U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thyroid malformation

MedGen UID:
209098
•Concept ID:
C0877367
•
Anatomical Abnormality
Synonyms: Thyroid Gland Malformation; thyroid gland malformation; Thyroid Malformation; thyroid malformation
 
Monarch Initiative: MONDO:0004564

Definition

An anatomic abnormality of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid malformation

Professional guidelines

PubMed

AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Medical Care of Adults With Down Syndrome: A Clinical Guideline.
Tsou AY, Bulova P, Capone G, Chicoine B, Gelaro B, Harville TO, Martin BA, McGuire DE, McKelvey KD, Peterson M, Tyler C, Wells M, Whitten MS; Global Down Syndrome Foundation Medical Care Guidelines for Adults with Down Syndrome Workgroup
JAMA 2020 Oct 20;324(15):1543-1556. doi: 10.1001/jama.2020.17024. PMID: 33079159
Amenorrhea: A Systematic Approach to Diagnosis and Management.
Klein DA, Paradise SL, Reeder RM
Am Fam Physician 2019 Jul 1;100(1):39-48. PMID: 31259490

Recent clinical studies

Etiology

Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.
Derakhshan A, Peeters RP, Taylor PN, Bliddal S, Carty DM, Meems M, Vaidya B, Chen L, Knight BA, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan CM, French R, Boucai L, Vafeiadi M, Grineva EN, Pop VJM, Vrijkotte TG, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Rebagliato M, Lu X, Pirzada A, Männistö T, Delles C, Feldt-Rasmussen U, Alexander EK, Nelson SM, Chaker L, Pearce EN, Guxens M, Steegers EAP, Walsh JP, Korevaar TIM
Lancet Diabetes Endocrinol 2020 Jun;8(6):501-510. doi: 10.1016/S2213-8587(20)30061-9. PMID: 32445737Free PMC Article
Congenital Hypothyroidism.
Wassner AJ
Clin Perinatol 2018 Mar;45(1):1-18. doi: 10.1016/j.clp.2017.10.004. PMID: 29405999
Complications of acromegaly: thyroid and colon.
Tirosh A, Shimon I
Pituitary 2017 Feb;20(1):70-75. doi: 10.1007/s11102-016-0744-z. PMID: 27631334
Fetal thyroïdology.
Polak M, Luton D
Best Pract Res Clin Endocrinol Metab 2014 Mar;28(2):161-73. Epub 2013 Jun 6 doi: 10.1016/j.beem.2013.04.013. PMID: 24629859
Radiotherapy-induced thyroid disorders.
Jereczek-Fossa BA, Alterio D, Jassem J, Gibelli B, Tradati N, Orecchia R
Cancer Treat Rev 2004 Jun;30(4):369-84. doi: 10.1016/j.ctrv.2003.12.003. PMID: 15145511

Diagnosis

Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges.
Barbieri A, Prasad ML, Gilani SM
Ann Diagn Pathol 2020 Oct;48:151584. Epub 2020 Aug 15 doi: 10.1016/j.anndiagpath.2020.151584. PMID: 32871503
Congenital Heart Disease and Thyroid Dysfunction: Combination, Association, and Implication.
Lerner RK, Gruber N, Pollak U
World J Pediatr Congenit Heart Surg 2019 Sep;10(5):604-615. doi: 10.1177/2150135119857704. PMID: 31496400
Fetal thyroïdology.
Polak M, Luton D
Best Pract Res Clin Endocrinol Metab 2014 Mar;28(2):161-73. Epub 2013 Jun 6 doi: 10.1016/j.beem.2013.04.013. PMID: 24629859
Congenital hypothyroidism.
Abduljabbar MA, Afifi AM
J Pediatr Endocrinol Metab 2012;25(1-2):13-29. doi: 10.1515/jpem.2011.408. PMID: 22570946
Neonatal thyroid disorders.
Grüters A, Biebermann H, Krude H
Horm Res 2003;59 Suppl 1:24-9. doi: 10.1159/000067841. PMID: 12566717

Therapy

The interplay between thyroid and liver: implications for clinical practice.
Piantanida E, Ippolito S, Gallo D, Masiello E, Premoli P, Cusini C, Rosetti S, Sabatino J, Segato S, Trimarchi F, Bartalena L, Tanda ML
J Endocrinol Invest 2020 Jul;43(7):885-899. Epub 2020 Mar 12 doi: 10.1007/s40618-020-01208-6. PMID: 32166702
Thyroid and Fertility: Recent Advances.
Dosiou C
Thyroid 2020 Apr;30(4):479-486. Epub 2020 Feb 4 doi: 10.1089/thy.2019.0382. PMID: 31903865
Congenital Hypothyroidism.
Wassner AJ
Clin Perinatol 2018 Mar;45(1):1-18. doi: 10.1016/j.clp.2017.10.004. PMID: 29405999
Fetal thyroïdology.
Polak M, Luton D
Best Pract Res Clin Endocrinol Metab 2014 Mar;28(2):161-73. Epub 2013 Jun 6 doi: 10.1016/j.beem.2013.04.013. PMID: 24629859
Role of iodine, selenium and other micronutrients in thyroid function and disorders.
Triggiani V, Tafaro E, Giagulli VA, Sabbà C, Resta F, Licchelli B, Guastamacchia E
Endocr Metab Immune Disord Drug Targets 2009 Sep;9(3):277-94. Epub 2009 Sep 1 doi: 10.2174/187153009789044392. PMID: 19594417

Prognosis

DUOX2 and DUOXA2 Variants Confer Susceptibility to Thyroid Dysgenesis and Gland-in-situ With Congenital Hypothyroidism.
Wang F, Zang Y, Li M, Liu W, Wang Y, Yu X, Li H, Wang F, Liu S
Front Endocrinol (Lausanne) 2020;11:237. Epub 2020 Apr 21 doi: 10.3389/fendo.2020.00237. PMID: 32425884Free PMC Article
Congenital Hypothyroidism.
Wassner AJ
Clin Perinatol 2018 Mar;45(1):1-18. doi: 10.1016/j.clp.2017.10.004. PMID: 29405999
Molecular pathology and thyroid FNA.
Poller DN, Glaysher S
Cytopathology 2017 Dec;28(6):475-481. doi: 10.1111/cyt.12492. PMID: 29165888
Thyroid dermopathy and acropachy.
Fatourechi V
Best Pract Res Clin Endocrinol Metab 2012 Aug;26(4):553-65. Epub 2012 May 22 doi: 10.1016/j.beem.2011.10.001. PMID: 22863396
Congenital hypothyroidism.
Abduljabbar MA, Afifi AM
J Pediatr Endocrinol Metab 2012;25(1-2):13-29. doi: 10.1515/jpem.2011.408. PMID: 22570946

Clinical prediction guides

The interplay between thyroid and liver: implications for clinical practice.
Piantanida E, Ippolito S, Gallo D, Masiello E, Premoli P, Cusini C, Rosetti S, Sabatino J, Segato S, Trimarchi F, Bartalena L, Tanda ML
J Endocrinol Invest 2020 Jul;43(7):885-899. Epub 2020 Mar 12 doi: 10.1007/s40618-020-01208-6. PMID: 32166702
Subclinical hypothyroidism in children: is it always subclinical?
Gallizzi R, Crisafulli C, Aversa T, Salzano G, De Luca F, Valenzise M, Zirilli G
Ital J Pediatr 2018 Feb 17;44(1):25. doi: 10.1186/s13052-018-0462-4. PMID: 29454373Free PMC Article
Complications of acromegaly: thyroid and colon.
Tirosh A, Shimon I
Pituitary 2017 Feb;20(1):70-75. doi: 10.1007/s11102-016-0744-z. PMID: 27631334
Thyroid dermopathy and acropachy.
Fatourechi V
Best Pract Res Clin Endocrinol Metab 2012 Aug;26(4):553-65. Epub 2012 May 22 doi: 10.1016/j.beem.2011.10.001. PMID: 22863396
Holoprosencephaly.
Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V
Orphanet J Rare Dis 2007 Feb 2;2:8. doi: 10.1186/1750-1172-2-8. PMID: 17274816Free PMC Article

Recent systematic reviews

Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis.
Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, Chen L, Taylor P, Mosso L, Oken E, Suvanto E, Itoh S, Kishi R, Bassols J, Auvinen J, López-Bermejo A, Brown SJ, Boucai L, Hisada A, Yoshinaga J, Shilova E, Grineva EN, Vrijkotte TGM, Sunyer J, Jiménez-Zabala A, Riaño-Galan I, Lopez-Espinosa MJ, Prokop LJ, Singh Ospina N, Brito JP, Rodriguez-Gutierrez R, Alexander EK, Chaker L, Pearce EN, Peeters RP, Feldt-Rasmussen U, Guxens M, Chatzi L, Delles C, Roeters van Lennep JE, Pop VJM, Lu X, Walsh JP, Nelson SM, Korevaar TIM, Maraka S
Lancet Diabetes Endocrinol 2022 Apr;10(4):243-252. Epub 2022 Mar 4 doi: 10.1016/S2213-8587(22)00007-9. PMID: 35255260Free PMC Article
The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis.
Shigesi N, Kvaskoff M, Kirtley S, Feng Q, Fang H, Knight JC, Missmer SA, Rahmioglu N, Zondervan KT, Becker CM
Hum Reprod Update 2019 Jul 1;25(4):486-503. doi: 10.1093/humupd/dmz014. PMID: 31260048Free PMC Article
Differentiated Thyroid Cancer-Treatment: State of the Art.
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893
Lithium toxicity profile: a systematic review and meta-analysis.
McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR
Lancet 2012 Feb 25;379(9817):721-8. Epub 2012 Jan 20 doi: 10.1016/S0140-6736(11)61516-X. PMID: 22265699

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...