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Pelvic organ prolapse

MedGen UID:
209090
•Concept ID:
C0877015
•
Disease or Syndrome
Synonyms: Organ Prolapse, Pelvic; Organ Prolapses, Pelvic; Pelvic Organ Prolapse; Pelvic Organ Prolapses; Prolapse, Pelvic Organ; Prolapse, Urogenital; Prolapses, Pelvic Organ; Prolapses, Urogenital; Urogenital Prolapse; Urogenital Prolapses
 
HPO: HP:0031607
Monarch Initiative: MONDO:0000082

Definition

Weakness in the supporting structures of the pelvic floor allowing the pelvic viscera to descend or one or more of the pelvic organs drop from their normal position. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPelvic organ prolapse

Professional guidelines

PubMed

Evaluation and Management of Pelvic Organ Prolapse.
Raju R, Linder BJ
Mayo Clin Proc 2021 Dec;96(12):3122-3129. doi: 10.1016/j.mayocp.2021.09.005. PMID: 34863399
Pelvic floor physical therapy in the treatment of pelvic floor dysfunction in women.
Wallace SL, Miller LD, Mishra K
Curr Opin Obstet Gynecol 2019 Dec;31(6):485-493. doi: 10.1097/GCO.0000000000000584. PMID: 31609735
Urinary Incontinence in Women: Evaluation and Management.
Hu JS, Pierre EF
Am Fam Physician 2019 Sep 15;100(6):339-348. PMID: 31524367

Recent clinical studies

Etiology

Urinary Incontinence and Pelvic Organ Prolapse in Women.
Tunn R, Baessler K, Knüpfer S, Hampel C
Dtsch Arztebl Int 2023 Feb 3;120(5):71-80. doi: 10.3238/arztebl.m2022.0406. PMID: 36647585Free PMC Article
Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis.
Schulten SFM, Claas-Quax MJ, Weemhoff M, van Eijndhoven HW, van Leijsen SA, Vergeldt TF, IntHout J, Kluivers KB
Am J Obstet Gynecol 2022 Aug;227(2):192-208. Epub 2022 Apr 30 doi: 10.1016/j.ajog.2022.04.046. PMID: 35500611
Evaluation and Management of Pelvic Organ Prolapse.
Raju R, Linder BJ
Mayo Clin Proc 2021 Dec;96(12):3122-3129. doi: 10.1016/j.mayocp.2021.09.005. PMID: 34863399
Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse.
Weintraub AY, Glinter H, Marcus-Braun N
Int Braz J Urol 2020 Jan-Feb;46(1):5-14. doi: 10.1590/S1677-5538.IBJU.2018.0581. PMID: 31851453Free PMC Article
Pelvic Organ Prolapse.
American College of Obstetricians and Gynecologists and the American Urogynecologic Society; INTERIM UPDATE: This Practice Bulletin is updated as highlighted to reflect the US Food and Drug Administration order to stop the sale of transvaginal synthetic mesh products for the repair of pelvic organ prolapse.
Female Pelvic Med Reconstr Surg 2019 Nov/Dec;25(6):397-408. doi: 10.1097/SPV.0000000000000794. PMID: 31663890

Diagnosis

Pelvic Organ Prolapse.
Collins S, Lewicky-Gaupp C
Gastroenterol Clin North Am 2022 Mar;51(1):177-193. Epub 2022 Jan 8 doi: 10.1016/j.gtc.2021.10.011. PMID: 35135661
Evaluation and Management of Pelvic Organ Prolapse.
Raju R, Linder BJ
Mayo Clin Proc 2021 Dec;96(12):3122-3129. doi: 10.1016/j.mayocp.2021.09.005. PMID: 34863399
Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse.
Weintraub AY, Glinter H, Marcus-Braun N
Int Braz J Urol 2020 Jan-Feb;46(1):5-14. doi: 10.1590/S1677-5538.IBJU.2018.0581. PMID: 31851453Free PMC Article
Pelvic Floor Disorders.
Good MM, Solomon ER
Obstet Gynecol Clin North Am 2019 Sep;46(3):527-540. doi: 10.1016/j.ogc.2019.04.010. PMID: 31378293
Pelvic Organ Prolapse.
Iglesia CB, Smithling KR
Am Fam Physician 2017 Aug 1;96(3):179-185. PMID: 28762694

Therapy

Effect of Pessary vs Surgery on Patient-Reported Improvement in Patients With Symptomatic Pelvic Organ Prolapse: A Randomized Clinical Trial.
van der Vaart LR, Vollebregt A, Milani AL, Lagro-Janssen AL, Duijnhoven RG, Roovers JWR, van der Vaart CH
JAMA 2022 Dec 20;328(23):2312-2323. doi: 10.1001/jama.2022.22385. PMID: 36538310Free PMC Article
Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis.
Schulten SFM, Claas-Quax MJ, Weemhoff M, van Eijndhoven HW, van Leijsen SA, Vergeldt TF, IntHout J, Kluivers KB
Am J Obstet Gynecol 2022 Aug;227(2):192-208. Epub 2022 Apr 30 doi: 10.1016/j.ajog.2022.04.046. PMID: 35500611
Pessaries (mechanical devices) for managing pelvic organ prolapse in women.
Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Surgery for women with pelvic organ prolapse with or without stress urinary incontinence.
Baessler K, Christmann-Schmid C, Maher C, Haya N, Crawford TJ, Brown J
Cochrane Database Syst Rev 2018 Aug 19;8(8):CD013108. doi: 10.1002/14651858.CD013108. PMID: 30121956Free PMC Article
Surgical management of pelvic organ prolapse in women.
Maher C, Feiner B, Baessler K, Schmid C
Cochrane Database Syst Rev 2013 Apr 30;(4):CD004014. doi: 10.1002/14651858.CD004014.pub5. PMID: 23633316

Prognosis

Urinary Incontinence and Pelvic Organ Prolapse in Women.
Tunn R, Baessler K, Knüpfer S, Hampel C
Dtsch Arztebl Int 2023 Feb 3;120(5):71-80. doi: 10.3238/arztebl.m2022.0406. PMID: 36647585Free PMC Article
Pelvic floor muscle strength and the incidence of pelvic floor disorders after vaginal and cesarean delivery.
Blomquist JL, Carroll M, Muñoz A, Handa VL
Am J Obstet Gynecol 2020 Jan;222(1):62.e1-62.e8. Epub 2019 Aug 8 doi: 10.1016/j.ajog.2019.08.003. PMID: 31422064
Association of Delivery Mode With Pelvic Floor Disorders After Childbirth.
Blomquist JL, Muñoz A, Carroll M, Handa VL
JAMA 2018 Dec 18;320(23):2438-2447. doi: 10.1001/jama.2018.18315. PMID: 30561480Free PMC Article
Pelvic organ prolapse.
Jelovsek JE, Maher C, Barber MD
Lancet 2007 Mar 24;369(9566):1027-38. doi: 10.1016/S0140-6736(07)60462-0. PMID: 17382829
Pelvic organ prolapse.
Harrison BP, Cespedes RD
Emerg Med Clin North Am 2001 Aug;19(3):781-97. doi: 10.1016/s0733-8627(05)70215-7. PMID: 11554287

Clinical prediction guides

Cognitive function following surgery for pelvic organ prolapse.
Hassani D, Koelper N, Borodyanskaya Y, Arya NG, Rao H, Andy U
Neurourol Urodyn 2022 Nov;41(8):1853-1861. Epub 2022 Sep 1 doi: 10.1002/nau.25035. PMID: 36047412Free PMC Article
Abdominal pressure and pelvic organ prolapse: is there an association?
Tan YH, Gillor M, Dietz HP
Int Urogynecol J 2022 Feb;33(2):337-342. Epub 2021 May 4 doi: 10.1007/s00192-021-04811-0. PMID: 33944978
Pelvic organ prolapse surgery and health-related quality of life: a follow-up study.
Belayneh T, Gebeyehu A, Adefris M, Rortveit G, Gjerde JL, Ayele TA
BMC Womens Health 2021 Jan 2;21(1):4. doi: 10.1186/s12905-020-01146-8. PMID: 33388056Free PMC Article
Robotic Sacral Colpopexy.
Powell CR, Tachibana I, Eckrich B, Rothenberg J, Hathaway J
J Endourol 2018 May;32(S1):S111-S116. doi: 10.1089/end.2018.0054. PMID: 29774820
An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction.
Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN; International Urogynecological Association; International Continence Society
Neurourol Urodyn 2010;29(1):4-20. doi: 10.1002/nau.20798. PMID: 19941278

Recent systematic reviews

Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis.
Schulten SFM, Claas-Quax MJ, Weemhoff M, van Eijndhoven HW, van Leijsen SA, Vergeldt TF, IntHout J, Kluivers KB
Am J Obstet Gynecol 2022 Aug;227(2):192-208. Epub 2022 Apr 30 doi: 10.1016/j.ajog.2022.04.046. PMID: 35500611
Surgery for women with pelvic organ prolapse with or without stress urinary incontinence.
Baessler K, Christmann-Schmid C, Maher C, Haya N, Crawford TJ, Brown J
Cochrane Database Syst Rev 2018 Aug 19;8(8):CD013108. doi: 10.1002/14651858.CD013108. PMID: 30121956Free PMC Article
The efficacy of pelvic floor muscle training for pelvic organ prolapse: a systematic review and meta-analysis.
Li C, Gong Y, Wang B
Int Urogynecol J 2016 Jul;27(7):981-92. Epub 2015 Sep 25 doi: 10.1007/s00192-015-2846-y. PMID: 26407564
Risk factors for pelvic organ prolapse and its recurrence: a systematic review.
Vergeldt TF, Weemhoff M, IntHout J, Kluivers KB
Int Urogynecol J 2015 Nov;26(11):1559-73. Epub 2015 May 13 doi: 10.1007/s00192-015-2695-8. PMID: 25966804Free PMC Article
Surgical management of pelvic organ prolapse in women.
Maher C, Feiner B, Baessler K, Schmid C
Cochrane Database Syst Rev 2013 Apr 30;(4):CD004014. doi: 10.1002/14651858.CD004014.pub5. PMID: 23633316

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