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Pineal region germinoma

MedGen UID:
208928
Concept ID:
C0854912
Neoplastic Process
Synonyms: Germinoma of the central nervous system; Pineal Germinoma; pineal germinoma; Pineal Region Germinoma; pineal region germinoma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0004216
Orphanet: ORPHA91352

Definition

A rare primary germ cell tumor of central nervous system characterized by a space-occupying lesion usually arising in structures around the third ventricle, most commonly the region of the pineal gland and the suprasellar compartment. It is composed of uniform cells resembling primitive germ cells. Clinical manifestations depend on the tumor site and include hydrocephalus, visual disturbances, and endocrine abnormalities. Prognosis is favorable in pure germinomas due to high radiosensitivity. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPineal region germinoma

Professional guidelines

PubMed

Stephens S, Kuchel A, Cheuk R, Alexander H, Robertson T, Rajah T, Tran Q, Inglis PL
J Clin Neurosci 2021 Aug;90:1-7. Epub 2021 May 21 doi: 10.1016/j.jocn.2021.05.006. PMID: 34275531
Blakeley JO, Grossman SA
Curr Treat Options Oncol 2006 Nov;7(6):505-16. doi: 10.1007/s11864-006-0025-6. PMID: 17032562
Smirniotopoulos JG, Rushing EJ, Mena H
Radiographics 1992 May;12(3):577-96. doi: 10.1148/radiographics.12.3.1609147. PMID: 1609147

Recent clinical studies

Etiology

Fan Y, Huo X, Li X, Wang L, Wu Z
Radiother Oncol 2022 Feb;167:277-284. Epub 2022 Jan 13 doi: 10.1016/j.radonc.2022.01.005. PMID: 35033600

Diagnosis

Fan Y, Huo X, Li X, Wang L, Wu Z
Radiother Oncol 2022 Feb;167:277-284. Epub 2022 Jan 13 doi: 10.1016/j.radonc.2022.01.005. PMID: 35033600
Tan GC, Sallapan S, Haworth K, Finlay J, Boue DR, Pierson CR
Malays J Pathol 2019 Apr;41(1):71-73. PMID: 31025642
Morrison AL, Smith AB, Benjamin V, Allen JC, Rushing EJ
J Clin Neurosci 2011 Aug;18(8):1126-7. Epub 2011 May 19 doi: 10.1016/j.jocn.2010.11.030. PMID: 21600775
Akimoto J, Murakami M, Fukami S, Ikeda Y, Haraoka J
J Clin Neurosci 2009 May;16(5):705-8. Epub 2009 Mar 17 doi: 10.1016/j.jocn.2008.06.009. PMID: 19282178
Reddy AT, Wellons JC 3rd, Allen JC, Fiveash JB, Abdullatif H, Braune KW, Grabb PA
Neuro Oncol 2004 Apr;6(2):127-33. doi: 10.1215/s1152851703000243. PMID: 15134627Free PMC Article

Therapy

Fan Y, Huo X, Li X, Wang L, Wu Z
Radiother Oncol 2022 Feb;167:277-284. Epub 2022 Jan 13 doi: 10.1016/j.radonc.2022.01.005. PMID: 35033600

Prognosis

Fan Y, Huo X, Li X, Wang L, Wu Z
Radiother Oncol 2022 Feb;167:277-284. Epub 2022 Jan 13 doi: 10.1016/j.radonc.2022.01.005. PMID: 35033600
Reddy AT, Wellons JC 3rd, Allen JC, Fiveash JB, Abdullatif H, Braune KW, Grabb PA
Neuro Oncol 2004 Apr;6(2):127-33. doi: 10.1215/s1152851703000243. PMID: 15134627Free PMC Article

Clinical prediction guides

Fan Y, Huo X, Li X, Wang L, Wu Z
Radiother Oncol 2022 Feb;167:277-284. Epub 2022 Jan 13 doi: 10.1016/j.radonc.2022.01.005. PMID: 35033600
Tan GC, Sallapan S, Haworth K, Finlay J, Boue DR, Pierson CR
Malays J Pathol 2019 Apr;41(1):71-73. PMID: 31025642
Akimoto J, Murakami M, Fukami S, Ikeda Y, Haraoka J
J Clin Neurosci 2009 May;16(5):705-8. Epub 2009 Mar 17 doi: 10.1016/j.jocn.2008.06.009. PMID: 19282178
Reddy AT, Wellons JC 3rd, Allen JC, Fiveash JB, Abdullatif H, Braune KW, Grabb PA
Neuro Oncol 2004 Apr;6(2):127-33. doi: 10.1215/s1152851703000243. PMID: 15134627Free PMC Article

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