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Esophageal small cell neuroendocrine carcinoma

MedGen UID:
207270
Concept ID:
C1112474
Neoplastic Process
Synonyms: esophageal Oat cell carcinoma; Esophageal Small Cell Carcinoma; esophageal small cell carcinoma; Esophageal Small Cell NEC; esophageal small cell NEC; Esophageal Small Cell Neuroendocrine Carcinoma; esophageal small cell neuroendocrine carcinoma; esophagus Oat cell carcinoma; Esophagus Small Cell Carcinoma; esophagus small cell carcinoma; Oat cell carcinoma of esophagus; Oat cell carcinoma of oesophagus; Oat cell carcinoma of the esophagus; Oat cell carcinoma of the oesophagus; oesophagus Oat cell carcinoma; oesophagus small cell carcinoma; Small Cell Carcinoma of Esophagus; small cell carcinoma of esophagus; small cell carcinoma of oesophagus; Small Cell Carcinoma of the Esophagus; small cell carcinoma of the esophagus; small cell carcinoma of the oesophagus; Small Cell Carcinoma, Esophagus; small cell carcinoma, esophagus; small cell carcinoma, oesophagus
 
Monarch Initiative: MONDO:0004116

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Bansal P, Dwivedi DK, Hatwal D, Sharma P, Gupta V, Goyal S, Maithani M
Anticancer Agents Med Chem 2021;21(18):2478-2486. doi: 10.2174/1871520621666210121093852. PMID: 33475078
Khan T, Relitti N, Brindisi M, Magnano S, Zisterer D, Gemma S, Butini S, Campiani G
Med Res Rev 2020 May;40(3):1002-1060. Epub 2019 Nov 19 doi: 10.1002/med.21646. PMID: 31742748
De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M
Eur J Cardiothorac Surg 2014 May;45(5):787-98. Epub 2014 Feb 26 doi: 10.1093/ejcts/ezu028. PMID: 24578407

Recent clinical studies

Etiology

Soroush A, Etemadi A, Abrams JA
Dig Dis Sci 2022 Jul;67(7):2754-2762. Epub 2021 Jul 8 doi: 10.1007/s10620-021-07127-7. PMID: 34236559
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S, Nishiwaki Y, Watanabe K, Noda K, Tamura T, Fukuda H, Saijo N
J Clin Oncol 2002 Jul 15;20(14):3054-60. doi: 10.1200/JCO.2002.12.071. PMID: 12118018
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Diagnosis

Mohammadi E, Aliarab A, Babaei G, Habibi NK, Jafari SM, Mir SM, Memar MY
Pathol Res Pract 2022 Dec;240:154196. Epub 2022 Nov 2 doi: 10.1016/j.prp.2022.154196. PMID: 36356334
Li K, Lin Y, Luo Y, Xiong X, Wang L, Durante K, Li J, Zhou F, Guo Y, Chen S, Chen Y, Zhang D, Yeung SJ, Zhang H
Mol Cancer 2022 Jan 18;21(1):21. doi: 10.1186/s12943-022-01499-8. PMID: 35042519Free PMC Article
Zarrilli G, Galuppini F, Angerilli V, Munari G, Sabbadin M, Lazzarin V, Nicolè L, Biancotti R, Fassan M
Int J Mol Sci 2021 Mar 31;22(7) doi: 10.3390/ijms22073640. PMID: 33807389Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Rajendra S, Pavey D, McKay O, Merrett N, Gautam SD
Ann N Y Acad Sci 2020 Dec;1482(1):36-48. Epub 2020 Oct 25 doi: 10.1111/nyas.14509. PMID: 33103249

Therapy

Zhao Q, Yu J, Meng X
Cancer Med 2019 Aug;8(10):4519-4526. Epub 2019 Jun 23 doi: 10.1002/cam4.2336. PMID: 31231980Free PMC Article
Hoy SM
Drugs 2019 Feb;79(3):341-346. doi: 10.1007/s40265-019-1066-z. PMID: 30742278
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S, Nishiwaki Y, Watanabe K, Noda K, Tamura T, Fukuda H, Saijo N
J Clin Oncol 2002 Jul 15;20(14):3054-60. doi: 10.1200/JCO.2002.12.071. PMID: 12118018
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Prognosis

Wu H, Yu Z, Liu Y, Guo L, Teng L, Guo L, Liang L, Wang J, Gao J, Li R, Yang L, Nie X, Su D, Liang Z
Cancer Commun (Lond) 2022 Dec;42(12):1367-1386. Epub 2022 Oct 20 doi: 10.1002/cac2.12372. PMID: 36264285Free PMC Article
Li J, Zhang X, Xu X, Zhao Q, Yang Q, He M, Chen X, Zhao J
Dis Markers 2022;2022:5615009. Epub 2022 Sep 30 doi: 10.1155/2022/5615009. PMID: 36246556Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Clinical prediction guides

Li J, Zhang X, Xu X, Zhao Q, Yang Q, He M, Chen X, Zhao J
Dis Markers 2022;2022:5615009. Epub 2022 Sep 30 doi: 10.1155/2022/5615009. PMID: 36246556Free PMC Article
Chen C, Hu H, Zheng Z, Yang Y, Chen W, Qiao X, Li P, Zhang S
Cancer Med 2022 Dec;11(24):4935-4945. Epub 2022 May 21 doi: 10.1002/cam4.4829. PMID: 35596661Free PMC Article
Li K, Lin Y, Luo Y, Xiong X, Wang L, Durante K, Li J, Zhou F, Guo Y, Chen S, Chen Y, Zhang D, Yeung SJ, Zhang H
Mol Cancer 2022 Jan 18;21(1):21. doi: 10.1186/s12943-022-01499-8. PMID: 35042519Free PMC Article
Soroush A, Etemadi A, Abrams JA
Dig Dis Sci 2022 Jul;67(7):2754-2762. Epub 2021 Jul 8 doi: 10.1007/s10620-021-07127-7. PMID: 34236559
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article

Recent systematic reviews

Chen Y, Luo H, Liu R, Tan M, Wang Q, Wu X, Du T, Liu Z, Sun S, Zhang Q, Wang X
Radiat Oncol 2023 May 22;18(1):86. doi: 10.1186/s13014-023-02264-x. PMID: 37217970Free PMC Article
Li X, Wang F, Jia H, Lian Z, Ren K, Yuan Z, Wang P, Zhao L
Future Oncol 2022 Sep;18(27):3055-3065. Epub 2022 Aug 10 doi: 10.2217/fon-2022-0491. PMID: 35947522
Zhang H, Huang Z, Zou X, Liu T
Oncotarget 2016 Dec 13;7(50):82473-82481. doi: 10.18632/oncotarget.12666. PMID: 27756883Free PMC Article
Palma DA, Warner A, Louie AV, Senan S, Slotman B, Rodrigues GB
Clin Lung Cancer 2016 Jul;17(4):239-44. Epub 2015 Oct 1 doi: 10.1016/j.cllc.2015.09.007. PMID: 26498503
Fang Y, Xiao F, An Z, Hao L
Asian Pac J Cancer Prev 2011;12(7):1861-6. PMID: 22126580

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