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Esophageal small cell neuroendocrine carcinoma

MedGen UID:
207270
Concept ID:
C1112474
Neoplastic Process
Synonyms: esophageal Oat cell carcinoma; Esophageal Small Cell Carcinoma; esophageal small cell carcinoma; Esophageal Small Cell NEC; esophageal small cell NEC; Esophageal Small Cell Neuroendocrine Carcinoma; esophageal small cell neuroendocrine carcinoma; esophagus Oat cell carcinoma; Esophagus Small Cell Carcinoma; esophagus small cell carcinoma; Oat cell carcinoma of esophagus; Oat cell carcinoma of oesophagus; Oat cell carcinoma of the esophagus; Oat cell carcinoma of the oesophagus; oesophagus Oat cell carcinoma; oesophagus small cell carcinoma; Small Cell Carcinoma of Esophagus; small cell carcinoma of esophagus; small cell carcinoma of oesophagus; Small Cell Carcinoma of the Esophagus; small cell carcinoma of the esophagus; small cell carcinoma of the oesophagus; Small Cell Carcinoma, Esophagus; small cell carcinoma, esophagus; small cell carcinoma, oesophagus
 
Monarch Initiative: MONDO:0004116

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Ellis A, Risk JM, Maruthappu T, Kelsell DP
Orphanet J Rare Dis 2015 Sep 29;10:126. doi: 10.1186/s13023-015-0346-2. PMID: 26419362Free PMC Article
De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M
Eur J Cardiothorac Surg 2014 May;45(5):787-98. Epub 2014 Feb 26 doi: 10.1093/ejcts/ezu028. PMID: 24578407
Tougeron D, Richer JP, Silvain C
J Visc Surg 2011 Jun;148(3):e161-70. Epub 2011 Jun 28 doi: 10.1016/j.jviscsurg.2011.05.008. PMID: 21715236

Recent clinical studies

Etiology

Yuan XL, Liu W, Lin YX, Deng QY, Gao YP, Wan L, Zhang B, Zhang T, Zhang WH, Bi XG, Yang GD, Zhu BH, Zhang F, Qin XB, Pan F, Zeng XH, Chaudhry H, Pang MY, Yang J, Zhang JY, Hu B
Lancet Gastroenterol Hepatol 2024 Jan;9(1):34-44. Epub 2023 Nov 10 doi: 10.1016/S2468-1253(23)00276-5. PMID: 37952555
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S, Nishiwaki Y, Watanabe K, Noda K, Tamura T, Fukuda H, Saijo N
J Clin Oncol 2002 Jul 15;20(14):3054-60. doi: 10.1200/JCO.2002.12.071. PMID: 12118018
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Diagnosis

Yuan XL, Liu W, Lin YX, Deng QY, Gao YP, Wan L, Zhang B, Zhang T, Zhang WH, Bi XG, Yang GD, Zhu BH, Zhang F, Qin XB, Pan F, Zeng XH, Chaudhry H, Pang MY, Yang J, Zhang JY, Hu B
Lancet Gastroenterol Hepatol 2024 Jan;9(1):34-44. Epub 2023 Nov 10 doi: 10.1016/S2468-1253(23)00276-5. PMID: 37952555
Mohammadi E, Aliarab A, Babaei G, Habibi NK, Jafari SM, Mir SM, Memar MY
Pathol Res Pract 2022 Dec;240:154196. Epub 2022 Nov 2 doi: 10.1016/j.prp.2022.154196. PMID: 36356334
Li K, Lin Y, Luo Y, Xiong X, Wang L, Durante K, Li J, Zhou F, Guo Y, Chen S, Chen Y, Zhang D, Yeung SJ, Zhang H
Mol Cancer 2022 Jan 18;21(1):21. doi: 10.1186/s12943-022-01499-8. PMID: 35042519Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Tougeron D, Richer JP, Silvain C
J Visc Surg 2011 Jun;148(3):e161-70. Epub 2011 Jun 28 doi: 10.1016/j.jviscsurg.2011.05.008. PMID: 21715236

Therapy

Yuan XL, Liu W, Lin YX, Deng QY, Gao YP, Wan L, Zhang B, Zhang T, Zhang WH, Bi XG, Yang GD, Zhu BH, Zhang F, Qin XB, Pan F, Zeng XH, Chaudhry H, Pang MY, Yang J, Zhang JY, Hu B
Lancet Gastroenterol Hepatol 2024 Jan;9(1):34-44. Epub 2023 Nov 10 doi: 10.1016/S2468-1253(23)00276-5. PMID: 37952555
Hoy SM
Drugs 2019 Feb;79(3):341-346. doi: 10.1007/s40265-019-1066-z. PMID: 30742278
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S, Nishiwaki Y, Watanabe K, Noda K, Tamura T, Fukuda H, Saijo N
J Clin Oncol 2002 Jul 15;20(14):3054-60. doi: 10.1200/JCO.2002.12.071. PMID: 12118018
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Prognosis

Wu H, Yu Z, Liu Y, Guo L, Teng L, Guo L, Liang L, Wang J, Gao J, Li R, Yang L, Nie X, Su D, Liang Z
Cancer Commun (Lond) 2022 Dec;42(12):1367-1386. Epub 2022 Oct 20 doi: 10.1002/cac2.12372. PMID: 36264285Free PMC Article
Li J, Zhang X, Xu X, Zhao Q, Yang Q, He M, Chen X, Zhao J
Dis Markers 2022;2022:5615009. Epub 2022 Sep 30 doi: 10.1155/2022/5615009. PMID: 36246556Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Clinical prediction guides

Yuan XL, Liu W, Lin YX, Deng QY, Gao YP, Wan L, Zhang B, Zhang T, Zhang WH, Bi XG, Yang GD, Zhu BH, Zhang F, Qin XB, Pan F, Zeng XH, Chaudhry H, Pang MY, Yang J, Zhang JY, Hu B
Lancet Gastroenterol Hepatol 2024 Jan;9(1):34-44. Epub 2023 Nov 10 doi: 10.1016/S2468-1253(23)00276-5. PMID: 37952555
Wang X, Wang P, Huang X, Han Y, Zhang P
Front Immunol 2023;14:1117523. Epub 2023 May 1 doi: 10.3389/fimmu.2023.1117523. PMID: 37197663Free PMC Article
Wu HX, Pan YQ, He Y, Wang ZX, Guan WL, Chen YX, Yao YC, Shao NY, Xu RH, Wang F
J Clin Oncol 2023 Mar 20;41(9):1735-1746. Epub 2022 Dec 6 doi: 10.1200/JCO.22.01490. PMID: 36473145Free PMC Article
Li K, Lin Y, Luo Y, Xiong X, Wang L, Durante K, Li J, Zhou F, Guo Y, Chen S, Chen Y, Zhang D, Yeung SJ, Zhang H
Mol Cancer 2022 Jan 18;21(1):21. doi: 10.1186/s12943-022-01499-8. PMID: 35042519Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article

Recent systematic reviews

Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Chen Y, Luo H, Liu R, Tan M, Wang Q, Wu X, Du T, Liu Z, Sun S, Zhang Q, Wang X
Radiat Oncol 2023 May 22;18(1):86. doi: 10.1186/s13014-023-02264-x. PMID: 37217970Free PMC Article
Li X, Wang F, Jia H, Lian Z, Ren K, Yuan Z, Wang P, Zhao L
Future Oncol 2022 Sep;18(27):3055-3065. Epub 2022 Aug 10 doi: 10.2217/fon-2022-0491. PMID: 35947522
Palma DA, Warner A, Louie AV, Senan S, Slotman B, Rodrigues GB
Clin Lung Cancer 2016 Jul;17(4):239-44. Epub 2015 Oct 1 doi: 10.1016/j.cllc.2015.09.007. PMID: 26498503
Fang Y, Xiao F, An Z, Hao L
Asian Pac J Cancer Prev 2011;12(7):1861-6. PMID: 22126580

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