U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Helicobacter pylori infection

MedGen UID:
208857
Concept ID:
C0850666
Disease or Syndrome
Synonyms: H. pylori Infection; Helicobacter Pylori Infection; Infection caused by H. pylori (Helicobacter pylori); Infection caused by Helicobacter pylori
SNOMED CT: Infection caused by Helicobacter pylori (721730009); Helicobacter pylori infection (721730009); Infection caused by H. pylori (Helicobacter pylori) (721730009)
 
HPO: HP:0005202

Definition

A recurrent infection of the GI tract with helicobacter pylori, a gram-negative, microaerophilic bacterium usually found in the stomach. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHelicobacter pylori infection

Conditions with this feature

Helicobacter pylori infection, susceptibility to
MedGen UID:
325004
Concept ID:
C1838332
Disease or Syndrome
Helicobacter pylori is a microaerophilic, gram-negative bacterium that colonizes the gastric mucosa of approximately 50% of the world's population, and is a primary pathogenic factor in benign and malignant gastroduodenal disease (Warren and Marshall, 1983; Blaser and Parsonnet, 1994). Tomb et al. (1997) reported the complete sequence of the circular genome of H. pylori. The 1,667,867-bp genome contains 1,590 predicted coding sequences (genes). Sequence analysis of these genes indicated that the organism has systems for motility, for scavenging iron, and for DNA restriction and modification. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.
Severe combined immunodeficiency due to CARMIL2 deficiency
MedGen UID:
1648422
Concept ID:
C4748304
Disease or Syndrome
Immunodeficiency-58 is an autosomal recessive primary immunologic disorder characterized by early-onset skin lesions, including eczematous dermatitis, infectious abscesses, and warts, recurrent respiratory infections or allergies, and chronic persistent infections with candida, Molluscum contagiosum, mycobacteria, EBV, bacteria, and viruses. Some patients may have gastrointestinal involvement, including inflammatory bowel disease, EBV+ smooth muscle tumors, and esophagitis. Immunologic analysis shows defective T-cell function with decreased Treg cells and deficient CD3/CD28 costimulation responses in both CD4+ and CD8+ T cells. B-cell function may also be impaired (summary by Wang et al., 2016 and Alazami et al., 2018).

Professional guidelines

PubMed

Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Kavitt RT, Lipowska AM, Anyane-Yeboa A, Gralnek IM
Am J Med 2019 Apr;132(4):447-456. Epub 2019 Jan 3 doi: 10.1016/j.amjmed.2018.12.009. PMID: 30611829
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Curated

UK NICE Clinical Guideline CG184, Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, 2019

Recent clinical studies

Etiology

Basmaci N, Karataş A, Ergin M, Dumlu GŞ
Medicine (Baltimore) 2023 Oct 20;102(42):e35591. doi: 10.1097/MD.0000000000035591. PMID: 37861565Free PMC Article
Romano M, Gravina AG, Eusebi LH, Pellegrino R, Palladino G, Frazzoni L, Dajti E, Gasbarrini A, Di Mario F, Zagari RM; Members of SIGE; Members of SIED National Council
Dig Liver Dis 2022 Sep;54(9):1153-1161. Epub 2022 Jul 10 doi: 10.1016/j.dld.2022.06.019. PMID: 35831212
Diaconu S, Predescu A, Moldoveanu A, Pop CS, Fierbințeanu-Braticevici C
J Med Life 2017 Apr-Jun;10(2):112-117. PMID: 28616085Free PMC Article
Dror G, Muhsen K
J Pediatr Gastroenterol Nutr 2016 Jun;62(6):e48-59. doi: 10.1097/MPG.0000000000001045. PMID: 26628446
Mégraud F, Bessède E, Varon C
Clin Microbiol Infect 2015 Nov;21(11):984-90. Epub 2015 Jun 15 doi: 10.1016/j.cmi.2015.06.004. PMID: 26086571

Diagnosis

Nat Rev Dis Primers 2023 Apr 20;9(1):20. doi: 10.1038/s41572-023-00434-5. PMID: 37081017
Romano M, Gravina AG, Eusebi LH, Pellegrino R, Palladino G, Frazzoni L, Dajti E, Gasbarrini A, Di Mario F, Zagari RM; Members of SIGE; Members of SIED National Council
Dig Liver Dis 2022 Sep;54(9):1153-1161. Epub 2022 Jul 10 doi: 10.1016/j.dld.2022.06.019. PMID: 35831212
Lee YC, Dore MP, Graham DY
Annu Rev Med 2022 Jan 27;73:183-195. doi: 10.1146/annurev-med-042220-020814. PMID: 35084993
Qiu E, Li Z, Han S
Braz J Microbiol 2021 Dec;52(4):2057-2062. Epub 2021 Aug 15 doi: 10.1007/s42770-021-00589-x. PMID: 34392499Free PMC Article
Cho J, Prashar A, Jones NL, Moss SF
Gastroenterol Clin North Am 2021 Jun;50(2):261-282. doi: 10.1016/j.gtc.2021.02.001. PMID: 34024441

Therapy

Qian HS, Li WJ, Dang YN, Li LR, Xu XB, Yuan L, Zhang WF, Yang Z, Gao X, Zhang M, Li X, Zhang GX
Am J Gastroenterol 2023 Apr 1;118(4):627-634. Epub 2022 Dec 2 doi: 10.14309/ajg.0000000000002086. PMID: 36729890
Hawkey C, Avery A, Coupland CAC, Crooks C, Dumbleton J, Hobbs FDR, Kendrick D, Moore M, Morris C, Rubin G, Smith M, Stevenson D; HEAT Trialists
Lancet 2022 Nov 5;400(10363):1597-1606. doi: 10.1016/S0140-6736(22)01843-8. PMID: 36335970
Chey WD, Mégraud F, Laine L, López LJ, Hunt BJ, Howden CW
Gastroenterology 2022 Sep;163(3):608-619. Epub 2022 Jun 6 doi: 10.1053/j.gastro.2022.05.055. PMID: 35679950
Rokkas T, Gisbert JP, Malfertheiner P, Niv Y, Gasbarrini A, Leja M, Megraud F, O'Morain C, Graham DY
Gastroenterology 2021 Aug;161(2):495-507.e4. Epub 2021 Apr 8 doi: 10.1053/j.gastro.2021.04.012. PMID: 33839101
Chen L, Xu W, Lee A, He J, Huang B, Zheng W, Su T, Lai S, Long Y, Chu H, Chen Y, Wang L, Wang K, Si J, Chen S
EBioMedicine 2018 Sep;35:87-96. Epub 2018 Aug 23 doi: 10.1016/j.ebiom.2018.08.028. PMID: 30145102Free PMC Article

Prognosis

Ilic M, Ilic I
World J Gastroenterol 2022 Mar 28;28(12):1187-1203. doi: 10.3748/wjg.v28.i12.1187. PMID: 35431510Free PMC Article
Petryszyn P, Chapelle N, Matysiak-Budnik T
Dig Dis 2020;38(4):280-285. Epub 2020 Feb 17 doi: 10.1159/000506509. PMID: 32062657
Mentis A, Lehours P, Mégraud F
Helicobacter 2015 Sep;20 Suppl 1:1-7. doi: 10.1111/hel.12250. PMID: 26372818
Tielleman T, Bujanda D, Cryer B
Gastrointest Endosc Clin N Am 2015 Jul;25(3):415-28. doi: 10.1016/j.giec.2015.02.010. PMID: 26142028
Brenner H, Rothenbacher D, Arndt V
Methods Mol Biol 2009;472:467-77. doi: 10.1007/978-1-60327-492-0_23. PMID: 19107449

Clinical prediction guides

Luo F, Zhou P, Ran X, Gu M, Zhou S
Sci Rep 2023 Oct 29;13(1):18544. doi: 10.1038/s41598-023-45545-x. PMID: 37899462Free PMC Article
Xiong YJ, Du LL, Diao YL, Wen J, Meng XB, Gao J, Shao CL, Wang WY, Zhu XY, Tang YD
J Transl Med 2023 Aug 12;21(1):538. doi: 10.1186/s12967-023-04398-8. PMID: 37573314Free PMC Article
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Toyoshima O, Nishizawa T, Koike K
World J Gastroenterol 2020 Feb 7;26(5):466-477. doi: 10.3748/wjg.v26.i5.466. PMID: 32089624Free PMC Article
Wang YK, Kuo FC, Liu CJ, Wu MC, Shih HY, Wang SS, Wu JY, Kuo CH, Huang YK, Wu DC
World J Gastroenterol 2015 Oct 28;21(40):11221-35. doi: 10.3748/wjg.v21.i40.11221. PMID: 26523098Free PMC Article

Recent systematic reviews

Li Y, Choi H, Leung K, Jiang F, Graham DY, Leung WK
Lancet Gastroenterol Hepatol 2023 Jun;8(6):553-564. Epub 2023 Apr 20 doi: 10.1016/S2468-1253(23)00070-5. PMID: 37086739
Ren S, Cai P, Liu Y, Wang T, Zhang Y, Li Q, Gu Y, Wei L, Yan C, Jin G
J Gastroenterol Hepatol 2022 Mar;37(3):464-470. Epub 2021 Dec 13 doi: 10.1111/jgh.15751. PMID: 34862656
Gisbert JP, Alcedo J, Amador J, Bujanda L, Calvet X, Castro-Fernández M, Fernández-Salazar L, Gené E, Lanas Á, Lucendo AJ, Molina-Infante J, Nyssen OP, Pérez-Aisa A, Puig I
Gastroenterol Hepatol 2022 May;45(5):392-417. Epub 2021 Oct 7 doi: 10.1016/j.gastrohep.2021.07.011. PMID: 34629204
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262
Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VWS, Wu JCY, Chan FKL, Sung JJY, Kaplan GG, Ng SC
Gastroenterology 2017 Aug;153(2):420-429. Epub 2017 Apr 27 doi: 10.1053/j.gastro.2017.04.022. PMID: 28456631

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2019
      UK NICE Clinical Guideline CG184, Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, 2019

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...