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Metastatic Malignant Testicular Germ Cell Tumor

MedGen UID:
202116
Concept ID:
C1096715
Neoplastic Process
Synonym: Metastatic Testicular Cancer

Definition

A malignant germ cell tumor that arises from the testis and has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Testicular Germ Cell Tumor

Professional guidelines

PubMed

Wee CE, Gilligan TD
Clin Adv Hematol Oncol 2023 Apr;21(4):179-188. PMID: 37039725
Heidenreich A, Pfister D, Paffenholz P
Curr Opin Urol 2021 May 1;31(3):206-213. doi: 10.1097/MOU.0000000000000875. PMID: 33742980
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Expert Rev Anticancer Ther 2019 Apr;19(4):291-300. Epub 2019 Feb 22 doi: 10.1080/14737140.2019.1580146. PMID: 30793990

Recent clinical studies

Etiology

Patrikidou A, Cazzaniga W, Berney D, Boormans J, de Angst I, Di Nardo D, Fankhauser C, Fischer S, Gravina C, Gremmels H, Heidenreich A, Janisch F, Leão R, Nicolai N, Oing C, Oldenburg J, Shepherd R, Tandstad T, Nicol D
Eur Urol 2023 Sep;84(3):289-301. Epub 2023 May 12 doi: 10.1016/j.eururo.2023.04.010. PMID: 37183161
Wee CE, Gilligan TD
Clin Adv Hematol Oncol 2023 Apr;21(4):179-188. PMID: 37039725
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Beyer J
Andrology 2019 Jul;7(4):475-478. Epub 2019 Apr 10 doi: 10.1111/andr.12615. PMID: 30969027
Alsdorf W, Seidel C, Bokemeyer C, Oing C
Expert Opin Pharmacother 2019 May;20(7):837-850. Epub 2019 Mar 8 doi: 10.1080/14656566.2019.1583745. PMID: 30849243

Diagnosis

Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Patrikidou A, Cazzaniga W, Berney D, Boormans J, de Angst I, Di Nardo D, Fankhauser C, Fischer S, Gravina C, Gremmels H, Heidenreich A, Janisch F, Leão R, Nicolai N, Oing C, Oldenburg J, Shepherd R, Tandstad T, Nicol D
Eur Urol 2023 Sep;84(3):289-301. Epub 2023 May 12 doi: 10.1016/j.eururo.2023.04.010. PMID: 37183161
Wee CE, Gilligan TD
Clin Adv Hematol Oncol 2023 Apr;21(4):179-188. PMID: 37039725
Murez T, Fléchon A, Branger N, Savoie PH, Rocher L, Camparo P, Neuville P, Ferretti L, Van Hove A, Roupret M
Prog Urol 2022 Nov;32(15):1066-1101. doi: 10.1016/j.purol.2022.09.009. PMID: 36400478
Beyer J
Andrology 2019 Jul;7(4):475-478. Epub 2019 Apr 10 doi: 10.1111/andr.12615. PMID: 30969027

Therapy

Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Wee CE, Gilligan TD
Clin Adv Hematol Oncol 2023 Apr;21(4):179-188. PMID: 37039725
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Murez T, Fléchon A, Branger N, Savoie PH, Rocher L, Camparo P, Neuville P, Ferretti L, Van Hove A, Roupret M
Prog Urol 2022 Nov;32(15):1066-1101. doi: 10.1016/j.purol.2022.09.009. PMID: 36400478
Alsdorf W, Seidel C, Bokemeyer C, Oing C
Expert Opin Pharmacother 2019 May;20(7):837-850. Epub 2019 Mar 8 doi: 10.1080/14656566.2019.1583745. PMID: 30849243

Prognosis

Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Patrikidou A, Cazzaniga W, Berney D, Boormans J, de Angst I, Di Nardo D, Fankhauser C, Fischer S, Gravina C, Gremmels H, Heidenreich A, Janisch F, Leão R, Nicolai N, Oing C, Oldenburg J, Shepherd R, Tandstad T, Nicol D
Eur Urol 2023 Sep;84(3):289-301. Epub 2023 May 12 doi: 10.1016/j.eururo.2023.04.010. PMID: 37183161
Murez T, Fléchon A, Branger N, Savoie PH, Rocher L, Camparo P, Neuville P, Ferretti L, Van Hove A, Roupret M
Prog Urol 2022 Nov;32(15):1066-1101. doi: 10.1016/j.purol.2022.09.009. PMID: 36400478
Beyer J
Andrology 2019 Jul;7(4):475-478. Epub 2019 Apr 10 doi: 10.1111/andr.12615. PMID: 30969027
Alsdorf W, Seidel C, Bokemeyer C, Oing C
Expert Opin Pharmacother 2019 May;20(7):837-850. Epub 2019 Mar 8 doi: 10.1080/14656566.2019.1583745. PMID: 30849243

Clinical prediction guides

Urbini M, Bleve S, Schepisi G, Menna C, Gurioli G, Gianni C, De Giorgi U
Int J Mol Sci 2023 Nov 28;24(23) doi: 10.3390/ijms242316872. PMID: 38069192Free PMC Article
Heidenreich A, Pfister D, Paffenholz P
Curr Opin Urol 2021 May 1;31(3):206-213. doi: 10.1097/MOU.0000000000000875. PMID: 33742980
Kozakova K, Mego M, Cheng L, Chovanec M
Expert Rev Anticancer Ther 2021 Jan;21(1):53-69. Epub 2020 Nov 2 doi: 10.1080/14737140.2021.1838279. PMID: 33138660
de Vries G, Rosas-Plaza X, van Vugt MATM, Gietema JA, de Jong S
Cancer Treat Rev 2020 Aug;88:102054. Epub 2020 Jun 8 doi: 10.1016/j.ctrv.2020.102054. PMID: 32593915
O'Shaughnessy MJ, Feldman DR, Carver BS, Sheinfeld J
Urol Clin North Am 2015 Aug;42(3):359-68. Epub 2015 Jun 16 doi: 10.1016/j.ucl.2015.04.010. PMID: 26216823

Recent systematic reviews

Leão R, Albersen M, Looijenga LHJ, Tandstad T, Kollmannsberger C, Murray MJ, Culine S, Coleman N, Belge G, Hamilton RJ, Dieckmann KP
Eur Urol 2021 Oct;80(4):456-466. Epub 2021 Jun 24 doi: 10.1016/j.eururo.2021.06.006. PMID: 34175151
Pierorazio PM, Cheaib JG, Patel HD, Gupta M, Sharma R, Zhang A, Tema G, Bass EB
J Urol 2021 Feb;205(2):370-382. Epub 2020 Sep 11 doi: 10.1097/JU.0000000000001364. PMID: 32915080
Haarsma R, Blok JM, van Putten K, Meijer RP
Eur J Surg Oncol 2020 Jun;46(6):999-1005. Epub 2020 Feb 26 doi: 10.1016/j.ejso.2020.02.035. PMID: 32173176
Loebenstein M, Thorup J, Cortes D, Clasen-Linde E, Hutson JM, Li R
J Pediatr Surg 2020 Jul;55(7):1201-1210. Epub 2019 Jul 5 doi: 10.1016/j.jpedsurg.2019.06.023. PMID: 31327540
Vergouwe Y, Steyerberg EW, Eijkemans MJ, Albers P, Habbema JD
J Clin Oncol 2003 Nov 15;21(22):4092-9. Epub 2003 Oct 14 doi: 10.1200/JCO.2003.01.094. PMID: 14559885

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