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Diabetic cardiomyopathy

MedGen UID:
208887
•Concept ID:
C0853897
•
Disease or Syndrome
Synonyms: Cardiomyopathies, Diabetic; Cardiomyopathy, Diabetic; Diabetic Cardiomyopathies; Diabetic Cardiomyopathy
SNOMED CT: Diabetic cardiomyopathy (788878000); Cardiomyopathy due to diabetes mellitus (788878000)

Definition

Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic cardiomyopathy

Professional guidelines

PubMed

Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms.
Huang K, Luo X, Liao B, Li G, Feng J
Cardiovasc Diabetol 2023 Apr 13;22(1):86. doi: 10.1186/s12933-023-01816-5. PMID: 37055837Free PMC Article
Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Perioperative management of adult diabetic patients. Preoperative period.
Cheisson G, Jacqueminet S, Cosson E, Ichai C, Leguerrier AM, Nicolescu-Catargi B, Ouattara A, Tauveron I, Valensi P, Benhamou D; working party approved by the French Society of Anaesthesia and Intensive Care Medicine (SFAR), the French Society for the study of Diabetes (SFD)
Anaesth Crit Care Pain Med 2018 Jun;37 Suppl 1:S9-S19. Epub 2018 Mar 17 doi: 10.1016/j.accpm.2018.02.020. PMID: 29559406

Recent clinical studies

Etiology

Diabetic cardiomyopathy: Clinical phenotype and practice.
Zhao X, Liu S, Wang X, Chen Y, Pang P, Yang Q, Lin J, Deng S, Wu S, Fan G, Wang B
Front Endocrinol (Lausanne) 2022;13:1032268. Epub 2022 Dec 7 doi: 10.3389/fendo.2022.1032268. PMID: 36568097Free PMC Article
Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Diabetic Cardiomyopathy.
Dillmann WH
Circ Res 2019 Apr 12;124(8):1160-1162. doi: 10.1161/CIRCRESAHA.118.314665. PMID: 30973809Free PMC Article
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article
Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease.
Jia G, Whaley-Connell A, Sowers JR
Diabetologia 2018 Jan;61(1):21-28. Epub 2017 Aug 3 doi: 10.1007/s00125-017-4390-4. PMID: 28776083Free PMC Article

Diagnosis

Diabetic cardiomyopathy: Clinical phenotype and practice.
Zhao X, Liu S, Wang X, Chen Y, Pang P, Yang Q, Lin J, Deng S, Wu S, Fan G, Wang B
Front Endocrinol (Lausanne) 2022;13:1032268. Epub 2022 Dec 7 doi: 10.3389/fendo.2022.1032268. PMID: 36568097Free PMC Article
Diabetic cardiomyopathy.
Lorenzo-Almorós A, Cepeda-Rodrigo JM, Lorenzo Ó
Rev Clin Esp (Barc) 2022 Feb;222(2):100-111. Epub 2020 Oct 23 doi: 10.1016/j.rceng.2019.10.012. PMID: 35115137
Emerging roles of exosomal miRNAs in diabetes mellitus.
He X, Kuang G, Wu Y, Ou C
Clin Transl Med 2021 Jun;11(6):e468. doi: 10.1002/ctm2.468. PMID: 34185424Free PMC Article
PPAR control of metabolism and cardiovascular functions.
Montaigne D, Butruille L, Staels B
Nat Rev Cardiol 2021 Dec;18(12):809-823. Epub 2021 Jun 14 doi: 10.1038/s41569-021-00569-6. PMID: 34127848
Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications.
Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, Di Napoli P, Esposito I, Ambrosio A, Ianniruberto M, Mennella R, Paolillo R, Gargiulo P
Heart Fail Clin 2019 Jul;15(3):341-347. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.003. PMID: 31079692

Therapy

USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart.
Xie SY, Liu SQ, Zhang T, Shi WK, Xing Y, Fang WX, Zhang M, Chen MY, Xu SC, Fan MQ, Li LL, Zhang H, Zhao N, Zeng ZX, Chen S, Zeng XF, Deng W, Tang QZ
Circulation 2024 Feb 27;149(9):684-706. Epub 2023 Nov 23 doi: 10.1161/CIRCULATIONAHA.123.065603. PMID: 37994595
Diabetic cardiomyopathy: Clinical phenotype and practice.
Zhao X, Liu S, Wang X, Chen Y, Pang P, Yang Q, Lin J, Deng S, Wu S, Fan G, Wang B
Front Endocrinol (Lausanne) 2022;13:1032268. Epub 2022 Dec 7 doi: 10.3389/fendo.2022.1032268. PMID: 36568097Free PMC Article
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
Nat Rev Cardiol 2020 Sep;17(9):585-607. Epub 2020 Feb 20 doi: 10.1038/s41569-020-0339-2. PMID: 32080423Free PMC Article
Diabetic Cardiomyopathy.
Dillmann WH
Circ Res 2019 Apr 12;124(8):1160-1162. doi: 10.1161/CIRCRESAHA.118.314665. PMID: 30973809Free PMC Article
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article

Prognosis

Diabetic cardiomyopathy: Clinical phenotype and practice.
Zhao X, Liu S, Wang X, Chen Y, Pang P, Yang Q, Lin J, Deng S, Wu S, Fan G, Wang B
Front Endocrinol (Lausanne) 2022;13:1032268. Epub 2022 Dec 7 doi: 10.3389/fendo.2022.1032268. PMID: 36568097Free PMC Article
Basic Mechanisms of Diabetic Heart Disease.
Ritchie RH, Abel ED
Circ Res 2020 May 22;126(11):1501-1525. Epub 2020 May 21 doi: 10.1161/CIRCRESAHA.120.315913. PMID: 32437308Free PMC Article
Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications.
Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, Di Napoli P, Esposito I, Ambrosio A, Ianniruberto M, Mennella R, Paolillo R, Gargiulo P
Heart Fail Clin 2019 Jul;15(3):341-347. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.003. PMID: 31079692
Diabetic cardiomyopathy - A comprehensive updated review.
Murtaza G, Virk HUH, Khalid M, Lavie CJ, Ventura H, Mukherjee D, Ramu V, Bhogal S, Kumar G, Shanmugasundaram M, Paul TK
Prog Cardiovasc Dis 2019 Jul-Aug;62(4):315-326. Epub 2019 Mar 25 doi: 10.1016/j.pcad.2019.03.003. PMID: 30922976
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article

Clinical prediction guides

Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
FGF1(ΔHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Wang D, Yin Y, Wang S, Zhao T, Gong F, Zhao Y, Wang B, Huang Y, Cheng Z, Zhu G, Wang Z, Wang Y, Ren J, Liang G, Li X, Huang Z
Signal Transduct Target Ther 2021 Mar 24;6(1):133. doi: 10.1038/s41392-021-00542-2. PMID: 33762571Free PMC Article
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
Knapp M, Tu X, Wu R
Acta Pharmacol Sin 2019 Jan;40(1):1-8. Epub 2018 Jun 4 doi: 10.1038/s41401-018-0042-6. PMID: 29867137Free PMC Article
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
Jia G, DeMarco VG, Sowers JR
Nat Rev Endocrinol 2016 Mar;12(3):144-53. Epub 2015 Dec 18 doi: 10.1038/nrendo.2015.216. PMID: 26678809Free PMC Article
Diabetic cardiomyopathy.
Fein FS, Sonnenblick EH
Cardiovasc Drugs Ther 1994 Feb;8(1):65-73. doi: 10.1007/BF00877091. PMID: 8086330

Recent systematic reviews

Progress in the treatment of diabetic cardiomyopathy, a systematic review.
Shou Y, Li X, Fang Q, Xie A, Zhang Y, Fu X, Wang M, Gong W, Zhang X, Yang D
Pharmacol Res Perspect 2024 Apr;12(2):e1177. doi: 10.1002/prp2.1177. PMID: 38407563Free PMC Article
What is the impact of ferroptosis on diabetic cardiomyopathy: a systematic review.
Lou X, Zhang Y, Guo J, Gao L, Ding Y, Zhuo X, Lei Q, Bian J, Lei R, Gong W, Zhang X, Jiao Q
Heart Fail Rev 2024 Jan;29(1):1-11. Epub 2023 Aug 9 doi: 10.1007/s10741-023-10336-z. PMID: 37555989
Preclinical Evidence for the Effectiveness of Mesenchymal Stromal Cells for Diabetic Cardiomyopathy: A Systematic Review and Meta-analysis.
Liu B, Zhang J, Zhou Z, Feng B, He J, Yan W, Zhou X, Amponsah AE, Guo R, Du X, Liu X, Cui H, O'Brien T, Ma J
Curr Stem Cell Res Ther 2024;19(2):220-233. doi: 10.2174/1574888X18666230510111302. PMID: 37165495
Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases.
Liu X, Xu X, Zhang T, Xu L, Tao H, Liu Y, Zhang Y, Meng X
Phytother Res 2023 Nov;37(11):4976-4998. Epub 2023 Aug 2 doi: 10.1002/ptr.7965. PMID: 37533230
Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications.
Fang ZY, Prins JB, Marwick TH
Endocr Rev 2004 Aug;25(4):543-67. doi: 10.1210/er.2003-0012. PMID: 15294881

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