U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Unilateral retinoblastoma

MedGen UID:
208929
•Concept ID:
C0854915
•
Neoplastic Process
Synonyms: Unilateral Retinoblastoma; unilateral retinoblastoma
 
Monarch Initiative: MONDO:0003076

Definition

A retinoblastoma that only involves a single eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnilateral retinoblastoma

Professional guidelines

PubMed

Treatment of Nonmetastatic Unilateral Retinoblastoma in Children.
Pérez V, Sampor C, Rey G, Parareda-Salles A, Kopp K, Dabezies AP, Dufort G, Zelter M, López JP, Urbieta M, Alcalde-Ruiz E, Catala-Mora J, Suñol M, Ossandon D, Fandiño AC, Croxatto JO, de Dávila MTG, Reaman G, Ravindranath Y, Chantada GL
JAMA Ophthalmol 2018 Jul 1;136(7):747-752. doi: 10.1001/jamaophthalmol.2018.1501. PMID: 29799944Free PMC Article
Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Lally SE, Leahey AM, Jabbour PM, Caywood EH, Schwendeman R, Shields JA
Curr Opin Ophthalmol 2014 Sep;25(5):374-85. doi: 10.1097/ICU.0000000000000091. PMID: 25014750
Current concepts for diagnosis and treatment of retinoblastoma in Germany: aiming for safe tumor control and vision preservation.
Temming P, Lohmann D, Bornfeld N, Sauerwein W, Goericke SL, Eggert A
Klin Padiatr 2012 Oct;224(6):339-47. Epub 2012 Nov 9 doi: 10.1055/s-0032-1327563. PMID: 23143761

Recent clinical studies

Etiology

Prenatal ambient pesticide exposure and childhood retinoblastoma.
Thompson S, Ritz B, Cockburn M, Heck JE
Int J Hyg Environ Health 2022 Aug;245:114025. Epub 2022 Aug 26 doi: 10.1016/j.ijheh.2022.114025. PMID: 36037576Free PMC Article
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Treatment of Nonmetastatic Unilateral Retinoblastoma in Children.
Pérez V, Sampor C, Rey G, Parareda-Salles A, Kopp K, Dabezies AP, Dufort G, Zelter M, López JP, Urbieta M, Alcalde-Ruiz E, Catala-Mora J, Suñol M, Ossandon D, Fandiño AC, Croxatto JO, de Dávila MTG, Reaman G, Ravindranath Y, Chantada GL
JAMA Ophthalmol 2018 Jul 1;136(7):747-752. doi: 10.1001/jamaophthalmol.2018.1501. PMID: 29799944Free PMC Article
Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Lally SE, Leahey AM, Jabbour PM, Caywood EH, Schwendeman R, Shields JA
Curr Opin Ophthalmol 2014 Sep;25(5):374-85. doi: 10.1097/ICU.0000000000000091. PMID: 25014750
Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Fulco EM, Arias JD, Alarcon C, Pellegrini M, Rishi P, Kaliki S, Bianciotto CG, Shields JA
Eye (Lond) 2013 Feb;27(2):253-64. Epub 2012 Sep 21 doi: 10.1038/eye.2012.175. PMID: 22995941Free PMC Article

Diagnosis

The Genetics of Unilateral Retinoblastoma Clarified.
Wagner RS
J Pediatr Ophthalmol Strabismus 2021 Nov-Dec;58(6):344. Epub 2021 Nov 1 doi: 10.3928/01913913-20211012-01. PMID: 34851786
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Fulco EM, Arias JD, Alarcon C, Pellegrini M, Rishi P, Kaliki S, Bianciotto CG, Shields JA
Eye (Lond) 2013 Feb;27(2):253-64. Epub 2012 Sep 21 doi: 10.1038/eye.2012.175. PMID: 22995941Free PMC Article
Current concepts for diagnosis and treatment of retinoblastoma in Germany: aiming for safe tumor control and vision preservation.
Temming P, Lohmann D, Bornfeld N, Sauerwein W, Goericke SL, Eggert A
Klin Padiatr 2012 Oct;224(6):339-47. Epub 2012 Nov 9 doi: 10.1055/s-0032-1327563. PMID: 23143761
Trilateral retinoblastoma.
Limn YS, Juraida E, Alagaratnam J, Menon BS
Med J Malaysia 2011 Jun;66(2):156-7. PMID: 22106703

Therapy

Prenatal ambient pesticide exposure and childhood retinoblastoma.
Thompson S, Ritz B, Cockburn M, Heck JE
Int J Hyg Environ Health 2022 Aug;245:114025. Epub 2022 Aug 26 doi: 10.1016/j.ijheh.2022.114025. PMID: 36037576Free PMC Article
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Treatment of Nonmetastatic Unilateral Retinoblastoma in Children.
Pérez V, Sampor C, Rey G, Parareda-Salles A, Kopp K, Dabezies AP, Dufort G, Zelter M, López JP, Urbieta M, Alcalde-Ruiz E, Catala-Mora J, Suñol M, Ossandon D, Fandiño AC, Croxatto JO, de Dávila MTG, Reaman G, Ravindranath Y, Chantada GL
JAMA Ophthalmol 2018 Jul 1;136(7):747-752. doi: 10.1001/jamaophthalmol.2018.1501. PMID: 29799944Free PMC Article
Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Lally SE, Leahey AM, Jabbour PM, Caywood EH, Schwendeman R, Shields JA
Curr Opin Ophthalmol 2014 Sep;25(5):374-85. doi: 10.1097/ICU.0000000000000091. PMID: 25014750
Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.
Shields CL, Fulco EM, Arias JD, Alarcon C, Pellegrini M, Rishi P, Kaliki S, Bianciotto CG, Shields JA
Eye (Lond) 2013 Feb;27(2):253-64. Epub 2012 Sep 21 doi: 10.1038/eye.2012.175. PMID: 22995941Free PMC Article

Prognosis

Clinical characteristics, treatment and prognosis of children with unilateral retinoblastoma and intracranial segment of Retrobulbar optic nerve invasion.
Wang YZ, Zhang Y, Huang DS, Shi JT, Ma JM, Li B, Xu XL, Zhou Y, Gu HL
BMC Ophthalmol 2021 Jan 14;21(1):38. doi: 10.1186/s12886-020-01768-4. PMID: 33446150Free PMC Article
Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
El Zomor H, Nour R, Saad A, Taha H, Shelil AE, Aleieldin A, Saad Zaghloul M, Alfaar AS
Eye (Lond) 2021 Sep;35(9):2564-2572. Epub 2020 Nov 13 doi: 10.1038/s41433-020-01275-2. PMID: 33188294Free PMC Article
Treatment of Nonmetastatic Unilateral Retinoblastoma in Children.
Pérez V, Sampor C, Rey G, Parareda-Salles A, Kopp K, Dabezies AP, Dufort G, Zelter M, López JP, Urbieta M, Alcalde-Ruiz E, Catala-Mora J, Suñol M, Ossandon D, Fandiño AC, Croxatto JO, de Dávila MTG, Reaman G, Ravindranath Y, Chantada GL
JAMA Ophthalmol 2018 Jul 1;136(7):747-752. doi: 10.1001/jamaophthalmol.2018.1501. PMID: 29799944Free PMC Article
Trilateral retinoblastoma.
Limn YS, Juraida E, Alagaratnam J, Menon BS
Med J Malaysia 2011 Jun;66(2):156-7. PMID: 22106703
Basic understanding of current classification and management of retinoblastoma.
Shields CL, Shields JA
Curr Opin Ophthalmol 2006 Jun;17(3):228-34. doi: 10.1097/01.icu.0000193079.55240.18. PMID: 16794434

Clinical prediction guides

RB1 germline mutation spectrum and clinical features in patients with unilateral retinoblastomas.
Fang X, Chen J, Wang Y, Zhao M, Zhang X, Yang L, Ni X, Zhao J, Gallie BL
Ophthalmic Genet 2021 Oct;42(5):593-599. Epub 2021 Jun 30 doi: 10.1080/13816810.2021.1946703. PMID: 34190019
Excessive folic acid intake and relation to adverse health outcome.
Selhub J, Rosenberg IH
Biochimie 2016 Jul;126:71-8. Epub 2016 Apr 27 doi: 10.1016/j.biochi.2016.04.010. PMID: 27131640
Socioeconomic and psychological impact of treatment for unilateral intraocular retinoblastoma.
Soliman SE, Dimaras H, Souka AA, Ashry MH, Gallie BL
J Fr Ophtalmol 2015 Jun;38(6):550-8. Epub 2015 May 14 doi: 10.1016/j.jfo.2015.03.003. PMID: 25982424
Maternal diet during pregnancy and unilateral retinoblastoma.
Lombardi C, Ganguly A, Bunin GR, Azary S, Alfonso V, Ritz B, Heck JE
Cancer Causes Control 2015 Mar;26(3):387-97. Epub 2014 Dec 27 doi: 10.1007/s10552-014-0514-z. PMID: 25542139Free PMC Article
Basic understanding of current classification and management of retinoblastoma.
Shields CL, Shields JA
Curr Opin Ophthalmol 2006 Jun;17(3):228-34. doi: 10.1097/01.icu.0000193079.55240.18. PMID: 16794434

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...