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Raynaud disease

MedGen UID:
20473
•Concept ID:
C0034734
•
Disease or Syndrome
Synonyms: COLD FINGERS, HEREDITARY; Raynaud's disease
SNOMED CT: Raynaud disease (195295006); Raynauds disease (195295006); Raynaud's disease (195295006)
 
Monarch Initiative: MONDO:0008364
OMIM®: 179600

Definition

An episodic vasoconstriction resulting in discoloration of the skin and pain in the affected areas, often involving fingers or toes. Classically associated with triphasic color changes (white, blue, red) but may be biphasic. Often occurs in response to cold temperatures or emotional stress. May be primary or secondary to an underlying autoimmune disease. [from MONDO]

Clinical features

From HPO
Raynaud phenomenon
MedGen UID:
20474
•Concept ID:
C0034735
•
Disease or Syndrome
An episodic vasoconstriction resulting in discoloration of the skin and pain in the affected areas, often involving fingers or toes. Classically associated with triphasic color changes (white, blue, red) but may be biphasic. Often occurs in response to cold temperatures or emotional stress. May be primary or secondary to an underlying autoimmune disease.
See: Feature record | Search on this feature
Abnormality of the skeletal system
MedGen UID:
867418
•Concept ID:
C4021790
•
Anatomical Abnormality
An abnormality of the skeletal system.
See: Feature record | Search on this feature
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Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRaynaud disease

Professional guidelines

PubMed

The Use of Ultrasound Guidance for the Treatment of Raynaud Disease of the Hand With Botulinum Toxin.
Lobb DC, Pierce J, Perry M, DeGeorge B
Ann Plast Surg 2020 Jun;84(6S Suppl 5):S386-S388. doi: 10.1097/SAP.0000000000002303. PMID: 32356950
Botulinum toxin A treatment of Raynaud's phenomenon: a review.
Iorio ML, Masden DL, Higgins JP
Semin Arthritis Rheum 2012 Feb;41(4):599-603. Epub 2011 Aug 24 doi: 10.1016/j.semarthrit.2011.07.006. PMID: 21868066
Treatment of complications associated with systemic sclerosis.
Moore SC, Desantis ER
Am J Health Syst Pharm 2008 Feb 15;65(4):315-21. doi: 10.2146/ajhp070024. PMID: 18238768

Recent clinical studies

Etiology

Raynaud Phenomenon and Other Vasospastic Disorders.
Casanegra AI, Shepherd RF
Cardiol Clin 2021 Nov;39(4):583-599. doi: 10.1016/j.ccl.2021.06.010. PMID: 34686269
ESVM guidelines - the diagnosis and management of Raynaud's phenomenon.
Belch J, Carlizza A, Carpentier PH, Constans J, Khan F, Wautrecht JC, Visona A, Heiss C, Brodeman M, Pécsvárady Z, Roztocil K, Colgan MP, Vasic D, Gottsäter A, Amann-Vesti B, Chraim A, Poredoš P, Olinic DM, Madaric J, Nikol S, Herrick AL, Sprynger M, Klein-Weigel P, Hafner F, Staub D, Zeman Z
Vasa 2017 Oct;46(6):413-423. Epub 2017 Sep 12 doi: 10.1024/0301-1526/a000661. PMID: 28895508
Raynaud's phenomenon and digital ischaemia--pharmacologic approach and alternative treatment options.
Linnemann B, Erbe M
Vasa 2016;45(3):201-12. doi: 10.1024/0301-1526/a000526. PMID: 27129065
Capillaroscopy.
Jung P, Trautinger F
J Dtsch Dermatol Ges 2013 Aug;11(8):731-6. Epub 2013 Jun 5 doi: 10.1111/ddg.12137. PMID: 23738531
Raynaud's phenomenon.
Wigley FM
Curr Opin Rheumatol 1993 Nov;5(6):773-84. doi: 10.1097/00002281-199305060-00013. PMID: 8117541

Diagnosis

Raynaud's phenomenon.
Herrick AL, Wigley FM
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101474. Epub 2020 Jan 29 doi: 10.1016/j.berh.2019.101474. PMID: 32007400
Raynaud's phenomenon.
Devgire V, Hughes M
Br J Hosp Med (Lond) 2019 Nov 2;80(11):658-664. doi: 10.12968/hmed.2019.80.11.658. PMID: 31707892
Raynaud's phenomenon-an update on diagnosis, classification and management.
Pauling JD, Hughes M, Pope JE
Clin Rheumatol 2019 Dec;38(12):3317-3330. Epub 2019 Aug 16 doi: 10.1007/s10067-019-04745-5. PMID: 31420815
ESVM guidelines - the diagnosis and management of Raynaud's phenomenon.
Belch J, Carlizza A, Carpentier PH, Constans J, Khan F, Wautrecht JC, Visona A, Heiss C, Brodeman M, Pécsvárady Z, Roztocil K, Colgan MP, Vasic D, Gottsäter A, Amann-Vesti B, Chraim A, Poredoš P, Olinic DM, Madaric J, Nikol S, Herrick AL, Sprynger M, Klein-Weigel P, Hafner F, Staub D, Zeman Z
Vasa 2017 Oct;46(6):413-423. Epub 2017 Sep 12 doi: 10.1024/0301-1526/a000661. PMID: 28895508
A Review of Raynaud's Disease.
Temprano KK
Mo Med 2016 Mar-Apr;113(2):123-6. PMID: 27311222Free PMC Article

Therapy

ESVM guidelines - the diagnosis and management of Raynaud's phenomenon.
Belch J, Carlizza A, Carpentier PH, Constans J, Khan F, Wautrecht JC, Visona A, Heiss C, Brodeman M, Pécsvárady Z, Roztocil K, Colgan MP, Vasic D, Gottsäter A, Amann-Vesti B, Chraim A, Poredoš P, Olinic DM, Madaric J, Nikol S, Herrick AL, Sprynger M, Klein-Weigel P, Hafner F, Staub D, Zeman Z
Vasa 2017 Oct;46(6):413-423. Epub 2017 Sep 12 doi: 10.1024/0301-1526/a000661. PMID: 28895508
Raynaud's Phenomenon.
Wigley FM, Flavahan NA
N Engl J Med 2016 Aug 11;375(6):556-65. doi: 10.1056/NEJMra1507638. PMID: 27509103
Raynaud disease.
Butendieck RR, Murray PM
J Hand Surg Am 2014 Jan;39(1):121-4. Epub 2013 Nov 6 doi: 10.1016/j.jhsa.2013.08.117. PMID: 24211176
Capillaroscopy.
Cutolo M, Pizzorni C, Sulli A
Best Pract Res Clin Rheumatol 2005 Jun;19(3):437-52. doi: 10.1016/j.berh.2005.01.001. PMID: 15939368
Raynaud's phenomenon.
O'connor CM
J Vasc Nurs 2001 Sep;19(3):87-92; quiz 93-4. doi: 10.1067/mvn.2001.117786. PMID: 11533581

Prognosis

Raynaud's phenomenon.
Herrick AL, Wigley FM
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101474. Epub 2020 Jan 29 doi: 10.1016/j.berh.2019.101474. PMID: 32007400
ESVM guidelines - the diagnosis and management of Raynaud's phenomenon.
Belch J, Carlizza A, Carpentier PH, Constans J, Khan F, Wautrecht JC, Visona A, Heiss C, Brodeman M, Pécsvárady Z, Roztocil K, Colgan MP, Vasic D, Gottsäter A, Amann-Vesti B, Chraim A, Poredoš P, Olinic DM, Madaric J, Nikol S, Herrick AL, Sprynger M, Klein-Weigel P, Hafner F, Staub D, Zeman Z
Vasa 2017 Oct;46(6):413-423. Epub 2017 Sep 12 doi: 10.1024/0301-1526/a000661. PMID: 28895508
Raynaud's phenomenon.
Hughes M, Herrick AL
Best Pract Res Clin Rheumatol 2016 Feb;30(1):112-32. Epub 2016 May 11 doi: 10.1016/j.berh.2016.04.001. PMID: 27421220
Capillaroscopy.
Jung P, Trautinger F
J Dtsch Dermatol Ges 2013 Aug;11(8):731-6. Epub 2013 Jun 5 doi: 10.1111/ddg.12137. PMID: 23738531
Systemic sclerosis.
Ng SC
Singapore Med J 1992 Apr;33(2):189-92. PMID: 1621127

Clinical prediction guides

Systemic sclerosis in adults. Part II: management and therapeutics.
Jerjen R, Nikpour M, Krieg T, Denton CP, Saracino AM
J Am Acad Dermatol 2022 Nov;87(5):957-978. Epub 2022 Feb 4 doi: 10.1016/j.jaad.2021.10.066. PMID: 35131401
Raynaud's phenomenon.
Herrick AL, Wigley FM
Best Pract Res Clin Rheumatol 2020 Feb;34(1):101474. Epub 2020 Jan 29 doi: 10.1016/j.berh.2019.101474. PMID: 32007400
Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis.
Smith V, Herrick AL, Ingegnoli F, Damjanov N, De Angelis R, Denton CP, Distler O, Espejo K, Foeldvari I, Frech T, Garro B, Gutierrez M, Gyger G, Hachulla E, Hesselstrand R, Iagnocco A, Kayser C, Melsens K, Müller-Ladner U, Paolino S, Pizzorni C, Radic M, Riccieri V, Snow M, Stevens W, Sulli A, van Laar JM, Vonk MC, Vanhaecke A, Cutolo M; EULAR Study Group on Microcirculation in Rheumatic Diseases and the Scleroderma Clinical Trials Consortium Group on Capillaroscopy
Autoimmun Rev 2020 Mar;19(3):102458. Epub 2020 Jan 10 doi: 10.1016/j.autrev.2020.102458. PMID: 31927087
ESVM guidelines - the diagnosis and management of Raynaud's phenomenon.
Belch J, Carlizza A, Carpentier PH, Constans J, Khan F, Wautrecht JC, Visona A, Heiss C, Brodeman M, Pécsvárady Z, Roztocil K, Colgan MP, Vasic D, Gottsäter A, Amann-Vesti B, Chraim A, Poredoš P, Olinic DM, Madaric J, Nikol S, Herrick AL, Sprynger M, Klein-Weigel P, Hafner F, Staub D, Zeman Z
Vasa 2017 Oct;46(6):413-423. Epub 2017 Sep 12 doi: 10.1024/0301-1526/a000661. PMID: 28895508
Capillaroscopy.
Jung P, Trautinger F
J Dtsch Dermatol Ges 2013 Aug;11(8):731-6. Epub 2013 Jun 5 doi: 10.1111/ddg.12137. PMID: 23738531

Recent systematic reviews

A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies.
Oldroyd AGS, Allard AB, Callen JP, Chinoy H, Chung L, Fiorentino D, George MD, Gordon P, Kolstad K, Kurtzman DJB, Machado PM, McHugh NJ, Postolova A, Selva-O'Callaghan A, Schmidt J, Tansley S, Vleugels RA, Werth VP, Aggarwal R
Rheumatology (Oxford) 2021 Jun 18;60(6):2615-2628. doi: 10.1093/rheumatology/keab166. PMID: 33599244Free PMC Article
Update of EULAR recommendations for the treatment of systemic sclerosis.
Kowal-Bielecka O, Fransen J, Avouac J, Becker M, Kulak A, Allanore Y, Distler O, Clements P, Cutolo M, Czirjak L, Damjanov N, Del Galdo F, Denton CP, Distler JHW, Foeldvari I, Figelstone K, Frerix M, Furst DE, Guiducci S, Hunzelmann N, Khanna D, Matucci-Cerinic M, Herrick AL, van den Hoogen F, van Laar JM, Riemekasten G, Silver R, Smith V, Sulli A, Tarner I, Tyndall A, Welling J, Wigley F, Valentini G, Walker UA, Zulian F, Müller-Ladner U; EUSTAR Coauthors
Ann Rheum Dis 2017 Aug;76(8):1327-1339. Epub 2016 Nov 9 doi: 10.1136/annrheumdis-2016-209909. PMID: 27941129
Raynaud's phenomenon (secondary).
Herrick A, Muir L
BMJ Clin Evid 2014 Oct 14;2014 PMID: 25322727Free PMC Article
Raynaud's phenomenon (primary).
Pope J
BMJ Clin Evid 2013 Oct 10;2013:1119. PMID: 24112969Free PMC Article
Raynaud's phenomenon (primary).
Pope JE
BMJ Clin Evid 2011 Mar 14;2011 PMID: 21401971Free PMC Article

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