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Stromal Neoplasm

MedGen UID:: 209308
•Concept ID:: C0879615
•: Neoplastic Process

Synonyms:	Stromal tumor; Stromal Tumor
SNOMED CT:	Stromal tumor (128752000)

Definition

A benign or malignant mesenchymal neoplasm composed of stromal cells. Representative examples include gastrointestinal stromal tumor, endometrial stromal sarcoma, and prostate stromal sarcoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVStromal Neoplasm

Pathological process
- Disease
  - Disorder by Site
    - Connective and Soft Tissue Disorder
      - Connective and soft tissue neoplasm
        Mesenchymal cell neoplasm
        Stromal Neoplasm
        Breast Periductal Stromal Tumor
        Conjunctival Stromal Tumor
        Endometrioid stromal and related neoplasms
        Endometrial stromal sarcoma
        Low Grade Endometrioid Stromal Sarcoma
        Uterine corpus endometrial stromal sarcoma
        Endometrioid stromal and related neoplasms of the cervix
        Cervical Low Grade Endometrioid Stromal Sarcoma
        Endocervical Undifferentiated Sarcoma
        Endometrioid stromal and related neoplasms of the vagina
        Vaginal Low Grade Endometrioid Stromal Sarcoma
        Vaginal Undifferentiated Sarcoma
        Ovarian endometrioid stromal and related neoplasms
        Ovarian Low Grade Endometrioid Stromal Sarcoma
        Ovarian Undifferentiated Sarcoma
        Undifferentiated Stromal Sarcoma
        Uterine Corpus High Grade Endometrial Stromal Sarcoma
        Uterine Corpus Endometrial Stromal and Related Neoplasms
        Endometrial stromal nodule
        Uterine Corpus Tumor Resembling Ovarian Sex Cord Tumor
        Gastrointestinal stromal tumor
        Benign Gastrointestinal Stromal Tumor
        Benign Gastric Gastrointestinal Stromal Tumor
        Childhood Gastrointestinal Stromal Tumor
        Epithelioid Cell Type Gastrointestinal Stromal Tumor
        Benign Epithelioid Cell Type Gastrointestinal Stromal Tumor
        Malignant Epithelioid Cell Type Gastrointestinal Stromal Tumor
        Extragastrointestinal Gastrointestinal Stromal Tumor
        Peritoneal Gastrointestinal Stromal Tumor
        Retroperitoneal Gastrointestinal Stromal Tumor
        Gastrointestinal Stromal Tumor of the Gastrointestinal Tract
        Colorectal gastrointestinal stromal tumor
        Esophageal Gastrointestinal Stromal Tumor
        Gastric Gastrointestinal Stromal Tumor
        Gastrointestinal stromal tumor of small intestine
        Gastrointestinal Stromal Tumor of Uncertain Malignant Potential
        Gastric Gastrointestinal Stromal Tumor of Uncertain Malignant Potential
        Malignant Gastrointestinal Stromal Tumor
        Dedifferentiated Gastrointestinal Stromal Tumor
        Gastric Malignant Gastrointestinal Stromal Tumor
        Gastrointestinal Stromal Tumor by AJCC v8 Stage
        Metastatic Gastrointestinal Stromal Tumor
        Unresectable Malignant Gastrointestinal Stromal Tumor
        Mixed Cell Type Gastrointestinal Stromal Tumor
        Recurrent Gastrointestinal Stromal Tumor
        Spindle Cell Type Gastrointestinal Stromal Tumor
        Stromal sarcoma
        Adenosarcoma
        Broad Ligament Adenosarcoma
        Cervical adenosarcoma
        Fallopian tube adenosarcoma
        Ovarian adenosarcoma
        Uterine corpus adenosarcoma
        Vaginal adenosarcoma
        Prostate stromal sarcoma
        Tumor of Specialized Prostatic Stroma
        Prostate Stromal Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Ovarian Signet-ring Stromal Tumor: A Morphologic, Immunohistochemical, and Molecular Study of 7 Cases With Discussion of the Differential Diagnosis.

Tchrakian N, Oliva E, Chong AS, Rivera-Polo B, Bennett JA, Nucci MR, Sah S, Schoolmeester JK, van der Griend RA, Foulkes WD, Clarke BA, Young RH, McCluggage WG
Am J Surg Pathol 2022 Dec 1;46(12):1599-1610. Epub 2022 Aug 29 doi: 10.1097/PAS.0000000000001954. PMID: 36040033

See all (1)

Recent clinical studies

Etiology

An Unusual Endometrial Stromal Neoplasm With JAZF1-BCORL1 Rearrangement.

Moghaddam PA, Young RH, Ismiil ND, Bennett JA, Oliva E
Int J Gynecol Pathol 2024 Jan 1;43(1):33-40. Epub 2023 Jan 23 doi: 10.1097/PGP.0000000000000941. PMID: 36811828

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis.

Inzani F, Santoro A, Travaglino A, D'Alessandris N, Raffone A, Straccia P, Angelico G, Arciuolo D, Scaglione G, Valente M, Tralongo P, Gallotta V, Zannoni GF
Arch Gynecol Obstet 2022 Aug;306(2):315-321. Epub 2021 Nov 19 doi: 10.1007/s00404-021-06305-2. PMID: 34799743

Inflammatory Myofibroblastic Tumor in Female Genital Tract.

Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784

Phyllodes tumor of the breast: an update.

Tse GM, Niu Y, Shi HJ
Breast Cancer 2010;17(1):29-34. Epub 2009 May 12 doi: 10.1007/s12282-009-0114-z. PMID: 19434472

Uterine tumors resembling ovarian sex cord tumors: an update.

Czernobilsky B
Int J Gynecol Pathol 2008 Apr;27(2):229-35. doi: 10.1097/PGP.0b013e3181569a21. PMID: 18317219

See all (10)

Diagnosis

An Unusual Endometrial Stromal Neoplasm With JAZF1-BCORL1 Rearrangement.

Moghaddam PA, Young RH, Ismiil ND, Bennett JA, Oliva E
Int J Gynecol Pathol 2024 Jan 1;43(1):33-40. Epub 2023 Jan 23 doi: 10.1097/PGP.0000000000000941. PMID: 36811828

Endometrial Stromal Neoplasm in the Placenta.

Heller D, Hatem F
Int J Gynecol Pathol 2019 Nov;38(6):e2. doi: 10.1097/PGP.0000000000000597. PMID: 31593030

Inflammatory Myofibroblastic Tumor in Female Genital Tract.

Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784

Morcellating uterine mesenchymal tumors: The pathologist's view.

Pavlakis K, Messini I, Yiannou P, Gavresea T, Chrysanthakis D, Hilaris G, Panoskaltsis T
J Obstet Gynaecol Res 2017 Mar;43(3):580-586. Epub 2017 Jan 25 doi: 10.1111/jog.13240. PMID: 28120430

Uterine tumors resembling ovarian sex cord tumors: an update.

Czernobilsky B
Int J Gynecol Pathol 2008 Apr;27(2):229-35. doi: 10.1097/PGP.0b013e3181569a21. PMID: 18317219

See all (32)

Therapy

Malignant gastrointestinal stromal neoplasm.

Jovine E, Biolchini F, Lerro FM, Mastrangelo L, Martuzzi F
Surgery 2006 Nov;140(5):832-4. doi: 10.1016/j.surg.2005.10.007. PMID: 17084730

Aspiration cytology of the collagenized variant of mammary myofibroblastoma: a case report with review of the literature.

Simsir A, Cangiarella J, Boppana S, Waisman J
Diagn Cytopathol 2001 Jun;24(6):399-402. doi: 10.1002/dc.1088. PMID: 11391821

See all (2)

Prognosis

Ileal gastrointestinal stromal tumor presenting as retroperitoneal mass.

Ergenç M, Uprak TK
J Cancer Res Ther 2022 Dec;18(Supplement):S460-S462. doi: 10.4103/jcrt.jcrt_1089_21. PMID: 36511004

Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma.

Agaimy A, Clarke BA, Kolin DL, Lee CH, Lee JC, McCluggage WG, Pöschke P, Stoehr R, Swanson D, Turashvili G, Beckmann MW, Hartmann A, Antonescu CR, Dickson BC
Am J Surg Pathol 2022 Sep 1;46(9):1298-1308. Epub 2022 May 17 doi: 10.1097/PAS.0000000000001915. PMID: 35575789 Free PMC Article

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis.

Phyllodes tumor of the breast: an update.

Tse GM, Niu Y, Shi HJ
Breast Cancer 2010;17(1):29-34. Epub 2009 May 12 doi: 10.1007/s12282-009-0114-z. PMID: 19434472

Uterine tumors resembling ovarian sex cord tumors: an update.

Czernobilsky B
Int J Gynecol Pathol 2008 Apr;27(2):229-35. doi: 10.1097/PGP.0b013e3181569a21. PMID: 18317219

See all (10)

Clinical prediction guides

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis.

On the pathogenesis of sclerosing stromal tumor of the ovary: a neoplasm in transition.

Roth LM, Gaba AR, Cheng L
Int J Gynecol Pathol 2014 Sep;33(5):449-62. doi: 10.1097/PGP.0000000000000084. PMID: 25083960

Phyllodes tumor of the breast: an update.

Tse GM, Niu Y, Shi HJ
Breast Cancer 2010;17(1):29-34. Epub 2009 May 12 doi: 10.1007/s12282-009-0114-z. PMID: 19434472

Uterine tumors resembling ovarian sex cord tumors: an update.

Czernobilsky B
Int J Gynecol Pathol 2008 Apr;27(2):229-35. doi: 10.1097/PGP.0b013e3181569a21. PMID: 18317219

Utility of MIB-1 and estrogen and progesterone receptor in distinguishing between endometrial stromal sarcomas and endometrial stromal nodules, highly cellular leiomyomas.

Kir G, Cetiner H, Karateke A, Gurbuz A, Bulbul D
Int J Gynecol Cancer 2005 Mar-Apr;15(2):337-42. doi: 10.1111/j.1525-1438.2005.15226.x. PMID: 15823122

See all (7)

Recent systematic reviews

Prognostic predictors in recurrent adult granulosa cell tumors of the ovary: a systematic review and meta-analysis.

See all (1)

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Stromal Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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