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Unresectable Hepatocellular Carcinoma

MedGen UID:
207269
Concept ID:
C1112459
Neoplastic Process
Synonym: Non-Resectable Hepatocellular Carcinoma

Definition

A hepatocellular carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Hepatocellular Carcinoma

Professional guidelines

PubMed

Leowattana W, Leowattana T, Leowattana P
World J Gastroenterol 2023 Mar 14;29(10):1551-1568. doi: 10.3748/wjg.v29.i10.1551. PMID: 36970588Free PMC Article
Hiraoka A, Kumada T, Tada T, Hirooka M, Kariyama K, Tani J, Atsukawa M, Takaguchi K, Itobayashi E, Fukunishi S, Tsuji K, Ishikawa T, Tajiri K, Ochi H, Yasuda S, Toyoda H, Ogawa C, Nishimura T, Hatanaka T, Kakizaki S, Shimada N, Kawata K, Naganuma A, Kosaka H, Shibata H, Aoki T, Tanaka T, Ohama H, Nouso K, Morishita A, Tsutsui A, Nagano T, Itokawa N, Okubo T, Arai T, Imai M, Koizumi Y, Nakamura S, Joko K, Iijima H, Kaibori M, Hiasa Y, Kudo M; Real-life Practice Experts for HCC (RELPEC) Study Group and HCC 48 Group (hepatocellular carcinoma experts from 48 clinics in Japan)
Cancer Med 2023 Jan;12(1):325-334. Epub 2022 Jun 3 doi: 10.1002/cam4.4854. PMID: 35666040Free PMC Article
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article

Recent clinical studies

Etiology

Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Lim HY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Ma N, Nicholas A, Wang Y, Li L, Zhu AX, Finn RS
J Hepatol 2022 Apr;76(4):862-873. Epub 2021 Dec 11 doi: 10.1016/j.jhep.2021.11.030. PMID: 34902530
Li QJ, He MK, Chen HW, Fang WQ, Zhou YM, Xu L, Wei W, Zhang YJ, Guo Y, Guo RP, Chen MS, Shi M
J Clin Oncol 2022 Jan 10;40(2):150-160. Epub 2021 Oct 14 doi: 10.1200/JCO.21.00608. PMID: 34648352
Lee MS, Ryoo BY, Hsu CH, Numata K, Stein S, Verret W, Hack SP, Spahn J, Liu B, Abdullah H, Wang Y, He AR, Lee KH; GO30140 investigators
Lancet Oncol 2020 Jun;21(6):808-820. doi: 10.1016/S1470-2045(20)30156-X. PMID: 32502443
Finn RS, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Xu DZ, Hernandez S, Liu J, Huang C, Mulla S, Wang Y, Lim HY, Zhu AX, Cheng AL; IMbrave150 Investigators
N Engl J Med 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745. PMID: 32402160
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Diagnosis

Liu K, Zhu Y, Zhu H
Front Immunol 2022;13:1103055. Epub 2023 Jan 11 doi: 10.3389/fimmu.2022.1103055. PMID: 36713376Free PMC Article
Zhao M, Pan X, Yin Y, Hu H, Wei J, Bai Z, Tang W
Front Public Health 2022;10:869960. Epub 2022 Apr 15 doi: 10.3389/fpubh.2022.869960. PMID: 35493395Free PMC Article
Ren Z, Xu J, Bai Y, Xu A, Cang S, Du C, Li Q, Lu Y, Chen Y, Guo Y, Chen Z, Liu B, Jia W, Wu J, Wang J, Shao G, Zhang B, Shan Y, Meng Z, Wu J, Gu S, Yang W, Liu C, Shi X, Gao Z, Yin T, Cui J, Huang M, Xing B, Mao Y, Teng G, Qin Y, Wang J, Xia F, Yin G, Yang Y, Chen M, Wang Y, Zhou H, Fan J; ORIENT-32 study group
Lancet Oncol 2021 Jul;22(7):977-990. Epub 2021 Jun 15 doi: 10.1016/S1470-2045(21)00252-7. PMID: 34143971
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article
Melchiorre F, Patella F, Pescatori L, Pesapane F, Fumarola E, Biondetti P, Brambillasca P, Monaco C, Ierardi AM, Franceschelli G, Carrafiello G
Future Oncol 2018 Dec;14(28):2969-2984. Epub 2018 Jul 10 doi: 10.2217/fon-2018-0136. PMID: 29987957

Therapy

Zhu AX, Abbas AR, de Galarreta MR, Guan Y, Lu S, Koeppen H, Zhang W, Hsu CH, He AR, Ryoo BY, Yau T, Kaseb AO, Burgoyne AM, Dayyani F, Spahn J, Verret W, Finn RS, Toh HC, Lujambio A, Wang Y
Nat Med 2022 Aug;28(8):1599-1611. Epub 2022 Jun 23 doi: 10.1038/s41591-022-01868-2. PMID: 35739268
Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Lim HY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Ma N, Nicholas A, Wang Y, Li L, Zhu AX, Finn RS
J Hepatol 2022 Apr;76(4):862-873. Epub 2021 Dec 11 doi: 10.1016/j.jhep.2021.11.030. PMID: 34902530
Finn RS, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Xu DZ, Hernandez S, Liu J, Huang C, Mulla S, Wang Y, Lim HY, Zhu AX, Cheng AL; IMbrave150 Investigators
N Engl J Med 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745. PMID: 32402160
Al-Salama ZT, Syed YY, Scott LJ
Drugs 2019 Apr;79(6):665-674. doi: 10.1007/s40265-019-01116-x. PMID: 30993651
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Prognosis

Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Cheng AL, Vogel A, Tovoli F, Ueshima K, Aikata H, López CL, Pracht M, Meng Z, Daniele B, Park JW, Palmer D, Tamai T, Saito K, Dutcus CE, Lencioni R
J Hepatol 2023 Jan;78(1):133-141. Epub 2022 Sep 20 doi: 10.1016/j.jhep.2022.09.006. PMID: 36341767
Lee PC, Wu CJ, Hung YW, Lee CJ, Chi CT, Lee IC, Yu-Lun K, Chou SH, Luo JC, Hou MC, Huang YH
J Immunother Cancer 2022 Jun;10(6) doi: 10.1136/jitc-2022-004779. PMID: 35738801Free PMC Article
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article
Qin S, Finn RS, Kudo M, Meyer T, Vogel A, Ducreux M, Macarulla TM, Tomasello G, Boisserie F, Hou J, Li X, Song J, Zhu AX
Future Oncol 2019 Jun;15(16):1811-1822. Epub 2019 Apr 10 doi: 10.2217/fon-2019-0097. PMID: 30969136
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Clinical prediction guides

Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Song X, Kelley RK, Khan AA, Standifer N, Zhou D, Lim K, Krishna R, Liu L, Wang K, McCoon P, Negro A, He P, Gibbs M, Kurland JF, Abou-Alfa GK
Clin Cancer Res 2023 Feb 16;29(4):754-763. doi: 10.1158/1078-0432.CCR-22-1983. PMID: 36477555Free PMC Article
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Cheng AL, Vogel A, Tovoli F, Ueshima K, Aikata H, López CL, Pracht M, Meng Z, Daniele B, Park JW, Palmer D, Tamai T, Saito K, Dutcus CE, Lencioni R
J Hepatol 2023 Jan;78(1):133-141. Epub 2022 Sep 20 doi: 10.1016/j.jhep.2022.09.006. PMID: 36341767
Yamashita T, Kudo M, Ikeda K, Izumi N, Tateishi R, Ikeda M, Aikata H, Kawaguchi Y, Wada Y, Numata K, Inaba Y, Kuromatsu R, Kobayashi M, Okusaka T, Tamai T, Kitamura C, Saito K, Haruna K, Okita K, Kumada H
J Gastroenterol 2020 Jan;55(1):113-122. Epub 2019 Nov 12 doi: 10.1007/s00535-019-01642-1. PMID: 31720835Free PMC Article
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Recent systematic reviews

Zhang L, Sun J, Wang K, Zhao H, Zhang X, Ren Z
Curr Oncol 2022 Sep 30;29(10):7305-7326. doi: 10.3390/curroncol29100575. PMID: 36290852Free PMC Article
Jácome AA, Castro ACG, Vasconcelos JPS, Silva MHCR, Lessa MAO, Moraes ED, Andrade AC, Lima FMT, Farias JPF, Gil RA, Prolla G, Garicochea B
JAMA Netw Open 2021 Dec 1;4(12):e2136128. doi: 10.1001/jamanetworkopen.2021.36128. PMID: 34870682Free PMC Article
Abdel-Rahman O, Elsayed Z
Cochrane Database Syst Rev 2017 Mar 7;3(3):CD011314. doi: 10.1002/14651858.CD011314.pub2. PMID: 28267205Free PMC Article
Lobo L, Yakoub D, Picado O, Ripat C, Pendola F, Sharma R, ElTawil R, Kwon D, Venkat S, Portelance L, Yechieli R
Cardiovasc Intervent Radiol 2016 Nov;39(11):1580-1588. Epub 2016 Sep 1 doi: 10.1007/s00270-016-1426-y. PMID: 27586657
Rognoni C, Ciani O, Sommariva S, Facciorusso A, Tarricone R, Bhoori S, Mazzaferro V
Oncotarget 2016 Nov 1;7(44):72343-72355. doi: 10.18632/oncotarget.11644. PMID: 27579537Free PMC Article

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