mar 30 doi: 10.1080/00015385.2017.1305163. PMID: 28636521
Porcelain heart.
Hajsadeghi F, Ahmadi N, Eshaghian S, Budoff M
J Cardiovasc Comput Tomogr 2011 May-Jun;5(3):183-5. Epub 2011 Jan 28 doi: 10.1016/j.jcct.2011.01.010. PMID: 21367683

Clinical prediction guides

Reversible Myocardial Calcification Following Acute Heart Failure and Kidney Injury Caused by Valsalva Sinus Rupture.
Chen W, Liu J, Ma G, Liu X, Miao Q, Zhang C
Heart Surg Forum 2022 Jul 12;25(4):E510-E513. doi: 10.1532/hsf.4759. PMID: 36052913
Myocardial calcification found in Epstein-Barr viral myocarditis and rhabdomyolysis: A case report.
Sui M, Tang W, Wu C
Medicine (Baltimore) 2018 Dec;97(49):e13582. doi: 10.1097/MD.0000000000013582. PMID: 30544481Free PMC Article
Cardiac Calcifications in Adults with Congenital Heart Defects.
Halpern DG, Steigner ML, Prabhu SP, Valente AM, Sanders SP
Congenit Heart Dis 2015 Sep-Oct;10(5):396-402. Epub 2015 Jan 7 doi: 10.1111/chd.12243. PMID: 25564755
Porcelain heart.
Hajsadeghi F, Ahmadi N, Eshaghian S, Budoff M
J Cardiovasc Comput Tomogr 2011 May-Jun;5(3):183-5. Epub 2011 Jan 28 doi: 10.1016/j.jcct.2011.01.010. PMID: 21367683
Primary hyperparathyroidism and heart disease--a review.
Andersson P, Rydberg E, Willenheimer R
Eur Heart J 2004 Oct;25(20):1776-87. doi: 10.1016/j.ehj.2004.07.010. PMID: 15474692

Recent systematic reviews

A systematic review of radiological and histological findings of septic myocardial calcifications.
Cappelletti S, Piacentino D, Ciallella C
J Forensic Leg Med 2020 Aug;74:102026. Epub 2020 Jul 25 doi: 10.1016/j.jflm.2020.102026. PMID: 32755766

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