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Childhood spinal cord tumor

MedGen UID:
209512
•Concept ID:
C1134515
•
Neoplastic Process
Synonyms: Childhood Spinal Cord Neoplasm; childhood spinal cord neoplasm; Childhood Spinal Cord Tumor; childhood spinal cord tumor; paediatric spinal cord neoplasm; pediatric spinal cord neoplasm; spinal cord neoplasm of childhood
 
Monarch Initiative: MONDO:0002716

Definition

A benign or malignant neoplasm affecting the spinal cord during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood spinal cord tumor

Professional guidelines

PubMed

Paediatric spinal cord low-grade gliomas-evaluation and management of post-surgical residual disease.
Silva AHD, Constantinides M, Valetopoulou A, Sgardelis P, Mankad K, D'Arco F, Jankovic I, Thompson D
Childs Nerv Syst 2022 Mar;38(3):577-586. Epub 2021 Dec 2 doi: 10.1007/s00381-021-05412-4. PMID: 34855000
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies.
Findlay IJ, De Iuliis GN, Duchatel RJ, Jackson ER, Vitanza NA, Cain JE, Waszak SM, Dun MD
Oncogene 2022 Jan;41(4):461-475. Epub 2021 Nov 10 doi: 10.1038/s41388-021-02102-y. PMID: 34759345Free PMC Article
Diagnosis and management of brain and spinal cord tumors in the neonate.
Hwang SW, Su JM, Jea A
Semin Fetal Neonatal Med 2012 Aug;17(4):202-206. Epub 2012 Mar 30 doi: 10.1016/j.siny.2012.03.001. PMID: 22465555

Recent clinical studies

Etiology

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Paediatric spinal cord low-grade gliomas-evaluation and management of post-surgical residual disease.
Silva AHD, Constantinides M, Valetopoulou A, Sgardelis P, Mankad K, D'Arco F, Jankovic I, Thompson D
Childs Nerv Syst 2022 Mar;38(3):577-586. Epub 2021 Dec 2 doi: 10.1007/s00381-021-05412-4. PMID: 34855000
Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.
Kurucu N, Akyüz C, Varan A, Akçören Z, Aydin B, Yalçin B, Kutluk T
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e395-e400. doi: 10.1097/MPH.0000000000001858. PMID: 32520843
Understanding Ependymoma Oncogenesis: an Update on Recent Molecular Advances and Current Perspectives.
Gupta K, Salunke P
Mol Neurobiol 2017 Jan;54(1):15-21. Epub 2015 Dec 28 doi: 10.1007/s12035-015-9646-8. PMID: 26712502
Oncologic emergencies.
Kelly KM, Lange B
Pediatr Clin North Am 1997 Aug;44(4):809-30. doi: 10.1016/s0031-3955(05)70531-9. PMID: 9286286

Diagnosis

Primary leptomeningeal medulloblastoma: a case-based review.
Russo C, Scala MR, Spennato P, Nastro A, Errico ME, De Martino L, Cinalli G
Childs Nerv Syst 2022 Mar;38(3):527-536. Epub 2022 Jan 21 doi: 10.1007/s00381-021-05435-x. PMID: 35059784
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW
Neuro Oncol 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106. PMID: 34185076Free PMC Article
Neonatal Central Nervous System Tumors.
Shahab S, Fangusaro J
Clin Perinatol 2021 Mar;48(1):35-51. Epub 2021 Jan 11 doi: 10.1016/j.clp.2020.11.003. PMID: 33583506
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304
Oncologic emergencies.
Kelly KM, Lange B
Pediatr Clin North Am 1997 Aug;44(4):809-30. doi: 10.1016/s0031-3955(05)70531-9. PMID: 9286286

Therapy

Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.
Kurucu N, Akyüz C, Varan A, Akçören Z, Aydin B, Yalçin B, Kutluk T
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e395-e400. doi: 10.1097/MPH.0000000000001858. PMID: 32520843
Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening.
Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M
Sci Transl Med 2019 Nov 20;11(519) doi: 10.1126/scitranslmed.aaw0064. PMID: 31748226Free PMC Article
AGORA, a data- and biobank for birth defects and childhood cancer.
van Rooij IA, van der Zanden LF, Bongers EM, Renkema KY, Wijers CH, Thonissen M, Dokter EM, Marcelis CL, de Blaauw I, Wijnen MH, Hoogerbrugge PM, Bokkerink JP, Schreuder MF, Koster-Kamphuis L, Cornelissen EA, Kapusta L, van Heijst AF, Liem KD, de Gier RP, Kuijpers-Jagtman AM, Admiraal RJ, Bergé SJ, van der Biezen JJ, Verdonck A, Vander Poorten V, Hens G, Roosenboom J, Lilien MR, de Jong TP, Broens P, Wijnen R, Brooks A, Franke B, Brunner HG, Carels CE, Knoers NV, Feitz WF, Roeleveld N
Birth Defects Res A Clin Mol Teratol 2016 Aug;106(8):675-84. Epub 2016 May 6 doi: 10.1002/bdra.23512. PMID: 27150573
Neurologic complications of radiation.
Rogers LR
Continuum (Minneap Minn) 2012 Apr;18(2):343-54. doi: 10.1212/01.CON.0000413662.35174.a8. PMID: 22810131
Posterior mediastinal masses.
Saenz NC, Schnitzer JJ, Eraklis AE, Hendren WH, Grier HE, Macklis RM, Shamberger RC
J Pediatr Surg 1993 Feb;28(2):172-6. doi: 10.1016/s0022-3468(05)80268-4. PMID: 8437074

Prognosis

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Neonatal Central Nervous System Tumors.
Shahab S, Fangusaro J
Clin Perinatol 2021 Mar;48(1):35-51. Epub 2021 Jan 11 doi: 10.1016/j.clp.2020.11.003. PMID: 33583506
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304
Spinal cord ependymomas in children and adolescents.
Benesch M, Frappaz D, Massimino M
Childs Nerv Syst 2012 Dec;28(12):2017-28. Epub 2012 Sep 8 doi: 10.1007/s00381-012-1908-4. PMID: 22961356
Oncologic emergencies.
Kelly KM, Lange B
Pediatr Clin North Am 1997 Aug;44(4):809-30. doi: 10.1016/s0031-3955(05)70531-9. PMID: 9286286

Clinical prediction guides

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.
Kurucu N, Akyüz C, Varan A, Akçören Z, Aydin B, Yalçin B, Kutluk T
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e395-e400. doi: 10.1097/MPH.0000000000001858. PMID: 32520843
Understanding Ependymoma Oncogenesis: an Update on Recent Molecular Advances and Current Perspectives.
Gupta K, Salunke P
Mol Neurobiol 2017 Jan;54(1):15-21. Epub 2015 Dec 28 doi: 10.1007/s12035-015-9646-8. PMID: 26712502
Pediatric spinal tumors.
Hsu W, Jallo GI
Handb Clin Neurol 2013;112:959-65. doi: 10.1016/B978-0-444-52910-7.00016-7. PMID: 23622304
Oncologic emergencies.
Kelly KM, Lange B
Pediatr Clin North Am 1997 Aug;44(4):809-30. doi: 10.1016/s0031-3955(05)70531-9. PMID: 9286286

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