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Thrombocytopenic purpura

MedGen UID:
208992
•Concept ID:
C0857305
•
Disease or Syndrome
Synonyms: Purpura, Thrombocytopenic; Purpura, Thrombopenic; Purpuras, Thrombocytopenic; Purpuras, Thrombopenic; Thrombocytopenic Purpura; Thrombocytopenic Purpuras; Thrombopenic Purpura; Thrombopenic Purpuras
SNOMED CT: Thrombocytopenic purpura (302873008)
 
Monarch Initiative: MONDO:0043768

Definition

Purpura associated with a reduction in circulating blood platelets which can result from a variety of factors. [from NCI]

Professional guidelines

PubMed

Diagnosis and treatment of thrombotic microangiopathy.
Thompson GL, Kavanagh D
Int J Lab Hematol 2022 Sep;44 Suppl 1(Suppl 1):101-113. doi: 10.1111/ijlh.13954. PMID: 36074708Free PMC Article
ISTH guidelines for treatment of thrombotic thrombocytopenic purpura.
Zheng XL, Vesely SK, Cataland SR, Coppo P, Geldziler B, Iorio A, Matsumoto M, Mustafa RA, Pai M, Rock G, Russell L, Tarawneh R, Valdes J, Peyvandi F
J Thromb Haemost 2020 Oct;18(10):2496-2502. Epub 2020 Sep 11 doi: 10.1111/jth.15010. PMID: 32914526Free PMC Article
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Recent clinical studies

Etiology

How I treat immune-mediated thrombotic thrombocytopenic purpura after hospital discharge.
Akwaa F, Antun A, Cataland SR
Blood 2022 Aug 4;140(5):438-444. doi: 10.1182/blood.2021014514. PMID: 35667044
Advances in the management of TTP.
Subhan M, Scully M
Blood Rev 2022 Sep;55:100945. Epub 2022 Feb 17 doi: 10.1016/j.blre.2022.100945. PMID: 35216839
Idiopathic thrombocytopenic purpura (ITP) - new era for an old disease.
Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H
Rom J Intern Med 2019 Dec 1;57(4):273-283. doi: 10.2478/rjim-2019-0014. PMID: 31199777
Pediatric ITP: is it different from adult ITP?
Despotovic JM, Grimes AB
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):405-411. doi: 10.1182/asheducation-2018.1.405. PMID: 30504339Free PMC Article
Clinical updates in adult immune thrombocytopenia.
Lambert MP, Gernsheimer TB
Blood 2017 May 25;129(21):2829-2835. Epub 2017 Apr 17 doi: 10.1182/blood-2017-03-754119. PMID: 28416506Free PMC Article

Diagnosis

Hematology Emergencies in Critically Ill Adults: Benign Hematology.
Spring J, Munshi L
Chest 2022 May;161(5):1285-1296. Epub 2022 Jan 7 doi: 10.1016/j.chest.2021.12.650. PMID: 35007552
Idiopathic thrombocytopenic purpura (ITP) - new era for an old disease.
Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H
Rom J Intern Med 2019 Dec 1;57(4):273-283. doi: 10.2478/rjim-2019-0014. PMID: 31199777
An update on pathogenesis and diagnosis of thrombotic thrombocytopenic purpura.
Joly BS, Coppo P, Veyradier A
Expert Rev Hematol 2019 Jun;12(6):383-395. Epub 2019 May 20 doi: 10.1080/17474086.2019.1611423. PMID: 31107120
Thrombotic thrombocytopenic purpura.
Atrash S, Sajjad H, Jeanette R, Konstantinos A
J Ark Med Soc 2015 Feb;111(9):187-9. PMID: 25993768
Immune thrombocytopenia.
Kistangari G, McCrae KR
Hematol Oncol Clin North Am 2013 Jun;27(3):495-520. doi: 10.1016/j.hoc.2013.03.001. PMID: 23714309Free PMC Article

Therapy

Recent progress in ITP treatment.
Rodeghiero F
Int J Hematol 2023 Mar;117(3):316-330. Epub 2023 Jan 9 doi: 10.1007/s12185-022-03527-1. PMID: 36622549
The standard of care for immune thrombotic thrombocytopenic purpura today.
Zheng XL
J Thromb Haemost 2021 Aug;19(8):1864-1871. Epub 2021 Jun 30 doi: 10.1111/jth.15406. PMID: 34060225Free PMC Article
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment.
Miltiadous O, Hou M, Bussel JB
Blood 2020 Feb 13;135(7):472-490. doi: 10.1182/blood.2019003599. PMID: 31756253Free PMC Article
Thrombopoietin receptor agonists: ten years later.
Ghanima W, Cooper N, Rodeghiero F, Godeau B, Bussel JB
Haematologica 2019 Jun;104(6):1112-1123. Epub 2019 May 9 doi: 10.3324/haematol.2018.212845. PMID: 31073079Free PMC Article
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.
Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators
N Engl J Med 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9 doi: 10.1056/NEJMoa1806311. PMID: 30625070

Prognosis

Long-term follow-up of patients treated with caplacizumab and safety and efficacy of repeat caplacizumab use: Post-HERCULES study.
Scully M, de la Rubia J, Pavenski K, Metjian A, Knöbl P, Peyvandi F, Cataland S, Coppo P, Kremer Hovinga JA, Minkue Mi Edou J, De Passos Sousa R, Callewaert F, Gunawardena S, Lin J
J Thromb Haemost 2022 Dec;20(12):2810-2822. Epub 2022 Oct 21 doi: 10.1111/jth.15892. PMID: 36138517Free PMC Article
Epidemiology and Clinical Manifestations of Immune Thrombocytopenia.
Kohli R, Chaturvedi S
Hamostaseologie 2019 Aug;39(3):238-249. Epub 2019 Mar 13 doi: 10.1055/s-0039-1683416. PMID: 30868551
Etiology and Outcomes of Thrombotic Microangiopathies.
Bayer G, von Tokarski F, Thoreau B, Bauvois A, Barbet C, Cloarec S, Mérieau E, Lachot S, Garot D, Bernard L, Gyan E, Perrotin F, Pouplard C, Maillot F, Gatault P, Sautenet B, Rusch E, Buchler M, Vigneau C, Fakhouri F, Halimi JM
Clin J Am Soc Nephrol 2019 Apr 5;14(4):557-566. Epub 2019 Mar 12 doi: 10.2215/CJN.11470918. PMID: 30862697Free PMC Article
Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry.
Mansouri Taleghani M, von Krogh AS, Fujimura Y, George JN, Hrachovinová I, Knöbl PN, Quist-Paulsen P, Schneppenheim R, Lämmle B, Kremer Hovinga JA
Hamostaseologie 2013 May 29;33(2):138-43. doi: 10.5482/HAMO-13-04-0026. PMID: 23715103
Post-varicella thrombocytopenic purpura.
Amir A, Gilad O, Yacobovich J, Scheuerman O, Tamary H, Garty BZ
Acta Paediatr 2010 Sep;99(9):1385-8. doi: 10.1111/j.1651-2227.2010.01842.x. PMID: 20456262

Clinical prediction guides

Thrombotic microangiopathy during pregnancy.
Zununi Vahed S, Rahbar Saadat Y, Ardalan M
Microvasc Res 2021 Nov;138:104226. Epub 2021 Jul 9 doi: 10.1016/j.mvr.2021.104226. PMID: 34252400
Clinical and laboratory diagnosis of TTP: an integrated approach.
Chiasakul T, Cuker A
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):530-538. doi: 10.1182/asheducation-2018.1.530. PMID: 30504354Free PMC Article
Pediatric thrombotic thrombocytopenic purpura.
Joly BS, Coppo P, Veyradier A
Eur J Haematol 2018 Oct;101(4):425-434. Epub 2018 Aug 22 doi: 10.1111/ejh.13107. PMID: 29889319
Thrombotic microangiopathies of pregnancy: Differential diagnosis.
Gupta M, Feinberg BB, Burwick RM
Pregnancy Hypertens 2018 Apr;12:29-34. Epub 2018 Feb 16 doi: 10.1016/j.preghy.2018.02.007. PMID: 29674195
Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group.
Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kühne T, Ruggeri M, George JN
Blood 2009 Mar 12;113(11):2386-93. Epub 2008 Nov 12 doi: 10.1182/blood-2008-07-162503. PMID: 19005182

Recent systematic reviews

Pediatric refractory immune thrombocytopenia: A systematic review.
Ibrahim L, Dong SX, O'Hearn K, Grimes AB, Kaicker S, FritchLilla S, Breakey VR, Grace RF, Lebensburger JD, Klaassen RJ, Lambert M
Pediatr Blood Cancer 2023 Mar;70(3):e30173. Epub 2022 Dec 29 doi: 10.1002/pbc.30173. PMID: 36579787
Thrombotic thrombocytopenic purpura (TTP) after COVID-19 vaccination: A systematic review of reported cases.
Saluja P, Gautam N, Yadala S, Venkata AN
Thromb Res 2022 Jun;214:115-121. Epub 2022 May 2 doi: 10.1016/j.thromres.2022.04.020. PMID: 35533526Free PMC Article
Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis.
Kim AY, Woo W, Yon DK, Lee SW, Yang JW, Kim JH, Park S, Koyanagi A, Kim MS, Lee S, Shin JI, Smith L
Int J Infect Dis 2022 Jun;119:130-139. Epub 2022 Mar 24 doi: 10.1016/j.ijid.2022.03.034. PMID: 35339716Free PMC Article
Vaccines for measles, mumps, rubella, and varicella in children.
Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli V
Cochrane Database Syst Rev 2020 Apr 20;4(4):CD004407. doi: 10.1002/14651858.CD004407.pub4. PMID: 32309885Free PMC Article
Drug-induced thrombotic microangiopathy: a systematic review of published reports.
Al-Nouri ZL, Reese JA, Terrell DR, Vesely SK, George JN
Blood 2015 Jan 22;125(4):616-8. Epub 2014 Nov 20 doi: 10.1182/blood-2014-11-611335. PMID: 25414441Free PMC Article

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