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Refractory Hodgkin Lymphoma

MedGen UID:
208949
Concept ID:
C0855082
Neoplastic Process
Synonyms: Refractory Hodgkin lymphoma; Refractory Hodgkin's disease; Refractory Hodgkin's Disease; Refractory Hodgkin's Lymphoma; Refractory Hodgkin's lymphoma
SNOMED CT: Refractory Hodgkin's disease (461311000124107); Refractory Hodgkin's lymphoma (461311000124107); Refractory Hodgkin lymphoma (461311000124107)

Definition

Hodgkin lymphoma resistant to treatment [from NCI]

Professional guidelines

PubMed

Blum KA
Cancer J 2018 Sep/Oct;24(5):244-248. doi: 10.1097/PPO.0000000000000330. PMID: 30247260
Constine LS, Yahalom J, Ng AK, Hodgson DC, Wirth A, Milgrom SA, Mikhaeel NG, Eich HT, Illidge T, Ricardi U, Dieckmann K, Moskowitz CH, Advani R, Mauch PM, Specht L, Hoppe RT
Int J Radiat Oncol Biol Phys 2018 Apr 1;100(5):1100-1118. Epub 2018 Jan 9 doi: 10.1016/j.ijrobp.2018.01.011. PMID: 29722655
von Tresckow B, Moskowitz CH
Semin Hematol 2016 Jul;53(3):180-5. Epub 2016 May 12 doi: 10.1053/j.seminhematol.2016.05.010. PMID: 27496309Free PMC Article

Recent clinical studies

Etiology

Advani RH, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Christian BA, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood 2021 Aug 12;138(6):427-438. doi: 10.1182/blood.2020009178. PMID: 33827139
Chen R, Zinzani PL, Lee HJ, Armand P, Johnson NA, Brice P, Radford J, Ribrag V, Molin D, Vassilakopoulos TP, Tomita A, von Tresckow B, Shipp MA, Lin J, Kim E, Nahar A, Balakumaran A, Moskowitz CH
Blood 2019 Oct 3;134(14):1144-1153. Epub 2019 Aug 13 doi: 10.1182/blood.2019000324. PMID: 31409671Free PMC Article
Constine LS, Yahalom J, Ng AK, Hodgson DC, Wirth A, Milgrom SA, Mikhaeel NG, Eich HT, Illidge T, Ricardi U, Dieckmann K, Moskowitz CH, Advani R, Mauch PM, Specht L, Hoppe RT
Int J Radiat Oncol Biol Phys 2018 Apr 1;100(5):1100-1118. Epub 2018 Jan 9 doi: 10.1016/j.ijrobp.2018.01.011. PMID: 29722655
Shah GL, Moskowitz CH
Blood 2018 Apr 12;131(15):1689-1697. Epub 2018 Mar 2 doi: 10.1182/blood-2017-09-772673. PMID: 29500170Free PMC Article
von Tresckow B, Engert A
Curr Opin Oncol 2013 Sep;25(5):463-9. doi: 10.1097/01.cco.0000432524.62475.60. PMID: 23942291

Diagnosis

Aoki T, Jiang A, Xu A, Yin Y, Gamboa A, Milne K, Takata K, Miyata-Takata T, Chung S, Rai S, Wu S, Warren M, Strong C, Goodyear T, Morris K, Chong LC, Hav M, Colombo AR, Telenius A, Boyle M, Ben-Neriah S, Power M, Gerrie AS, Weng AP, Karsan A, Roth A, Farinha P, Scott DW, Savage KJ, Nelson BH, Merchant A, Steidl C
J Clin Oncol 2024 Mar 20;42(9):1077-1087. Epub 2023 Dec 19 doi: 10.1200/JCO.23.01115. PMID: 38113419Free PMC Article
Shah GL, Moskowitz CH
Clin Adv Hematol Oncol 2018 Jan;16(1):45-55. PMID: 29741505
von Tresckow B, Moskowitz CH
Semin Hematol 2016 Jul;53(3):180-5. Epub 2016 May 12 doi: 10.1053/j.seminhematol.2016.05.010. PMID: 27496309Free PMC Article
von Tresckow B, Engert A
Curr Opin Oncol 2013 Sep;25(5):463-9. doi: 10.1097/01.cco.0000432524.62475.60. PMID: 23942291
van de Donk NW, Dhimolea E
MAbs 2012 Jul-Aug;4(4):458-65. Epub 2012 Jul 1 doi: 10.4161/mabs.20230. PMID: 22684302Free PMC Article

Therapy

Advani RH, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Christian BA, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood 2021 Aug 12;138(6):427-438. doi: 10.1182/blood.2020009178. PMID: 33827139
Ramos CA, Grover NS, Beaven AW, Lulla PD, Wu MF, Ivanova A, Wang T, Shea TC, Rooney CM, Dittus C, Park SI, Gee AP, Eldridge PW, McKay KL, Mehta B, Cheng CJ, Buchanan FB, Grilley BJ, Morrison K, Brenner MK, Serody JS, Dotti G, Heslop HE, Savoldo B
J Clin Oncol 2020 Nov 10;38(32):3794-3804. Epub 2020 Jul 23 doi: 10.1200/JCO.20.01342. PMID: 32701411Free PMC Article
Chen R, Zinzani PL, Lee HJ, Armand P, Johnson NA, Brice P, Radford J, Ribrag V, Molin D, Vassilakopoulos TP, Tomita A, von Tresckow B, Shipp MA, Lin J, Kim E, Nahar A, Balakumaran A, Moskowitz CH
Blood 2019 Oct 3;134(14):1144-1153. Epub 2019 Aug 13 doi: 10.1182/blood.2019000324. PMID: 31409671Free PMC Article
Constine LS, Yahalom J, Ng AK, Hodgson DC, Wirth A, Milgrom SA, Mikhaeel NG, Eich HT, Illidge T, Ricardi U, Dieckmann K, Moskowitz CH, Advani R, Mauch PM, Specht L, Hoppe RT
Int J Radiat Oncol Biol Phys 2018 Apr 1;100(5):1100-1118. Epub 2018 Jan 9 doi: 10.1016/j.ijrobp.2018.01.011. PMID: 29722655
LaCasce AS, Bociek RG, Sawas A, Caimi P, Agura E, Matous J, Ansell SM, Crosswell HE, Islas-Ohlmayer M, Behler C, Cheung E, Forero-Torres A, Vose J, O'Connor OA, Josephson N, Wang Y, Advani R
Blood 2018 Jul 5;132(1):40-48. Epub 2018 Apr 27 doi: 10.1182/blood-2017-11-815183. PMID: 29703778Free PMC Article

Prognosis

Advani RH, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Christian BA, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood 2021 Aug 12;138(6):427-438. doi: 10.1182/blood.2020009178. PMID: 33827139
Chen R, Zinzani PL, Lee HJ, Armand P, Johnson NA, Brice P, Radford J, Ribrag V, Molin D, Vassilakopoulos TP, Tomita A, von Tresckow B, Shipp MA, Lin J, Kim E, Nahar A, Balakumaran A, Moskowitz CH
Blood 2019 Oct 3;134(14):1144-1153. Epub 2019 Aug 13 doi: 10.1182/blood.2019000324. PMID: 31409671Free PMC Article
LaCasce AS, Bociek RG, Sawas A, Caimi P, Agura E, Matous J, Ansell SM, Crosswell HE, Islas-Ohlmayer M, Behler C, Cheung E, Forero-Torres A, Vose J, O'Connor OA, Josephson N, Wang Y, Advani R
Blood 2018 Jul 5;132(1):40-48. Epub 2018 Apr 27 doi: 10.1182/blood-2017-11-815183. PMID: 29703778Free PMC Article
von Tresckow B, Moskowitz CH
Semin Hematol 2016 Jul;53(3):180-5. Epub 2016 May 12 doi: 10.1053/j.seminhematol.2016.05.010. PMID: 27496309Free PMC Article
von Tresckow B, Engert A
Curr Opin Oncol 2013 Sep;25(5):463-9. doi: 10.1097/01.cco.0000432524.62475.60. PMID: 23942291

Clinical prediction guides

Aoki T, Jiang A, Xu A, Yin Y, Gamboa A, Milne K, Takata K, Miyata-Takata T, Chung S, Rai S, Wu S, Warren M, Strong C, Goodyear T, Morris K, Chong LC, Hav M, Colombo AR, Telenius A, Boyle M, Ben-Neriah S, Power M, Gerrie AS, Weng AP, Karsan A, Roth A, Farinha P, Scott DW, Savage KJ, Nelson BH, Merchant A, Steidl C
J Clin Oncol 2024 Mar 20;42(9):1077-1087. Epub 2023 Dec 19 doi: 10.1200/JCO.23.01115. PMID: 38113419Free PMC Article
Spinner MA, Sica RA, Tamaresis JS, Lu Y, Chang C, Lowsky R, Frank MJ, Johnston LJ, Miklos DB, Muffly LS, Negrin RS, Rezvani AR, Shiraz P, Shizuru JA, Weng WK, Binkley MS, Hoppe RT, Advani RH, Arai S
Blood 2023 Jun 1;141(22):2727-2737. doi: 10.1182/blood.2022018827. PMID: 36857637
Ramos CA, Grover NS, Beaven AW, Lulla PD, Wu MF, Ivanova A, Wang T, Shea TC, Rooney CM, Dittus C, Park SI, Gee AP, Eldridge PW, McKay KL, Mehta B, Cheng CJ, Buchanan FB, Grilley BJ, Morrison K, Brenner MK, Serody JS, Dotti G, Heslop HE, Savoldo B
J Clin Oncol 2020 Nov 10;38(32):3794-3804. Epub 2020 Jul 23 doi: 10.1200/JCO.20.01342. PMID: 32701411Free PMC Article
LaCasce AS, Bociek RG, Sawas A, Caimi P, Agura E, Matous J, Ansell SM, Crosswell HE, Islas-Ohlmayer M, Behler C, Cheung E, Forero-Torres A, Vose J, O'Connor OA, Josephson N, Wang Y, Advani R
Blood 2018 Jul 5;132(1):40-48. Epub 2018 Apr 27 doi: 10.1182/blood-2017-11-815183. PMID: 29703778Free PMC Article
Herrera AF, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Ansell SM, Moskowitz CH, Fenton K, Ogden CA, Taft D, Zhang Q, Kato K, Campbell M, Advani RH
Blood 2018 Mar 15;131(11):1183-1194. Epub 2017 Dec 11 doi: 10.1182/blood-2017-10-811224. PMID: 29229594Free PMC Article

Recent systematic reviews

Plattel WJ, Bergamasco A, Trinchese F, Gavini F, Bent-Ennakhil N, Zomas A, Castillon G, Arredondo-Bisono T, Cristarella T, Moride Y, von Tresckow B
Leuk Lymphoma 2021 Dec;62(14):3320-3332. Epub 2021 Jul 29 doi: 10.1080/10428194.2021.1957865. PMID: 34323643
Zinzani PL, Sasse S, Radford J, Gautam A, Bonthapally V
Crit Rev Oncol Hematol 2016 Aug;104:65-70. Epub 2016 May 21 doi: 10.1016/j.critrevonc.2016.04.019. PMID: 27279289
Dada R, Zekri J, Al Saadi R
Expert Opin Biol Ther 2016 Jun;16(6):739-45. Epub 2016 May 3 doi: 10.1080/14712598.2016.1180362. PMID: 27096887
Martino M, Festuccia M, Fedele R, Console G, Cimminiello M, Gavarotti P, Bruno B
Expert Opin Biol Ther 2016;16(3):347-64. Epub 2016 Feb 6 doi: 10.1517/14712598.2015.1130821. PMID: 26652934
Bonthapally V, Wu E, Macalalad A, Yang H, Shonukan O, Liu Y, Chi A, Huebner D
Curr Med Res Opin 2015 May;31(5):993-1001. Epub 2015 Apr 9 doi: 10.1185/03007995.2015.1030378. PMID: 25772232

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