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Nephrotic Syndrome with Lesion of Hypocomplementemic Glomerulonephritis

MedGen UID:
209027
•Concept ID:
C0866112
•
Disease or Syndrome

Definition

Nephrotic syndrome caused by glomerulonephritis associated with complement deficiency. It can result from an acute post-infectious glomerulonephritis, membranoproliferative glomerulonephritis or lupus glomerulonephritis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrotic Syndrome with Lesion of Hypocomplementemic Glomerulonephritis

Professional guidelines

PubMed

Treatment of hepatitis C-related kidney disease.
Fabrizi F, Martin P, Cacoub P, Messa P, Donato FM
Expert Opin Pharmacother 2015;16(12):1815-27. Epub 2015 Jul 10 doi: 10.1517/14656566.2015.1066333. PMID: 26161511
Immunosuppressive treatment of the nephrotic syndrome due to mesangial lesions.
Faedda R, Pirisi M, Satta A, Tanda F, Bartoli E
Clin Nephrol 1996 Oct;46(4):237-44. PMID: 8905208
Is renal biopsy justified for the diagnosis and management of the nephrotic syndrome in the elderly?
Moran D, Korzets Z, Bernheim J, Bernheim J, Yaretzky A
Gerontology 1993;39(1):49-54. doi: 10.1159/000213514. PMID: 8440490

Recent clinical studies

Etiology

Epidemiology of Pediatric Renal Diseases and its Histopathological Spectrum - A Single-Center Experience from India.
Yadav S, Kandalkar B
Saudi J Kidney Dis Transpl 2021 Nov-Dec;32(6):1744-1753. doi: 10.4103/1319-2442.352437. PMID: 35946289
Clinical and morphologic spectrum of renal involvement in patients with HBV-associated cryoglobulinaemia.
Li SJ, Xu ST, Chen HP, Zhang MC, Xu F, Cheng SQ, Liu ZH
Nephrology (Carlton) 2017 Jun;22(6):449-455. doi: 10.1111/nep.12795. PMID: 27062412
Hepatitis C and renal disease: epidemiology, diagnosis, pathogenesis and therapy.
Morales JM, Kamar N, Rostaing L
Contrib Nephrol 2012;176:10-23. Epub 2012 Jan 30 doi: 10.1159/000333772. PMID: 22310777
Spectrum of glomerulonephritides in adults with nephrotic syndrome in Pakistan.
Kazi JI, Mubarak M, Ahmed E, Akhter F, Naqvi SA, Rizvi SA
Clin Exp Nephrol 2009 Feb;13(1):38-43. Epub 2008 Aug 7 doi: 10.1007/s10157-008-0075-0. PMID: 18685922
Virus-related glomerular diseases: histological and clinical aspects.
di Belgiojoso GB, Ferrario F, Landriani N
J Nephrol 2002 Sep-Oct;15(5):469-79. PMID: 12455712

Diagnosis

Epidemiology of Pediatric Renal Diseases and its Histopathological Spectrum - A Single-Center Experience from India.
Yadav S, Kandalkar B
Saudi J Kidney Dis Transpl 2021 Nov-Dec;32(6):1744-1753. doi: 10.4103/1319-2442.352437. PMID: 35946289
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective.
Bridoux F, Javaugue V, Nasr SH, Leung N
Nephrol Dial Transplant 2021 Jan 25;36(2):208-215. doi: 10.1093/ndt/gfz176. PMID: 33494099
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.
Higashihara T, Okada A, Nakamura Y, Saigusa H, Homma S, Matsumura M, Kusano T, Shimizu A, Takano H
Intern Med 2020 Feb 15;59(4):557-562. Epub 2019 Oct 15 doi: 10.2169/internalmedicine.2993-19. PMID: 31611527Free PMC Article
Clinical and morphologic spectrum of renal involvement in patients with HBV-associated cryoglobulinaemia.
Li SJ, Xu ST, Chen HP, Zhang MC, Xu F, Cheng SQ, Liu ZH
Nephrology (Carlton) 2017 Jun;22(6):449-455. doi: 10.1111/nep.12795. PMID: 27062412
Hepatitis C and renal disease: epidemiology, diagnosis, pathogenesis and therapy.
Morales JM, Kamar N, Rostaing L
Contrib Nephrol 2012;176:10-23. Epub 2012 Jan 30 doi: 10.1159/000333772. PMID: 22310777

Therapy

Cyclosporine therapy could be considered for membranoproliferative glomerulonephritis with immunoglobulin A deposits: a case report.
Hidaka Y, Tamura H, Furuie K, Kuraoka S, Nagata H, Nakazato H
BMC Nephrol 2022 Nov 7;23(1):358. doi: 10.1186/s12882-022-02983-5. PMID: 36344919Free PMC Article
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Clinical and morphologic spectrum of renal involvement in patients with HBV-associated cryoglobulinaemia.
Li SJ, Xu ST, Chen HP, Zhang MC, Xu F, Cheng SQ, Liu ZH
Nephrology (Carlton) 2017 Jun;22(6):449-455. doi: 10.1111/nep.12795. PMID: 27062412
Treatment of hepatitis C-related kidney disease.
Fabrizi F, Martin P, Cacoub P, Messa P, Donato FM
Expert Opin Pharmacother 2015;16(12):1815-27. Epub 2015 Jul 10 doi: 10.1517/14656566.2015.1066333. PMID: 26161511
Hepatitis C and renal disease: epidemiology, diagnosis, pathogenesis and therapy.
Morales JM, Kamar N, Rostaing L
Contrib Nephrol 2012;176:10-23. Epub 2012 Jan 30 doi: 10.1159/000333772. PMID: 22310777

Prognosis

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective.
Bridoux F, Javaugue V, Nasr SH, Leung N
Nephrol Dial Transplant 2021 Jan 25;36(2):208-215. doi: 10.1093/ndt/gfz176. PMID: 33494099
Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.
Higashihara T, Okada A, Nakamura Y, Saigusa H, Homma S, Matsumura M, Kusano T, Shimizu A, Takano H
Intern Med 2020 Feb 15;59(4):557-562. Epub 2019 Oct 15 doi: 10.2169/internalmedicine.2993-19. PMID: 31611527Free PMC Article
Pathology of idiopathic nephrotic syndrome in children: are the adolescents different from young children?
Mubarak M, Kazi JI, Lanewala A, Hashmi S, Akhter F
Nephrol Dial Transplant 2012 Feb;27(2):722-6. Epub 2011 May 5 doi: 10.1093/ndt/gfr221. PMID: 21551090
Virus-related glomerular diseases: histological and clinical aspects.
di Belgiojoso GB, Ferrario F, Landriani N
J Nephrol 2002 Sep-Oct;15(5):469-79. PMID: 12455712

Clinical prediction guides

Clinical and morphologic spectrum of renal involvement in idiopathic hypereosinophilic syndrome.
Dong JH, Xu ST, Xu F, Zhou YC, Li Z, Li SJ
Clin Exp Nephrol 2021 Mar;25(3):270-278. Epub 2021 Jan 4 doi: 10.1007/s10157-020-02012-5. PMID: 33398597
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.
Higashihara T, Okada A, Nakamura Y, Saigusa H, Homma S, Matsumura M, Kusano T, Shimizu A, Takano H
Intern Med 2020 Feb 15;59(4):557-562. Epub 2019 Oct 15 doi: 10.2169/internalmedicine.2993-19. PMID: 31611527Free PMC Article
Clinical and morphologic spectrum of renal involvement in patients with HBV-associated cryoglobulinaemia.
Li SJ, Xu ST, Chen HP, Zhang MC, Xu F, Cheng SQ, Liu ZH
Nephrology (Carlton) 2017 Jun;22(6):449-455. doi: 10.1111/nep.12795. PMID: 27062412
Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil.
dos-Santos WL, Sweet GM, Bahiense-Oliveira M, Rocha PN
Mem Inst Oswaldo Cruz 2011 Nov;106(7):901-4. doi: 10.1590/s0074-02762011000700017. PMID: 22124564
Pathology, clinical presentations, and outcomes of C1q nephropathy.
Vizjak A, Ferluga D, Rozic M, Hvala A, Lindic J, Levart TK, Jurcić V, Jennette JC
J Am Soc Nephrol 2008 Nov;19(11):2237-44. Epub 2008 Jul 23 doi: 10.1681/ASN.2007080929. PMID: 18650484Free PMC Article

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