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monoclonal gammopathy

MedGen UID:
210153
Concept ID:
C1136085
Neoplastic Process
Synonyms: Gammapathy, Monoclonal; Gammopathy, Monoclonal; Monoclonal Gammapathies; Monoclonal Gammapathy; Monoclonal Gammopathies; Monoclonal Gammopathy
SNOMED CT: Monoclonal gammopathy (clinical) (109983007); Monoclonal gammopathy (109983007); Monoclonal paraproteinemia (109983007); Monoclonal gammopathy (35601003)
 
Monarch Initiative: MONDO:0004960

Definition

An abnormal laboratory test result indicating the presence of monoclonal immunoglobulins in the blood or urine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVmonoclonal gammopathy

Professional guidelines

PubMed

Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM
Haematologica 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953. PMID: 35770530Free PMC Article
Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH
Med Sci (Basel) 2021 Jan 20;9(1) doi: 10.3390/medsci9010003. PMID: 33498356Free PMC Article
Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH
Nat Rev Nephrol 2019 Jan;15(1):45-59. doi: 10.1038/s41581-018-0077-4. PMID: 30510265Free PMC Article

Recent clinical studies

Etiology

Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848

Diagnosis

Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Therapy

Kapoor P, Rajkumar SV
Blood Rev 2023 Nov;62:101129. Epub 2023 Aug 26 doi: 10.1016/j.blre.2023.101129. PMID: 37659912Free PMC Article
Palladini G, Milani P, Merlini G
Blood 2020 Dec 3;136(23):2620-2627. doi: 10.1182/blood.2020006913. PMID: 33270858
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
Kazandjian D
Semin Oncol 2016 Dec;43(6):676-681. Epub 2016 Nov 10 doi: 10.1053/j.seminoncol.2016.11.004. PMID: 28061985Free PMC Article

Prognosis

Alejo E, Puertas B, Mateos MV
Med Clin (Barc) 2023 Sep 8;161(5):217-224. Epub 2023 Jun 15 doi: 10.1016/j.medcli.2023.05.006. PMID: 37330390
Gozzetti A, Guarnieri A, Zamagni E, Zakharova E, Coriu D, Bittrich M, Pika T, Tovar N, Schutz N, Ciofini S, Peña C, Rocchi S, Rassner M, Avivi I, Waszczuk-Gajda A, Chhabra S, Usnarska-Zubkiewicz L, González-Calle V, Mateos MV, Bocchia M, Bigi F, Füllgraf H, Bhasin-Chhabra B, Gentile M, Davila J, Vesole DH, Cavo M, Thapa B, Crusoe E, Einsele H, Legiec W, Charliński G, Jurczyszyn A
Am J Hematol 2022 Jul;97(7):877-884. Epub 2022 Apr 20 doi: 10.1002/ajh.26566. PMID: 35389534Free PMC Article
Ho M, Patel A, Goh CY, Moscvin M, Zhang L, Bianchi G
Leukemia 2020 Dec;34(12):3111-3125. Epub 2020 Oct 12 doi: 10.1038/s41375-020-01051-x. PMID: 33046818
Kyle RA, Larson DR, Therneau TM, Dispenzieri A, Kumar S, Cerhan JR, Rajkumar SV
N Engl J Med 2018 Jan 18;378(3):241-249. doi: 10.1056/NEJMoa1709974. PMID: 29342381Free PMC Article
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797

Clinical prediction guides

Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Fermand JP, Bridoux F, Dispenzieri A, Jaccard A, Kyle RA, Leung N, Merlini G
Blood 2018 Oct 4;132(14):1478-1485. Epub 2018 Jul 16 doi: 10.1182/blood-2018-04-839480. PMID: 30012636
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Recent systematic reviews

Gertz MA, Dispenzieri A
JAMA 2020 Jul 7;324(1):79-89. doi: 10.1001/jama.2020.5493. PMID: 32633805
Veronese N, Luchini C, Solmi M, Sergi G, Manzato E, Stubbs B
J Bone Miner Metab 2018 Jan;36(1):128-132. Epub 2017 Feb 27 doi: 10.1007/s00774-017-0817-8. PMID: 28243796
Miguel D, Lukacs J, Illing T, Elsner P
J Eur Acad Dermatol Venereol 2017 Feb;31(2):221-235. Epub 2016 Jul 19 doi: 10.1111/jdv.13786. PMID: 27436448
Arends M, van Dussen L, Biegstraaten M, Hollak CE
Br J Haematol 2013 Jun;161(6):832-42. Epub 2013 Apr 18 doi: 10.1111/bjh.12335. PMID: 23594419
Wadhera RK, Rajkumar SV
Mayo Clin Proc 2010 Oct;85(10):933-42. Epub 2010 Aug 16 doi: 10.4065/mcp.2010.0337. PMID: 20713974Free PMC Article

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