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Hereditary kidney oncocytoma

MedGen UID:
209307
•Concept ID:
C0879606
•
Neoplastic Process
Synonyms: Familial Renal Oncocytoma; familial renal oncocytoma; Hereditary Kidney Oncocytoma; hereditary kidney oncocytoma; Hereditary Renal Oncocytoma; hereditary renal oncocytoma
 
Monarch Initiative: MONDO:0003824

Definition

An inherited condition characterized by the development of kidney oncocytomas which are often bilateral and multifocal. This condition may be connected to Birt-Hogg-Dube syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHereditary kidney oncocytoma

Professional guidelines

PubMed

Assessment of Risk of Hereditary Predisposition in Patients With Melanoma and/or Mesothelioma and Renal Neoplasia.
Gupta S, Erickson LA, Lohse CM, Shen W, Pitel BA, Knight SM, Halling KC, Herrera-Hernandez L, Boorjian SA, Thompson RH, Leibovich BC, Jimenez RE, Cheville JC
JAMA Netw Open 2021 Nov 1;4(11):e2132615. doi: 10.1001/jamanetworkopen.2021.32615. PMID: 34767027Free PMC Article
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427

Recent clinical studies

Etiology

The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
Assessment of Risk of Hereditary Predisposition in Patients With Melanoma and/or Mesothelioma and Renal Neoplasia.
Gupta S, Erickson LA, Lohse CM, Shen W, Pitel BA, Knight SM, Halling KC, Herrera-Hernandez L, Boorjian SA, Thompson RH, Leibovich BC, Jimenez RE, Cheville JC
JAMA Netw Open 2021 Nov 1;4(11):e2132615. doi: 10.1001/jamanetworkopen.2021.32615. PMID: 34767027Free PMC Article
(18)Fluorodeoxyglucose-positron emission tomography/computed tomography for differentiation of renal tumors in hereditary kidney cancer syndromes.
Nikpanah M, Paschall AK, Ahlman MA, Civelek AC, Farhadi F, Mirmomen SM, Li X, Saboury B, Ball MW, Merino MJ, Srinivasan R, Jones EC, Linehan WM, Malayeri AA
Abdom Radiol (NY) 2021 Jul;46(7):3301-3308. Epub 2021 Mar 10 doi: 10.1007/s00261-021-02999-9. PMID: 33688985Free PMC Article
Localized renal cell carcinoma.
Russo P
Curr Treat Options Oncol 2001 Oct;2(5):447-55. doi: 10.1007/s11864-001-0050-4. PMID: 12057108

Diagnosis

Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Diagnostic approach to eosinophilic renal neoplasms.
Kryvenko ON, Jorda M, Argani P, Epstein JI
Arch Pathol Lab Med 2014 Nov;138(11):1531-41. doi: 10.5858/arpa.2013-0653-RA. PMID: 25357116Free PMC Article
Oncocytic renal neoplasms: diagnostic considerations.
Abrahams NA, Tamboli P
Clin Lab Med 2005 Jun;25(2):317-39, vi. doi: 10.1016/j.cll.2005.01.006. PMID: 15848739
Hereditary renal cancers.
Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM
Radiology 2003 Jan;226(1):33-46. doi: 10.1148/radiol.2261011296. PMID: 12511666

Therapy

Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome.
Hasumi H, Baba M, Hasumi Y, Furuya M, Yao M
Int J Urol 2016 Mar;23(3):204-10. Epub 2015 Nov 25 doi: 10.1111/iju.13015. PMID: 26608100

Prognosis

Low grade oncocytic tumors of the kidney: a clinically relevant approach for the workup and accurate diagnosis.
Amin MB, McKenney JK, Martignoni G, Campbell SC, Pal S, Tickoo SK
Mod Pathol 2022 Oct;35(10):1306-1316. Epub 2022 Jul 27 doi: 10.1038/s41379-022-01108-5. PMID: 35896615
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
The genetic basis of cancer of the kidney.
Linehan WM, Walther MM, Zbar B
J Urol 2003 Dec;170(6 Pt 1):2163-72. doi: 10.1097/01.ju.0000096060.92397.ed. PMID: 14634372
Localized renal cell carcinoma.
Russo P
Curr Treat Options Oncol 2001 Oct;2(5):447-55. doi: 10.1007/s11864-001-0050-4. PMID: 12057108
The genetic basis of renal epithelial tumors: advances in research and its impact on prognosis and therapy.
Phillips JL, Pavlovich CP, Walther M, Ried T, Linehan WM
Curr Opin Urol 2001 Sep;11(5):463-9. doi: 10.1097/00042307-200109000-00003. PMID: 11493766

Clinical prediction guides

Immunoexpression of SDHB, FH, and CK20 among eosinophilic renal tumors: A tissue microarray study.
Karatay H, Ozluk Y, Dogan MA, Erdem S, Kilicaslan I
Ann Diagn Pathol 2021 Oct;54:151788. Epub 2021 Jul 2 doi: 10.1016/j.anndiagpath.2021.151788. PMID: 34246177
(18)Fluorodeoxyglucose-positron emission tomography/computed tomography for differentiation of renal tumors in hereditary kidney cancer syndromes.
Nikpanah M, Paschall AK, Ahlman MA, Civelek AC, Farhadi F, Mirmomen SM, Li X, Saboury B, Ball MW, Merino MJ, Srinivasan R, Jones EC, Linehan WM, Malayeri AA
Abdom Radiol (NY) 2021 Jul;46(7):3301-3308. Epub 2021 Mar 10 doi: 10.1007/s00261-021-02999-9. PMID: 33688985Free PMC Article
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis.
Henderson A, Douglas F, Perros P, Morgan C, Maher ER
Fam Cancer 2009;8(3):257-60. Epub 2009 Jan 29 doi: 10.1007/s10689-009-9234-z. PMID: 19184535
Origin of renal cell carcinomas.
Valladares Ayerbes M, Aparicio Gallego G, Díaz Prado S, Jiménez Fonseca P, García Campelo R, Antón Aparicio LM
Clin Transl Oncol 2008 Nov;10(11):697-712. doi: 10.1007/s12094-008-0276-8. PMID: 19015066

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