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Breakthrough pain

MedGen UID:
210036
Concept ID:
C1135120
Sign or Symptom
Synonyms: Breakthrough Pain; Breakthrough Pains; Pain, Breakthrough; Pains, Breakthrough
SNOMED CT: Breakthrough pain (879969009)
 
HPO: HP:0032149

Definition

A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreakthrough pain

Professional guidelines

PubMed

Kang RA, Ko JS
Curr Opin Organ Transplant 2023 Dec 1;28(6):391-396. Epub 2023 Sep 7 doi: 10.1097/MOT.0000000000001099. PMID: 37678396
Virgen CG, Kelkar N, Tran A, Rosa CM, Cruz-Topete D, Amatya S, Cornett EM, Urits I, Viswanath O, Kaye AD
Biomed Pharmacother 2022 Dec;156:113871. Epub 2022 Oct 19 doi: 10.1016/j.biopha.2022.113871. PMID: 36272265
De Giorgio R, Zucco FM, Chiarioni G, Mercadante S, Corazziari ES, Caraceni A, Odetti P, Giusti R, Marinangeli F, Pinto C
Adv Ther 2021 Jul;38(7):3589-3621. Epub 2021 Jun 4 doi: 10.1007/s12325-021-01766-y. PMID: 34086265Free PMC Article

Recent clinical studies

Etiology

Virgen CG, Kelkar N, Tran A, Rosa CM, Cruz-Topete D, Amatya S, Cornett EM, Urits I, Viswanath O, Kaye AD
Biomed Pharmacother 2022 Dec;156:113871. Epub 2022 Oct 19 doi: 10.1016/j.biopha.2022.113871. PMID: 36272265
De Giorgio R, Zucco FM, Chiarioni G, Mercadante S, Corazziari ES, Caraceni A, Odetti P, Giusti R, Marinangeli F, Pinto C
Adv Ther 2021 Jul;38(7):3589-3621. Epub 2021 Jun 4 doi: 10.1007/s12325-021-01766-y. PMID: 34086265Free PMC Article
Roofthooft E, Barbé A, Schildermans J, Cromheecke S, Devroe S, Fieuws S, Rex S, Wong CA, Van de Velde M
Anaesthesia 2020 Dec;75(12):1635-1642. Epub 2020 Jun 12 doi: 10.1111/anae.15149. PMID: 32530518
Davies AN
Curr Pain Headache Rep 2014 Jun;18(6):420. doi: 10.1007/s11916-014-0420-9. PMID: 24760489
Patt RB, Ellison NM
Oncology (Williston Park) 1998 Jul;12(7):1035-46; discussion 1049-52. PMID: 9684277

Diagnosis

Kang RA, Ko JS
Curr Opin Organ Transplant 2023 Dec 1;28(6):391-396. Epub 2023 Sep 7 doi: 10.1097/MOT.0000000000001099. PMID: 37678396
Virgen CG, Kelkar N, Tran A, Rosa CM, Cruz-Topete D, Amatya S, Cornett EM, Urits I, Viswanath O, Kaye AD
Biomed Pharmacother 2022 Dec;156:113871. Epub 2022 Oct 19 doi: 10.1016/j.biopha.2022.113871. PMID: 36272265
Liossi C, Greenfield K, Schoth DE, Mott C, Jassal S, Fraser LK, Rajapakse D, Howard RF, Johnson M, Anderson AK, Harrop E
J Pain Symptom Manage 2021 Nov;62(5):1041-1064. Epub 2021 Apr 30 doi: 10.1016/j.jpainsymman.2021.04.018. PMID: 33933619
Fink RM, Gallagher E
Semin Oncol Nurs 2019 Jun;35(3):229-234. Epub 2019 Apr 26 doi: 10.1016/j.soncn.2019.04.003. PMID: 31036386
Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, Ripamonti CI; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv166-iv191. doi: 10.1093/annonc/mdy152. PMID: 30052758

Therapy

Roofthooft E, Barbé A, Schildermans J, Cromheecke S, Devroe S, Fieuws S, Rex S, Wong CA, Van de Velde M
Anaesthesia 2020 Dec;75(12):1635-1642. Epub 2020 Jun 12 doi: 10.1111/anae.15149. PMID: 32530518
Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, Ripamonti CI; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv166-iv191. doi: 10.1093/annonc/mdy152. PMID: 30052758
Mercadante S
Expert Rev Anticancer Ther 2018 May;18(5):445-449. Epub 2018 Mar 16 doi: 10.1080/14737140.2018.1443813. PMID: 29478355
Davies AN
Curr Pain Headache Rep 2014 Jun;18(6):420. doi: 10.1007/s11916-014-0420-9. PMID: 24760489
McCaffery M, Pasero C
Am J Nurs 2003 Apr;103(4):83-4, 86. doi: 10.1097/00000446-200304000-00027. PMID: 12677130

Prognosis

Virgen CG, Kelkar N, Tran A, Rosa CM, Cruz-Topete D, Amatya S, Cornett EM, Urits I, Viswanath O, Kaye AD
Biomed Pharmacother 2022 Dec;156:113871. Epub 2022 Oct 19 doi: 10.1016/j.biopha.2022.113871. PMID: 36272265
Løhre ET, Thronæs M, Klepstad P
Curr Opin Support Palliat Care 2020 Jun;14(2):94-99. doi: 10.1097/SPC.0000000000000494. PMID: 32332210
Schug SA, Ting S
Drugs 2017 May;77(7):747-763. doi: 10.1007/s40265-017-0727-z. PMID: 28337672
Messina J, Darwish M, Fine PG
Drugs Today (Barc) 2008 Jan;44(1):41-54. doi: 10.1358/dot.2008.44.1.1178469. PMID: 18301803
Patt RB, Ellison NM
Oncology (Williston Park) 1998 Jul;12(7):1035-46; discussion 1049-52. PMID: 9684277

Clinical prediction guides

Roofthooft E, Filetici N, Van Houwe M, Van Houwe P, Barbé A, Fieuws S, Rex S, Wong CA, Van de Velde M
Anaesthesia 2023 Sep;78(9):1129-1138. Epub 2023 Jun 20 doi: 10.1111/anae.16060. PMID: 37340620
Roofthooft E, Barbé A, Schildermans J, Cromheecke S, Devroe S, Fieuws S, Rex S, Wong CA, Van de Velde M
Anaesthesia 2020 Dec;75(12):1635-1642. Epub 2020 Jun 12 doi: 10.1111/anae.15149. PMID: 32530518
Løhre ET, Thronæs M, Klepstad P
Curr Opin Support Palliat Care 2020 Jun;14(2):94-99. doi: 10.1097/SPC.0000000000000494. PMID: 32332210
Schug SA, Ting S
Drugs 2017 May;77(7):747-763. doi: 10.1007/s40265-017-0727-z. PMID: 28337672
Patt RB, Ellison NM
Oncology (Williston Park) 1998 Jul;12(7):1035-46; discussion 1049-52. PMID: 9684277

Recent systematic reviews

Liossi C, Greenfield K, Schoth DE, Mott C, Jassal S, Fraser LK, Rajapakse D, Howard RF, Johnson M, Anderson AK, Harrop E
J Pain Symptom Manage 2021 Nov;62(5):1041-1064. Epub 2021 Apr 30 doi: 10.1016/j.jpainsymman.2021.04.018. PMID: 33933619
Brant JM, Rodgers BB, Gallagher E, Sundaramurthi T
Clin J Oncol Nurs 2017 Jun 1;21(3 Suppl):71-80. doi: 10.1188/17.CJON.S3.71-80. PMID: 28524907
Davies AN
Curr Pain Headache Rep 2014 Jun;18(6):420. doi: 10.1007/s11916-014-0420-9. PMID: 24760489
Deandrea S, Corli O, Consonni D, Villani W, Greco MT, Apolone G
J Pain Symptom Manage 2014 Jan;47(1):57-76. Epub 2013 Jun 21 doi: 10.1016/j.jpainsymman.2013.02.015. PMID: 23796584
Haugen DF, Hjermstad MJ, Hagen N, Caraceni A, Kaasa S; European Palliative Care Research Collaborative (EPCRC)
Pain 2010 Jun;149(3):476-482. Epub 2010 Mar 16 doi: 10.1016/j.pain.2010.02.035. PMID: 20236762

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