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HIV-Associated Lipodystrophy Syndrome

MedGen UID:: 210205
•Concept ID:: C1136321
•: Disease or Syndrome

Synonyms:

HIV Associated Lipodystrophy; HIV Associated Lipodystrophy Syndrome; HIV Lipodystrophy Syndrome; HIV-Associated Lipodystrophy; Lipodystrophy Syndrome, HIV; Lipodystrophy Syndrome, HIV-Associated; Lipodystrophy, HIV-Associated

Definition

Defective metabolism leading to fat maldistribution in patients infected with HIV. The etiology appears to be multifactorial and probably involves some combination of infection-induced alterations in metabolism, direct effects of antiretroviral therapy, and patient-related factors. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHIV-Associated Lipodystrophy Syndrome

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease Attributes
    - Infectious disease
      - Blood-Borne Infections
        Human immunodeficiency virus infection
        HIV-Associated Lipodystrophy Syndrome

Professional guidelines

PubMed

Recombinant human growth hormone: rationale for use in the treatment of HIV-associated lipodystrophy.

Benedini S, Terruzzi I, Lazzarin A, Luzi L
BioDrugs 2008;22(2):101-12. doi: 10.2165/00063030-200822020-00003. PMID: 18345707

Treatment options for lipodystrophy in HIV-positive patients.

Behrens GM
Expert Opin Pharmacother 2008 Jan;9(1):39-52. doi: 10.1517/14656566.9.1.39. PMID: 18076337

HIV and HIV treatment: effects on fats, glucose and lipids.

Gkrania-Klotsas E, Klotsas AE
Br Med Bull 2007;84:49-68. Epub 2007 Nov 2 doi: 10.1093/bmb/ldm030. PMID: 17981955

See all (8)

Recent clinical studies

Etiology

Impact of inflammatory cytokine and adipokine gene variations in the development of HIV-associated lipodystrophy.

Namdev G, Choudhari R, Shyamveer, Khan AA, Ali N, Rashid S, Singh HO
J Gene Med 2023 Aug;25(8):e3512. Epub 2023 Apr 26 doi: 10.1002/jgm.3512. PMID: 37186064

Thiazolidinediones in the treatment of HIV/HAART-associated lipodystrophy syndrome.

Edgeworth A, Treacy MP, Hurst TP
AIDS Rev 2013 Jul-Sep;15(3):171-80. PMID: 24002201

Nutrition and the HIV-associated lipodystrophy syndrome.

Loonam CR, Mullen A
Nutr Res Rev 2012 Dec;25(2):267-87. doi: 10.1017/S0954422411000138. PMID: 23174511

Drug-induced lipotoxicity: lipodystrophy associated with HIV-1 infection and antiretroviral treatment.

Villarroya F, Domingo P, Giralt M
Biochim Biophys Acta 2010 Mar;1801(3):392-9. Epub 2009 Sep 30 doi: 10.1016/j.bbalip.2009.09.018. PMID: 19800025

HIV-associated facial lipoatrophy.

James J, Carruthers A, Carruthers J
Dermatol Surg 2002 Nov;28(11):979-86. doi: 10.1046/j.1524-4725.2002.02099.x. PMID: 12460289

See all (616)

Diagnosis

Clinical Features and Management of Non-HIV-Related Lipodystrophy in Children: A Systematic Review.

Gupta N, Asi N, Farah W, Almasri J, Barrionuevo P, Alsawas M, Wang Z, Haymond MW, Brown RJ, Murad MH
J Clin Endocrinol Metab 2017 Feb 1;102(2):363-374. doi: 10.1210/jc.2016-2271. PMID: 27967300 Free PMC Article

Leptin in congenital and HIV-associated lipodystrophy.

Tsoukas MA, Farr OM, Mantzoros CS
Metabolism 2015 Jan;64(1):47-59. Epub 2014 Aug 12 doi: 10.1016/j.metabol.2014.07.017. PMID: 25267014

Thiazolidinediones in the treatment of HIV/HAART-associated lipodystrophy syndrome.

Edgeworth A, Treacy MP, Hurst TP
AIDS Rev 2013 Jul-Sep;15(3):171-80. PMID: 24002201

Thiazolidinediones in dermatology.

Boyd AS
Int J Dermatol 2007 Jun;46(6):557-63. doi: 10.1111/j.1365-4632.2007.03273.x. PMID: 17550551

Panniculitis and lipodystrophy.

Eberhard BA, Ilowite NT
Curr Opin Rheumatol 2002 Sep;14(5):566-70. doi: 10.1097/00002281-200209000-00015. PMID: 12192256

See all (289)

Therapy

HIV-associated lipodystrophy: impact of antiretroviral therapy.

Guaraldi G, Stentarelli C, Zona S, Santoro A
Drugs 2013 Sep;73(13):1431-50. doi: 10.1007/s40265-013-0108-1. PMID: 24002702

Nutrition and the HIV-associated lipodystrophy syndrome.

Loonam CR, Mullen A
Nutr Res Rev 2012 Dec;25(2):267-87. doi: 10.1017/S0954422411000138. PMID: 23174511

Tesamorelin.

Grunfeld C, Dritselis A, Kirkpatrick P
Nat Rev Drug Discov 2011 Feb;10(2):95-6. doi: 10.1038/nrd3362. PMID: 21283099

HIV-associated facial lipoatrophy.

James J, Carruthers A, Carruthers J
Dermatol Surg 2002 Nov;28(11):979-86. doi: 10.1046/j.1524-4725.2002.02099.x. PMID: 12460289

Panniculitis and lipodystrophy.

Eberhard BA, Ilowite NT
Curr Opin Rheumatol 2002 Sep;14(5):566-70. doi: 10.1097/00002281-200209000-00015. PMID: 12192256

See all (819)

Prognosis

HIV infection and cardiovascular disease.

Hemkens LG, Bucher HC
Eur Heart J 2014 Jun 1;35(21):1373-81. Epub 2014 Jan 9 doi: 10.1093/eurheartj/eht528. PMID: 24408888

Adipokines in the HIV/HAART-associated lipodystrophy syndrome.

Paruthi J, Gill N, Mantzoros CS
Metabolism 2013 Sep;62(9):1199-205. Epub 2013 May 24 doi: 10.1016/j.metabol.2013.04.014. PMID: 23706880

HIV therapy, metabolic syndrome, and cardiovascular risk.

Pao V, Lee GA, Grunfeld C
Curr Atheroscler Rep 2008 Feb;10(1):61-70. doi: 10.1007/s11883-008-0010-6. PMID: 18366987 Free PMC Article

HIV lipodystrophy and its metabolic consequences: implications for clinical practice.

Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641

Lipodystrophy syndrome by HAART in HIV-infected patients: manifestation, mechanisms and management.

Hirsch HH, Battegay M
Infection 2002 Oct;30(5):293-8. doi: 10.1007/s15010-002-3044-7. PMID: 12382089

See all (174)

Clinical prediction guides

Can Biomarkers Advance HIV Research and Care in the Antiretroviral Therapy Era?

Justice AC, Erlandson KM, Hunt PW, Landay A, Miotti P, Tracy RP
J Infect Dis 2018 Jan 30;217(4):521-528. doi: 10.1093/infdis/jix586. PMID: 29165684 Free PMC Article

Clinical Features and Management of Non-HIV-Related Lipodystrophy in Children: A Systematic Review.

Leptin in congenital and HIV-associated lipodystrophy.

Tsoukas MA, Farr OM, Mantzoros CS
Metabolism 2015 Jan;64(1):47-59. Epub 2014 Aug 12 doi: 10.1016/j.metabol.2014.07.017. PMID: 25267014

HIV-associated lipodystrophy: impact of antiretroviral therapy.

Guaraldi G, Stentarelli C, Zona S, Santoro A
Drugs 2013 Sep;73(13):1431-50. doi: 10.1007/s40265-013-0108-1. PMID: 24002702

Kino T, Mirani M, Alesci S, Chrousos GP
Horm Metab Res 2003 Mar;35(3):129-36. doi: 10.1055/s-2003-39072. PMID: 12734771

See all (325)

Recent systematic reviews

Clinical Features and Management of Non-HIV-Related Lipodystrophy in Children: A Systematic Review.

Effects of physical training for people with HIV-associated lipodystrophy syndrome: a systematic review.

Pedro RE, Guariglia DA, Peres SB, Moraes SM
J Sports Med Phys Fitness 2017 May;57(5):685-694. Epub 2016 Oct 20 doi: 10.23736/S0022-4707.16.06234-4. PMID: 27763579

A systematic review of filler agents for aesthetic treatment of HIV facial lipoatrophy (FLA).

Jagdeo J, Ho D, Lo A, Carruthers A
J Am Acad Dermatol 2015 Dec;73(6):1040-54.e14. Epub 2015 Oct 23 doi: 10.1016/j.jaad.2015.08.040. PMID: 26481056

Growth hormone axis treatments for HIV-associated lipodystrophy: a systematic review of placebo-controlled trials.

Sivakumar T, Mechanic O, Fehmie DA, Paul B
HIV Med 2011 Sep;12(8):453-62. Epub 2011 Jan 25 doi: 10.1111/j.1468-1293.2010.00906.x. PMID: 21265979

A systematic review of permanent and semipermanent dermal fillers for HIV-associated facial lipoatrophy.

Sturm LP, Cooter RD, Mutimer KL, Graham JC, Maddern GJ
AIDS Patient Care STDS 2009 Sep;23(9):699-714. doi: 10.1089/apc.2008.0230. PMID: 19673594

See all (8)

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HIV-Associated Lipodystrophy Syndrome

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity