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Dedifferentiated chondrosarcoma

MedGen UID:
209021
•Concept ID:
C0862878
•
Neoplastic Process
Synonyms: DDCHS; Dedifferentiated Chondrosarcoma; dedifferentiated chondrosarcoma
SNOMED CT: Dedifferentiated chondrosarcoma (128776008)
 
Monarch Initiative: MONDO:0005013

Definition

An aggressive morphologic variant of chondrosarcoma. It is composed of a low grade chondrosarcoma and a high grade non-cartilagenous sarcomatous component. Due to the aggressive nature of the disease, its prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDedifferentiated chondrosarcoma

Professional guidelines

PubMed

Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Clinical features and treatment outcomes of dedifferentiated and grade 3 chondrosarcoma: A multi-institutional study.
Kozawa E, Nishida Y, Kawai A, Hayakawa K, Setsu N, Kawashima H, Iwata S, Tsuchiya H, Tsukushi S, Takenaka S, Imanishi J, Baba I, Nagano A, Morii T, Shirai T, Shimizu K, Kawano H
Cancer Sci 2022 Jul;113(7):2397-2408. Epub 2022 May 18 doi: 10.1111/cas.15382. PMID: 35485870Free PMC Article
Prognostic Factors and Treatment Options for Patients with High-Grade Chondrosarcoma.
Gao Z, Lu T, Song H, Gao Z, Ren F, Ouyang P, Wang Y, Zhu J, Zhou S, He X
Med Sci Monit 2019 Nov 25;25:8952-8967. doi: 10.12659/MSM.917959. PMID: 31765367Free PMC Article

Recent clinical studies

Etiology

Clinical features and treatment outcomes of dedifferentiated and grade 3 chondrosarcoma: A multi-institutional study.
Kozawa E, Nishida Y, Kawai A, Hayakawa K, Setsu N, Kawashima H, Iwata S, Tsuchiya H, Tsukushi S, Takenaka S, Imanishi J, Baba I, Nagano A, Morii T, Shirai T, Shimizu K, Kawano H
Cancer Sci 2022 Jul;113(7):2397-2408. Epub 2022 May 18 doi: 10.1111/cas.15382. PMID: 35485870Free PMC Article
Dedifferentiated chondrosarcoma: Radiological features, prognostic factors and survival statistics in 23 patients.
Liu C, Xi Y, Li M, Jiao Q, Zhang H, Yang Q, Yao W
PLoS One 2017;12(3):e0173665. Epub 2017 Mar 16 doi: 10.1371/journal.pone.0173665. PMID: 28301537Free PMC Article
The many faces of chondrosarcoma of bone, own cases and review of the literature with an emphasis on radiology, pathology and treatment.
Herget GW, Uhl M, Opitz OG, Adler CP, Südkamp NP, Knöller S
Acta Chir Orthop Traumatol Cech 2011;78(6):501-9. PMID: 22217402
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896
Dedifferentiated chondrosarcoma.
Capanna R, Bertoni F, Bettelli G, Picci P, Bacchini P, Present D, Giunti A, Campanacci M
J Bone Joint Surg Am 1988 Jan;70(1):60-9. PMID: 3335575

Diagnosis

Dedifferentiated chondrosarcoma: current standards of care.
Kattepur AK, Jones RL, Gulia A
Future Oncol 2021 Dec;17(35):4983-4991. Epub 2021 Nov 4 doi: 10.2217/fon-2021-0830. PMID: 34734747
Dedifferentiated and undifferentiated neoplasms: A conceptual approach.
Baraban E, Cooper K
Semin Diagn Pathol 2021 Nov;38(6):119-126. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.002. PMID: 32948384
Dedifferentiated chondrosarcoma revisited.
Mavrogenis AF, Ruggieri P, Mercuri M, Papagelopoulos PJ
J Surg Orthop Adv 2011 Summer;20(2):106-11. PMID: 21838071
The clinical approach towards chondrosarcoma.
Gelderblom H, Hogendoorn PC, Dijkstra SD, van Rijswijk CS, Krol AD, Taminiau AH, Bovée JV
Oncologist 2008 Mar;13(3):320-9. doi: 10.1634/theoncologist.2007-0237. PMID: 18378543
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Therapy

Outcome in dedifferentiated chondrosarcoma for patients treated with multimodal therapy: Results from the EUROpean Bone Over 40 Sarcoma Study.
Hompland I, Ferrari S, Bielack S, Palmerini E, Hall KS, Picci P, Hecker-Nolting S, Donati DM, Blattmann C, Bjerkehagen B, Staals E, Kager L, Gambarotti M, Kühne T, Eriksson M, Ferraresi V, Kevric M, Biagini R, Baumhoer D, Brosjø O, Comandone A, Schwarz R, Bertulli R, Kessler T, Hansson L, Apice G, Heydrich BN, Setola E, Flörcken A, Ruggieri P, Krasniqi F, Hofmann-Wackersreuther G, Casali P, Reichardt P, Smeland S
Eur J Cancer 2021 Jul;151:150-158. Epub 2021 May 11 doi: 10.1016/j.ejca.2021.04.017. PMID: 33990016
Dedifferentiated Chondrosarcoma Demonstrating Osteosarcomatous Differentiation.
Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785
Radiation-induced dedifferentiated chondrosarcoma with orbital invasion.
Davies BW, Prescott CR, Said SA, Campana J, Attié-Castro FA, Velasco E Cruz AA, Durairaj VD
Ophthalmic Plast Reconstr Surg 2014 May-Jun;30(3):205-8. doi: 10.1097/IOP.0000000000000168. PMID: 24807535
Does ifosfamide therapy improve survival of patients with dedifferentiated chondrosarcoma?
Kawaguchi S, Sun T, Lin PP, Deavers M, Harun N, Lewis VO
Clin Orthop Relat Res 2014 Mar;472(3):983-9. Epub 2013 Nov 7 doi: 10.1007/s11999-013-3360-5. PMID: 24197392Free PMC Article
Grade 1 chondrosarcoma of bone: a diagnostic and treatment dilemma.
Randall RL, Gowski W
J Natl Compr Canc Netw 2005 Mar;3(2):149-56. doi: 10.6004/jnccn.2005.0011. PMID: 19817027

Prognosis

Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options.
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Dedifferentiated chondrosarcoma: current standards of care.
Kattepur AK, Jones RL, Gulia A
Future Oncol 2021 Dec;17(35):4983-4991. Epub 2021 Nov 4 doi: 10.2217/fon-2021-0830. PMID: 34734747
Dedifferentiated chondrosarcoma revisited.
Mavrogenis AF, Ruggieri P, Mercuri M, Papagelopoulos PJ
J Surg Orthop Adv 2011 Summer;20(2):106-11. PMID: 21838071
The clinical approach towards chondrosarcoma.
Gelderblom H, Hogendoorn PC, Dijkstra SD, van Rijswijk CS, Krol AD, Taminiau AH, Bovée JV
Oncologist 2008 Mar;13(3):320-9. doi: 10.1634/theoncologist.2007-0237. PMID: 18378543
Dedifferentiated chondrosarcoma.
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Clinical prediction guides

Prognostic Significance of Percentage and Size of Dedifferentiation in Dedifferentiated Chondrosarcoma.
Hung YP, Chebib I, Bredella MA, Berner EA, Taylor-Black Q, Choy E, Cote GM, Chen YL, MacDonald SM, Schwab JH, Raskin KA, Newman ET, Selig MK, Deshpande V, Hornick JL, Lozano-Calderón SA, Nielsen GP
Mod Pathol 2023 Mar;36(3):100069. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100069. PMID: 36788104
Peripheral and periosteal chondrosarcoma: MRI-pathological correlation in 58 cases.
Tilden W, Andrei V, O'Donnell P, Saifuddin A
Skeletal Radiol 2022 Jun;51(6):1189-1199. Epub 2021 Oct 29 doi: 10.1007/s00256-021-03947-w. PMID: 34714386
Targeted Next-Generation Sequencing Identifies Molecular and Genetic Events in Dedifferentiated Chondrosarcoma.
Lucas CG, Grenert JP, Horvai A
Arch Pathol Lab Med 2021 Aug 1;145(8):1009-1017. doi: 10.5858/arpa.2020-0379-OA. PMID: 33147331
Pathological fracture does not affect prognosis in dedifferentiated chondrosarcoma of the limbs.
Sambri A, Tuzzato G, Donati DM, De Paolis M, Bianchi G
J Orthop Sci 2021 May;26(3):473-477. Epub 2020 Jun 18 doi: 10.1016/j.jos.2020.04.013. PMID: 32564907
Can Machine-learning Techniques Be Used for 5-year Survival Prediction of Patients With Chondrosarcoma?
Thio QCBS, Karhade AV, Ogink PT, Raskin KA, De Amorim Bernstein K, Lozano Calderon SA, Schwab JH
Clin Orthop Relat Res 2018 Oct;476(10):2040-2048. doi: 10.1097/CORR.0000000000000433. PMID: 30179954Free PMC Article

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