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Cardiovascular syphilis

MedGen UID:
21055
•Concept ID:
C0039130
•
Disease or Syndrome
Synonyms: Cardiovascular Syphilis; Syphilis, Cardiovascular
SNOMED CT: Cardiovascular syphilis (83883001)
 
Monarch Initiative: MONDO:0004911

Definition

A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiovascular syphilis

Professional guidelines

PubMed

Management of Adult Syphilis: Key Questions to Inform the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines.
Ghanem KG
Clin Infect Dis 2015 Dec 15;61 Suppl 8:S818-36. doi: 10.1093/cid/civ714. PMID: 26602620
Treatment of cardiovascular syphilis.
St John RK
J Am Vener Dis Assoc 1976 Dec;3(2 Pt 2):148-52. PMID: 1010781
Treatment of cardiovascular syphilis.
DAVIS JA Jr, HOLLEY HL
Postgrad Med 1952 Jul;12(1):84-8. doi: 10.1080/00325481.1952.11708053. PMID: 14957681

Recent clinical studies

Etiology

Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017.
Landry T, Smyczek P, Cooper R, Gratrix J, Bertholet L, Read R, Romanowski B, Singh AE
BMJ Open 2019 Jun 22;9(6):e025995. doi: 10.1136/bmjopen-2018-025995. PMID: 31230001Free PMC Article
Syphilitic aortic aneurysm.
Yuan SM
Z Rheumatol 2018 Oct;77(8):741-748. doi: 10.1007/s00393-018-0519-1. PMID: 30073493
Cardiovascular syphilis: down but not out!
Dang G, Saleh M, Tandon T, Sirineni G, Alla VM
Eur Heart J Cardiovasc Imaging 2018 Jun 1;19(6):1. doi: 10.1093/ehjci/jey052. PMID: 29608710
Syphilitic aortitis and its complications in the modern era.
Drago F, Merlo G, Rebora A, Parodi A
G Ital Dermatol Venereol 2018 Oct;153(5):698-706. Epub 2016 Dec 16 doi: 10.23736/S0392-0488.16.05522-X. PMID: 27982548
Current status of the treatment of syphilis.
Barrett-Connor E
West J Med 1975 Jan;122(1):7-11. PMID: 1089007Free PMC Article

Diagnosis

Syphilitic Aortitis.
Miller SA, Ladich ER
N Engl J Med 2022 May 19;386(20):e55. Epub 2022 May 14 doi: 10.1056/NEJMicm2110835. PMID: 35550616
Aortitis Presenting as Fever of Unknown Origin.
Yuan SM, Lin H
Ann Thorac Cardiovasc Surg 2018 Dec 20;24(6):279-287. Epub 2018 Aug 29 doi: 10.5761/atcs.ra.18-00136. PMID: 30158332Free PMC Article
Syphilitic aortic aneurysm.
Yuan SM
Z Rheumatol 2018 Oct;77(8):741-748. doi: 10.1007/s00393-018-0519-1. PMID: 30073493
Syphilitic aortitis and its complications in the modern era.
Drago F, Merlo G, Rebora A, Parodi A
G Ital Dermatol Venereol 2018 Oct;153(5):698-706. Epub 2016 Dec 16 doi: 10.23736/S0392-0488.16.05522-X. PMID: 27982548
Syphilis.
Crissey JT, Denenholz DA
Clin Dermatol 1984 Jan-Mar;2(1):1-166. doi: 10.1016/0738-081x(84)90003-8. PMID: 6400314

Therapy

Cardiovascular syphilis: down but not out!
Dang G, Saleh M, Tandon T, Sirineni G, Alla VM
Eur Heart J Cardiovasc Imaging 2018 Jun 1;19(6):1. doi: 10.1093/ehjci/jey052. PMID: 29608710
Syphilis and otolaryngology.
Pletcher SD, Cheung SW
Otolaryngol Clin North Am 2003 Aug;36(4):595-605, vi. doi: 10.1016/s0030-6665(03)00025-2. PMID: 14567055
Syphilis management and treatment.
van Voorst Vader PC
Dermatol Clin 1998 Oct;16(4):699-711, xi. doi: 10.1016/s0733-8635(05)70035-8. PMID: 9891669
Syphilis.
Crissey JT, Denenholz DA
Clin Dermatol 1984 Jan-Mar;2(1):1-166. doi: 10.1016/0738-081x(84)90003-8. PMID: 6400314
Penicillin and syphilis.
Lancet 1973 Mar 24;1(7804):649. PMID: 4121853

Prognosis

Trends in Deaths Due to Syphilis, United States, 1968-2015.
Peterman TA, Kidd SE
Sex Transm Dis 2019 Jan;46(1):37-40. doi: 10.1097/OLQ.0000000000000899. PMID: 30044338Free PMC Article
Aortitis Presenting as Fever of Unknown Origin.
Yuan SM, Lin H
Ann Thorac Cardiovasc Surg 2018 Dec 20;24(6):279-287. Epub 2018 Aug 29 doi: 10.5761/atcs.ra.18-00136. PMID: 30158332Free PMC Article
Cardiovascular syphilis: down but not out!
Dang G, Saleh M, Tandon T, Sirineni G, Alla VM
Eur Heart J Cardiovasc Imaging 2018 Jun 1;19(6):1. doi: 10.1093/ehjci/jey052. PMID: 29608710
Controversies regarding giant cell (temporal, cranial) arteritis.
Eshaghian J
Doc Ophthalmol 1979 Sep 17;47(1):43-67. doi: 10.1007/BF00145369. PMID: 391520
Current status of the treatment of syphilis.
Barrett-Connor E
West J Med 1975 Jan;122(1):7-11. PMID: 1089007Free PMC Article

Clinical prediction guides

Combined Cardiovascular Syphilis and Type A Acute Aortic Dissection.
Roberts WC, Roberts CS
Am J Cardiol 2022 Apr 1;168:159-162. Epub 2022 Feb 1 doi: 10.1016/j.amjcard.2021.10.040. PMID: 35115135
Peripheral blood mononuclear cell microRNA profiles in syphilitic patients with serofast status.
Jia X, Wang Z, Liu X, Zheng H, Li J
Mol Biol Rep 2020 May;47(5):3407-3421. Epub 2020 Apr 24 doi: 10.1007/s11033-020-05421-7. PMID: 32333247
Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017.
Landry T, Smyczek P, Cooper R, Gratrix J, Bertholet L, Read R, Romanowski B, Singh AE
BMJ Open 2019 Jun 22;9(6):e025995. doi: 10.1136/bmjopen-2018-025995. PMID: 31230001Free PMC Article
Aortitis Presenting as Fever of Unknown Origin.
Yuan SM, Lin H
Ann Thorac Cardiovasc Surg 2018 Dec 20;24(6):279-287. Epub 2018 Aug 29 doi: 10.5761/atcs.ra.18-00136. PMID: 30158332Free PMC Article
Syphilitic Aortitis Diagnosis in Clinical Setting.
Fernandes B, Santos A, Carvalho L
Rev Port Cir Cardiotorac Vasc 2017 Jul-Dec;24(3-4):166. PMID: 29701397

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