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Retinal drusen

MedGen UID:
20549
•Concept ID:
C0035312
•
Disease or Syndrome
Synonyms: Drusen, Retinal; Retinal Drusen
SNOMED CT: Colloid bodies in retina (247153005); Retinal drusen (247153005)
 
Monarch Initiative: MONDO:0006949

Definition

Colloid or hyaline bodies lying beneath the retinal pigment epithelium. They may occur either secondary to changes in the choroid that affect the pigment epithelium or as an autosomal dominant disorder of the retinal pigment epithelium. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinal drusen

Professional guidelines

PubMed

Application of artificial intelligence system for screening multiple fundus diseases in Chinese primary healthcare settings: a real-world, multicentre and cross-sectional study of 4795 cases.
Gu C, Wang Y, Jiang Y, Xu F, Wang S, Liu R, Yuan W, Abudureyimu N, Wang Y, Lu Y, Li X, Wu T, Dong L, Chen Y, Wang B, Zhang Y, Wei WB, Qiu Q, Zheng Z, Liu D, Chen J
Br J Ophthalmol 2024 Feb 21;108(3):424-431. doi: 10.1136/bjo-2022-322940. PMID: 36878715Free PMC Article
Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema.
Sibony PA, Kupersmith MJ, Kardon RH
J Neuroophthalmol 2021 Mar 1;41(1):77-92. doi: 10.1097/WNO.0000000000001078. PMID: 32909979Free PMC Article
Are Risk Factors for Growth of Choroidal Nevi Associated With Malignant Transformation? Assessment With a Validated Genomic Biomarker.
Harbour JW, Paez-Escamilla M, Cai L, Walter SD, Augsburger JJ, Correa ZM
Am J Ophthalmol 2019 Jan;197:168-179. Epub 2018 Sep 7 doi: 10.1016/j.ajo.2018.08.045. PMID: 30195895Free PMC Article

Recent clinical studies

Etiology

Retinal findings in glomerulonephritis.
Mack HG, Colville DJ, Harraka P, Savige JA, Invernizzi A, Fraser-Bell S
Clin Exp Optom 2022 Jul;105(5):474-486. Epub 2021 Dec 8 doi: 10.1080/08164622.2021.2003691. PMID: 34877922
Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Agrón E, Mares J, Clemons TE, Swaroop A, Chew EY, Keenan TDL; AREDS and AREDS2 Research Groups
Ophthalmology 2021 Mar;128(3):425-442. Epub 2020 Aug 25 doi: 10.1016/j.ophtha.2020.08.018. PMID: 32858063Free PMC Article
AGE-RELATED MACULAR DEGENERATION.
Gheorghe A, Mahdi L, Musat O
Rom J Ophthalmol 2015 Apr-Jun;59(2):74-7. PMID: 26978865Free PMC Article
The proteomics of drusen.
Crabb JW
Cold Spring Harb Perspect Med 2014 May 5;4(7):a017194. doi: 10.1101/cshperspect.a017194. PMID: 24799364Free PMC Article
Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group.
Ophthalmology 1991 May;98(5 Suppl):786-806. PMID: 2062513

Diagnosis

Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Agrón E, Mares J, Clemons TE, Swaroop A, Chew EY, Keenan TDL; AREDS and AREDS2 Research Groups
Ophthalmology 2021 Mar;128(3):425-442. Epub 2020 Aug 25 doi: 10.1016/j.ophtha.2020.08.018. PMID: 32858063Free PMC Article
Multimodal Imaging of Nonneovascular Age-Related Macular Degeneration.
Garrity ST, Sarraf D, Freund KB, Sadda SR
Invest Ophthalmol Vis Sci 2018 Mar 20;59(4):AMD48-AMD64. doi: 10.1167/iovs.18-24158. PMID: 30025107
Subretinal drusenoid deposits AKA pseudodrusen.
Spaide RF, Ooto S, Curcio CA
Surv Ophthalmol 2018 Nov-Dec;63(6):782-815. Epub 2018 May 31 doi: 10.1016/j.survophthal.2018.05.005. PMID: 29859199
AGE-RELATED MACULAR DEGENERATION.
Gheorghe A, Mahdi L, Musat O
Rom J Ophthalmol 2015 Apr-Jun;59(2):74-7. PMID: 26978865Free PMC Article
Flecked retina disorders.
De Laey JJ
Bull Soc Belge Ophtalmol 1993;249:11-22. PMID: 7952338

Therapy

Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Agrón E, Mares J, Clemons TE, Swaroop A, Chew EY, Keenan TDL; AREDS and AREDS2 Research Groups
Ophthalmology 2021 Mar;128(3):425-442. Epub 2020 Aug 25 doi: 10.1016/j.ophtha.2020.08.018. PMID: 32858063Free PMC Article
Characterization of Drusen and Hyperreflective Foci as Biomarkers for Disease Progression in Age-Related Macular Degeneration Using Artificial Intelligence in Optical Coherence Tomography.
Waldstein SM, Vogl WD, Bogunovic H, Sadeghipour A, Riedl S, Schmidt-Erfurth U
JAMA Ophthalmol 2020 Jul 1;138(7):740-747. doi: 10.1001/jamaophthalmol.2020.1376. PMID: 32379287Free PMC Article
A DOUBLE-MASKED, RANDOMIZED, SHAM-CONTROLLED, SINGLE-CENTER STUDY WITH PHOTOBIOMODULATION FOR THE TREATMENT OF DRY AGE-RELATED MACULAR DEGENERATION.
Markowitz SN, Devenyi RG, Munk MR, Croissant CL, Tedford SE, Rückert R, Walker MG, Patino BE, Chen L, Nido M, Tedford CE
Retina 2020 Aug;40(8):1471-1482. doi: 10.1097/IAE.0000000000002632. PMID: 31404033Free PMC Article
Age-related macular degeneration (AMD): pathogenesis and therapy.
Nowak JZ
Pharmacol Rep 2006 May-Jun;58(3):353-63. PMID: 16845209
Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group.
Ophthalmology 1991 May;98(5 Suppl):786-806. PMID: 2062513

Prognosis

Lipid metabolism and retinal diseases.
Gabrielle PH
Acta Ophthalmol 2022 Sep;100 Suppl 269:3-43. doi: 10.1111/aos.15226. PMID: 36117363
Age-Related Macular Degeneration: Epidemiology and Clinical Aspects.
Keenan TDL, Cukras CA, Chew EY
Adv Exp Med Biol 2021;1256:1-31. doi: 10.1007/978-3-030-66014-7_1. PMID: 33847996
Drusen and pachydrusen: the definition, pathogenesis, and clinical significance.
Zhang X, Sivaprasad S
Eye (Lond) 2021 Jan;35(1):121-133. Epub 2020 Nov 18 doi: 10.1038/s41433-020-01265-4. PMID: 33208847Free PMC Article
Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Agrón E, Mares J, Clemons TE, Swaroop A, Chew EY, Keenan TDL; AREDS and AREDS2 Research Groups
Ophthalmology 2021 Mar;128(3):425-442. Epub 2020 Aug 25 doi: 10.1016/j.ophtha.2020.08.018. PMID: 32858063Free PMC Article
Characterization of Drusen and Hyperreflective Foci as Biomarkers for Disease Progression in Age-Related Macular Degeneration Using Artificial Intelligence in Optical Coherence Tomography.
Waldstein SM, Vogl WD, Bogunovic H, Sadeghipour A, Riedl S, Schmidt-Erfurth U
JAMA Ophthalmol 2020 Jul 1;138(7):740-747. doi: 10.1001/jamaophthalmol.2020.1376. PMID: 32379287Free PMC Article

Clinical prediction guides

Age-Related Macular Degeneration: Epidemiology and Clinical Aspects.
Keenan TDL, Cukras CA, Chew EY
Adv Exp Med Biol 2021;1256:1-31. doi: 10.1007/978-3-030-66014-7_1. PMID: 33847996
Drusen and pachydrusen: the definition, pathogenesis, and clinical significance.
Zhang X, Sivaprasad S
Eye (Lond) 2021 Jan;35(1):121-133. Epub 2020 Nov 18 doi: 10.1038/s41433-020-01265-4. PMID: 33208847Free PMC Article
Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Agrón E, Mares J, Clemons TE, Swaroop A, Chew EY, Keenan TDL; AREDS and AREDS2 Research Groups
Ophthalmology 2021 Mar;128(3):425-442. Epub 2020 Aug 25 doi: 10.1016/j.ophtha.2020.08.018. PMID: 32858063Free PMC Article
Characterization of Drusen and Hyperreflective Foci as Biomarkers for Disease Progression in Age-Related Macular Degeneration Using Artificial Intelligence in Optical Coherence Tomography.
Waldstein SM, Vogl WD, Bogunovic H, Sadeghipour A, Riedl S, Schmidt-Erfurth U
JAMA Ophthalmol 2020 Jul 1;138(7):740-747. doi: 10.1001/jamaophthalmol.2020.1376. PMID: 32379287Free PMC Article
A DOUBLE-MASKED, RANDOMIZED, SHAM-CONTROLLED, SINGLE-CENTER STUDY WITH PHOTOBIOMODULATION FOR THE TREATMENT OF DRY AGE-RELATED MACULAR DEGENERATION.
Markowitz SN, Devenyi RG, Munk MR, Croissant CL, Tedford SE, Rückert R, Walker MG, Patino BE, Chen L, Nido M, Tedford CE
Retina 2020 Aug;40(8):1471-1482. doi: 10.1097/IAE.0000000000002632. PMID: 31404033Free PMC Article

Recent systematic reviews

Systematic review of prognostic factors associated with progression to late age-related macular degeneration: Pinnacle study report 2.
Hagag AM, Kaye R, Hoang V, Riedl S, Anders P, Stuart B, Traber G, Appenzeller-Herzog C, Schmidt-Erfurth U, Bogunovic H, Scholl HP, Prevost T, Fritsche L, Rueckert D, Sivaprasad S, Lotery AJ
Surv Ophthalmol 2024 Mar-Apr;69(2):165-172. Epub 2023 Oct 27 doi: 10.1016/j.survophthal.2023.10.010. PMID: 37890677
A SYSTEMATIC REVIEW OF DEEP LEARNING APPLICATIONS FOR OPTICAL COHERENCE TOMOGRAPHY IN AGE-RELATED MACULAR DEGENERATION.
Paul SK, Pan I, Sobol WM
Retina 2022 Aug 1;42(8):1417-1424. doi: 10.1097/IAE.0000000000003535. PMID: 35877964
AGE-RELATED MACULAR DEGENERATION.
Gheorghe A, Mahdi L, Musat O
Rom J Ophthalmol 2015 Apr-Jun;59(2):74-7. PMID: 26978865Free PMC Article
Laser treatment of drusen to prevent progression to advanced age-related macular degeneration.
Virgili G, Michelessi M, Parodi MB, Bacherini D, Evans JR
Cochrane Database Syst Rev 2015 Oct 23;2015(10):CD006537. doi: 10.1002/14651858.CD006537.pub3. PMID: 26493180Free PMC Article
Laser treatment of drusen to prevent progression to advanced age-related macular degeneration.
Parodi MB, Virgili G, Evans JR
Cochrane Database Syst Rev 2009 Jul 8;(3):CD006537. doi: 10.1002/14651858.CD006537.pub2. PMID: 19588397

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