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Gestational trophoblastic neoplasm

MedGen UID:
210107
Concept ID:
C1135868
Neoplastic Process
Synonyms: Gestational Trophoblastic Neoplasia; Gestational Trophoblastic Neoplasm; Gestational Trophoblastic Neoplasms; Neoplasia, Gestational Trophoblastic; Neoplasm, Gestational Trophoblastic; Neoplasms, Gestational Trophoblastic; Trophoblastic Neoplasia, Gestational; Trophoblastic Neoplasm, Gestational; Trophoblastic Neoplasms, Gestational
SNOMED CT: Persistent trophoblastic disease (609519004); Gestational trophoblastic neoplasia (609517002); Persistent gestational trophoblastic disease (609519004); Gestational trophoblastic neoplasia (609519004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018944
Orphanet: ORPHA59305

Definition

Disorder characterised by abnormal proliferation of trophoblasts during pregnancy, of a type which is invasive or metastatic. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGestational trophoblastic neoplasm
Follow this link to review classifications for Gestational trophoblastic neoplasm in Orphanet.

Professional guidelines

PubMed

Wang A, Zhang H
Contrast Media Mol Imaging 2022;2022:3932460. Epub 2022 Aug 11 doi: 10.1155/2022/3932460. PMID: 36017013Free PMC Article
Kanno T, Matsui H, Akizawa Y, Usui H, Shozu M
J Gynecol Oncol 2018 Nov;29(6):e89. doi: 10.3802/jgo.2018.29.e89. PMID: 30207097Free PMC Article
Tepper R, Shulman A, Altaras M, Goldberger S, Maymon R, Holzinger M, Beyth Y
Gynecol Obstet Invest 1994;38(1):14-7. doi: 10.1159/000292436. PMID: 7959318

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2022

Recent clinical studies

Etiology

Wu Q, Peng M, Lv C, Chen L, Mao X, Lin T, Sun P, Wang Y
Clin Transl Oncol 2023 Apr;25(4):1114-1123. Epub 2022 Dec 5 doi: 10.1007/s12094-022-03021-4. PMID: 36471225
Li Y, Chen D, Yu H, Xia R, Zhang X, Zheng W
Curr Probl Cancer 2022 Jun;46(3):100861. Epub 2022 Mar 29 doi: 10.1016/j.currproblcancer.2022.100861. PMID: 35421635
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Cho EJ, Chun SM, Park H, Sung CO, Kim KR
Gynecol Oncol 2020 Apr;157(1):151-160. Epub 2020 Jan 15 doi: 10.1016/j.ygyno.2019.09.022. PMID: 31954539
Monchek R, Wiedaseck S
J Midwifery Womens Health 2012 May-Jun;57(3):255-9. Epub 2012 May 15 doi: 10.1111/j.1542-2011.2012.00177.x. PMID: 22587615

Diagnosis

Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Xu D, Feng F, Pei Y, Zhang Y, Wu Y, Guo Y, Cui W
Am J Reprod Immunol 2020 May;83(5):e13233. Epub 2020 Apr 16 doi: 10.1111/aji.13233. PMID: 32187420
Banach P, Dereziński P, Matysiak J, Horała A, Swiatly A, Jasiński P, Kokot ZJ, Nowak-Markwitz E
Life Sci 2018 Oct 15;211:25-30. Epub 2018 Sep 6 doi: 10.1016/j.lfs.2018.08.070. PMID: 30195618
Monchek R, Wiedaseck S
J Midwifery Womens Health 2012 May-Jun;57(3):255-9. Epub 2012 May 15 doi: 10.1111/j.1542-2011.2012.00177.x. PMID: 22587615
Behtash N, Karimi Zarchi M
J Cancer Res Clin Oncol 2008 Jan;134(1):1-6. Epub 2007 Aug 16 doi: 10.1007/s00432-007-0208-y. PMID: 17701427

Therapy

Patel SP, Othus M, Chae YK, Dennis MJ, Gordon S, Mutch D, Samlowski W, Robinson WRR, Sharon E, Ryan C, Lopez G, Plets M, Blanke C, Kurzrock R
Clin Cancer Res 2024 Jan 5;30(1):33-38. doi: 10.1158/1078-0432.CCR-23-2293. PMID: 37882676Free PMC Article
Loo KCY, Lim YN, Kiu DKL, Sim WW
BMJ Case Rep 2022 May 18;15(5) doi: 10.1136/bcr-2022-249474. PMID: 35584862Free PMC Article
Li Y, Chen D, Yu H, Xia R, Zhang X, Zheng W
Curr Probl Cancer 2022 Jun;46(3):100861. Epub 2022 Mar 29 doi: 10.1016/j.currproblcancer.2022.100861. PMID: 35421635
Anantharaju AA, Pallavi VR, Bafna UD, Rathod PS, R VC, K S, Kundargi R
Int J Gynecol Cancer 2019 Mar;29(3):547-553. Epub 2019 Jan 29 doi: 10.1136/ijgc-2018-000050. PMID: 30700567
Mousavi AS, Zamani A, Khorasanizadeh F, Gilani MM, Zendehdel K
J Obstet Gynaecol Res 2015 May;41(5):776-83. Epub 2014 Dec 10 doi: 10.1111/jog.12613. PMID: 25492546

Prognosis

Wu Q, Peng M, Lv C, Chen L, Mao X, Lin T, Sun P, Wang Y
Clin Transl Oncol 2023 Apr;25(4):1114-1123. Epub 2022 Dec 5 doi: 10.1007/s12094-022-03021-4. PMID: 36471225
Li Y, Chen D, Yu H, Xia R, Zhang X, Zheng W
Curr Probl Cancer 2022 Jun;46(3):100861. Epub 2022 Mar 29 doi: 10.1016/j.currproblcancer.2022.100861. PMID: 35421635
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Xu D, Feng F, Pei Y, Zhang Y, Wu Y, Guo Y, Cui W
Am J Reprod Immunol 2020 May;83(5):e13233. Epub 2020 Apr 16 doi: 10.1111/aji.13233. PMID: 32187420
Banach P, Dereziński P, Matysiak J, Horała A, Swiatly A, Jasiński P, Kokot ZJ, Nowak-Markwitz E
Life Sci 2018 Oct 15;211:25-30. Epub 2018 Sep 6 doi: 10.1016/j.lfs.2018.08.070. PMID: 30195618

Clinical prediction guides

Patel SP, Othus M, Chae YK, Dennis MJ, Gordon S, Mutch D, Samlowski W, Robinson WRR, Sharon E, Ryan C, Lopez G, Plets M, Blanke C, Kurzrock R
Clin Cancer Res 2024 Jan 5;30(1):33-38. doi: 10.1158/1078-0432.CCR-23-2293. PMID: 37882676Free PMC Article
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Xu D, Feng F, Pei Y, Zhang Y, Wu Y, Guo Y, Cui W
Am J Reprod Immunol 2020 May;83(5):e13233. Epub 2020 Apr 16 doi: 10.1111/aji.13233. PMID: 32187420
Anantharaju AA, Pallavi VR, Bafna UD, Rathod PS, R VC, K S, Kundargi R
Int J Gynecol Cancer 2019 Mar;29(3):547-553. Epub 2019 Jan 29 doi: 10.1136/ijgc-2018-000050. PMID: 30700567
Sreenivasan P, Kumar S, Kumar KK
Indian Pediatr 2014 Sep;51(9):745-6. PMID: 25228614

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2022
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2022

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