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monoclonal gammopathy

MedGen UID:
210153
•Concept ID:
C1136085
•
Neoplastic Process
Synonyms: Gammapathy, Monoclonal; Gammopathy, Monoclonal; Monoclonal Gammapathies; Monoclonal Gammapathy; Monoclonal Gammopathies; Monoclonal Gammopathy
SNOMED CT: Monoclonal gammopathy (clinical) (109983007); Monoclonal gammopathy (109983007); Monoclonal paraproteinemia (109983007); Monoclonal gammopathy (35601003)
 
Monarch Initiative: MONDO:0004960

Definition

An abnormal laboratory test result indicating the presence of monoclonal immunoglobulins in the blood or urine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVmonoclonal gammopathy

Professional guidelines

PubMed

IgM monoclonal gammopathies of clinical significance: diagnosis and management.
Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM
Haematologica 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953. PMID: 35770530Free PMC Article
Immunoglobulin light chain amyloidosis: 2022 update on diagnosis, prognosis, and treatment.
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Epidemiology, Staging, and Management of Multiple Myeloma.
Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH
Med Sci (Basel) 2021 Jan 20;9(1) doi: 10.3390/medsci9010003. PMID: 33498356Free PMC Article

Recent clinical studies

Etiology

Monoclonal Gammopathy of Undetermined Significance.
Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
Smoldering multiple myeloma current treatment algorithms.
Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
Multiple myeloma.
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Monoclonal gammopathy of renal significance (MGRS) histopathologic classification, diagnostic workup, and therapeutic options.
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Monoclonal gammopathy of undetermined significance.
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848

Diagnosis

Monoclonal Gammopathy of Undetermined Significance.
Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
Multiple myeloma.
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Monoclonal gammopathy of renal significance (MGRS) histopathologic classification, diagnostic workup, and therapeutic options.
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Monoclonal Gammopathy-Associated Peripheral Neuropathy: Diagnosis and Management.
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
Understanding and interpreting serum protein electrophoresis.
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Therapy

Management of AL amyloidosis in 2020.
Palladini G, Milani P, Merlini G
Blood 2020 Dec 3;136(23):2620-2627. doi: 10.1182/blood.2020006913. PMID: 33270858
Multiple myeloma.
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Monoclonal Gammopathy-Associated Peripheral Neuropathy: Diagnosis and Management.
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
Multiple myeloma epidemiology and survival: A unique malignancy.
Kazandjian D
Semin Oncol 2016 Dec;43(6):676-681. Epub 2016 Nov 10 doi: 10.1053/j.seminoncol.2016.11.004. PMID: 28061985Free PMC Article
Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant.
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group
Blood 2012 Nov 22;120(22):4292-5. Epub 2012 Oct 9 doi: 10.1182/blood-2012-07-445304. PMID: 23047823

Prognosis

Monoclonal gammopathy of renal significance (MGRS): Real-world data on outcomes and prognostic factors.
Gozzetti A, Guarnieri A, Zamagni E, Zakharova E, Coriu D, Bittrich M, Pika T, Tovar N, Schutz N, Ciofini S, Peña C, Rocchi S, Rassner M, Avivi I, Waszczuk-Gajda A, Chhabra S, Usnarska-Zubkiewicz L, González-Calle V, Mateos MV, Bocchia M, Bigi F, Füllgraf H, Bhasin-Chhabra B, Gentile M, Davila J, Vesole DH, Cavo M, Thapa B, Crusoe E, Einsele H, Legiec W, Charliński G, Jurczyszyn A
Am J Hematol 2022 Jul;97(7):877-884. Epub 2022 Apr 20 doi: 10.1002/ajh.26566. PMID: 35389534Free PMC Article
Changing paradigms in diagnosis and treatment of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).
Ho M, Patel A, Goh CY, Moscvin M, Zhang L, Bianchi G
Leukemia 2020 Dec;34(12):3111-3125. Epub 2020 Oct 12 doi: 10.1038/s41375-020-01051-x. PMID: 33046818
Monoclonal Gammopathy of Undetermined Significance (MGUS)Monoclonal Gammopathy of Undetermined Significance (MGUS).
Viera S, Ludek P, Zdeněk A, Marta K, Martin Š, Sabina Š, Zdeněk K
Klin Onkol 2018 Summer;31(4):270-276. doi: 10.14735/amko2018270. PMID: 30541309
Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance.
Kyle RA, Larson DR, Therneau TM, Dispenzieri A, Kumar S, Cerhan JR, Rajkumar SV
N Engl J Med 2018 Jan 18;378(3):241-249. doi: 10.1056/NEJMoa1709974. PMID: 29342381Free PMC Article
Multiple myeloma.
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797

Clinical prediction guides

Smoldering multiple myeloma current treatment algorithms.
Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
Update on the Diagnosis and Treatment of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes) Syndrome: A Review.
Khouri J, Nakashima M, Wong S
JAMA Oncol 2021 Sep 1;7(9):1383-1391. doi: 10.1001/jamaoncol.2021.0586. PMID: 34081097
Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications.
Fermand JP, Bridoux F, Dispenzieri A, Jaccard A, Kyle RA, Leung N, Merlini G
Blood 2018 Oct 4;132(14):1478-1485. Epub 2018 Jul 16 doi: 10.1182/blood-2018-04-839480. PMID: 30012636
Multiple myeloma.
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Understanding and interpreting serum protein electrophoresis.
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Recent systematic reviews

Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review.
Gertz MA, Dispenzieri A
JAMA 2020 Jul 7;324(1):79-89. doi: 10.1001/jama.2020.5493. PMID: 32633805
Monoclonal gammopathy of undetermined significance and bone health outcomes: a systematic review and exploratory meta-analysis.
Veronese N, Luchini C, Solmi M, Sergi G, Manzato E, Stubbs B
J Bone Miner Metab 2018 Jan;36(1):128-132. Epub 2017 Feb 27 doi: 10.1007/s00774-017-0817-8. PMID: 28243796
Treatment of necrobiotic xanthogranuloma - a systematic review.
Miguel D, Lukacs J, Illing T, Elsner P
J Eur Acad Dermatol Venereol 2017 Feb;31(2):221-235. Epub 2016 Jul 19 doi: 10.1111/jdv.13786. PMID: 27436448
Malignancies and monoclonal gammopathy in Gaucher disease; a systematic review of the literature.
Arends M, van Dussen L, Biegstraaten M, Hollak CE
Br J Haematol 2013 Jun;161(6):832-42. Epub 2013 Apr 18 doi: 10.1111/bjh.12335. PMID: 23594419
Prevalence of monoclonal gammopathy of undetermined significance: a systematic review.
Wadhera RK, Rajkumar SV
Mayo Clin Proc 2010 Oct;85(10):933-42. Epub 2010 Aug 16 doi: 10.4065/mcp.2010.0337. PMID: 20713974Free PMC Article

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