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DNA Strand Break

MedGen UID:
209054
•Concept ID:
C0872150
•
Cell or Molecular Dysfunction

Definition

A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in one or in both strands of a DNA molecule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Strand Break

Professional guidelines

PubMed

Management of hereditary breast and ovarian cancer.
Yamauchi H, Takei J
Int J Clin Oncol 2018 Feb;23(1):45-51. Epub 2017 Nov 28 doi: 10.1007/s10147-017-1208-9. PMID: 29185095
Characterization, Detection, and Treatment Approaches for Homologous Recombination Deficiency in Cancer.
O'Kane GM, Connor AA, Gallinger S
Trends Mol Med 2017 Dec;23(12):1121-1137. Epub 2017 Nov 10 doi: 10.1016/j.molmed.2017.10.007. PMID: 29133135
Taxane- and epothilone-based chemotherapy: from molecule cargo cytoskeletal logistics to management of castration-resistant prostate carcinoma.
Alberti C
Eur Rev Med Pharmacol Sci 2013 Jun;17(12):1658-64. PMID: 23832735

Recent clinical studies

Etiology

Neurological disorders associated with DNA strand-break processing enzymes.
Jiang B, Glover JN, Weinfeld M
Mech Ageing Dev 2017 Jan;161(Pt A):130-140. Epub 2016 Jul 25 doi: 10.1016/j.mad.2016.07.009. PMID: 27470939Free PMC Article
Evidence for DNA damage as a biological link between diabetes and cancer.
Lee SC, Chan JC
Chin Med J (Engl) 2015 Jun 5;128(11):1543-8. doi: 10.4103/0366-6999.157693. PMID: 26021514Free PMC Article
Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress.
Morath J, Moreno-Villanueva M, Hamuni G, Kolassa S, Ruf-Leuschner M, Schauer M, Elbert T, Bürkle A, Kolassa IT
Psychother Psychosom 2014;83(5):289-97. Epub 2014 Aug 6 doi: 10.1159/000362739. PMID: 25116690
Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability.
Hartwig A, Asmuss M, Blessing H, Hoffmann S, Jahnke G, Khandelwal S, Pelzer A, Bürkle A
Food Chem Toxicol 2002 Aug;40(8):1179-84. doi: 10.1016/s0278-6915(02)00043-1. PMID: 12067581
Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR.
Pfeifer GP, Drouin R, Holmquist GP
Mutat Res 1993 Jul;288(1):39-46. doi: 10.1016/0027-5107(93)90206-u. PMID: 7686264

Diagnosis

Tumor hypoxia as a modifier of DNA strand break and cross-link repair.
Chan N, Koch CJ, Bristow RG
Curr Mol Med 2009 May;9(4):401-10. doi: 10.2174/156652409788167050. PMID: 19519397
Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability.
Hartwig A, Asmuss M, Blessing H, Hoffmann S, Jahnke G, Khandelwal S, Pelzer A, Bürkle A
Food Chem Toxicol 2002 Aug;40(8):1179-84. doi: 10.1016/s0278-6915(02)00043-1. PMID: 12067581
The comet assay: a comprehensive review.
Fairbairn DW, Olive PL, O'Neill KL
Mutat Res 1995 Feb;339(1):37-59. doi: 10.1016/0165-1110(94)00013-3. PMID: 7877644
Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR.
Pfeifer GP, Drouin R, Holmquist GP
Mutat Res 1993 Jul;288(1):39-46. doi: 10.1016/0027-5107(93)90206-u. PMID: 7686264
DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma rays.
Van der Schans GP, Paterson MC, Cross WG
Int J Radiat Biol Relat Stud Phys Chem Med 1983 Jul;44(1):75-85. doi: 10.1080/09553008314550881. PMID: 6602790

Therapy

Inhibitors of DNA double-strand break repair at the crossroads of cancer therapy and genome editing.
Ray U, Raghavan SC
Biochem Pharmacol 2020 Dec;182:114195. Epub 2020 Aug 13 doi: 10.1016/j.bcp.2020.114195. PMID: 32798465
Perspectives on PARPs in S Phase.
Hanzlikova H, Caldecott KW
Trends Genet 2019 Jun;35(6):412-422. Epub 2019 Apr 26 doi: 10.1016/j.tig.2019.03.008. PMID: 31036342
Effects of psychotherapy on DNA strand break accumulation originating from traumatic stress.
Morath J, Moreno-Villanueva M, Hamuni G, Kolassa S, Ruf-Leuschner M, Schauer M, Elbert T, Bürkle A, Kolassa IT
Psychother Psychosom 2014;83(5):289-97. Epub 2014 Aug 6 doi: 10.1159/000362739. PMID: 25116690
Targeted cancer therapies based on the inhibition of DNA strand break repair.
O'Connor MJ, Martin NM, Smith GC
Oncogene 2007 Dec 10;26(56):7816-24. doi: 10.1038/sj.onc.1210879. PMID: 18066095
Role of abnormal methionine metabolism in alcoholic liver injury.
Lu SC, Tsukamoto H, Mato JM
Alcohol 2002 Jul;27(3):155-62. doi: 10.1016/s0741-8329(02)00226-4. PMID: 12163143

Prognosis

Transcriptional roles of PARP1 in cancer.
Schiewer MJ, Knudsen KE
Mol Cancer Res 2014 Aug;12(8):1069-80. Epub 2014 Jun 10 doi: 10.1158/1541-7786.MCR-13-0672. PMID: 24916104Free PMC Article
Tumor hypoxia as a modifier of DNA strand break and cross-link repair.
Chan N, Koch CJ, Bristow RG
Curr Mol Med 2009 May;9(4):401-10. doi: 10.2174/156652409788167050. PMID: 19519397
Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites.
Srinivasan A, Lehmler HJ, Robertson LW, Ludewig G
Toxicol Sci 2001 Mar;60(1):92-102. doi: 10.1093/toxsci/60.1.92. PMID: 11222876
DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma rays.
Van der Schans GP, Paterson MC, Cross WG
Int J Radiat Biol Relat Stud Phys Chem Med 1983 Jul;44(1):75-85. doi: 10.1080/09553008314550881. PMID: 6602790
Induction and repair of DNA damage in normal and ataxia-telangiectasia skin fibroblasts treated with neocarzinostatin.
Shiloh Y, van der Schans GP, Lohman PH, Becker Y
Carcinogenesis 1983;4(7):917-21. doi: 10.1093/carcin/4.7.917. PMID: 6223717

Clinical prediction guides

Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy.
Krüger A, Bürkle A, Hauser K, Mangerich A
Nat Commun 2020 May 1;11(1):2174. doi: 10.1038/s41467-020-15858-w. PMID: 32358582Free PMC Article
DNA strand break repair and neurodegeneration.
Rulten SL, Caldecott KW
DNA Repair (Amst) 2013 Aug;12(8):558-67. Epub 2013 May 24 doi: 10.1016/j.dnarep.2013.04.008. PMID: 23712058
Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells.
Garm C, Moreno-Villanueva M, Bürkle A, Petersen I, Bohr VA, Christensen K, Stevnsner T
Aging Cell 2013 Feb;12(1):58-66. Epub 2012 Nov 26 doi: 10.1111/acel.12019. PMID: 23088435Free PMC Article
Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability.
Hartwig A, Asmuss M, Blessing H, Hoffmann S, Jahnke G, Khandelwal S, Pelzer A, Bürkle A
Food Chem Toxicol 2002 Aug;40(8):1179-84. doi: 10.1016/s0278-6915(02)00043-1. PMID: 12067581
Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation.
Masutani M, Nozaki T, Wakabayashi K, Sugimura T
Biochimie 1995;77(6):462-5. doi: 10.1016/0300-9084(96)88161-2. PMID: 7578430

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