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Askin tumor

MedGen UID:
209112
•Concept ID:
C0877849
•
Neoplastic Process
Synonym: Askin's tumor (PNET of the chest wall) (type)
SNOMED CT: Askin's tumor (128783001); Askin tumor (128783001)
 
Monarch Initiative: MONDO:0006094
OMIM®: 612219

Definition

A primitive neuroectodermal tumor (small round blue cell tumor) of the thorax which can involve the periosteum, thoracic wall and/or pleura though it spares the lung parenchyma. [from NCI]

Professional guidelines

PubMed

Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Emerging chemotherapeutic strategies and the role of treatment stratification in Ewing sarcoma.
Seddon BM, Whelan JS
Paediatr Drugs 2008;10(2):93-105. doi: 10.2165/00148581-200810020-00004. PMID: 18345719
Current treatment for Ewing's sarcoma.
Thacker MM, Temple HT, Scully SP
Expert Rev Anticancer Ther 2005 Apr;5(2):319-31. doi: 10.1586/14737140.5.2.319. PMID: 15877528

Recent clinical studies

Etiology

Askin tumor: CT and FDG-PET/CT imaging findings and follow-up.
Xia T, Guan Y, Chen Y, Li J
Medicine (Baltimore) 2014 Jul;93(6):e42. doi: 10.1097/MD.0000000000000042. PMID: 25058144Free PMC Article
Askin's tumor: a case report and literature review.
Benbrahim Z, Arifi S, Daoudi K, Serraj M, Amara B, Benjelloun MC, Mellas N, El Mesbahi O
World J Surg Oncol 2013 Jan 22;11:10. doi: 10.1186/1477-7819-11-10. PMID: 23339634Free PMC Article
Ewing's sarcoma family of tumors: an overview from diagnosis to survivorship.
Lahl M, Fisher VL, Laschinger K
Clin J Oncol Nurs 2008 Feb;12(1):89-97. doi: 10.1188/08.CJON.89-97. PMID: 18258578
Current treatment for Ewing's sarcoma.
Thacker MM, Temple HT, Scully SP
Expert Rev Anticancer Ther 2005 Apr;5(2):319-31. doi: 10.1586/14737140.5.2.319. PMID: 15877528
Ewing tumor: tumor biology and clinical applications.
de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351

Diagnosis

Rapidly fatal Askin's tumor: a case report and literature review.
Laine M, Ghorfi IA, Lambatten D, Kettani F, Abid A
Pan Afr Med J 2014;18:104. Epub 2014 May 30 doi: 10.11604/pamj.2014.18.104.4549. PMID: 25404964Free PMC Article
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up.
Xia T, Guan Y, Chen Y, Li J
Medicine (Baltimore) 2014 Jul;93(6):e42. doi: 10.1097/MD.0000000000000042. PMID: 25058144Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Ewing tumor: tumor biology and clinical applications.
de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351
Malignant small-cell tumor of the thoracopulmonary region: 'Askin tumor'.
Bourque MD, Di Lorenzo M, Collin PP, Russo P, Laberge JM, Moir C
J Pediatr Surg 1989 Oct;24(10):1079-83. doi: 10.1016/s0022-3468(89)80221-0. PMID: 2553909

Therapy

Survival after high-dose chemotherapy for refractory and recurrent Ewing sarcoma.
Windsor R, Hamilton A, McTiernan A, Dileo P, Michelagnoli M, Seddon B, Strauss SJ, Whelan J
Eur J Cancer 2022 Jul;170:131-139. Epub 2022 May 26 doi: 10.1016/j.ejca.2022.04.007. PMID: 35635934
Askin's tumor: a case report and literature review.
Benbrahim Z, Arifi S, Daoudi K, Serraj M, Amara B, Benjelloun MC, Mellas N, El Mesbahi O
World J Surg Oncol 2013 Jan 22;11:10. doi: 10.1186/1477-7819-11-10. PMID: 23339634Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Ewing's sarcoma family of tumors: an overview from diagnosis to survivorship.
Lahl M, Fisher VL, Laschinger K
Clin J Oncol Nurs 2008 Feb;12(1):89-97. doi: 10.1188/08.CJON.89-97. PMID: 18258578
Current treatment for Ewing's sarcoma.
Thacker MM, Temple HT, Scully SP
Expert Rev Anticancer Ther 2005 Apr;5(2):319-31. doi: 10.1586/14737140.5.2.319. PMID: 15877528

Prognosis

Rapidly fatal Askin's tumor: a case report and literature review.
Laine M, Ghorfi IA, Lambatten D, Kettani F, Abid A
Pan Afr Med J 2014;18:104. Epub 2014 May 30 doi: 10.11604/pamj.2014.18.104.4549. PMID: 25404964Free PMC Article
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up.
Xia T, Guan Y, Chen Y, Li J
Medicine (Baltimore) 2014 Jul;93(6):e42. doi: 10.1097/MD.0000000000000042. PMID: 25058144Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Ewing's sarcoma family of tumors: an overview from diagnosis to survivorship.
Lahl M, Fisher VL, Laschinger K
Clin J Oncol Nurs 2008 Feb;12(1):89-97. doi: 10.1188/08.CJON.89-97. PMID: 18258578
Ewing tumor: tumor biology and clinical applications.
de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351

Clinical prediction guides

Survival after high-dose chemotherapy for refractory and recurrent Ewing sarcoma.
Windsor R, Hamilton A, McTiernan A, Dileo P, Michelagnoli M, Seddon B, Strauss SJ, Whelan J
Eur J Cancer 2022 Jul;170:131-139. Epub 2022 May 26 doi: 10.1016/j.ejca.2022.04.007. PMID: 35635934
Askin tumor mimicking a hydatid cyst of the lung in children: case report.
Kabiri el H, Al Bouzidi A, Kabiri M
Pan Afr Med J 2014;17:131. Epub 2014 Feb 25 doi: 10.11604/pamj.2014.17.131.1056. PMID: 25374636Free PMC Article
Eponyms in cardiothoracic radiology: Part I. Neoplasms.
Mohammed TL, Saettele MR, Saettele T, Patel V, Kanne JP
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):91-8. doi: 10.1067/j.cpradiol.2013.12.003. PMID: 24629662
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Activation of trkA induces differentiation and inhibits the growth of JK-GMS Askin tumor cells.
Kim GJ, Kim CJ, Cho SY, Chung IP, Park SH, Lee MJ, Chi JG
Lab Invest 2002 Feb;82(2):221-9. doi: 10.1038/labinvest.3780414. PMID: 11850535

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