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Diabetic cardiomyopathy

MedGen UID:
208887
•Concept ID:
C0853897
•
Disease or Syndrome
Synonyms: Cardiomyopathies, Diabetic; Cardiomyopathy, Diabetic; Diabetic Cardiomyopathies; Diabetic Cardiomyopathy
SNOMED CT: Diabetic cardiomyopathy (788878000); Cardiomyopathy due to diabetes mellitus (788878000)

Definition

Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic cardiomyopathy

Professional guidelines

PubMed

Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Effect of Astragalus polysaccharide in treatment of diabetes mellitus: a narrative review.
Zhang Z, Zhang L, Xu H
J Tradit Chin Med 2019 Feb;39(1):133-138. PMID: 32186034
Perioperative management of adult diabetic patients. Preoperative period.
Cheisson G, Jacqueminet S, Cosson E, Ichai C, Leguerrier AM, Nicolescu-Catargi B, Ouattara A, Tauveron I, Valensi P, Benhamou D; working party approved by the French Society of Anaesthesia and Intensive Care Medicine (SFAR), the French Society for the study of Diabetes (SFD)
Anaesth Crit Care Pain Med 2018 Jun;37 Suppl 1:S9-S19. Epub 2018 Mar 17 doi: 10.1016/j.accpm.2018.02.020. PMID: 29559406

Recent clinical studies

Etiology

Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Diabetic Cardiomyopathy.
Dillmann WH
Circ Res 2019 Apr 12;124(8):1160-1162. doi: 10.1161/CIRCRESAHA.118.314665. PMID: 30973809Free PMC Article
Diabetic cardiomyopathy - A comprehensive updated review.
Murtaza G, Virk HUH, Khalid M, Lavie CJ, Ventura H, Mukherjee D, Ramu V, Bhogal S, Kumar G, Shanmugasundaram M, Paul TK
Prog Cardiovasc Dis 2019 Jul-Aug;62(4):315-326. Epub 2019 Mar 25 doi: 10.1016/j.pcad.2019.03.003. PMID: 30922976
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article
Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease.
Jia G, Whaley-Connell A, Sowers JR
Diabetologia 2018 Jan;61(1):21-28. Epub 2017 Aug 3 doi: 10.1007/s00125-017-4390-4. PMID: 28776083Free PMC Article

Diagnosis

Diabetic cardiomyopathy.
Lorenzo-Almorós A, Cepeda-Rodrigo JM, Lorenzo Ó
Rev Clin Esp (Barc) 2022 Feb;222(2):100-111. Epub 2020 Oct 23 doi: 10.1016/j.rceng.2019.10.012. PMID: 35115137
Emerging roles of exosomal miRNAs in diabetes mellitus.
He X, Kuang G, Wu Y, Ou C
Clin Transl Med 2021 Jun;11(6):e468. doi: 10.1002/ctm2.468. PMID: 34185424Free PMC Article
PPAR control of metabolism and cardiovascular functions.
Montaigne D, Butruille L, Staels B
Nat Rev Cardiol 2021 Dec;18(12):809-823. Epub 2021 Jun 14 doi: 10.1038/s41569-021-00569-6. PMID: 34127848
Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications.
Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, Di Napoli P, Esposito I, Ambrosio A, Ianniruberto M, Mennella R, Paolillo R, Gargiulo P
Heart Fail Clin 2019 Jul;15(3):341-347. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.003. PMID: 31079692
Diabetic cardiomyopathy - A comprehensive updated review.
Murtaza G, Virk HUH, Khalid M, Lavie CJ, Ventura H, Mukherjee D, Ramu V, Bhogal S, Kumar G, Shanmugasundaram M, Paul TK
Prog Cardiovasc Dis 2019 Jul-Aug;62(4):315-326. Epub 2019 Mar 25 doi: 10.1016/j.pcad.2019.03.003. PMID: 30922976

Therapy

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
Nat Rev Cardiol 2020 Sep;17(9):585-607. Epub 2020 Feb 20 doi: 10.1038/s41569-020-0339-2. PMID: 32080423Free PMC Article
A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications.
Huang DD, Shi G, Jiang Y, Yao C, Zhu C
Biomed Pharmacother 2020 May;125:109767. Epub 2020 Feb 12 doi: 10.1016/j.biopha.2019.109767. PMID: 32058210
Diabetic Cardiomyopathy.
Dillmann WH
Circ Res 2019 Apr 12;124(8):1160-1162. doi: 10.1161/CIRCRESAHA.118.314665. PMID: 30973809Free PMC Article
Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy.
Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J
Circ Res 2019 Apr 26;124(9):1360-1371. doi: 10.1161/CIRCRESAHA.118.314607. PMID: 30786833Free PMC Article
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article

Prognosis

Diabetic cardiomyopathy: Clinical phenotype and practice.
Zhao X, Liu S, Wang X, Chen Y, Pang P, Yang Q, Lin J, Deng S, Wu S, Fan G, Wang B
Front Endocrinol (Lausanne) 2022;13:1032268. Epub 2022 Dec 7 doi: 10.3389/fendo.2022.1032268. PMID: 36568097Free PMC Article
Basic Mechanisms of Diabetic Heart Disease.
Ritchie RH, Abel ED
Circ Res 2020 May 22;126(11):1501-1525. Epub 2020 May 21 doi: 10.1161/CIRCRESAHA.120.315913. PMID: 32437308Free PMC Article
Diabetic Cardiomyopathy: Definition, Diagnosis, and Therapeutic Implications.
Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, Di Napoli P, Esposito I, Ambrosio A, Ianniruberto M, Mennella R, Paolillo R, Gargiulo P
Heart Fail Clin 2019 Jul;15(3):341-347. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.003. PMID: 31079692
Diabetic cardiomyopathy - A comprehensive updated review.
Murtaza G, Virk HUH, Khalid M, Lavie CJ, Ventura H, Mukherjee D, Ramu V, Bhogal S, Kumar G, Shanmugasundaram M, Paul TK
Prog Cardiovasc Dis 2019 Jul-Aug;62(4):315-326. Epub 2019 Mar 25 doi: 10.1016/j.pcad.2019.03.003. PMID: 30922976
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article

Clinical prediction guides

Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Pharmacology of apocynin: a natural acetophenone.
Savla SR, Laddha AP, Kulkarni YA
Drug Metab Rev 2021 Nov;53(4):542-562. Epub 2021 Mar 10 doi: 10.1080/03602532.2021.1895203. PMID: 33689526
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
Knapp M, Tu X, Wu R
Acta Pharmacol Sin 2019 Jan;40(1):1-8. Epub 2018 Jun 4 doi: 10.1038/s41401-018-0042-6. PMID: 29867137Free PMC Article
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
Riehle C, Bauersachs J
Basic Res Cardiol 2018 Nov 15;114(1):2. doi: 10.1007/s00395-018-0711-0. PMID: 30443826Free PMC Article
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
Jia G, DeMarco VG, Sowers JR
Nat Rev Endocrinol 2016 Mar;12(3):144-53. Epub 2015 Dec 18 doi: 10.1038/nrendo.2015.216. PMID: 26678809Free PMC Article

Recent systematic reviews

Emerging Role of Epitranscriptomics in Diabetes Mellitus and Its Complications.
Geng X, Li Z, Yang Y
Front Endocrinol (Lausanne) 2022;13:907060. Epub 2022 May 27 doi: 10.3389/fendo.2022.907060. PMID: 35692393Free PMC Article
Three-Dimensional Global Left Ventricular Myocardial Strain Reduced in All Directions in Subclinical Diabetic Cardiomyopathy: A Systematic Review and Meta-Analysis.
Ghoreyshi-Hefzabad SM, Jeyaprakash P, Gupta A, Vo HQ, Pathan F, Negishi K
J Am Heart Assoc 2021 Oct 5;10(19):e020811. Epub 2021 Sep 29 doi: 10.1161/JAHA.121.020811. PMID: 34585594Free PMC Article
Protective effects of medicinal plant against diabetes induced cardiac disorder: A review.
Shabab S, Gholamnezhad Z, Mahmoudabady M
J Ethnopharmacol 2021 Jan 30;265:113328. Epub 2020 Aug 29 doi: 10.1016/j.jep.2020.113328. PMID: 32871233
The role of invasive diagnostics and its impact on the treatment of dilated cardiomyopathy: A systematic review.
Gil KE, Pawlak A, Gil RJ, Frontczak-Baniewicz M, Bil J
Adv Med Sci 2016 Sep;61(2):331-343. Epub 2016 Aug 2 doi: 10.1016/j.advms.2016.07.001. PMID: 27589574
Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications.
Fang ZY, Prins JB, Marwick TH
Endocr Rev 2004 Aug;25(4):543-67. doi: 10.1210/er.2003-0012. PMID: 15294881

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