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Refractory Diffuse Large B-Cell Lymphoma

MedGen UID:
208957
Concept ID:
C0855112
Neoplastic Process
Synonym: Diffuse Large B-Cell Lymphoma Refractory

Definition

Diffuse large B-cell lymphoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Alderuccio JP, Sharman JP
Blood Rev 2022 Nov;56:100967. Epub 2022 Apr 22 doi: 10.1016/j.blre.2022.100967. PMID: 35489963
Yakoub-Agha I, Chabannon C, Bader P, Basak GW, Bonig H, Ciceri F, Corbacioglu S, Duarte RF, Einsele H, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Robinson S, Saccardi R, Sanchez-Guijo F, Snowden JA, Srour M, Styczynski J, Urbano-Ispizua A, Hayden PJ, Kröger N
Haematologica 2020;105(2):297-316. Epub 2020 Jan 31 doi: 10.3324/haematol.2019.229781. PMID: 31753925Free PMC Article
Ng AK, Yahalom J, Goda JS, Constine LS, Pinnix CC, Kelsey CR, Hoppe B, Oguchi M, Suh CO, Wirth A, Qi S, Davies A, Moskowitz CH, Laskar S, Li Y, Mauch PM, Specht L, Illidge T
Int J Radiat Oncol Biol Phys 2018 Mar 1;100(3):652-669. doi: 10.1016/j.ijrobp.2017.12.005. PMID: 29413279

Recent clinical studies

Etiology

Caimi PF, Ai W, Alderuccio JP, Ardeshna KM, Hamadani M, Hess B, Kahl BS, Radford J, Solh M, Stathis A, Zinzani PL, Havenith K, Feingold J, He S, Qin Y, Ungar D, Zhang X, Carlo-Stella C
Lancet Oncol 2021 Jun;22(6):790-800. Epub 2021 May 11 doi: 10.1016/S1470-2045(21)00139-X. PMID: 33989558
Salles G, Duell J, González Barca E, Tournilhac O, Jurczak W, Liberati AM, Nagy Z, Obr A, Gaidano G, André M, Kalakonda N, Dreyling M, Weirather J, Dirnberger-Hertweck M, Ambarkhane S, Fingerle-Rowson G, Maddocks K
Lancet Oncol 2020 Jul;21(7):978-988. Epub 2020 Jun 5 doi: 10.1016/S1470-2045(20)30225-4. PMID: 32511983
Sehn LH, Herrera AF, Flowers CR, Kamdar MK, McMillan A, Hertzberg M, Assouline S, Kim TM, Kim WS, Ozcan M, Hirata J, Penuel E, Paulson JN, Cheng J, Ku G, Matasar MJ
J Clin Oncol 2020 Jan 10;38(2):155-165. Epub 2019 Nov 6 doi: 10.1200/JCO.19.00172. PMID: 31693429Free PMC Article
Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, Jäger U, Jaglowski S, Andreadis C, Westin JR, Fleury I, Bachanova V, Foley SR, Ho PJ, Mielke S, Magenau JM, Holte H, Pantano S, Pacaud LB, Awasthi R, Chu J, Anak Ö, Salles G, Maziarz RT; JULIET Investigators
N Engl J Med 2019 Jan 3;380(1):45-56. Epub 2018 Dec 1 doi: 10.1056/NEJMoa1804980. PMID: 30501490
Crump M, Neelapu SS, Farooq U, Van Den Neste E, Kuruvilla J, Westin J, Link BK, Hay A, Cerhan JR, Zhu L, Boussetta S, Feng L, Maurer MJ, Navale L, Wiezorek J, Go WY, Gisselbrecht C
Blood 2017 Oct 19;130(16):1800-1808. Epub 2017 Aug 3 doi: 10.1182/blood-2017-03-769620. PMID: 28774879Free PMC Article

Diagnosis

Kawasaki N, Nishito Y, Yoshimura Y, Yoshiura S
Br J Haematol 2022 Oct;199(2):245-255. Epub 2022 Jun 28 doi: 10.1111/bjh.18341. PMID: 35764309Free PMC Article
Duell J, Maddocks KJ, González-Barca E, Jurczak W, Liberati AM, De Vos S, Nagy Z, Obr A, Gaidano G, Abrisqueta P, Kalakonda N, André M, Dreyling M, Menne T, Tournilhac O, Augustin M, Rosenwald A, Dirnberger-Hertweck M, Weirather J, Ambarkhane S, Salles G
Haematologica 2021 Sep 1;106(9):2417-2426. doi: 10.3324/haematol.2020.275958. PMID: 34196165Free PMC Article
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article
Ng AK, Yahalom J, Goda JS, Constine LS, Pinnix CC, Kelsey CR, Hoppe B, Oguchi M, Suh CO, Wirth A, Qi S, Davies A, Moskowitz CH, Laskar S, Li Y, Mauch PM, Specht L, Illidge T
Int J Radiat Oncol Biol Phys 2018 Mar 1;100(3):652-669. doi: 10.1016/j.ijrobp.2017.12.005. PMID: 29413279
Friedberg JW
Hematology Am Soc Hematol Educ Program 2011;2011:498-505. doi: 10.1182/asheducation-2011.1.498. PMID: 22160081

Therapy

Dickinson MJ, Carlo-Stella C, Morschhauser F, Bachy E, Corradini P, Iacoboni G, Khan C, Wróbel T, Offner F, Trněný M, Wu SJ, Cartron G, Hertzberg M, Sureda A, Perez-Callejo D, Lundberg L, Relf J, Dixon M, Clark E, Humphrey K, Hutchings M
N Engl J Med 2022 Dec 15;387(24):2220-2231. Epub 2022 Dec 11 doi: 10.1056/NEJMoa2206913. PMID: 36507690
Caimi PF, Ai W, Alderuccio JP, Ardeshna KM, Hamadani M, Hess B, Kahl BS, Radford J, Solh M, Stathis A, Zinzani PL, Havenith K, Feingold J, He S, Qin Y, Ungar D, Zhang X, Carlo-Stella C
Lancet Oncol 2021 Jun;22(6):790-800. Epub 2021 May 11 doi: 10.1016/S1470-2045(21)00139-X. PMID: 33989558
Salles G, Duell J, González Barca E, Tournilhac O, Jurczak W, Liberati AM, Nagy Z, Obr A, Gaidano G, André M, Kalakonda N, Dreyling M, Weirather J, Dirnberger-Hertweck M, Ambarkhane S, Fingerle-Rowson G, Maddocks K
Lancet Oncol 2020 Jul;21(7):978-988. Epub 2020 Jun 5 doi: 10.1016/S1470-2045(20)30225-4. PMID: 32511983
Sehn LH, Herrera AF, Flowers CR, Kamdar MK, McMillan A, Hertzberg M, Assouline S, Kim TM, Kim WS, Ozcan M, Hirata J, Penuel E, Paulson JN, Cheng J, Ku G, Matasar MJ
J Clin Oncol 2020 Jan 10;38(2):155-165. Epub 2019 Nov 6 doi: 10.1200/JCO.19.00172. PMID: 31693429Free PMC Article
Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, Jäger U, Jaglowski S, Andreadis C, Westin JR, Fleury I, Bachanova V, Foley SR, Ho PJ, Mielke S, Magenau JM, Holte H, Pantano S, Pacaud LB, Awasthi R, Chu J, Anak Ö, Salles G, Maziarz RT; JULIET Investigators
N Engl J Med 2019 Jan 3;380(1):45-56. Epub 2018 Dec 1 doi: 10.1056/NEJMoa1804980. PMID: 30501490

Prognosis

Dickinson MJ, Carlo-Stella C, Morschhauser F, Bachy E, Corradini P, Iacoboni G, Khan C, Wróbel T, Offner F, Trněný M, Wu SJ, Cartron G, Hertzberg M, Sureda A, Perez-Callejo D, Lundberg L, Relf J, Dixon M, Clark E, Humphrey K, Hutchings M
N Engl J Med 2022 Dec 15;387(24):2220-2231. Epub 2022 Dec 11 doi: 10.1056/NEJMoa2206913. PMID: 36507690
Caimi PF, Ai W, Alderuccio JP, Ardeshna KM, Hamadani M, Hess B, Kahl BS, Radford J, Solh M, Stathis A, Zinzani PL, Havenith K, Feingold J, He S, Qin Y, Ungar D, Zhang X, Carlo-Stella C
Lancet Oncol 2021 Jun;22(6):790-800. Epub 2021 May 11 doi: 10.1016/S1470-2045(21)00139-X. PMID: 33989558
Salles G, Duell J, González Barca E, Tournilhac O, Jurczak W, Liberati AM, Nagy Z, Obr A, Gaidano G, André M, Kalakonda N, Dreyling M, Weirather J, Dirnberger-Hertweck M, Ambarkhane S, Fingerle-Rowson G, Maddocks K
Lancet Oncol 2020 Jul;21(7):978-988. Epub 2020 Jun 5 doi: 10.1016/S1470-2045(20)30225-4. PMID: 32511983
Sehn LH, Herrera AF, Flowers CR, Kamdar MK, McMillan A, Hertzberg M, Assouline S, Kim TM, Kim WS, Ozcan M, Hirata J, Penuel E, Paulson JN, Cheng J, Ku G, Matasar MJ
J Clin Oncol 2020 Jan 10;38(2):155-165. Epub 2019 Nov 6 doi: 10.1200/JCO.19.00172. PMID: 31693429Free PMC Article
Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, Jäger U, Jaglowski S, Andreadis C, Westin JR, Fleury I, Bachanova V, Foley SR, Ho PJ, Mielke S, Magenau JM, Holte H, Pantano S, Pacaud LB, Awasthi R, Chu J, Anak Ö, Salles G, Maziarz RT; JULIET Investigators
N Engl J Med 2019 Jan 3;380(1):45-56. Epub 2018 Dec 1 doi: 10.1056/NEJMoa1804980. PMID: 30501490

Clinical prediction guides

Bachy E, Le Gouill S, Di Blasi R, Sesques P, Manson G, Cartron G, Beauvais D, Roulin L, Gros FX, Rubio MT, Bories P, Bay JO, Llorente CC, Choquet S, Casasnovas RO, Mohty M, Guidez S, Joris M, Loschi M, Carras S, Abraham J, Chauchet A, Drieu La Rochelle L, Deau-Fischer B, Hermine O, Gastinne T, Tudesq JJ, Gat E, Broussais F, Thieblemont C, Houot R, Morschhauser F
Nat Med 2022 Oct;28(10):2145-2154. Epub 2022 Sep 22 doi: 10.1038/s41591-022-01969-y. PMID: 36138152Free PMC Article
Ernst M, Oeser A, Besiroglu B, Caro-Valenzuela J, Abd El Aziz M, Monsef I, Borchmann P, Estcourt LJ, Skoetz N, Goldkuhle M
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD013365. doi: 10.1002/14651858.CD013365.pub2. PMID: 34515338Free PMC Article
Hutchings M, Mous R, Clausen MR, Johnson P, Linton KM, Chamuleau MED, Lewis DJ, Sureda Balari A, Cunningham D, Oliveri RS, Elliott B, DeMarco D, Azaryan A, Chiu C, Li T, Chen KM, Ahmadi T, Lugtenburg PJ
Lancet 2021 Sep 25;398(10306):1157-1169. Epub 2021 Sep 8 doi: 10.1016/S0140-6736(21)00889-8. PMID: 34508654
Schuster SJ, Svoboda J, Chong EA, Nasta SD, Mato AR, Anak Ö, Brogdon JL, Pruteanu-Malinici I, Bhoj V, Landsburg D, Wasik M, Levine BL, Lacey SF, Melenhorst JJ, Porter DL, June CH
N Engl J Med 2017 Dec 28;377(26):2545-2554. Epub 2017 Dec 10 doi: 10.1056/NEJMoa1708566. PMID: 29226764Free PMC Article
Crump M, Neelapu SS, Farooq U, Van Den Neste E, Kuruvilla J, Westin J, Link BK, Hay A, Cerhan JR, Zhu L, Boussetta S, Feng L, Maurer MJ, Navale L, Wiezorek J, Go WY, Gisselbrecht C
Blood 2017 Oct 19;130(16):1800-1808. Epub 2017 Aug 3 doi: 10.1182/blood-2017-03-769620. PMID: 28774879Free PMC Article

Recent systematic reviews

Kim J, Cho J, Yoon SE, Kim WS, Kim SJ
Cancer Res Treat 2023 Jul;55(3):1031-1047. Epub 2023 Mar 13 doi: 10.4143/crt.2022.1658. PMID: 36915243Free PMC Article
Miller SD, Lozano-Ortega G, Mutebi A, Briggs O, Sail K, Elliott B, Kalsekar A
J Comp Eff Res 2023 Jan;12(1):e220146. Epub 2022 Nov 23 doi: 10.2217/cer-2022-0146. PMID: 36417238Free PMC Article
Tian L, Li C, Sun J, Zhai Y, Wang J, Liu S, Jiang Y, Wu W, Xing D, Lv Y, Guo J, Xu H, Sun H, Li Y, Li L, Zhao Z
Front Immunol 2022;13:1041177. Epub 2023 Jan 17 doi: 10.3389/fimmu.2022.1041177. PMID: 36733398Free PMC Article
Ernst M, Oeser A, Besiroglu B, Caro-Valenzuela J, Abd El Aziz M, Monsef I, Borchmann P, Estcourt LJ, Skoetz N, Goldkuhle M
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD013365. doi: 10.1002/14651858.CD013365.pub2. PMID: 34515338Free PMC Article
Colosia A, Njue A, Trask PC, Olivares R, Khan S, Abbe A, Police R, Wang J, Ruiz-Soto R, Kaye JA, Awan F
Clin Lymphoma Myeloma Leuk 2014 Oct;14(5):343-355.e6. Epub 2014 Mar 1 doi: 10.1016/j.clml.2014.02.012. PMID: 24768510

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