U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Relapsed/refractory diffuse large B-cell lymphoma

MedGen UID:
208957
Concept ID:
C0855112
Neoplastic Process
Synonyms: Diffuse Large B-Cell Lymphoma Refractory; Refractory Diffuse Large B-Cell Lymphoma; relapsed/refractory diffuse large B-cell lymphoma
 
Monarch Initiative: MONDO:0000901

Definition

Diffuse large B-cell lymphoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Yakoub-Agha I, Chabannon C, Bader P, Basak GW, Bonig H, Ciceri F, Corbacioglu S, Duarte RF, Einsele H, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Robinson S, Saccardi R, Sanchez-Guijo F, Snowden JA, Srour M, Styczynski J, Urbano-Ispizua A, Hayden PJ, Kröger N
Haematologica 2020;105(2):297-316. Epub 2020 Jan 31 doi: 10.3324/haematol.2019.229781. PMID: 31753925Free PMC Article
Ng AK, Yahalom J, Goda JS, Constine LS, Pinnix CC, Kelsey CR, Hoppe B, Oguchi M, Suh CO, Wirth A, Qi S, Davies A, Moskowitz CH, Laskar S, Li Y, Mauch PM, Specht L, Illidge T
Int J Radiat Oncol Biol Phys 2018 Mar 1;100(3):652-669. doi: 10.1016/j.ijrobp.2017.12.005. PMID: 29413279
Lukenbill J, Hill B
Leuk Lymphoma 2015 Feb;56(2):293-300. Epub 2014 Jun 16 doi: 10.3109/10428194.2014.910660. PMID: 24813764

Recent clinical studies

Etiology

Duell J, Abrisqueta P, Andre M, Gaidano G, Gonzales-Barca E, Jurczak W, Kalakonda N, Liberati AM, Maddocks KJ, Menne T, Nagy Z, Tournilhac O, Kuffer C, Bakuli A, Amin A, Gurbanov K, Salles G
Haematologica 2024 Feb 1;109(2):553-566. doi: 10.3324/haematol.2023.283480. PMID: 37646664Free PMC Article
Nowakowski GS, Yoon DH, Mondello P, Joffe E, Peters A, Fleury I, Greil R, Ku M, Marks R, Kim K, Zinzani PL, Trotman J, Sabatelli L, Waltl EE, Winderlich M, Sporchia A, Kurukulasuriya NC, Cordoba R, Hess G, Salles G
Ann Hematol 2023 Jul;102(7):1773-1787. Epub 2023 May 12 doi: 10.1007/s00277-023-05196-4. PMID: 37171597Free PMC Article
Duell J, Maddocks KJ, González-Barca E, Jurczak W, Liberati AM, De Vos S, Nagy Z, Obr A, Gaidano G, Abrisqueta P, Kalakonda N, André M, Dreyling M, Menne T, Tournilhac O, Augustin M, Rosenwald A, Dirnberger-Hertweck M, Weirather J, Ambarkhane S, Salles G
Haematologica 2021 Sep 1;106(9):2417-2426. doi: 10.3324/haematol.2020.275958. PMID: 34196165Free PMC Article
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article
Ng AK, Yahalom J, Goda JS, Constine LS, Pinnix CC, Kelsey CR, Hoppe B, Oguchi M, Suh CO, Wirth A, Qi S, Davies A, Moskowitz CH, Laskar S, Li Y, Mauch PM, Specht L, Illidge T
Int J Radiat Oncol Biol Phys 2018 Mar 1;100(3):652-669. doi: 10.1016/j.ijrobp.2017.12.005. PMID: 29413279

Diagnosis

Vodicka P, Benesova K, Janikova A, Prochazka V, Belada D, Mocikova H, Steinerova K, Duras J, Karban J, Hanackova V, Sykorova A, Obr A, Trneny M
Eur J Haematol 2022 Aug;109(2):162-165. Epub 2022 May 11 doi: 10.1111/ejh.13784. PMID: 35502609
Duell J, Maddocks KJ, González-Barca E, Jurczak W, Liberati AM, De Vos S, Nagy Z, Obr A, Gaidano G, Abrisqueta P, Kalakonda N, André M, Dreyling M, Menne T, Tournilhac O, Augustin M, Rosenwald A, Dirnberger-Hertweck M, Weirather J, Ambarkhane S, Salles G
Haematologica 2021 Sep 1;106(9):2417-2426. doi: 10.3324/haematol.2020.275958. PMID: 34196165Free PMC Article
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article
Ng AK, Yahalom J, Goda JS, Constine LS, Pinnix CC, Kelsey CR, Hoppe B, Oguchi M, Suh CO, Wirth A, Qi S, Davies A, Moskowitz CH, Laskar S, Li Y, Mauch PM, Specht L, Illidge T
Int J Radiat Oncol Biol Phys 2018 Mar 1;100(3):652-669. doi: 10.1016/j.ijrobp.2017.12.005. PMID: 29413279
Friedberg JW
Hematology Am Soc Hematol Educ Program 2011;2011:498-505. doi: 10.1182/asheducation-2011.1.498. PMID: 22160081

Therapy

Duell J, Abrisqueta P, Andre M, Gaidano G, Gonzales-Barca E, Jurczak W, Kalakonda N, Liberati AM, Maddocks KJ, Menne T, Nagy Z, Tournilhac O, Kuffer C, Bakuli A, Amin A, Gurbanov K, Salles G
Haematologica 2024 Feb 1;109(2):553-566. doi: 10.3324/haematol.2023.283480. PMID: 37646664Free PMC Article
Varma G, Goldstein J, Advani RH
Hematol Oncol 2023 Jun;41 Suppl 1:92-106. doi: 10.1002/hon.3143. PMID: 37294966
Nowakowski GS, Yoon DH, Mondello P, Joffe E, Peters A, Fleury I, Greil R, Ku M, Marks R, Kim K, Zinzani PL, Trotman J, Sabatelli L, Waltl EE, Winderlich M, Sporchia A, Kurukulasuriya NC, Cordoba R, Hess G, Salles G
Ann Hematol 2023 Jul;102(7):1773-1787. Epub 2023 May 12 doi: 10.1007/s00277-023-05196-4. PMID: 37171597Free PMC Article
Sehn LH, Hertzberg M, Opat S, Herrera AF, Assouline S, Flowers CR, Kim TM, McMillan A, Ozcan M, Safar V, Salles G, Ku G, Hirata J, Chang YM, Musick L, Matasar MJ
Blood Adv 2022 Jan 25;6(2):533-543. doi: 10.1182/bloodadvances.2021005794. PMID: 34749395Free PMC Article
Ng AK, Yahalom J, Goda JS, Constine LS, Pinnix CC, Kelsey CR, Hoppe B, Oguchi M, Suh CO, Wirth A, Qi S, Davies A, Moskowitz CH, Laskar S, Li Y, Mauch PM, Specht L, Illidge T
Int J Radiat Oncol Biol Phys 2018 Mar 1;100(3):652-669. doi: 10.1016/j.ijrobp.2017.12.005. PMID: 29413279

Prognosis

Izutsu K, Kumode T, Yuda J, Nagai H, Mishima Y, Suehiro Y, Yamamoto K, Fujisaki T, Ishitsuka K, Ishizawa K, Ikezoe T, Nishikori M, Akahane D, Fujita J, Dinh M, Soong D, Noguchi H, Buchbjerg JK, Favaro E, Fukuhara N
Cancer Sci 2023 Dec;114(12):4643-4653. Epub 2023 Nov 3 doi: 10.1111/cas.15996. PMID: 37921363Free PMC Article
Belada D, Kopeckova K, Bergua Burgues JM, Stevens D, André M, Persona EP, Pichler P, Staber PB, Trneny M, Duell J, Waldron-Lynch M, Wagner S, Mukhopadhyay A, Dirnberger-Hertweck M, Burke JM, Nowakowski GS
Blood 2023 Oct 19;142(16):1348-1358. doi: 10.1182/blood.2023020637. PMID: 37369099Free PMC Article
Noel R, Zemmour C, Montes de Oca C, Belmecheri N, Aurran-Schleinitz T, Coso D, Lopez Almeida L, Mescam L, Vey N, Bladé JS, Slama B, Bouabdallah R, Schiano de Colella JM
Hematology 2023 Dec;28(1):2207948. doi: 10.1080/16078454.2023.2207948. PMID: 37133334
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article
Lukenbill J, Hill B
Leuk Lymphoma 2015 Feb;56(2):293-300. Epub 2014 Jun 16 doi: 10.3109/10428194.2014.910660. PMID: 24813764

Clinical prediction guides

Izutsu K, Kumode T, Yuda J, Nagai H, Mishima Y, Suehiro Y, Yamamoto K, Fujisaki T, Ishitsuka K, Ishizawa K, Ikezoe T, Nishikori M, Akahane D, Fujita J, Dinh M, Soong D, Noguchi H, Buchbjerg JK, Favaro E, Fukuhara N
Cancer Sci 2023 Dec;114(12):4643-4653. Epub 2023 Nov 3 doi: 10.1111/cas.15996. PMID: 37921363Free PMC Article
Nowakowski GS, Yoon DH, Mondello P, Joffe E, Peters A, Fleury I, Greil R, Ku M, Marks R, Kim K, Zinzani PL, Trotman J, Sabatelli L, Waltl EE, Winderlich M, Sporchia A, Kurukulasuriya NC, Cordoba R, Hess G, Salles G
Ann Hematol 2023 Jul;102(7):1773-1787. Epub 2023 May 12 doi: 10.1007/s00277-023-05196-4. PMID: 37171597Free PMC Article
Terui Y, Rai S, Izutsu K, Yamaguchi M, Takizawa J, Kuroda J, Ishikawa T, Kato K, Suehiro Y, Fukuhara N, Ohmine K, Goto H, Yamamoto K, Kanemura N, Ueda Y, Ishizawa K, Kumagai K, Kawasaki A, Saito T, Hashizume M, Shibayama H
Cancer Sci 2021 Jul;112(7):2845-2854. Epub 2021 Jun 4 doi: 10.1111/cas.14937. PMID: 33942442Free PMC Article
Vercellino L, Di Blasi R, Kanoun S, Tessoulin B, Rossi C, D'Aveni-Piney M, Obéric L, Bodet-Milin C, Bories P, Olivier P, Lafon I, Berriolo-Riedinger A, Galli E, Bernard S, Rubio MT, Bossard C, Meignin V, Merlet P, Feugier P, Le Gouill S, Ysebaert L, Casasnovas O, Meignan M, Chevret S, Thieblemont C
Blood Adv 2020 Nov 24;4(22):5607-5615. doi: 10.1182/bloodadvances.2020003001. PMID: 33180899Free PMC Article
Awasthi R, Pacaud L, Waldron E, Tam CS, Jäger U, Borchmann P, Jaglowski S, Foley SR, van Besien K, Wagner-Johnston ND, Kersten MJ, Schuster SJ, Salles G, Maziarz RT, Anak Ö, Del Corral C, Chu J, Gershgorin I, Pruteanu-Malinici I, Chakraborty A, Mueller KT, Waller EK
Blood Adv 2020 Feb 11;4(3):560-572. doi: 10.1182/bloodadvances.2019000525. PMID: 32045475Free PMC Article

Recent systematic reviews

Miller SD, Lozano-Ortega G, Mutebi A, Briggs O, Sail K, Elliott B, Kalsekar A
J Comp Eff Res 2023 Jan;12(1):e220146. Epub 2022 Nov 23 doi: 10.2217/cer-2022-0146. PMID: 36417238Free PMC Article
Tian L, Li C, Sun J, Zhai Y, Wang J, Liu S, Jiang Y, Wu W, Xing D, Lv Y, Guo J, Xu H, Sun H, Li Y, Li L, Zhao Z
Front Immunol 2022;13:1041177. Epub 2023 Jan 17 doi: 10.3389/fimmu.2022.1041177. PMID: 36733398Free PMC Article
Carey N, Harte M, Mc Cullagh L
J Clin Epidemiol 2022 Sep;149:53-59. Epub 2022 May 30 doi: 10.1016/j.jclinepi.2022.05.017. PMID: 35654270
Colosia A, Njue A, Trask PC, Olivares R, Khan S, Abbe A, Police R, Wang J, Ruiz-Soto R, Kaye JA, Awan F
Clin Lymphoma Myeloma Leuk 2014 Oct;14(5):343-355.e6. Epub 2014 Mar 1 doi: 10.1016/j.clml.2014.02.012. PMID: 24768510

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...