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Diastolic heart failure

MedGen UID:
210051
•Concept ID:
C1135196
•
Disease or Syndrome
Synonyms: Diastolic Heart Failure; Diastolic Heart Failures; Heart Failure, Diastolic; Heart Failure, Normal Ejection Fraction; Heart Failure, Preserved Ejection Fraction
SNOMED CT: Diastolic heart failure (418304008)
 
Monarch Initiative: MONDO:0006727

Definition

Heart failure caused by abnormal myocardial relaxation during diastole leading to defective cardiac filling. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiastolic heart failure

Professional guidelines

PubMed

Management of Atrial Fibrillation Across the Spectrum of Heart Failure With Preserved and Reduced Ejection Fraction.
Reddy YNV, Borlaug BA, Gersh BJ
Circulation 2022 Jul 26;146(4):339-357. Epub 2022 Jul 25 doi: 10.1161/CIRCULATIONAHA.122.057444. PMID: 35877831
Diastolic Heart Failure: A Review of Current and Future Treatment Options.
Goldstein D, Frishman WH
Cardiol Rev 2021 Mar-Apr 01;29(2):82-88. doi: 10.1097/CRD.0000000000000303. PMID: 32101908
Constrictive pericarditis: diagnosis, management and clinical outcomes.
Welch TD
Heart 2018 May;104(9):725-731. Epub 2017 Nov 25 doi: 10.1136/heartjnl-2017-311683. PMID: 29175978

Recent clinical studies

Etiology

Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality.
Verbrugge FH, Omote K, Reddy YNV, Sorimachi H, Obokata M, Borlaug BA
Eur Heart J 2022 May 21;43(20):1941-1951. doi: 10.1093/eurheartj/ehab911. PMID: 35139159Free PMC Article
Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis.
Arenas DJ, Beltran S, Zhou S, Goldberg LR
Sci Rep 2020 Nov 13;10(1):19795. doi: 10.1038/s41598-020-76273-1. PMID: 33188223Free PMC Article
How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G
Eur Heart J 2019 Oct 21;40(40):3297-3317. doi: 10.1093/eurheartj/ehz641. PMID: 31504452
Prediabetes: Why Should We Care?
Zand A, Ibrahim K, Patham B
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):289-297. doi: 10.14797/mdcj-14-4-289. PMID: 30788015Free PMC Article
Constrictive pericarditis: diagnosis, management and clinical outcomes.
Welch TD
Heart 2018 May;104(9):725-731. Epub 2017 Nov 25 doi: 10.1136/heartjnl-2017-311683. PMID: 29175978

Diagnosis

Cardiac Amyloidosis.
Bloom MW, Gorevic PD
Ann Intern Med 2023 Mar;176(3):ITC33-ITC48. Epub 2023 Mar 14 doi: 10.7326/AITC202303210. PMID: 36913688
Diastolic Heart Failure: A Review of Current and Future Treatment Options.
Goldstein D, Frishman WH
Cardiol Rev 2021 Mar-Apr 01;29(2):82-88. doi: 10.1097/CRD.0000000000000303. PMID: 32101908
Prediabetes: Why Should We Care?
Zand A, Ibrahim K, Patham B
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):289-297. doi: 10.14797/mdcj-14-4-289. PMID: 30788015Free PMC Article
Constrictive Pericarditis.
Welch TD, Oh JK
Cardiol Clin 2017 Nov;35(4):539-549. doi: 10.1016/j.ccl.2017.07.007. PMID: 29025545
Diagnosis and evaluation of heart failure.
King M, Kingery J, Casey B
Am Fam Physician 2012 Jun 15;85(12):1161-8. PMID: 22962896

Therapy

NAD(+) Repletion Reverses Heart Failure With Preserved Ejection Fraction.
Tong D, Schiattarella GG, Jiang N, Altamirano F, Szweda PA, Elnwasany A, Lee DI, Yoo H, Kass DA, Szweda LI, Lavandero S, Verdin E, Gillette TG, Hill JA
Circ Res 2021 May 28;128(11):1629-1641. Epub 2021 Apr 22 doi: 10.1161/CIRCRESAHA.120.317046. PMID: 33882692Free PMC Article
Diastolic Heart Failure: A Review of Current and Future Treatment Options.
Goldstein D, Frishman WH
Cardiol Rev 2021 Mar-Apr 01;29(2):82-88. doi: 10.1097/CRD.0000000000000303. PMID: 32101908
Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis.
Arenas DJ, Beltran S, Zhou S, Goldberg LR
Sci Rep 2020 Nov 13;10(1):19795. doi: 10.1038/s41598-020-76273-1. PMID: 33188223Free PMC Article
Prediabetes: Why Should We Care?
Zand A, Ibrahim K, Patham B
Methodist Debakey Cardiovasc J 2018 Oct-Dec;14(4):289-297. doi: 10.14797/mdcj-14-4-289. PMID: 30788015Free PMC Article
Heart failure.
McKelvie RS
BMJ Clin Evid 2011 Aug 30;2011 PMID: 21878135Free PMC Article

Prognosis

Cardiac Amyloidosis.
Bloom MW, Gorevic PD
Ann Intern Med 2023 Mar;176(3):ITC33-ITC48. Epub 2023 Mar 14 doi: 10.7326/AITC202303210. PMID: 36913688
Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality.
Verbrugge FH, Omote K, Reddy YNV, Sorimachi H, Obokata M, Borlaug BA
Eur Heart J 2022 May 21;43(20):1941-1951. doi: 10.1093/eurheartj/ehab911. PMID: 35139159Free PMC Article
Left Atrial Structure and Function, and Left Ventricular Diastolic Dysfunction: JACC State-of-the-Art Review.
Thomas L, Marwick TH, Popescu BA, Donal E, Badano LP
J Am Coll Cardiol 2019 Apr 23;73(15):1961-1977. doi: 10.1016/j.jacc.2019.01.059. PMID: 31000000
A Test in Context: E/A and E/e' to Assess Diastolic Dysfunction and LV Filling Pressure.
Mitter SS, Shah SJ, Thomas JD
J Am Coll Cardiol 2017 Mar 21;69(11):1451-1464. doi: 10.1016/j.jacc.2016.12.037. PMID: 28302294
Exercise intolerance.
Kitzman DW, Groban L
Heart Fail Clin 2008 Jan;4(1):99-115. doi: 10.1016/j.hfc.2007.12.002. PMID: 18313628Free PMC Article

Clinical prediction guides

Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9.
Trogisch FA, Abouissa A, Keles M, Birke A, Fuhrmann M, Dittrich GM, Weinzierl N, Wink E, Cordero J, Elsherbiny A, Martin-Garrido A, Grein S, Hemanna S, Hofmann E, Nicin L, Bibli SI, Airik R, Kispert A, Kist R, Quanchao S, Kürschner SW, Winkler M, Gretz N, Mogler C, Korff T, Koch PS, Dimmeler S, Dobreva G, Heineke J
Sci Transl Med 2024 Feb 28;16(736):eabq4581. doi: 10.1126/scitranslmed.abq4581. PMID: 38416842
Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.
Mohiuddin MM, Singh AK, Scobie L, Goerlich CE, Grazioli A, Saharia K, Crossan C, Burke A, Drachenberg C, Oguz C, Zhang T, Lewis B, Hershfeld A, Sentz F, Tatarov I, Mudd S, Braileanu G, Rice K, Paolini JF, Bondensgaard K, Vaught T, Kuravi K, Sorrells L, Dandro A, Ayares D, Lau C, Griffith BP
Lancet 2023 Jul 29;402(10399):397-410. Epub 2023 Jun 29 doi: 10.1016/S0140-6736(23)00775-4. PMID: 37393920Free PMC Article
Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality.
Verbrugge FH, Omote K, Reddy YNV, Sorimachi H, Obokata M, Borlaug BA
Eur Heart J 2022 May 21;43(20):1941-1951. doi: 10.1093/eurheartj/ehab911. PMID: 35139159Free PMC Article
How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G
Eur Heart J 2019 Oct 21;40(40):3297-3317. doi: 10.1093/eurheartj/ehz641. PMID: 31504452
Heart failure.
McKelvie RS
BMJ Clin Evid 2011 Aug 30;2011 PMID: 21878135Free PMC Article

Recent systematic reviews

Cocaine, cardiomyopathy, and heart failure: a systematic review and meta-analysis.
Arenas DJ, Beltran S, Zhou S, Goldberg LR
Sci Rep 2020 Nov 13;10(1):19795. doi: 10.1038/s41598-020-76273-1. PMID: 33188223Free PMC Article
Effect of exercise on diastolic function in heart failure patients: a systematic review and meta-analysis.
Pearson MJ, Mungovan SF, Smart NA
Heart Fail Rev 2017 Mar;22(2):229-242. doi: 10.1007/s10741-017-9600-0. PMID: 28229273
Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis.
Sanfilippo F, Corredor C, Fletcher N, Landesberg G, Benedetto U, Foex P, Cecconi M
Intensive Care Med 2015 Jun;41(6):1004-13. Epub 2015 Mar 24 doi: 10.1007/s00134-015-3748-7. PMID: 25800584
Heart failure.
McKelvie RS
BMJ Clin Evid 2011 Aug 30;2011 PMID: 21878135Free PMC Article
Heart failure.
McKelvie RS
BMJ Clin Evid 2010 Feb 25;2010 PMID: 21718583Free PMC Article

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